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Journal Articles

Efficacy and safety of rocbrutinib, a highly selective 4th-generation Bruton's tyrosine kinase inhibitor, in relapsed/refractory Mantle Cell Lymphoma (R/R MCL): Updated results from the phase 1 study

Free
Yuqin Song, Qingqing Cai, Keshu Zhou, Zhengming Jin, Ming Jiang, Xiuhua Sun, Lei Zhang, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, MIN Zhou, Hongmei Jing, Wei Yang, Hui Zhou, Jun Ma, Zhigang Peng, Wei Xu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2025) 146 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2025-3587
Published: 2025
Journal Articles

Efficacy and safety of rocbrutinib, the fourth generation bruton's tyrosine kinase inhibitor, in patients with BTK inhibitor pre-treated relapsed or refractory Mantle Cell Lymphoma: Results from a Phase II rock-1 trial

Free
Yuqin Song, Qingqing Cai, Xiaoqiong Tang, Keshu Zhou, Lihong Liu, Zhigang Peng, Xiaojing Yan, Kaiyang Ding, Jianzhen Shen, Huijing Wu, Jie Cui, Hui Zhou, Jianqiu Wu, Hongmei Jing, Ming Jiang, Xiuhua Sun, Yu Yang, Kang Yu, Wei Yang, Zhifeng Li, Zhengming Jin, Shuhua Yi, Fei Li, Guowu Wu, Xiaolei Wei, Gaoxiang Wang, Yudan Wu, Ningjing Lin, Fenlai Tan, Yue Shen, Yejiang Lou, Xiang Xiao, Jun Zhu
Journal: Blood
Blood (2025) 146 (Supplement 1): 886.
https://doi.org/10.1182/blood-2025-886
Published: 2025
Journal Articles

Efficacy and safety of rocbrutinib, a highly selective 4th-generation BTK inhibitor, in Chinese patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)

Free
Yuqin Song, Qingqing Cai, Keshu Zhou, Zhengming Jin, Ming Jiang, Xiuhua Sun, Lei Zhang, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, MIN Zhou, Hongmei Jing, Wei Yang, Hui Zhou, Jun Ma, Zhigang Peng, Wei Xu, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2025) 146 (Supplement 1): 3896.
https://doi.org/10.1182/blood-2025-3896
Published: 2025
Journal Articles

Safety and Efficacy of Rocbrutinib in Patients with Relapsed/Refractory Marginal Zone Lymphoma

Free
Yuqin Song, Qingqing Cai, Keshu Zhou, Ming Jiang, Zhengming Jin, Lei Zhang, Xiuhua Sun, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, Hongmei Jing, Wei Yang, Min Zhou, Jun Ma, Zhigang Peng, Wei Xu, Hui Zhou, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 1635.
https://doi.org/10.1182/blood-2024-194572
Published: 2024
Journal Articles

Rocbrutinib, a New-Generation BTK Inhibitor, Demonstrates Safety and Efficacy in Relapsed/Refractory Non-GCB Diffuse Large B Cell Lymphoma

Free
Yuqin Song, Qingqing Cai, Keshu Zhou, Ming Jiang, Zhengming Jin, Lei Zhang, Xiuhua Sun, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, Hongmei Jing, Wei Yang, Min Zhou, Jun Ma, Zhigang Peng, Wei Xu, Hui Zhou, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3119.
https://doi.org/10.1182/blood-2024-194561
Published: 2024
Journal Articles

Pre-Clinical Evaluation of a New-Generation Orally Bioavailable Dual Bcl-2/Bcl-Xl Inhibitor LP-118 in Mantle Cell Lymphoma

Free
Ling-Ling Lee, Cong Zhu, Brianna Feldmeier, Yao Chen, Wenyu Li, Yu Chen, Stephen P. Anthony, Yue Shen, Fenlai Tan, Yi Chen, Bing Dai
Journal: Blood
Blood (2023) 142 (Supplement 1): 3640.
https://doi.org/10.1182/blood-2023-180190
Published: 2023
Journal Articles

Safety and Efficacy Results from the Phase I Study of a Novel Dual Covalent and Non-Covalent Next Generation Inhibitor of Bruton's Tyrosine Kinase LP-168 in Patients with Relapsed/Refractory Mantle Cell Lymphoma

Free
Yuqin Song, Qingqing Cai, Ming Jiang, Keshu Zhou, Lei Zhang, Xiuhua Sun, Zhengming Jin, Lanfang Li, Hongmei Jing, Zhigang Peng, Haiyan Yang, Junyuan Qi, Hui Zhou, Wei Yang, Min Zhou, Chunyan Ji, Wei Xu, Kaiyang Ding, Li Yu, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2023) 142 (Supplement 1): 3033.
https://doi.org/10.1182/blood-2023-180694
Published: 2023
Journal Articles

A Novel Dual Covalent and Non-Covalent Next Generation Inhibitor of Bruton's Tyrosine Kinase LP-168 in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma: Safety and Efficacy Results from a Phase 1 Study

Free
Yuqin Song, Qingqing Cai, Ming Jiang, Keshu Zhou, Lei Zhang, Xiuhua Sun, Zhengming Jin, Lanfang Li, Hongmei Jing, Zhigang Peng, Haiyan Yang, Junyuan Qi, Hui Zhou, Wei Yang, Min Zhou, Chunyan Ji, Wei Xu, Kaiyang Ding, Li Yu, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4400.
https://doi.org/10.1182/blood-2023-180485
Published: 2023
Journal Articles

LP-118, a Novel BCL2 Inhibitor, Shows Potent in Vitro Anti-Myeloma Activity

Free
Rodrigo Fonseca, Yuan Xiao Zhu, P. Leif Bergsagel, Marta Chesi, Akhilesh Pandey, Kiran Mangalaparthi, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, Bing Dai, Esteban Braggio, Rafael Fonseca
Journal: Blood
Blood (2022) 140 (Supplement 1): 7129–7130.
https://doi.org/10.1182/blood-2022-167372
Published: 2022
Journal Articles

LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML)

Free
Kristin L Koenig, Colin Brame, Steven Sher, Larry Beaver, Casey B. Cempre, Katie Williams, Matthew Purcell, Bonnie Harrington, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 9068–9069.
https://doi.org/10.1182/blood-2022-170578
Published: 2022
Journal Articles

Targeting Apoptosis with Novel BH3 Mimetics in T-Lineage Acute Lymphoblastic Leukemia

Free
Caner Saygin, Bartholomew Eisfelder, Giorgia Giordano, Anika Thomas-Toth, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, James LaBelle, Wendy Stock
Journal: Blood
Blood (2022) 140 (Supplement 1): 10689–10690.
https://doi.org/10.1182/blood-2022-163673
Published: 2022
Journal Articles

Characterization of LP-118, a Novel Small Molecule Inhibitor of Bcl-2 and Bcl-Xl in Chronic Lymphocytic Leukemia Resistant to Venetoclax

Free
Janani Ravikrishnan, Elizabeth M. Muhowski, Tzung-Huei Lai, Shrilekha Misra, Daisy Diaz Rohena, Felai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2021) 138 (Supplement 1): 679.
https://doi.org/10.1182/blood-2021-151852
Published: 2021
Journal Articles

Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds

Free
Yue Shen, Yongzhi Guo, Peter Mikus, Rima Sulniute, Malgorzata Wilczynska, Tor Ny, Jinan Li
Journal: Blood
Blood (2012) 119 (24): 5879–5887.
https://doi.org/10.1182/blood-2012-01-407825
Published: 2012
Includes: Supplemental data