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Journal Articles

Wildtype NUP98 cooperates with NPM1c to drive oncogenic transcription

Free
Sara Gama, Marcel Müller, Hannah González Dammers, Elena Haarer, Sara Peruzzi, José Gonçalves-Dias, Jan-Henning Klusmann, Lu Yang, Renee Chen, Chun-Wei Chen, Stamatis Papathanasiou, Brunangelo Falini, Lorenzo Brunetti, Hannah Uckelmann
Journal: Blood
Blood (2025) 146 (Supplement 1): 865.
https://doi.org/10.1182/blood-2025-865
Published: 2025
Journal Articles

The KMT2A-PTD oncoprotein depends on ENL but not menin to drive AML gene expression

Free
Daniela Wenge, Maria Wessels, Sydney Schweber, Meaghan Boileau, Christian Marinaccio, Wallace Bourgeois, Charles Hatton, Laura Godfrey, Yufan Shan, Thatcher Akele, Yanhe Wen, Jennifer Perry, Adrienne Dorrance, Omar Abdel-Wahab, Chun-Wei Chen, Michael Erb, Scott Armstrong
Journal: Blood
Blood (2025) 146 (Supplement 1): 321.
https://doi.org/10.1182/blood-2025-321
Published: 2025
Journal Articles

Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia

Free
Lili Ren, Honghai Zhang, Olga Bobileva, Francesco Nai, Hongjie Bi, Genevieve Baker, Lei Dong, David Guarin, Anthony Chan, Weidong Hu, Wei Li, Irena Leite, Xueer Wang, Xiaoxu Zhang, Meilin Xue, Haixia Wang, Hanjun Qin, Xiwei Wu, Lucy Ghoda, Lin Xu, Bin Zhang, Ling Li, Mark Wunderlich, James Mulloy, Courtney Jones, Seán O'Leary, Steven Rosen, Chun-Wei Chen, Nora Heisterkamp, J. Jefferson Perry, Yunsun Nam, Jianjun Chen, Xiaobo Li, Amedeo Caflisch, Rui Su
Journal: Blood
Blood (2025) 146 (Supplement 1): 2539.
https://doi.org/10.1182/blood-2025-2539
Published: 2025
Journal Articles

Therapeutic effect of menin inhibitors is reversible in AML treatment and could be enhanced by the targeting of differentiation associated chromatin complex

Free
Zhong Fan, John Mosior, Yanan Jiang, Jin Wang, Chun-Wei Chen, Xiaotian Zhang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3295.
https://doi.org/10.1182/blood-2025-3295
Published: 2025
Journal Articles

Stepwise leukemogenesis and therapeutic targets revealed in B-cell acute lymphoblastic leukemia driven by PAX5 mutations

Free
Zhilian Jia, Zunsong Hu, Lu Yang, Anthony Chan, Xiaohua Huang, Allen Mao, Ibrahim Aldoss, Lucy Ghoda, Michelle Afkhami, Guido Marcucci, Zhenhua Chen, Jianjun Chen, Chun-Wei Chen, Shai Izraeli, Markus Müschen, Nora Heisterkamp, Zhaohui Gu
Journal: Blood
Blood (2025) 146 (Supplement 1): 139.
https://doi.org/10.1182/blood-2025-139
Published: 2025
Journal Articles

CRISPR-tica.ai: A function-informed generative modeling pipeline for prioritizing drug discovery in AML

Free
Dhvani Vora, Anthony Chan, Sheela Pangeni Pokharel, Qiao Liu, Renee Chen, Bryan Chen, April Chen, Lu Yang, Chun-Wei Chen
Journal: Blood
Blood (2025) 146 (Supplement 1): 277.
https://doi.org/10.1182/blood-2025-277
Published: 2025
Journal Articles

DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

Free
Xueer Wang, Hongjie Bi, Wei Li, Lili Ren, Honghai Zhang, Lei Dong, Anthony Chan, Lu Yang, Xiaoxu Zhang, Meilin Xue, Hanjun Qin, Xiwei Wu, Johanna ten, Bin Zhang, Ling Li, Mark Wunderlich, James Mulloy, Steven Rosen, Jianjun Chen, Xiaobo Li, Chun-Wei Chen, Rui Su
Journal: Blood
Blood (2025) 146 (Supplement 1): 212.
https://doi.org/10.1182/blood-2025-212
Published: 2025
Journal Articles

Mitochondrial RNA pseudouridine reprograms metabolism and induces immunosuppression in myeloid leukemia

Free
Honghai Zhang, Xueer Wang, Lei Dong, Lili Ren, Hongjie Bi, Wei Li, Xiaoxu Zhang, Meilin Xue, Chaoling Wan, Lucy Ghoda, Mark Wunderlich, James Mulloy, Chun-Wei Chen, Ling Li, Bin Zhang, Steven Rosen, Nora Heisterkamp, Jianjun Chen, Marcin Kortylewski, Rui Su
Journal: Blood
Blood (2025) 146 (Supplement 1): 211.
https://doi.org/10.1182/blood-2025-211
Published: 2025
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Free
Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Free
Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Free
Margarita M. Dzama, Marlene Steiner, Johanna Rausch, Daniel Sasca, Jonas Schönfeld, Kerstin Kunz, Martha C. Taubert, Gerard M. McGeehan, Chun-Wei Chen, Annalisa Mupo, Patricia Hähnel, Matthias Theobald, Thomas Kindler, Richard P. Koche, George S. Vassiliou, Scott A. Armstrong, Michael W. M. Kühn
Journal: Blood
Blood (2020) 136 (21): 2442–2456.
https://doi.org/10.1182/blood.2020005037
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL -rearranged acute lymphoblastic leukemia

Free
Yinghui Zhu, Xin He, Yi-Chun Lin, Haojie Dong, Lei Zhang, Xianwei Chen, Zhihao Wang, Yudao Shen, Min Li, Hanying Wang, Jie Sun, Le Xuan Nguyen, Han Zhang, Wenjuan Jiang, Yanzhong Yang, Jianjun Chen, Markus Müschen, Chun-Wei Chen, Marina Y. Konopleva, Weili Sun, Jian Jin, Nadia Carlesso, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2019) 134 (15): 1257–1268.
https://doi.org/10.1182/blood.2019002457
Published: 2019
Includes: Supplemental data
Journal Articles

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD + acute myeloid leukemia

Free
Xin He, Yinghui Zhu, Yi-Chun Lin, Min Li, Juan Du, Haojie Dong, Jie Sun, Lei Zhu, Hanying Wang, Zonghui Ding, Lei Zhang, Lianjun Zhang, Dandan Zhao, Zhihao Wang, Herman Wu, Han Zhang, Wenjuan Jiang, Yang Xu, Jian Jin, Yudao Shen, Jeff Perry, Xinyang Zhao, Bin Zhang, Songbai Liu, Sheng-Li Xue, Binghui Shen, Chun-Wei Chen, Jianjun Chen, Samer Khaled, Ya-Huei Kuo, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2019) 134 (6): 548–560.
https://doi.org/10.1182/blood.2019001282
Published: 2019
Includes: Supplemental data
Journal Articles

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

Free
Yinghui Zhu, PhD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Lei Zhang, PhD, Yunan Miao, PhD, Jian Jin, PhD, Yudao Shen, PhD, Jianjun Chen, PhD, Markus Muschen, MD, Chun-Wei Chen, PhD, Marina Y. Konopleva, MD PhD, Weili Sun, MD PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD PhD, Guido Marcucci, Ling Li, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 892.
https://doi.org/10.1182/blood-2018-99-115139
Published: 2018
Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Free
Jae-Woong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Chun-Wei Chen, PhD, Raju Pillai, MD, Wing C Chan, MD, Stephen J Forman, Larry W Kwak, MD PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, David M Weinstock, MD, Ari M Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina Luger, MD, Mark R. Litzow, MD, Alexandre Belot, MDPhD, Gulbu Uzel, MD, Michael T McManus, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 776.
https://doi.org/10.1182/blood-2018-99-117553
Published: 2018
Journal Articles

High-Density CRISPR Scan Identifies Functional Regions of DOT1L That Mediate Therapeutic Response in MLL -r Leukemia

Free
Chun-Wei Chen, PhD, Lu Yang, PhD, Xi Wang, PhD, Anthony Chan, PhD, Chris Delaney, Kazuya Miyashita, PhD, Yanchun Guo, MD PhD, Wen-Han Chang, PhD, Sandra Li, Sheela Pokharel, Hongzhi Li, PhD, Yadira Soto-Feliciano, Takayuki Hoshii, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 179.
https://doi.org/10.1182/blood-2018-179
Published: 2018
Journal Articles

Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L

Free
Michael W.M. Kühn, MD, Michael Hadler, MSc, Scott R. Daigle, PhD, Chun-Wei Chen, PhD, Amit U. Sinha, PhD, Andrei V. Krivtsov, PhD, Edward J. Olhava, PhD, Michael A. Caligiuri, MD, James E Bradner, MD, Roy M. Pollock, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1256.
https://doi.org/10.1182/blood.V122.21.1256.1256
Published: 2013