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Yu-Hsuan Fu
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Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2024-208137
Published: 2024
Journal Articles

Single-Cell RNA-Seq Reveals Intermediate Cell States and Identifies Features Defining Cellular Heterogeneity in Inv(16) Acute Myeloid Leukemia (AML)

Yu-Hsuan Fu, Lianjun Zhang, Ying-Chieh Chen, David Frankhouser, Lisa Uechi, Denis O'Meally, Sergio Branciamore, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5683.
https://doi.org/10.1182/blood-2023-182484
Published: 2023
Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5700.
https://doi.org/10.1182/blood-2023-182215
Published: 2023
Journal Articles

Application of State Transition Theory and Treatment Modeling for Predicting Response to Chemotherapy in a Mouse Model of Acute Myeloid Leukemia

Lisa Uechi, Yu-Hsuan Fu, David Frankhouser, Denis O'Meally, Sergio Branciamore, Lianjun Zhang, Man Li, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 2961.
https://doi.org/10.1182/blood-2023-190603
Published: 2023
Journal Articles

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Lianjun Zhang, Dinh Hoa Hoang, Hyunjun Kang, Ying-Chieh Chen, Yu-Hsuan Fu, Khyatiben V. Pathak, Melissa Valerio, Fang Chen, Katrina Estrella, Ralf Buettner, Bin Zhang, Patrick Pirrotte, Guido Marcucci, Ya-Huei Kuo, Le Xuan Truong Nguyen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2023-186936
Published: 2023
Journal Articles

Modulating Metabolic Reprogramming By Phosphoglycerate Dehydrogenase (PHGDH) Inhibitors in Omipalisib-Refractory AML

Chi-Yang Tseng, Yu-Hsuan Fu, Ching-Ying Kuo, Hsin-An Hou, Da-Liang Ou, Liang-In Lin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1432.
https://doi.org/10.1182/blood-2023-185713
Published: 2023
Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 8692–8693.
https://doi.org/10.1182/blood-2022-160280
Published: 2022
Journal Articles

Transcriptomic-Based in silico Drug Screening Reveals Dual PI3K/mTOR Inhibitors Overcome Cabozantinib-Resistance of FLT3 -ITD AML Cells

Chi-Yang Tseng, Yu-Hsuan Fu, Ang-Chu Huang, Da-Liang Ou, Ching-Ying Kuo, Liang-In Lin
Journal: Blood
Blood (2022) 140 (Supplement 1): 4947–4948.
https://doi.org/10.1182/blood-2022-163124
Published: 2022
Journal Articles

Strategies for Alleviating Tyrosine Kinase Resistance in Acute Myeloid Leukemia By Modulating p53 Signaling Pathway with Small Molecules

Chi-Yang Tseng, Fang-Yu Lo, Yu-Hsuan Fu, Da-Liang Ou, Hsin-An Hou, Liang-In Lin
Journal: Blood
Blood (2022) 140 (Supplement 1): 3086–3087.
https://doi.org/10.1182/blood-2022-163072
Published: 2022
Journal Articles

Metabolic Profiling Reveals Cellular Reprogramming of Acute Myeloid Leukemia By Omipalisib through Serine Synthesis Pathway

Liang-In Lin, Tseng Chiyang, Yu-Hsuan Fu, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien
Journal: Blood
Blood (2021) 138 (Supplement 1): 3296.
https://doi.org/10.1182/blood-2021-149200
Published: 2021
Journal Articles

Pyrvinium Pamoate Overcomes Cabozantinib-Resistance of FLT3 -ITD AML Cells through Modulating the Mitochondria Functions and Signaling Pathways

Yu-Hsuan Fu, BS, Wen-Hui Lu, MS, Pei-Qi Lan, MS, Chung-Yi Hu, PhD, Chien-Yuan Chen, MD, PhD, Da-Liang Ou, PhD, Hwei-Fang Tien, MD, PhD, Liang-In Lin, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4683.
https://doi.org/10.1182/blood-2018-99-118476
Published: 2018