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Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2024-208137
Published: 2024
Journal Articles

Application of State Transition Theory and Treatment Modeling for Predicting Response to Chemotherapy in a Mouse Model of Acute Myeloid Leukemia

Lisa Uechi, Yu-Hsuan Fu, David Frankhouser, Denis O'Meally, Sergio Branciamore, Lianjun Zhang, Man Li, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 2961.
https://doi.org/10.1182/blood-2023-190603
Published: 2023
Journal Articles

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Lianjun Zhang, Dinh Hoa Hoang, Hyunjun Kang, Ying-Chieh Chen, Yu-Hsuan Fu, Khyatiben V. Pathak, Melissa Valerio, Fang Chen, Katrina Estrella, Ralf Buettner, Bin Zhang, Patrick Pirrotte, Guido Marcucci, Ya-Huei Kuo, Le Xuan Truong Nguyen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2023-186936
Published: 2023
Journal Articles

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

Fang Chen, Dandan Zhao, Yi Zhang, Yongfang Xu, Min-Hsuan Chen, Khyatiben V. Pathak, Yong Liang, Wei-Le Wang, Katrina Estrella, Xiwei Wu, Lucy Y. Ghoda, Ya-Huei Kuo, Haris Ali, Jianhua Yu, Michael A Caligiuri, Mark Boldin, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3152.
https://doi.org/10.1182/blood-2023-182587
Published: 2023
Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5700.
https://doi.org/10.1182/blood-2023-182215
Published: 2023
Journal Articles

Synergistic Activity of Adefovir Dipivoxil and Venetoclax to Target the Bioenergetic Metabolism of Acute Myeloid Leukemia

Xubo Gong, Yi Zhang, Ying-Chieh Chen, Dandan Zhao, Yongfang Xu, Xin He, Fang Chen, Lei Zhang, Lianjun Zhang, Katrina Estrella, Melissa Valerio, Lucy Y. Ghoda, Le Xuan Truong Nguyen, Ya-Huei Kuo, Weiwei Liu, Zhihua Tao, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4161.
https://doi.org/10.1182/blood-2023-187183
Published: 2023
Journal Articles

Uncovering the Transcriptional Landscape of CML Development and Therapeutic Interventions Via State-Transition Modeling

David Frankhouser, Dandan Zhao, Russell C. Rockne, Sergio Branciamore, Lisa Uechi, Denis O'Meally, Ya-Huei Kuo, Bin Zhang, Guido Marcucci
Journal: Blood
Blood (2023) 142 (Supplement 1): 3154.
https://doi.org/10.1182/blood-2023-188645
Published: 2023
Journal Articles

Single-Cell RNA-Seq Reveals Intermediate Cell States and Identifies Features Defining Cellular Heterogeneity in Inv(16) Acute Myeloid Leukemia (AML)

Yu-Hsuan Fu, Lianjun Zhang, Ying-Chieh Chen, David Frankhouser, Lisa Uechi, Denis O'Meally, Sergio Branciamore, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5683.
https://doi.org/10.1182/blood-2023-182484
Published: 2023
Journal Articles

Free Energy Changes at State-Transition Critical Points As a Patient-Specific Biomarker in Acute Myeloid Leukemia

Lisa Uechi, Swetha Vasudevan, Daniella Vilencki, Sergio Branciamore, David Frankhouser, Denis O'Meally, Soheil Meshinchi, Guido Marcucci, Ya-Huei Kuo, Nataly Kravchenko-Balasha, Russell C. Rockne
Journal: Blood
Blood (2023) 142 (Supplement 1): 6012.
https://doi.org/10.1182/blood-2023-190662
Published: 2023
Journal Articles

In Vivo Antileukemic Activity of Ost-01 in Acute Myeloid Leukemia (AML): A Novel Natural Product (NP) from Baccharis Coridifolia

Hyunjun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben V. Pathak, Lianjun Zhang, Ralf Buettner, Fang Chen, Katrina Estrella, William Graff, Ya-Huei Kuo, Bin Zhang, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Journal: Blood
Blood (2023) 142 (Supplement 1): 1565.
https://doi.org/10.1182/blood-2023-187736
Published: 2023
Journal Articles

CD84 Is a Therapeutically Targetable Driver of Leukemogenesis Via Disruption of Energy Supply in Acute Myeloid Leukemia

Yinghui Zhu, Miso Park, Mariam Murtadha, Enrico Caserta, Le Xuan Truong Nguyen, Mahmoud Singer, Marc Denisse Estepa, Lokesh Nigam, Ada Alice Dona', James F Sanchez, Theophilus Tandoh, Man Li, Bin Zhang, Ya-Huei Kuo, Guido Marcucci, John C Williams, Flavia Pichiorri
Journal: Blood
Blood (2022) 140 (Supplement 1): 89–90.
https://doi.org/10.1182/blood-2022-170300
Published: 2022
Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yichun Lin, Songbai Liu, Huafeng Wang, Wenfeng Huang, Sierra Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 4931–4933.
https://doi.org/10.1182/blood-2022-167366
Published: 2022
Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 8692–8693.
https://doi.org/10.1182/blood-2022-160280
Published: 2022
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yuhui Wu, Yinghui Zhu, Hanying Wang, Wenfeng Huang, Yichun Lin, Lianjun Zhang, Dandan Zhao, Juan Du, Rui Su, Ya-Huei Kuo, Jianjun Chen, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2021) 138 (Supplement 1): 358.
https://doi.org/10.1182/blood-2021-151679
Published: 2021
Journal Articles

Microrna-142 Deficiency Promotes Chronic Myeloid Leukemia (CML) Transformation from Chronic Phase (CP) to Blast Crisis (BC)

Bin Amber Zhang, PhD, Dandan Zhao, MD, Huafeng Wang, MD, Chen Liang, MD, Le Xuan Truong Nguyen, PhD, Junjing Qiao, MD PhD, Shanshan Suo, MD, Yasmin Elhajmoussa, Lucy Ghoda, PhD, David Frankhouser, Russell Rockne, PhD, Ling Li, PhD, Ya-Huei Kuo, PhD, Mark Boldin, MD PhD, Guido Marcucci, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-143202
Published: 2020
Journal Articles

HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation

Dijiong Wu, MD, Man Li, PhD, Lianjun Zhang, PhD, Jing Qi, PhD, Chun-Wei David Chen, PhD, Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Jie Sun, PhD, Ling Li, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 642.
https://doi.org/10.1182/blood-2019-124134
Published: 2019
Journal Articles

Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia

Huafeng Wang, MD, Jie Sun, PhD, Dandan Zhao, MD, Hongyan Tong, Herman Wu, BS, Xia Li, PhD, Yingwan Luo, MD, Dan Dong, PhD, Tinisha McDonald, MS, Anthony Stein, MD, Monzr M. Al Malki, MD, Flavia Pichiorri, PhD, Nadia Carlesso, MD, Ya-Huei Kuo, PhD, Bin Zhang, PhD, Guido Marcucci, MD, Ling Li, PhD, Jie Jin, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1707.
https://doi.org/10.1182/blood-2019-130375
Published: 2019
Journal Articles

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Dinh Hoa Hoang, BS, Dandan Zhao, MD, Sergio Branciamore, Davide Maestrini, PhD, Yu-Lin SU, PhD, Sonia Rodriguez, PhD, Flavia Pichiorri, PhD, Steven Rosen, MD, Michael A. Caligiuri, MD, Stephen J. Forman, MD, Ling Li, PhD, Marcin Kortylewski, PhD, Russell Rockne, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD, Guido Marcucci, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2722.
https://doi.org/10.1182/blood-2019-131871
Published: 2019
Journal Articles

Spred1 Insufficiency in the Hematopoietic and/or Vascular Compartments of the Bone Marrow (BM) Niche Promotes Aggressive Leukemogenesis in Chronic Myelogenous Leukemia (CML)

Junjing Qiao, MD PhD, Dandan Zhao, MD, Le Xuan Truong Nguyen, PhD, Herman Wu, BS, Gang Liu, PhD, Shanshan Suo, MD, Huafeng Wang, Yasmin Elhajmoussa, Chen Liang, MD, David Snyder, MD, Haris Ali, MD, Steven Rosen, MD, Nadia Carlesso, MD, Ling Li, PhD, Ya-Huei Kuo, PhD, Guido Marcucci, MD, Bin Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3791.
https://doi.org/10.1182/blood-2019-127616
Published: 2019