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Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2024-208137
Published: 2024
Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5700.
https://doi.org/10.1182/blood-2023-182215
Published: 2023
Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 8692–8693.
https://doi.org/10.1182/blood-2022-160280
Published: 2022
Journal Articles

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Wei-Kai Hua, Jing Qi, Qi Cai, Emily Carnahan, Maria Ayala Ramirez, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2017) 130 (24): 2619–2630.
https://doi.org/10.1182/blood-2017-03-771386
Published: 2017
Includes: Supplemental data
Journal Articles

HDAC8 Regulates Long-Term Hematopoietic Stem Cell Maintenance Under Stress By Modulating p53 Activity

Wei-Kai Hua, PhD, Jing Qi, PhD, Qi Cai, PhD, Emily Carnahan, MS, Maria Ayala Ramirez, Ling Li, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1146.
https://doi.org/10.1182/blood.V130.Suppl_1.1146.1146
Published: 2017
Journal Articles

MiR-126 Promotes Leukemogenesis in Inv(16) Acute Myeloid Leukemia

Casey J Brewer, PhD, Guerry Jeanne Cook, PhD, Bin Zhang, PhD, Le Xuan Truong Nguyen, PhD, Jing Qi, PhD, Wei-Kai Hua, PhD, Qi Cai, PhD, Emily Carnahan, MS, Ayelet Marom, PhD, Ling Li, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 301.
https://doi.org/10.1182/blood.V130.Suppl_1.301.301
Published: 2017
Journal Articles

HDAC8 Regulates Long-Term Hematopoietic Stem Cell Quiescence and Maintenance

Wei-Kai Hua, PhD, Jing Qi, PhD, Qi Cai, PhD, Emily Carnahan, Ling Li, PhD, Vu N. Ngo, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2016) 128 (22): 1468.
https://doi.org/10.1182/blood.V128.22.1468.1468
Published: 2016
Journal Articles

Time Sequential Transcriptome Analysis Identifies Mir-126 As an Early Biomarker for Inv(16) Acute Myeloid Leukemia (AML) Disease Progression

Jing Qi, PhD, Guerry J Cook, Bin Zhang, PhD, Wei-Kai Hua, PhD, Cai Qi, Emily Carnahan, Ayelet Marom, Le Xuan Truong Nguyen, Yang Lu, Sergio Branciamore, Herman Wu, BS, Yate-Ching Yuan, Xiwei Wu, PhD, Ling Li, PhD, Anthony S. Stein, MD, Russell Rockne, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2016) 128 (22): 773.
https://doi.org/10.1182/blood.V128.22.773.773
Published: 2016
Journal Articles

CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice

Qi Cai, Robin Jeannet, Wei-Kai Hua, Guerry J. Cook, Bin Zhang, Jing Qi, Hongjun Liu, Ling Li, Ching-Cheng Chen, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2016) 128 (11): 1503–1515.
https://doi.org/10.1182/blood-2016-01-693119
Published: 2016
Includes: Supplemental data