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Journal Articles

Systematic Evaluation of GAPs and Gefs Identifies ARHGAP45 As a Targetable Leukemia-Specific Dependency

Pu Zhang, Zhendong Cao, Xiangyu Pan, Yuqiao Liu, Cynthia Castro, Won Jun Kim, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Sanam Shahid, Jasmine S. Um, Erin R. Burns, Bing-Yi Chen, Winson Cai, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Anthony F. Daniyan, Christopher R. Vakoc, Omar Abdel-Wahab, Junwei Shi
Journal: Blood
Blood (2024) 144 (Supplement 1): 950.
https://doi.org/10.1182/blood-2024-198954
Published: 2024
Journal Articles

Discovery of the Unique GMP-Grade iPSC Clones That Give Rise to Functional, High Purity, Matured CD8 Alpha Beta T or Gamma Delta T with Exponential Expansion Capacity

Ying-Tsen Tung, Chih-Lung Chen, Annie Yi-Ting Lai, Chien-Yu Hsu, Chien-Hsi Chen, Po-Fan Chu, Lin-Yu Liao, Tzu-Chien Kuo, Chieh-Teng Cheng, Chun-Yu Lin, Wan-Chen Tsai, Wei-Ting Chen, Darien Zhing Herr Chan, Hsin-Hua Cho, Cheng-Kai Wang, Yo-Chuen Lin, Jin-Yi Lu, Lee-Yieng Lim, Jhang-Sian Yu, Ming-Chin Ko, Chia-Hung Lin, Yi-Han Dai, I-Ting Chen, Fang-Pei Chang, Shao-Ju Weng, Ting-Yi Wu, Yuan-Yu Hsia, Fu-Fei Hsu, Lillian Yi-Ting Lai, Shiou-Ling Jian, Shih-Wen Huang, Yu-Chih Peng, Ke-Hsun Hsu, Liang-Yi Chen, Ji-Kuan Wang, Yao-Yu Chen, Chih-Kai Yin, Yi-Hung Ou, Min-Ren Chiang, Wen-Hao Wang, Tsung-Hao Yeh, Xiaming Peng, Yang Shi, Pei Zhang, Ya-Chu Yu, Yun Gao, Yen-Hsien Lee, Pei-Chun Wu, Ta-Hsun Liao, De-Kuan Chang, Lien-Szu Wu, Jen-Chih Chi, Ching-Ying Huang, Alex Shih-Min Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 7195.
https://doi.org/10.1182/blood-2024-203106
Published: 2024
Journal Articles

Safety and Efficacy of Rocbrutinib in Patients with Relapsed/Refractory Marginal Zone Lymphoma

Yuqin Song, Qingqing Cai, Keshu Zhou, Ming Jiang, Zhengming Jin, Lei Zhang, Xiuhua Sun, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, Hongmei Jing, Wei Yang, Min Zhou, Jun Ma, Zhigang Peng, Wei Xu, Hui Zhou, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 1635.
https://doi.org/10.1182/blood-2024-194572
Published: 2024
Journal Articles

LP-168 (Rocbrutinib), a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase: Updates on the Phase 1 Trial and Initial Results of the CLL Gatekeeper Mutation Cohort

Jennifer A. Woyach, Danielle M. Brander, Boyu Hu, Kerry A. Rogers, Zulfa Omer, Deborah M. Stephens, Andrea Sitlinger, Fenlai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Kewei Shang, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 4622.
https://doi.org/10.1182/blood-2024-205775
Published: 2024
Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel LP-168 (Rocbrutinib) Combinations Targeting BCL-2 Protein Members for Chronic Lymphocytic Leukemia

Britten K. Gordon, Ethan C. Whipp, Lianbo Yu, Samon Benrashid, Andrew D. Mitchell, Alexander He, Jazmin Urrutia, Shrilekha Misra, Alexander R. Marr, Tzung-Huei Lai, Naina Karnati, Shanmugapriya Thangavadivel, Kerry A. Rogers, Seema A. Bhat, Nicole R. Grieselhuber, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Deepa Sampath, Rosa Lapalombella, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2024-203522
Published: 2024
Journal Articles

Burden of Anemia in Myelofibrosis Patients in Japan, South Korea, Taiwan, and Canada: A Real-World Survey and Multinational Database Analysis

Yi-Chen Chen, Katie Lewis, Maryam Munir, Yusuke Yasutomi, Maja Kalaba, Audrey Chang
Journal: Blood
Blood (2024) 144 (Supplement 1): 6647.
https://doi.org/10.1182/blood-2024-209001
Published: 2024
Journal Articles

A Phase 1, Multicenter, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Orally Administered LP-108 (Lacutoclax) As Monotherapy and in Combination with Azacitidine in Subjects with Relapsed or Refractory Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML)

Juan Miguel Bergua Burgues, Kristin Koenig, Pau Montesinos, Dale L. Bixby, Patrick W. Burke, Naval Daver, Stephen P. Anthony, Fenlai Tan, Yi Chen, Yu Chen, Ignacio Casas Aviles, Emily K Curran
Journal: Blood
Blood (2024) 144 (Supplement 1): 6009.
https://doi.org/10.1182/blood-2024-208792
Published: 2024
Journal Articles

Enhancing CAR T Cell Efficacy By Modulating PI3K Signaling Via a Synthetic CD28 Rheostat

Sanam Shahid, Winson Cai, Erin R. Burns, Jasmine S. Um, Serena Mathew, Sydney Souness, Sarah Yoo, Bing-Yi Chen, Takeshi Fujino, Renier Brentjens, Anthony F. Daniyan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4802.
https://doi.org/10.1182/blood-2024-209964
Published: 2024
Journal Articles

iPSC-Derived CAR-Gamma Delta T with Novel Combinatorial KO Demonstrated Extended Longevity and Profound Anti-Tumor Efficacy without Cytokine Support in Preclinical Studies

Jhang-Sian Yu, Chia-Hung Lin, Ying-Tsen Tung, Fang-Pei Chang, Edward Po-Fan Chu, Shiou-Ling Jian, Fu-Fei Hsu, Ming-Chin Ko, Yi-Han Dai, Chieh-Teng Cheng, Tzu-Chien Kuo, I-Ting Chen, Ting-Yi Wu, Jin-Yi Lu, Ke-Hsun Hsu, Wei-Ting Chen, Darien Zhing Herr Chan, Yi-Ting Lai, Shao-Ju Weng, Liang-Yi Chen, Yuan-Yu Hsia, Yi-Hung Ou, Yo-Chuen Lin, Shih-Wen Huang, Yu-Chih Peng, Chien-Hsi Chen, Chien-Yu Hsu, Yi-Ting Lai, Chih-Lung Chen, Chun-Yu Lin, Lin-Yu Liao, Wan-Chen Tsai, Hsin-Hua Cho, Cheng-Kai Wang, Lee-Yieng Lim, Ji-Kuan Wang, Yao-Yu Chen, Chih-Kai Yin, Wen-Hao Wang, Tsung-Hao Yeh, Min-Ren Chiang, Ruyue Ji, Jen-Chih Chi, Lien-Szu Wu, Jennifer Huang, De-Kuan Chang, Alex Shih-Min Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4790.
https://doi.org/10.1182/blood-2024-205086
Published: 2024
Journal Articles

Comparison of Outcomes between Haploidentical and Matched Related Donors for Chronic Myelomonocytic Leukemia: A Multicenter Real-World Study

Yuqian Sun, Lixin Wu, Yicheng Zhang, Ya-Jing Xu, Xiaobing Huang, Baodong Ye, Hailong Yuan, Jianying Zhou, Sujun Gao, Fang Zhou, Yue Liu, Xianmin Song, Yu Cai, Xiaoliang Liu, Yi Luo, Luxin Yang, Jianmin Yang, Libing Wang, Yuhua Li, Rui Huang, Shunqing Wang, Ming Zhou, Yujun Dong, Qian Wang, Yimei Feng, Xin Du, Wei Ling, Han Zhu, Zunmin Zhu, Xiangli Chen, Shiyun Wang, Fankai Meng, Kehong Bi, Ning Huang, Ming Jiang, Ting Niu, Jie Ji, Dingming Wan, Bian Zhilei, Yi Chen, Li Liu, Xueqian Yan, Xi Yang, Hai Yi, Xudong Wei, Xin Li, Qian Cheng, Chenglu Yuan, Wen Wang, Yuhong Zhou, Yu-Hong Chen, Fengrong WANG, YuanYuan Zhang, Zhi-Dong Wang, Xiao-Dong Mo, Wei Han, Jing-Zhi Wang, Yu Wang, Huan Chen, Xiangyu Zhao, Ying-jun Chang, Kaiyan Liu, Jia Feng, LanPing Xu, Hongyu Zhang, Xi Zhang, Xiaojun Huang, Xiaohui Zhang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2187.
https://doi.org/10.1182/blood-2024-206919
Published: 2024
Journal Articles

Rocbrutinib, a New-Generation BTK Inhibitor, Demonstrates Safety and Efficacy in Relapsed/Refractory Non-GCB Diffuse Large B Cell Lymphoma

Yuqin Song, Qingqing Cai, Keshu Zhou, Ming Jiang, Zhengming Jin, Lei Zhang, Xiuhua Sun, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, Hongmei Jing, Wei Yang, Min Zhou, Jun Ma, Zhigang Peng, Wei Xu, Hui Zhou, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3119.
https://doi.org/10.1182/blood-2024-194561
Published: 2024
Journal Articles

Easix Score Predicts Overall Survival and Non-Relapse Mortality in Elderly Patients Undergoing Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation

Lizhen Liu, Shipei Xiang, Xiaoyu Lai, Jimin Shi, Yanmin Zhao, Jian Yu, Ying Lu, Peipei Ye, Guifang Ouyang, Baodong Ye, Jianping Lan, Pengfei Shi, Haowen Xiao, Huarui Fu, Luxin Yang, Yishan Ye, Yi Chen, Yu Zhang, Yang Xu, Huixian Hu, Huifang Jiang, Yamin Tan, He Huang, Yi Luo
Journal: Blood
Blood (2024) 144 (Supplement 1): 2171.
https://doi.org/10.1182/blood-2024-212040
Published: 2024
Journal Articles

Stag2 Loss Drives Abnormal Chromatin Remodeling with Fli1 Hyperactivity in Npm1c Leukemia

Jane J. Xu, Viviana Scoca, Yi Chen, John Pantazi, Sebastian Fernando, Besmira Alija, Varun S. Sudunagunta, Aaron D. Viny
Journal: Blood
Blood (2024) 144 (Supplement 1): 2720.
https://doi.org/10.1182/blood-2024-211064
Published: 2024
Journal Articles

Development of CAR T Cells Targeting U5 snRNP200 for the Treatment of Acute Myeloid and B-Lymphoid Leukemias

Takeshi Fujino, Jennifer Lewis, Bing-Yi Chen, Quinlan Sievers, Winson Cai, Sarah Yoo, Serena Mathew, Sydney Souness, Erin R. Burns, Jasmine S. Um, Elisa De Stanchina, Qing Chang, Besnik Qeriqi, Kevin Chen, PU Zhang, Susan Dewolf, Alexander M. Lewis, Kenyon Weis, Brianna Gipson, Cynthia Castro, Nina Fox, Satoshi Kaito, Alyssa Fronk, Martin Akerman, Omar Abdel-Wahab, Anthony F. Daniyan
Journal: Blood
Blood (2024) 144 (Supplement 1): 371.
https://doi.org/10.1182/blood-2024-204143
Published: 2024
Journal Articles

Erythroid Dysplasia in Stag2 Deficient Murine Models Reveals Novel Erythropoietic Function for Stag2 Cohesin

Varun S. Sudunagunta, Yi Chen, Russell Kunes, Edna M. Stewart, Viviana Scoca, John Pantazi, Hongxia Yan, Jane J. Xu, Mohandas Narla, Aaron D. Viny
Journal: Blood
Blood (2024) 144 (Supplement 1): 1070.
https://doi.org/10.1182/blood-2024-208693
Published: 2024
Journal Articles

Pulmonary Infection Associated with Immune Dysfunction Predicting Dismal Prognosis in Patients with Myelodysplastic Syndrome Accompanied By TP53 Gene Abnormalities

Yi Chen, Jing Zheng, Yan Yan Qiu, Zhengjun Wu, Xiaofeng Luo, Liangfang Zhu, Yanjuan Lin
Journal: Blood
Blood (2023) 142 (Supplement 1): 6470.
https://doi.org/10.1182/blood-2023-174347
Published: 2023
Journal Articles

Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Myeloid Leukemia Harboring KMT2A Rearrangement and Its Prognostic Factors

Bingqian Jiang, Yanmin Zhao, Yi Luo, Jian Yu, Yi Chen, Baodong Ye, Huarui Fu, Xiaoyu Lai, Lizhen Liu, Yishan Ye, Weiyan Zheng, Jie Sun, Jingsong He, Yi Zhao, Guoqing Wei, Zhen Cai, He Huang, Jimin Shi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2243.
https://doi.org/10.1182/blood-2023-182809
Published: 2023
Journal Articles

Metformin Potentiates Gilteritinib Sensitivity Via Targeting PLK1 Signaling: A Strategy to Improve Outcomes and Reduce Costs in Treating FLT3-Mutated Acute Myeloid Leukemia

Meiling Chen, Chao Shen, Yi Chen, Keren Zhou, Wei Li, Zhenhua Chen, Chengwu Zeng, Ying Qing, Dong Wu, Kitty Wang, Xiaolan Deng, Jianda Hu, Yong Wu, Jianjun Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1427.
https://doi.org/10.1182/blood-2023-187751
Published: 2023
Journal Articles

Targeting Covalent and Non-Covalent Btki-Resistant CLL Using the Dual Irreversible/Reversible 4 th Generation BTK Inhibitor LP-168

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Kerry A Rogers, Adam S Kittai, Seema A Bhat, John C. Byrd, Deepa Sampath, Rosa Lapalombella, Weiguo Han, Neil E. Kay, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 416.
https://doi.org/10.1182/blood-2023-178259
Published: 2023
Journal Articles

Synergy of Stag2-Cohesin Loss Results in Expansion of Npm1c-Mutant Hematopoietic Stem and Progenitor Cells

Jane J Xu, Yi Chen, John Pantazi, Sebastian Fernando, Besmira Alija, Varun Sudunagunta, Govind Bhagat, Aaron D. Viny
Journal: Blood
Blood (2023) 142 (Supplement 1): 954.
https://doi.org/10.1182/blood-2023-190627
Published: 2023