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Renier Brentjens
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Journal Articles

CD371-Targeted CAR T-Cells Secreting Interleukin-18 Exhibit Robust Expansion and Disease Clearance in Patients with Refractory Acute Myeloid Leukemia

Mark Blaine Geyer, Susan DeWolf, Xiaoli Mi, Brian C. Shaffer, Briana Cadzin, Devin McAvoy, Kinga K. Hosszu, Kenyon Weis, Rachel Lorenc, Alexander M. Lewis, Narina N. Girotra, Erin R. Burns, Jasmine S. Um, Sarah Yoo, Zoe Katsamakis, Xiuyan Wang, Isabelle Riviere, Kevin J. Curran, Jae H. Park, Marcel R.M. van den Brink, Omar Abdel-Wahab, Renier Brentjens, Anthony F. Daniyan
Journal: Blood
Blood (2024) 144 (Supplement 1): 2070.
https://doi.org/10.1182/blood-2024-194162
Published: 2024
Journal Articles

Enhancing CAR T Cell Efficacy By Modulating PI3K Signaling Via a Synthetic CD28 Rheostat

Sanam Shahid, Winson Cai, Erin R. Burns, Jasmine S. Um, Serena Mathew, Sydney Souness, Sarah Yoo, Bing-Yi Chen, Takeshi Fujino, Renier Brentjens, Anthony F. Daniyan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4802.
https://doi.org/10.1182/blood-2024-209964
Published: 2024
Journal Articles

Developing an Optimal Fully-Human CD371-Targeting IL-18 Secreting CAR T Cell for the Treatment of Acute Myeloid Leukemia

Sanam Shahid, Serena Mathew, Sydney Souness, Erin R. Burns, Jasmine S. Um, Sarah Yoo, Winson Cai, Mary Ann Pohl, Takeshi Fujino, Pu Zhang, Jennifer Lewis, Sean M. Devlin, Ivo Lorenz, Renier Brentjens, Anthony F. Daniyan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3406.
https://doi.org/10.1182/blood-2024-194391
Published: 2024
Journal Articles

A Phase II Trial of Prophylactic Anakinra to Prevent Neurotoxicity in Patients Receiving Anti-CD19 CAR T-Cell Therapy for Relapsed or Refractory Lymphoma: Final Results from Cohort 2

Karthik Nath, Sean M. Devlin, Craig S Sauter, Maria Lia Palomba, Gunjan L. Shah, Parastoo Bahrami Dahi, Richard J. Lin, Michael Scordo, Miguel-Angel Perales, Lori A. Leslie, Roni Shouval, Sara Bekele, Elizabeth Cathcart, Elena Mead, Bianca Santomasso, Andrei Holodny, Renier Brentjens, Isabelle Riviere, Michel Sadelain, Jae H. Park
Journal: Blood
Blood (2023) 142 (Supplement 1): 357.
https://doi.org/10.1182/blood-2023-174728
Published: 2023
Journal Articles

Low Dose Total Body Irradiation Improves CD19 CAR-T Expansion, Persistence, and Trafficking, Leading to Enhanced Efficacy in Large B-Cell Lymphoma

Mohammad Alhomoud, Michelle Foley, Mayumi Sugita, Takahiro Yamazaki, Leandro Martinez, Samuel Yamshon, Alexandra Gomez-Arteaga, Paul Pagnini, Tsiporah B. Shore, Olivier Boyer, Renier Brentjens, Koen Van Besien, Lorenzo Galluzzi, Silvia Formenti, Jeremie Martinet, Monica L. Guzman
Journal: Blood
Blood (2023) 142 (Supplement 1): 1016.
https://doi.org/10.1182/blood-2023-185216
Published: 2023
Journal Articles

Disease Control Affects Outcomes of Patients with Relapsed Diffuse Large B Cell Lymphoma Treated with CD19 Directed CAR T-Cell Therapy

Dorothy C Pan, Showkat Hamid, Megan Herr, Kristopher Attwood, Philip L. McCarthy, Maureen Ross, Grant Schofield, Matthew J Cortese, Dominick Lamonica, Jerry Thwin Wong, Kai Fu, Peter Maslak, Marco Davila, Renier Brentjens, Francisco J. Hernandez-Ilizaliturri
Journal: Blood
Blood (2023) 142 (Supplement 1): 7376.
https://doi.org/10.1182/blood-2023-187631
Published: 2023
Journal Articles

CD19-CAR Cytokine Induced Killer Cells Armored with IL-18 Control Tumor Burden, Prolong Mouse Survival and Result in In Vivo Persistence of CAR-CIK Cells in a Model of B-Cell Acute Lymphoblastic Leukemia

Mark Debenedette, Terence J Purdon, James Ryan McCloud, Ana Plachco, Marcus Norris, Alicia Gamble, John F Krisko, Irina Y Tcherepanova, Charles A Nicolette, Renier Brentjens
Journal: Blood
Blood (2023) 142 (Supplement 1): 6826.
https://doi.org/10.1182/blood-2023-178793
Published: 2023
Journal Articles

Manufacturing, Characterization and Anti-Tumor Activity of Allogeneic CD19-CAR Cytokine-Induced Killer (CIK) Cells Engineered with Non-Viral Sleeping Beauty Transposon System and Armored with IL-18

Laura Contreras-Ruiz, Barcley Pace, Dora E Kohnke, Lindsey Viruet, Melissa Adams, John F Krisko, Noah Leesnitzer, Marissa Velie, Sarah Tettamanti, Ilaria Pisani, Giusi Melita, Andrea Biondi, Alessandro Rambaldi, Irina Y Tcherepanova, Renier Brentjens, Charles A Nicolette
Journal: Blood
Blood (2023) 142 (Supplement 1): 3450.
https://doi.org/10.1182/blood-2023-181005
Published: 2023
Journal Articles

Long Term Follow-up after Treatment with Allogeneic Off-the-Shelf CAR T Cell Therapy for Relapsed or Refractory B-Cell Malignancies

Sanam Shahid, Georgia C Flynn, Audrey Mauguen, Jennifer Bieler, Susan E Prockop, Andromachi Scaradavou, Jaap Jan Boelens, Craig S Sauter, Miguel-Angel Perales, Sergio A. Giralt, Xiuyan Wang, Isabelle Riviere, Michel Sadelain, Renier Brentjens, Nancy A Kernan, Richard J O'Reilly, Kevin J Curran
Journal: Blood
Blood (2023) 142 (Supplement 1): 3476.
https://doi.org/10.1182/blood-2023-180753
Published: 2023
Journal Articles

High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation

Doris M. Ponce, Patrick Hilden, Christen Mumaw, Sean M. Devlin, Marissa Lubin, Sergio Giralt, Jenna D. Goldberg, Alan Hanash, Katharine Hsu, Robert Jenq, Miguel-Angel Perales, Craig Sauter, Marcel R. M. van den Brink, James W. Young, Renier Brentjens, Nancy A. Kernan, Susan E. Prockop, Richard J. O’Reilly, Andromachi Scaradavou, Sophie Paczesny, Juliet N. Barker
Journal: Blood
Blood (2015) 125 (1): 199–205.
https://doi.org/10.1182/blood-2014-06-584789
Published: 2015
Includes: Supplemental data
Journal Articles

Influence of National Comprehensive Cancer Network (NCCN) Guidelines on Clinical Practice in Patients with Chronic Myelogenous Leukemia (CML) Treated At a Single Academic Medical Center

Ellin Berman, MD, Cyrus V. Hedvat, MD, PhD, Joseph G. Jurcic, MD, Mark Heaney, MD, PhD, Peter G. Maslak, M.D., Renier Brentjens, MD, PhD, Nicole Lamanna, MD, Todd L. Rosenblat, MD, Mark G. Frattini, MD, PhD, Ann A Jakubowski, MD, PhD, Suresh Jhanwar, PhD
Journal: Blood
Blood (2011) 118 (21): 4433.
https://doi.org/10.1182/blood.V118.21.4433.4433
Published: 2011
Journal Articles

In Vivo comparison of 3 Suicide Gene-Prodrug Combinations in a Mouse Graft-Versus-Host-Disease Model

Jae H. Park, MD, Raymond Yeh, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD, PhD, Renier Brentjens, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3121.
https://doi.org/10.1182/blood.V118.21.3121.3121
Published: 2011
Journal Articles

Elevated Mitochondrial Membrane Potential in CLL Cells Is Associated with a more aggressive Natural History

Jeffrey R Gardner, MBA, Kristina Knapp, Mark G. Frattini, MD, PhD, Nicole Lamanna, MD, Renier Brentjens, MD, PhD, Joseph G Jurcic, MD, Peter G. Maslak, M.D., Ellin Berman, MD, Mark Weiss, MD, David A. Scheinberg, MD, PhD, Mark Heaney, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1765.
https://doi.org/10.1182/blood.V118.21.1765.1765
Published: 2011
Journal Articles

Adoptive Therapy with Human CD19 (hCD19)-Targeted T Cells Further Modified to Express IL-12 Overcome the Need for Prior Lymphodepletion to Eradicate Established hCD19 + Tumors and Induce B Cell Aplasias In Immune Competent hCD19 + Transgenic Mice

Erik Hayman, BS, James Lee, MD, Hollie J. Pegram, PhD, Renier Brentjens, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2097.
https://doi.org/10.1182/blood.V116.21.2097.2097
Published: 2010
Journal Articles

Characteristic Proinflammatory Serum Cytokine Profiles In Patients with B-Cell Chronic Lymphocytic Leukemia

James J. Harding, MD, Raymond Yeh, PhD, Yan Nikhamin, MS, MBA, Mark Frattini, MD, Nicole Lamanna, MD, Joseph G Jurcic, MD, Mark Heaney, MD, PhD, Renier Brentjens, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3595.
https://doi.org/10.1182/blood.V116.21.3595.3595
Published: 2010
Journal Articles

CD19 Targeted Cord Blood Derived T Cells for Cancer Immunotherapy.

Hollie J. Pegram, PhD, Vincent LaRussa, PhD, Renier Brentjens, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3767.
https://doi.org/10.1182/blood.V116.21.3767.3767
Published: 2010
Journal Articles

Efficacy and Long Term Survival of Genetically Modified T Cells Targeting CD19 in a Syngeneic Immune Competent Transgenic Murine Tumor Model Is Dependent on Prior Lymphodepleting Chemotherapy.

James Lee, BA, Yan Nikhamin, MS, Gavin Imperato, MS, Adam Cohen, MD, Michel Sadelain, MD/PhD, Renier Brentjens, MD/PhD
Journal: Blood
Blood (2007) 110 (11): 2754.
https://doi.org/10.1182/blood.V110.11.2754.2754
Published: 2007
Journal Articles

Pentostatin, Cyclophosphamide, and Rituximab (PCR) Has Comparable Activity but Appears To Be Better Tolerated Than Fludarabine, Cyclophosphamide, and Rituximab (FCR) in Patients with Previously Treated Chronic Lymphocytic Leukemia.

Nicole Lamanna, MD, Matt Kalaycio, MD, Peter Maslak, MD, Mark L. Heaney, MD, PhD, Renier Brentjens, MD, PhD, Joseph Jurcic, MD, Emily Biederman, Alison N. Gencarelli, RN, Katherine S. Panageas, PhD, David A. Scheinberg, MD, PhD, Mark A. Weiss, MD
Journal: Blood
Blood (2005) 106 (11): 2127.
https://doi.org/10.1182/blood.V106.11.2127.2127
Published: 2005