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Journal Articles

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Zhangliang Cheng, Salim Oulghazi, Philipp Berning, David Fonseca-Arce, Kohei Kume, Jake Fontaine, Lai N Chan, Jaewoong Lee, Fang Yu, Zhijian Qian, Joo Y. Song, Wing Chung Chan, Jianjun Chen, Mark M Taketo, Hilde Schjerven, Markus Müschen

Blood (2024) 144 (Supplement 1): 4125.

https://doi.org/10.1182/blood-2024-208125

Published: 2024

Journal Articles

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Ruifeng Sun, Jaewoong Lee, Dewan Artadji, Mark E Robinson, Kohei Kume, Zhangliang Cheng, Kadriye Nehir Cosgun, Lai N Chan, Etienne Leveille, Ning Ma, Huimin Geng, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2024) 144 (Supplement 1): 632.

https://doi.org/10.1182/blood-2024-211038

Published: 2024

Journal Articles

Mechanism of Negative Feedback Regulation of Oncogenic BCR-Signaling in Mature B-Cell Lymphoma

Ruifeng Sun, Jaewoong Lee, Mark E Robinson, Kohei Kume, Chuanzong Zhan, Zhangliang Cheng, Kadriye Nehir Cosgun, Lai N Chan, Etienne Leveille, Shalin Kothari, Samuel G. Katz, Ning Ma, Vivasvan S Vykunta, Brian Shy, Daniel J Hodson, Alexander Marson, Nagarajan Vaidehi, Markus Müschen

Blood (2024) 144 (Supplement 1): 3003.

https://doi.org/10.1182/blood-2024-211693

Published: 2024

Journal Articles

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

Kohei Kume, Jaewoong Lee, Zhangliang Cheng, Mark E Robinson, Etienne Leveille, Kadriye Nehir Cosgun, Lai N Chan, Yanzhi Feng, David Fonseca Arce, Dhruv Khanduja, Derek Toomre, Markus Müschen

Blood (2023) 142 (Supplement 1): 4138.

https://doi.org/10.1182/blood-2023-190926

Published: 2023

Journal Articles

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Ruifeng Sun, Jaewoong Lee, Mark E Robinson, Kohei Kume, Ning Ma, Kadriye Nehir Cosgun, Lai N Chan, Irina Antoshkina, Dhruv Khanduja, Etienne Leveille, Samuel G. Katz, Jianjun Chen, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2023) 142 (Supplement 1): 719.

https://doi.org/10.1182/blood-2023-189742

Published: 2023

Journal Articles

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Blood (2023) 142 (Supplement 1): 2818.

https://doi.org/10.1182/blood-2023-190522

Published: 2023

Journal Articles

IFITM3 Acts As a PIP 3 Scaffold in TCR-PI3K Signaling

Andrew Takeda, Jaewoong Lee, Tim Wartewig, Alberto Bigogno, David Fonseca Arce, Markus Müschen

Blood (2022) 140 (Supplement 1): 3030–3031.

https://doi.org/10.1182/blood-2022-170540

Published: 2022

Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Blood (2022) 140 (Supplement 1): 1698–1699.

https://doi.org/10.1182/blood-2022-170324

Published: 2022

Journal Articles

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

Kohei Kume, Zhengshan Chen, Lai N. Chan, Mark E. Robinson, Etienne Leveille, Jaewoong Lee, Kadriye Nehir Cosgun, David Fonseca Arce, Dhruv Khanduja, Lars Klemm, Markus Müschen

Blood (2022) 140 (Supplement 1): 5900–5901.

https://doi.org/10.1182/blood-2022-170396

Published: 2022

Journal Articles

GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies

Kadriye Nehir Cosgun, Huda Jumaa, Mark E. Robinson, Lai N. Chan, Jaewoong Lee, Kohei Kume, David Fonseca Arce, Julia Jellusova, Markus Müschen

Blood (2022) 140 (Supplement 1): 3114–3115.

https://doi.org/10.1182/blood-2022-169961

Published: 2022

Journal Articles

CD25 As Feedback Regulator of Oncogenic TCR Signaling in T-Cell Lymphoma

Ruifeng Sun, Jaewoong Lee, Tim Wartewig, Mark E. Robinson, Alberto Bigogno, David Fonseca Arce, Abu-Sayeef Mirza, Andrew Takeda, Lars Klemm, Vivasvan Vykunta, Brian Shy, Alexander Marson, Markus Müschen

Blood (2022) 140 (Supplement 1): 5975–5976.

https://doi.org/10.1182/blood-2022-170076

Published: 2022

Journal Articles

Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

Jaewoong Lee, Mark E. Robinson, Ning Ma, Teresa Sadras, Kadriye Nehir Cosgun, Lai N. Chan, Kohei Kume, Andrei Thomas-Tikhonenko, David M. Weinstock, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen

Blood (2021) 138 (Supplement 1): 868.

https://doi.org/10.1182/blood-2021-149646

Published: 2021

Journal Articles

Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Lai N. Chan, Mark A. Murakami, Christian Hurtz, Kohei Kume, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Shai Izraeli, David M. Weinstock, Markus Müschen

Blood (2021) 138 (Supplement 1): 616.

https://doi.org/10.1182/blood-2021-149773

Published: 2021

Journal Articles

Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell Malignancies

Kohei Kume, Jaewoong Lee, Lai N. Chan, Mark E. Robinson, Kadriye Nehir Cosgun, Eric Meffre, Markus Müschen

Blood (2021) 138 (Supplement 1): 2267.

https://doi.org/10.1182/blood-2021-149806

Published: 2021

Journal Articles

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

Jaewoong Lee, Mark E. Robinson, Ning Ma, Kohei Kume, Dewan Artadji, Teresa Sadras, Kadriye Nehir Cosgun, Huimin Geng, Elisabeth M. Paietta, Maike Buchner, Nagarajan Vaidehi, David M. Weinstock, Markus Müschen

Blood (2021) 138 (Supplement 1): 355.

https://doi.org/10.1182/blood-2021-149189

Published: 2021

Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 748.

https://doi.org/10.1182/blood-2019-127263

Published: 2019

Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 2782.

https://doi.org/10.1182/blood-2019-127615

Published: 2019

Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Blood (2019) 134 (Supplement_1): 393.

https://doi.org/10.1182/blood-2019-131270

Published: 2019

Journal Articles

Autonomous Ca 2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Kohei Kume, PhD, Liting Chen, PhD, Jaewoong Lee, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 1253.

https://doi.org/10.1182/blood-2019-130708

Published: 2019

Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 3944.

https://doi.org/10.1182/blood-2019-130774

Published: 2019

NARROW

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Mechanism of Negative Feedback Regulation of Oncogenic BCR-Signaling in Mature B-Cell Lymphoma

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

IFITM3 Acts As a PIP 3 Scaffold in TCR-PI3K Signaling

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies

CD25 As Feedback Regulator of Oncogenic TCR Signaling in T-Cell Lymphoma

Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell Malignancies

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Autonomous Ca 2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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