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Journal Articles

Pharmacological Inhibition of miR-126 Enhances Venetoclax Activity in Acute Myeloid Leukemia

Blood blood.2025029875.

https://doi.org/10.1182/blood.2025029875

Published: 2025

Includes: Supplemental data

Journal Articles

ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia

Yu-Hsuan Fu, Man Li, Ying-Chieh Chen, Lianjun Zhang, Wancheng Guo, David Frankhouser, Denis O'Meally, Jihyun Irizarry, Jennifer Rangel Ambriz, Ziang Chen, Bin Zhang, Sergio Branciamore, Guido Marcucci, Russell Rockne, Ya-Huei Kuo

Blood (2025) 146 (Supplement 1): 1459.

https://doi.org/10.1182/blood-2025-1459

Published: 2025

Journal Articles

Chronic myeloid leukemia (CML) evolution is not encoded in single-cell microstates, but emerges from population-level macrostates

David Frankhouser, Dandan Zhao, Yu-Hsuan Fu, Anupam Dey, Ziang Chen, Jihyun Irizarry, Jennifer Rangel Ambriz, Sergio Branciamore, Denis O'Meally, Jeffrey Trent, Stephen Forman, Ya-Huei Kuo, Adam MacLean, Bin Zhang, Russell Rockne, Guido Marcucci

Blood (2025) 146 (Supplement 1): 5026.

https://doi.org/10.1182/blood-2025-5026

Published: 2025

Journal Articles

From theory to therapy: Predicting response to chemotherapy with multiomic longitudinal profiling of peripheral blood in AML

Jennifer Rangel Ambriz, Ziang Chen, Yu-Hsuan Fu, David Frankhouser, Denis O'Meally, Sergio Branciamore, Jihyun Irizarry, Bin Zhang, Lianjun Zhang, Ying-Chieh Chen, Guido Marcucci, Russell Rockne, Ya-Huei Kuo

Blood (2025) 146 (Supplement 1): 5284.

https://doi.org/10.1182/blood-2025-5284

Published: 2025

Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo

Blood (2024) 144 (Supplement 1): 1398.

https://doi.org/10.1182/blood-2024-208137

Published: 2024

Journal Articles

Single-Cell RNA-Seq Reveals Intermediate Cell States and Identifies Features Defining Cellular Heterogeneity in Inv(16) Acute Myeloid Leukemia (AML)

Yu-Hsuan Fu, Lianjun Zhang, Ying-Chieh Chen, David Frankhouser, Lisa Uechi, Denis O'Meally, Sergio Branciamore, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo

Blood (2023) 142 (Supplement 1): 5683.

https://doi.org/10.1182/blood-2023-182484

Published: 2023

Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo

Blood (2023) 142 (Supplement 1): 5700.

https://doi.org/10.1182/blood-2023-182215

Published: 2023

Journal Articles

Modulating Metabolic Reprogramming By Phosphoglycerate Dehydrogenase (PHGDH) Inhibitors in Omipalisib-Refractory AML

Chi-Yang Tseng, Yu-Hsuan Fu, Ching-Ying Kuo, Hsin-An Hou, Da-Liang Ou, Liang-In Lin

Blood (2023) 142 (Supplement 1): 1432.

https://doi.org/10.1182/blood-2023-185713

Published: 2023

Journal Articles

Application of State Transition Theory and Treatment Modeling for Predicting Response to Chemotherapy in a Mouse Model of Acute Myeloid Leukemia

Lisa Uechi, Yu-Hsuan Fu, David Frankhouser, Denis O'Meally, Sergio Branciamore, Lianjun Zhang, Man Li, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo

Blood (2023) 142 (Supplement 1): 2961.

https://doi.org/10.1182/blood-2023-190603

Published: 2023

Journal Articles

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Lianjun Zhang, Dinh Hoa Hoang, Hyunjun Kang, Ying-Chieh Chen, Yu-Hsuan Fu, Khyatiben V. Pathak, Melissa Valerio, Fang Chen, Katrina Estrella, Ralf Buettner, Bin Zhang, Patrick Pirrotte, Guido Marcucci, Ya-Huei Kuo, Le Xuan Truong Nguyen

Blood (2023) 142 (Supplement 1): 2953.

https://doi.org/10.1182/blood-2023-186936

Published: 2023

Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo

Blood (2022) 140 (Supplement 1): 8692–8693.

https://doi.org/10.1182/blood-2022-160280

Published: 2022

Journal Articles

Transcriptomic-Based in silico Drug Screening Reveals Dual PI3K/mTOR Inhibitors Overcome Cabozantinib-Resistance of FLT3 -ITD AML Cells

Chi-Yang Tseng, Yu-Hsuan Fu, Ang-Chu Huang, Da-Liang Ou, Ching-Ying Kuo, Liang-In Lin

Blood (2022) 140 (Supplement 1): 4947–4948.

https://doi.org/10.1182/blood-2022-163124

Published: 2022

Journal Articles

Strategies for Alleviating Tyrosine Kinase Resistance in Acute Myeloid Leukemia By Modulating p53 Signaling Pathway with Small Molecules

Chi-Yang Tseng, Fang-Yu Lo, Yu-Hsuan Fu, Da-Liang Ou, Hsin-An Hou, Liang-In Lin

Blood (2022) 140 (Supplement 1): 3086–3087.

https://doi.org/10.1182/blood-2022-163072

Published: 2022

Journal Articles

Metabolic Profiling Reveals Cellular Reprogramming of Acute Myeloid Leukemia By Omipalisib through Serine Synthesis Pathway

Liang-In Lin, Tseng Chiyang, Yu-Hsuan Fu, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien

Blood (2021) 138 (Supplement 1): 3296.

https://doi.org/10.1182/blood-2021-149200

Published: 2021

Journal Articles

Pyrvinium Pamoate Overcomes Cabozantinib-Resistance of FLT3 -ITD AML Cells through Modulating the Mitochondria Functions and Signaling Pathways

Yu-Hsuan Fu, BS, Wen-Hui Lu, MS, Pei-Qi Lan, MS, Chung-Yi Hu, PhD, Chien-Yuan Chen, MD, PhD, Da-Liang Ou, PhD, Hwei-Fang Tien, MD, PhD, Liang-In Lin, PhD

Blood (2018) 132 (Supplement 1): 4683.

https://doi.org/10.1182/blood-2018-99-118476

Published: 2018

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Pharmacological Inhibition of miR-126 Enhances Venetoclax Activity in Acute Myeloid Leukemia

ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia

Chronic myeloid leukemia (CML) evolution is not encoded in single-cell microstates, but emerges from population-level macrostates

From theory to therapy: Predicting response to chemotherapy with multiomic longitudinal profiling of peripheral blood in AML

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Single-Cell RNA-Seq Reveals Intermediate Cell States and Identifies Features Defining Cellular Heterogeneity in Inv(16) Acute Myeloid Leukemia (AML)

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Modulating Metabolic Reprogramming By Phosphoglycerate Dehydrogenase (PHGDH) Inhibitors in Omipalisib-Refractory AML

Application of State Transition Theory and Treatment Modeling for Predicting Response to Chemotherapy in a Mouse Model of Acute Myeloid Leukemia

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Transcriptomic-Based in silico Drug Screening Reveals Dual PI3K/mTOR Inhibitors Overcome Cabozantinib-Resistance of FLT3 -ITD AML Cells

Strategies for Alleviating Tyrosine Kinase Resistance in Acute Myeloid Leukemia By Modulating p53 Signaling Pathway with Small Molecules

Metabolic Profiling Reveals Cellular Reprogramming of Acute Myeloid Leukemia By Omipalisib through Serine Synthesis Pathway

Pyrvinium Pamoate Overcomes Cabozantinib-Resistance of FLT3 -ITD AML Cells through Modulating the Mitochondria Functions and Signaling Pathways

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American Society of Hematology

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