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Journal Articles

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

Kohei Kume, Jaewoong Lee, Zhangliang Cheng, Mark E Robinson, Etienne Leveille, Kadriye Nehir Cosgun, Lai N Chan, Yanzhi Feng, David Fonseca Arce, Dhruv Khanduja, Derek Toomre, Markus Müschen

Blood (2023) 142 (Supplement 1): 4138.

https://doi.org/10.1182/blood-2023-190926

Published: 2023

Journal Articles

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Kohei Kume, Zhengshan Chen, Mark E Robinson, Lai N Chan, Etienne Leveille, Kadriye Nehir Cosgun, Zhangliang Cheng, David Fonseca Arce, Dhruv Khanduja, Thomas Graeber, Markus Müschen

Blood (2023) 142 (Supplement 1): 2977.

https://doi.org/10.1182/blood-2023-191006

Published: 2023

Journal Articles

Immunoglobulin Light Chains Control Permissiveness to Malignant B-Cell Transformation By RAS-Pathway Lesions

Lai N Chan, Kohei Kume, Christian Hurtz, Mark E Robinson, Kadriye Nehir Cosgun, Markus Müschen

Blood (2023) 142 (Supplement 1): 2974.

https://doi.org/10.1182/blood-2023-190163

Published: 2023

Journal Articles

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Blood (2023) 142 (Supplement 1): 2818.

https://doi.org/10.1182/blood-2023-190522

Published: 2023

Journal Articles

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Ruifeng Sun, Jaewoong Lee, Mark E Robinson, Kohei Kume, Ning Ma, Kadriye Nehir Cosgun, Lai N Chan, Irina Antoshkina, Dhruv Khanduja, Etienne Leveille, Samuel G. Katz, Jianjun Chen, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2023) 142 (Supplement 1): 719.

https://doi.org/10.1182/blood-2023-189742

Published: 2023

Journal Articles

BCL6-Mediated Escape from Negative Selection Enables RAS-Driven B-Cell Transformation

Lai N. Chan, Christian Hurtz, Mark E. Robinson, Etienne Leveille, Huimin Geng, Rebecca Caeser, Liang Xu, Kohei Kume, Gang Xiao, Markus Müschen

Blood (2022) 140 (Supplement 1): 9177–9178.

https://doi.org/10.1182/blood-2022-169946

Published: 2022

Journal Articles

Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation

Lai N. Chan, Mark E. Robinson, Kadriye Nehir Cosgun, Xiaohui Yu, Etienne Leveille, Huimin Geng, Markus Müschen

Blood (2022) 140 (Supplement 1): 8758–8759.

https://doi.org/10.1182/blood-2022-170079

Published: 2022

Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Blood (2022) 140 (Supplement 1): 1698–1699.

https://doi.org/10.1182/blood-2022-170324

Published: 2022

Journal Articles

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

Kohei Kume, Zhengshan Chen, Lai N. Chan, Mark E. Robinson, Etienne Leveille, Jaewoong Lee, Kadriye Nehir Cosgun, David Fonseca Arce, Dhruv Khanduja, Lars Klemm, Markus Müschen

Blood (2022) 140 (Supplement 1): 5900–5901.

https://doi.org/10.1182/blood-2022-170396

Published: 2022

Journal Articles

GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies

Kadriye Nehir Cosgun, Huda Jumaa, Mark E. Robinson, Lai N. Chan, Jaewoong Lee, Kohei Kume, David Fonseca Arce, Julia Jellusova, Markus Müschen

Blood (2022) 140 (Supplement 1): 3114–3115.

https://doi.org/10.1182/blood-2022-169961

Published: 2022

Journal Articles

Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

Jaewoong Lee, Mark E. Robinson, Ning Ma, Teresa Sadras, Kadriye Nehir Cosgun, Lai N. Chan, Kohei Kume, Andrei Thomas-Tikhonenko, David M. Weinstock, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen

Blood (2021) 138 (Supplement 1): 868.

https://doi.org/10.1182/blood-2021-149646

Published: 2021

Journal Articles

Beta-Catenin Forms Repressive Complexes with Ikzf1 and Ikzf3 to Orchestrate Tumor-Suppression in B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E. Robinson, Lai N. Chan, Matthew Hur, Etienne Leveille, Joo Song, Wing (John) C. Chan, Markus Müschen

Blood (2021) 138 (Supplement 1): 29.

https://doi.org/10.1182/blood-2021-148597

Published: 2021

Journal Articles

Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Lai N. Chan, Mark A. Murakami, Christian Hurtz, Kohei Kume, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Shai Izraeli, David M. Weinstock, Markus Müschen

Blood (2021) 138 (Supplement 1): 616.

https://doi.org/10.1182/blood-2021-149773

Published: 2021

Journal Articles

Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell Malignancies

Kohei Kume, Jaewoong Lee, Lai N. Chan, Mark E. Robinson, Kadriye Nehir Cosgun, Eric Meffre, Markus Müschen

Blood (2021) 138 (Supplement 1): 2267.

https://doi.org/10.1182/blood-2021-149806

Published: 2021

Journal Articles

Identification of BCL6 As Synthetic Lethality in RAS-Driven B-Cell Transformation

Lai N. Chan, Christian Hurtz, Etienne Leveille, Kohei Kume, Mark E. Robinson, Huimin Geng, Kadriye Nehir Cosgun, Markus Müschen

Blood (2021) 138 (Supplement 1): 792.

https://doi.org/10.1182/blood-2021-148653

Published: 2021

Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 748.

https://doi.org/10.1182/blood-2019-127263

Published: 2019

Journal Articles

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Lai N Chan, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Erica Ballabio, Gang Xiao, PhD, Gauri Deb, MS, PhD, Haytham Khoury, MD PhD, Scott A. Armstrong, MD PhD, Patricia Ernst, PhD, Ari Melnick, MD, Tom Arthur Milne, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 1239.

https://doi.org/10.1182/blood-2019-131565

Published: 2019

Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 2782.

https://doi.org/10.1182/blood-2019-127615

Published: 2019

Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Blood (2019) 134 (Supplement_1): 393.

https://doi.org/10.1182/blood-2019-131270

Published: 2019

Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 3944.

https://doi.org/10.1182/blood-2019-130774

Published: 2019

NARROW

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Immunoglobulin Light Chains Control Permissiveness to Malignant B-Cell Transformation By RAS-Pathway Lesions

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

BCL6-Mediated Escape from Negative Selection Enables RAS-Driven B-Cell Transformation

Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies

Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

Beta-Catenin Forms Repressive Complexes with Ikzf1 and Ikzf3 to Orchestrate Tumor-Suppression in B-Cell Malignancies

Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell Malignancies

Identification of BCL6 As Synthetic Lethality in RAS-Driven B-Cell Transformation

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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