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Journal Articles

Evi1 Governs Kdm6b-Mediated Histone Demethylation to Regulate the Laptm4b-Driven mTOR Pathway in Hematopoietic Progenitor Cells

Qiong Wu, Chunjie Yu, Fang Yu, Yiran Guo, Yue Sheng, Liping Li, Yafang Li, Yutao Zhang, Chao Hu, Jue Wang, Tong-Chuan He, Yong Huang, Hongyu Ni, Zhigang Hou, Wenshu Wu, Greg G Wang, Jianxin Lyu, Zhijian Qian
Journal: Blood
Blood (2024) 144 (Supplement 1): 1337.
https://doi.org/10.1182/blood-2024-206390
Published: 2024
Journal Articles

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Zhangliang Cheng, Salim Oulghazi, Philipp Berning, David Fonseca-Arce, Kohei Kume, Jake Fontaine, Lai N Chan, Jaewoong Lee, Fang Yu, Zhijian Qian, Joo Y. Song, Wing Chung Chan, Jianjun Chen, Mark M Taketo, Hilde Schjerven, Markus Müschen
Journal: Blood
Blood (2024) 144 (Supplement 1): 4125.
https://doi.org/10.1182/blood-2024-208125
Published: 2024
Journal Articles

GADD45A: a key tumor suppressor in AML subtypes

Zhijian Qian, Fang Yu
Journal: Blood
Blood (2024) 144 (1): 6–7.
https://doi.org/10.1182/blood.2024024685
Published: 2024
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

A critical role of nuclear m 6 A reader YTHDC1 in leukemogenesis by regulating MCM complex–mediated DNA replication

Yue Sheng, Jiangbo Wei, Fang Yu, Huanzhou Xu, Chunjie Yu, Qiong Wu, Yin Liu, Lei Li, Xiao-long Cui, Xueying Gu, Bin Shen, Wei Li, Yong Huang, Sumita Bhaduri-McIntosh, Chuan He, Zhijian Qian
Journal: Blood
Blood (2021) 138 (26): 2838–2852.
https://doi.org/10.1182/blood.2021011707
Published: 2021
Includes: Supplemental data
Journal Articles

Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice

Yue Sheng, Rui Ma, Chunjie Yu, Qiong Wu, Steven Zhang, Kimberly Paulsen, Jiwang Zhang, Hongyu Ni, Yong Huang, Yi Zheng, Zhijian Qian
Journal: Blood
Blood (2021) 137 (5): 610–623.
https://doi.org/10.1182/blood.2019004688
Published: 2021
Includes: Supplemental data
Journal Articles

FoxM1 Haploinsufficiency Drives Clonal Hematopoiesis

Chunjie Yu, PhD, Yue Sheng, PhD, Zhijian Qian, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 726.
https://doi.org/10.1182/blood-2019-128429
Published: 2019
Journal Articles

FOXM1 Controls Leukemia Stem Cell Fate in MLL-Rearranged AML

Yue Sheng, PhD, Chao Hu, PhD, Chunjie Yu, PhD, Rui Ma, Master, Zhijian Qian, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2742.
https://doi.org/10.1182/blood-2018-99-116983
Published: 2018
Journal Articles

Cell Intrinsic and Extrinsic Mechanisms Mediate the Role of c-Myc Haploinsufficiency in Controlling HSC Fate

Yue Sheng, PhD, Chunjie Yu, PhD, Rui Ma, Master, Zhijian Qian, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2561.
https://doi.org/10.1182/blood-2018-99-116975
Published: 2018
Journal Articles

ALKBH5 Functions As an Oncogene in Acute Myeloid Leukemia

Chao Shen, PhD, Yue Sheng, PhD, Rui Su, PhD, Xiaolan Deng, Sean Robinson, Zhe Yin, MD, Lei Dong, PhD, Huilin Huang, PhD, Hengyou Weng, PhD, Chenying Li, MD, Zhijian Qian, Xi Jiang, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3910.
https://doi.org/10.1182/blood-2018-99-118988
Published: 2018
Journal Articles

Polycomb Repressive Complex 1 Enhances HSC Self-Renewal through Repressing the Canonical Wnt Signaling Pathway

Sisi Chen, BS, Xicheng Liu, Rui Gao, PhD, Michihiro Kobayashi, MD PhD, Hao Yu, PhD, Chonghua Yao, MD, Zhijian Qian, PhD, Rongwen Xi, PhD, Yan Liu, PhD
Journal: Blood
Blood (2015) 126 (23): 2378.
https://doi.org/10.1182/blood.V126.23.2378.2378
Published: 2015
Journal Articles

Fhl2 Regulates The Function Of Hematopoietic Stem/Progenitor Cells

Yu Hou, PhD, Zhijian Qian, PhD
Journal: Blood
Blood (2013) 122 (21): 2414.
https://doi.org/10.1182/blood.V122.21.2414.2414
Published: 2013
Journal Articles

Retroviral Insertional Mutagenesis In Egr1 +/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q

Angela Stoddart, PhD, Anthony Fernald, Rachel Joy Bergerson, PhD, Jianghong Wang, M.D., Megan E. McNerney, MD, PhD, Theodore Karrison, Ph.D., John Anastasi, MD, Elizabeth Bartom, Ph.D., Aaron G. Sarver, Ph.D., Zhijian Qian, PhD, Linda Wolff, PhD, David A. Largaespada, PhD, Michelle M. le Beau, PhD
Journal: Blood
Blood (2013) 122 (21): 1275.
https://doi.org/10.1182/blood.V122.21.1275.1275
Published: 2013
Journal Articles

Apc regulates the function of hematopoietic stem cells largely through β-catenin –dependent mechanisms

Wenshu Li, Yu Hou, Ming Ming, Long Yu, Amber Seba, Zhijian Qian
Journal: Blood
Blood (2013) 121 (20): 4063–4072.
https://doi.org/10.1182/blood-2012-12-473470
Published: 2013
Includes: Supplemental data
Journal Articles

Growth Inhibition of a Myeloid Leukemia Cell Line with 5q Deletion by Beta-Catenin Inhibition

Amber D. Seba, MD, Qi Wang, PhD, Ming Ming, PhD, Zhijian Qian, PhD
Journal: Blood
Blood (2012) 120 (21): 3608.
https://doi.org/10.1182/blood.V120.21.3608.3608
Published: 2012
Journal Articles

A Critical Role of Mir-9 in Myelopoesis and EVI1-Induced Leukemogenesis.

Vitalyi Senyuk, PhD, Yunyuan Zhang, Yang Liu, Ming Ming, PhD, Jianjun Chen, PhD, Janet D. Rowley, MD, Giuseppina Nucifora, PhD, Zhijian Qian, PhD
Journal: Blood
Blood (2012) 120 (21): 2332.
https://doi.org/10.1182/blood.V120.21.2332.2332
Published: 2012
Journal Articles

Haploinsufficiency of Apc leads to ineffective hematopoiesis

Jianghong Wang, Anthony A. Fernald, John Anastasi, Michelle M. Le Beau, Zhijian Qian
Journal: Blood
Blood (2010) 115 (17): 3481–3488.
https://doi.org/10.1182/blood-2009-11-251835
Published: 2010
Includes: Supplemental data
Journal Articles

MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations.

Zejuan Li, MD, PhD, Jun Lu, PhD, Miao Sun, MS, Shuangli Mi, PhD, Hao Zhang, MS, Roger T. Luo, PhD, Zhijian Qian, PhD, Mary Beth Neilly, MS, Yungui Wang, PhD, Jie Jin, MD, Yanming Zhang, MD, Stefan K. Bohlander, MD, Richard Larson, MD, Michelle LeBeau, PhD, Michael J. Thirman, MD, Todd R. Golub, MD, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2007) 110 (11): 3181.
https://doi.org/10.1182/blood.V110.11.3181.3181
Published: 2007
Journal Articles

MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.

Shuangli Mi, PhD, Jun Lu, Ph.D., Miao Sun, M.S., Zejuan Li, Ph.D., Hao Zhang, M.S., Mary Beth Neilly, M.S., Yungui Wang, Ph.D., Zhijian Qian, Ph.D., Jie Jin, M.D., Yanming Zhang, M.D., Stefan K. Bohlander, M.D., Michelle M. Le, B.A., Richard Larson, M.D., Todd R. Golub, M.D., Janet D. Rowley, M.D., Jianjun Chen, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 231.
https://doi.org/10.1182/blood.V110.11.231.231
Published: 2007
Journal Articles

Genetic Pathways in Therapy-Related Leukemia: FHL2 Cooperates with del(5q).

Zhijian Qian, PhD, Liqun Mao, Ms, Michelle Lebeau, Ph.D.
Journal: Blood
Blood (2005) 106 (11): 648.
https://doi.org/10.1182/blood.V106.11.648.648
Published: 2005