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Journal Articles

Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN

Edimara S. Reis, Rebecca Buonpane, Hamza Celik, Caroline Marty, Angela Lei, Fatoumata Jobe, Mark Rupar, Yue Zhang, Darlise DiMatteo, Rahel Awdew, Bianca L. Ferreira, Lynn Leffet, Lu Lu, Elodie Rosa, Maxime Evrard, Gaurang Trivedi, Brittney Wass, April Horsey, Xin He, Maryanne Covington, Alla Volgina, Florence Pasquier, Laurence Legros, Guillemette Fouquet, William Vainchenker, Yan-ou Yang, Breann Barker, Jing Zhou, Shaun Stewart, Ian S. Hitchcock, Dashyant Dhanak, Ricardo Macarron, Isabelle Plo, Horacio Nastri, Patrick A. Mayes
Journal: Blood
Blood (2024) 144 (22): 2336–2348.
https://doi.org/10.1182/blood.2024024373
Published: 2024
Includes: Supplemental data
Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2024-208137
Published: 2024
Journal Articles

Targeting PRMT9 Overcomes Venetoclax Resistance in AML By Modulating Splicing and Inhibiting Translation

Yang Li, Xin He, Haojie Dong, Lei Zhang, Umesh Yadav, Meng Liu, Lianjun Zhang, Guido Marcucci, Shaoyuan Wang, Ling Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 54.
https://doi.org/10.1182/blood-2024-203923
Published: 2024
Journal Articles

Modeling the Initiation and Progression of Human MLL -Rearranged Precursor B Cell Acute Lymphoblastic Leukemia in Mice

Zhenhua Chen, Lu Yang, Lillian Sau, Zunsong Hu, Meiling Chen, Chengwu Zeng, Chao Shen, Ying Qing, Yuan Che, Dong Wu, Tingting Tang, Zhaoxu Xu, Xin He, Lianjun Zhang, Pu Cheng, Hengyou Weng, Huilin Huang, Zhaohui Gu, Gang Xiao, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 2738.
https://doi.org/10.1182/blood-2024-199829
Published: 2024
Journal Articles

Targeting Cytidine Triphosphate Synthase 1 Promotes Anti-AML Immunity

Meng Liu, Lei Zhang, Haojie Dong, Xin He, Yang Li, Umesh Yadav, Guido Marcucci, Ling Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 3590.
https://doi.org/10.1182/blood-2024-203905
Published: 2024
Journal Articles

SAMHD1 Inhibitor Combined with Immune Checkpoint Inhibitor Elicits an Anti-AML Immunity

Lei Zhang, Haojie Dong, Xin He, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 47.
https://doi.org/10.1182/blood-2023-182463
Published: 2023
Journal Articles

Preclinical Evaluation of INCB160058 - a Novel and Potentially Disease-Modifying Therapy for JAK2V617F Mutant Myeloproliferative Neoplasms

Matthew C. Stubbs, Hamza Celik, Yanran Ai, Xin He, Hong Chang, Angela Lei, Mark Rupar, Brittney Wass, Melody Diamond, Xiaoming Wen, Jun Li, Nina Zolotarjova, Alex Margulis, Gaurang Trivedi, Angelo B.A. Laranjeira, Cooper A. Taylor, Jennifer Rocha, Christoph Pollmann, Jacob Piehler, Bianca L. Ferreira, Ian Hitchcock, Ricardo Macarrón, Eddy W. Yue, Sunkyu Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 860.
https://doi.org/10.1182/blood-2023-179369
Published: 2023
Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5700.
https://doi.org/10.1182/blood-2023-182215
Published: 2023
Journal Articles

Synergistic Activity of Adefovir Dipivoxil and Venetoclax to Target the Bioenergetic Metabolism of Acute Myeloid Leukemia

Xubo Gong, Yi Zhang, Ying-Chieh Chen, Dandan Zhao, Yongfang Xu, Xin He, Fang Chen, Lei Zhang, Lianjun Zhang, Katrina Estrella, Melissa Valerio, Lucy Y. Ghoda, Le Xuan Truong Nguyen, Ya-Huei Kuo, Weiwei Liu, Zhihua Tao, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4161.
https://doi.org/10.1182/blood-2023-187183
Published: 2023
Journal Articles

Targeting ADSS2 Enhances BH3 Mimetics Treatment Induced Mitochondrial Apoptosis in AML Cells

Xin He, Lei Zhang, Yang Li, Haojie Dong, Lianjun Zhang, Daisuke Nakada, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 577.
https://doi.org/10.1182/blood-2023-186907
Published: 2023
Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yichun Lin, Songbai Liu, Huafeng Wang, Wenfeng Huang, Sierra Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 4931–4933.
https://doi.org/10.1182/blood-2022-167366
Published: 2022
Journal Articles

Targeting SAMHD1 Promotes Anti-Tumor Immunity in Acute Myeloid Leukemia

Lei Zhang, Haojie Dong, Xin He, Yichun Lin, Weidong Hu, Amandeep Salhotra, Saro H. Armenian, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 679–680.
https://doi.org/10.1182/blood-2022-167653
Published: 2022
Journal Articles

IL-18 and IL-18 Binding Protein Are Related to Disease Severity of Myelodysplastic Syndromes

Ting Wang, Ningyuan Ran, Nianbin Li, Mengtong Zang, Xin He, Qiulin Chen, Zonghong Shao, Rong Fu
Journal: Blood
Blood (2022) 140 (Supplement 1): 12297.
https://doi.org/10.1182/blood-2022-168782
Published: 2022
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 8692–8693.
https://doi.org/10.1182/blood-2022-160280
Published: 2022
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yuhui Wu, Yinghui Zhu, Hanying Wang, Wenfeng Huang, Yichun Lin, Lianjun Zhang, Dandan Zhao, Juan Du, Rui Su, Ya-Huei Kuo, Jianjun Chen, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2021) 138 (Supplement 1): 358.
https://doi.org/10.1182/blood-2021-151679
Published: 2021
Journal Articles

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

Hanying Wang, Xin He, MD, Feiteng Huang, MS, Haojie Dong, PhD, Wei Chen, PhD, Zheng Li, MS, Jie Sun, PhD, Yinghui Zhu, PhD, Lei Zhang, MD, Yuhui Wu, MD, Lifeng Feng, PhD, Jing Zhang, PhD, Samer Khaled, MD, Guido Marcucci, MD, David Sykes, MD PhD, Hongchuan Jin, MD PhD, Xian Wang, MD PhD, Ling Li, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26.
https://doi.org/10.1182/blood-2020-139922
Published: 2020
Journal Articles

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

Xin He, Zijie Feng, Jian Ma, Sunbin Ling, Yan Cao, Buddha Gurung, Yuan Wu, Bryson W. Katona, Kienan P. O’Dwyer, Don L. Siegel, Carl H. June, Xianxin Hua
Journal: Blood
Blood (2020) 135 (10): 713–723.
https://doi.org/10.1182/blood.2019002779
Published: 2020
Includes: Supplemental data
Journal Articles

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

Yu-Lin Su, Xiuli Wang, Mati Mann, Tomasz P. Adamus, Dongfang Wang, Dayson F. Moreira, Zhuoran Zhang, Ching Ouyang, Xin He, Bin Zhang, Piotr M. Swiderski, Stephen J. Forman, David Baltimore, Ling Li, Guido Marcucci, Mark P. Boldin, Marcin Kortylewski
Journal: Blood
Blood (2020) 135 (3): 167–180.
https://doi.org/10.1182/blood.2019002045
Published: 2020
Includes: Supplemental data