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Journal Articles

TET1 Drives Myelodysplastic Syndromes and Represents a Promising Therapeutic Target

Chao Shen, Tingting Tang, Kitty Wang, Zunsong Hu, Yuan Che, Meiling Chen, Keren Zhou, Zhenhua Chen, Ying Qing, Wei Li, Dong Wu, Keith Leung, Lillian Sau, Zhaoxu Xu, Lucy Y. Ghoda, Guido Marcucci, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 3192.
https://doi.org/10.1182/blood-2024-199714
Published: 2024
Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2024-208137
Published: 2024
Journal Articles

Modeling the Initiation and Progression of Human MLL -Rearranged Precursor B Cell Acute Lymphoblastic Leukemia in Mice

Zhenhua Chen, Lu Yang, Lillian Sau, Zunsong Hu, Meiling Chen, Chengwu Zeng, Chao Shen, Ying Qing, Yuan Che, Dong Wu, Tingting Tang, Zhaoxu Xu, Xin He, Lianjun Zhang, Pu Cheng, Hengyou Weng, Huilin Huang, Zhaohui Gu, Gang Xiao, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 2738.
https://doi.org/10.1182/blood-2024-199829
Published: 2024
Journal Articles

Metformin Potentiates Gilteritinib Sensitivity Via Targeting PLK1 Signaling: A Strategy to Improve Outcomes and Reduce Costs in Treating FLT3-Mutated Acute Myeloid Leukemia

Meiling Chen, Chao Shen, Yi Chen, Keren Zhou, Wei Li, Zhenhua Chen, Chengwu Zeng, Ying Qing, Dong Wu, Kitty Wang, Xiaolan Deng, Jianda Hu, Yong Wu, Jianjun Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1427.
https://doi.org/10.1182/blood-2023-187751
Published: 2023
Journal Articles

Targeting Sumoylation Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

Li Du, Jiamin Guo, Zhenhua Chen, Jianjun Chen, Guido Marcucci, Steven T. Rosen
Journal: Blood
Blood (2023) 142 (Supplement 1): 411.
https://doi.org/10.1182/blood-2023-178037
Published: 2023
Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2975–2977.
https://doi.org/10.1182/blood-2022-162619
Published: 2022
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

TET1 Modulates DNA Replication in Leukemia Cells Via a Catalytic-Independent Mechanism through Cooperating with KAT8

Hengyou Weng, PhD, Huilin Huang, PhD, He Huang, Zhaojin Yu, Paulina Siejka-Zielinska, Zhenhua Chen, PhD, Emily Prince, Chao Shen, PhD, Zejuan Li, MD, Chunxiao Song, Yingming Zhao, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1249.
https://doi.org/10.1182/blood-2019-127321
Published: 2019
Journal Articles

The Oncogenic Role of N 6 -Methyladenosine Reader Protein IGF2BP3 in Acute Myeloid Leukemia

Huilin Huang, PhD, Hengyou Weng, PhD, Mingli Sun, Huizhe Wu, Zhenhua Chen, PhD, Savanna Stanford, Xiaolan Deng, Rui Su, PhD, Minjie Wei, Jianjun Chen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1334.
https://doi.org/10.1182/blood-2018-99-117535
Published: 2018