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Shrilekha Misra
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Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel LP-168 (Rocbrutinib) Combinations Targeting BCL-2 Protein Members for Chronic Lymphocytic Leukemia

Britten K. Gordon, Ethan C. Whipp, Lianbo Yu, Samon Benrashid, Andrew D. Mitchell, Alexander He, Jazmin Urrutia, Shrilekha Misra, Alexander R. Marr, Tzung-Huei Lai, Naina Karnati, Shanmugapriya Thangavadivel, Kerry A. Rogers, Seema A. Bhat, Nicole R. Grieselhuber, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Deepa Sampath, Rosa Lapalombella, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2024-203522
Published: 2024
Journal Articles

Single-Cell RNA-Seq Analysis Reveals Distinct Tumor and Immunosuppressive T Cell Phenotypes in CLL Patients Treated with Ibrutinib

Shanmugapriya Thangavadivel, Shrilekha Misra, Samon Benrashid, Britten Gordon, Alexander He, Tzung-Huei Lai, Kerry A Rogers, Seema A Bhat, Adam S Kittai, John C. Byrd, James S. Blachly, Jennifer A. Woyach, Bradley Wayne Blaser
Journal: Blood
Blood (2023) 142 (Supplement 1): 3262.
https://doi.org/10.1182/blood-2023-186604
Published: 2023
Journal Articles

T Cell Dysfunction and Exhaustion in Patients with CLL: The Impact of Long Term Ibrutinib Treatment

Shanmugapriya Thangavadivel, Charlene Mao, Meixiao Long, Shrilekha Misra, Samon Benrashid, Britten Gordon, Alexander He, Tzung-Huei Lai, Kerry A Rogers, Seema A Bhat, Adam S Kittai, John C. Byrd, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 4631.
https://doi.org/10.1182/blood-2023-189755
Published: 2023
Journal Articles

Targeting Covalent and Non-Covalent Btki-Resistant CLL Using the Dual Irreversible/Reversible 4 th Generation BTK Inhibitor LP-168

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Kerry A Rogers, Adam S Kittai, Seema A Bhat, John C. Byrd, Deepa Sampath, Rosa Lapalombella, Weiguo Han, Neil E. Kay, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 416.
https://doi.org/10.1182/blood-2023-178259
Published: 2023
Journal Articles

The PKC-β Inhibitor MS-553 Displays Preclinical Efficacy in BTK Inhibitor Resistant Chronic Lymphocytic Leukemia

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Shanmugapriya Thangavadivel, Samon Benrashid, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Nicole R. Grieselhuber, Kerry A Rogers, James S. Blachly, Adam S Kittai, Seema A Bhat, John C. Byrd, Michael Niesman, Kai Zhang, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2260.
https://doi.org/10.1182/blood-2023-182024
Published: 2023
Journal Articles

Subclonal evolution of CLL driver mutations is associated with relapse in ibrutinib- and acalabrutinib-treated patients

Clinical Trials & Observations
Gage S. Black, Xiaomeng Huang, Yi Qiao, Szabolcs Tarapcsak, Kerry A. Rogers, Shrilekha Misra, John C. Byrd, Gabor T. Marth, Deborah M. Stephens, Jennifer A. Woyach
Journal: Blood
Blood (2022) 140 (4): 401–405.
https://doi.org/10.1182/blood.2021015132
Published: 2022
Includes: Supplemental data
Journal Articles

Characterization of LP-118, a Novel Small Molecule Inhibitor of Bcl-2 and Bcl-Xl in Chronic Lymphocytic Leukemia Resistant to Venetoclax

Janani Ravikrishnan, Elizabeth M. Muhowski, Tzung-Huei Lai, Shrilekha Misra, Daisy Diaz Rohena, Felai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2021) 138 (Supplement 1): 679.
https://doi.org/10.1182/blood-2021-151852
Published: 2021
Journal Articles

Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BT K/PLCG2 mutations

Fabienne Lucas, Karylin Larkin, C. Thomas Gregory, Shelley Orwick, Tzyy-Jye Doong, Arletta Lozanski, Gerard Lozanski, Shrilekha Misra, Apollinaire Ngankeu, Hatice Gulcin Ozer, Deepa Sampath, Shanmugapriya Thangavadivel, Selen A. Yilmaz, Kerry A. Rogers, John C. Byrd, Jennifer A. Woyach, James S. Blachly
Journal: Blood
Blood (2020) 135 (24): 2192–2195.
https://doi.org/10.1182/blood.2019003722
Published: 2020
Includes: Supplemental data
Journal Articles

The Protein Kinase C Inhibitor MS-553 for the Treatment of Chronic Lymphocytic Leukemia

Elizabeth M. Muhowski, Amy M. Lehman, M.A.S, Sean D. Reiff, PhD, Janani Ravikrishnan, Rose Mantel, Shrilekha Misra, Michael Niesman, PhD, Kai Zhang, MD, James S. Blachly, MD, Deepa Sampath, PhD, John C. Byrd, MD, Jennifer Woyach, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2077.
https://doi.org/10.1182/blood-2019-128871
Published: 2019