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Journal Articles

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

Jaewoong Lee, Mark E. Robinson, Ning Ma, Kohei Kume, Dewan Artadji, Teresa Sadras, Kadriye Nehir Cosgun, Huimin Geng, Elisabeth M. Paietta, Maike Buchner, Nagarajan Vaidehi, David M. Weinstock, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 355.
https://doi.org/10.1182/blood-2021-149189
Published: 2021
Journal Articles

Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

Jaewoong Lee, Mark E. Robinson, Ning Ma, Teresa Sadras, Kadriye Nehir Cosgun, Lai N. Chan, Kohei Kume, Andrei Thomas-Tikhonenko, David M. Weinstock, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 868.
https://doi.org/10.1182/blood-2021-149646
Published: 2021
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Teresa Sadras, PhD, Mickaël Martin, MD PhD, Lauren Kim-Sing, Jevon Cutler, PhD, Gal Lenz, PhD, Anne Marie Knapp, Dana Ghergus, MD PhD, Fabien Delmotte, Cédric Schleiss, Anne-Sophie Korganow, MD PhD, Pauline Soulas-Sprauel, PharmD, PhD, Zhengshan Chen, MD PhD, Akhilesh Pandey, MD PhD, David M. Weinstock, MD, Hassan Jumaa, PhD, Eric Meffre, PhD, Thierry Martin, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 295.
https://doi.org/10.1182/blood-2019-128999
Published: 2019
Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3944.
https://doi.org/10.1182/blood-2019-130774
Published: 2019
Journal Articles

Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies

Teresa Sadras, PhD, Jevon Cutler, Julia Aguade-Gorgorio, PhD, Zhengshan Chen, MD PhD, Kadriye Nehir Cosgun, PhD, Akhilesh Pandey, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3922.
https://doi.org/10.1182/blood-2018-99-116954
Published: 2018
Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 547.
https://doi.org/10.1182/blood-2018-99-116956
Published: 2018
Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 568.
https://doi.org/10.1182/blood-2018-99-115536
Published: 2018
Journal Articles

In Vitro Modeling of Ph-like ALL Fusions Identifies Novel Kinase-Domain Mutations As Mode of TKI-Resistance - Implications for Targeted Therapy

Kartini Asari, Susan L Heatley, PhD MD, Teresa Sadras, PhD, Tamara M Leclercq, PhD, Stephen Fitter, PhD, Chung Hoow Kok, PhD, Andrew C W Zannettino, PhD, Timothy P. Hughes, MD FRACP, FRCPA, MBBS, Deborah L White, PhD FFSc (RCPA)
Journal: Blood
Blood (2016) 128 (22): 3957.
https://doi.org/10.1182/blood.V128.22.3957.3957
Published: 2016
Journal Articles

High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk Adapted Treatment

Susan L Heatley, PhD MD, Teresa Sadras, PhD, Eva Nievergall, PhD, Chung Hoow Kok, PhD, Phuong Dang, BSci (Hon), Kelly Quek, PhD, Nicola C Venn, Sarah Moore, BSc (Hon), FFSc (RCPA), Tamara Law, BSc (Hons), Anthea Ng, BAppSc, MSc, Murray D Norris, PhD, Tamas Revesz, MD PhD, Michael P Osborn, MBBS, Chris Fraser, FRACP, MBBS, MPH, Frank Alvaro, MBBS, FRACP, Glenn M Marshall, MBBS, MD FRACP, Luciano Dalla Pozza, MBBS, FRACP, Timothy P. Hughes, MD MBBS, FRACP, FRCPA, Charles G. Mullighan, MBBS, MSc, MD, Rosemary Sutton, PhD, Deborah L White, PhD FFSc (RCPA)
Journal: Blood
Blood (2015) 126 (23): 1419.
https://doi.org/10.1182/blood.V126.23.1419.1419
Published: 2015
Journal Articles

An ENU Mutagenesis Screen of FLT3-ITD Knock-in Mice Identifies Novel Gene Mutations That Lead to an Exacerbated Myeloproliferative Neoplasm

Anna L Brown, PhD, Teresa Sadras, PhD, Grant A Engler, BSc (Hons), Robert Tunningley, PhD, Jennifer Kofler, BSc, Paul J Leo, PhD, Jesse Cheah, BSc, Adrienne Laskowski, BSc, Ann Frazier, PhD, David Stroud, PhD, Michael Ryan, PhD, David Thorburn, PhDFHGSA FFSc(RCPA), D Gary Gilliland, MDPhD, Ian D Lewis, MBBS, PhD, Thomas J Gonda, PhD, Richard J D'Andrea, PhD
Journal: Blood
Blood (2014) 124 (21): 3591.
https://doi.org/10.1182/blood.V124.21.3591.3591
Published: 2014