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Paul G. Ekert
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Journal Articles

Co-Targeting BCL-2 and MCL1 (via CDK9) in Pre-Clinical Models of High-Risk Acute Lymphoblastic Leukemia

Donia M. Moujalled, Seong Lin Khaw, Teresa Sadras, Giovanna Pomilio, Thomas Morley, Veronique Litalien, Louise Ludlow, Paul G. Ekert, Diane Hanna
Journal: Blood
Blood (2024) 144 (Supplement 1): 1419.
https://doi.org/10.1182/blood-2024-202757
Published: 2024
Journal Articles

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Georgina L. Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, Jing Ma, Mahsa Khanlari, Jeffrey E. Rubnitz, Rhonda E. Ries, Hansen J. Kosasih, Paul G. Ekert, Hwee Ngee Goh, Ing S. Tiong, Sean M. Grimmond, Claudia Haferlach, Ryan B. Day, Timothy J. Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, Jeffery M. Klco
Journal: Blood
Blood (2023) 141 (7): 800–805.
https://doi.org/10.1182/blood.2022017874
Published: 2023
Includes: Supplemental data
Journal Articles

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Journal: Blood
Blood (2022) 139 (26): 3737–3751.
https://doi.org/10.1182/blood.2021013277
Published: 2022
Includes: Supplemental data
Journal Articles

Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia

Shunsuke Kimura, Lindsey Montefiori, Ilaria Iacobucci, Yaqi Zhao, Qingsong Gao, Elisabeth M. Paietta, Claudia Haferlach, A. Douglas Laird, Paul E. Mead, Zhaohui Gu, Wendy Stock, Mark Litzow, Jacob M. Rowe, Selina M. Luger, Stephen P. Hunger, Georgina L. Ryland, Breon Schmidt, Paul G. Ekert, Alicia Oshlack, Sean M. Grimmond, Jacqueline Rehn, James Breen, David Yeung, Deborah L. White, Ibrahim Aldoss, Elias J. Jabbour, Ching-Hon Pui, Manja Meggendorfer, Wencke Walter, Wolfgang Kern, Torsten Haferlach, Samuel Brady, Jinghui Zhang, Kathryn G. Roberts, Piers Blombery, Charles G. Mullighan
Journal: Blood
Blood (2022) 139 (24): 3519–3531.
https://doi.org/10.1182/blood.2022015444
Published: 2022
Includes: Supplemental data
Journal Articles

Diagnostic Utility of Multimodal Genomic Profiling for Molecular Classification and MRD Assessment in Adult B-Cell Acute Lymphoblastic Leukemia

Georgina L Ryland, Ashish Bajel, Michael Dickinson, Paul G Ekert, Oliver Hofmann, Maarten IJzerman, Ashley P Ng, Alicia Oshlack, Breon Schmidt, Ing S Tiong, Martin Vu, David Alan Westerman, Sean Grimmond, Piers Blombery
Journal: Blood
Blood (2021) 138 (Supplement 1): 274.
https://doi.org/10.1182/blood-2021-146396
Published: 2021
Journal Articles

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

Lauren M Brown, BSc, Hannah Huckstep, BSc, Jarrod Sandow, PhD, Ray C Bartolo, PhD, Nadia Davidson, PhD, Breon Schmidt, BSc, Stefan Bjelosevic, BSc, Ricky W Johnstone, PhD, Alicia Oshlack, PhD, Melissa Davis, PhD, Paul G Ekert
Journal: Blood
Blood (2018) 132 (Supplement 1): 2628.
https://doi.org/10.1182/blood-2018-99-117844
Published: 2018
Journal Articles

Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML

Jessica M Salmon, PhD, Giovanna Pomilio, Donia M Moujalled, PhD, Sarah Macraild, Charis E Teh, PhD, Sewa Riajl, PhD, Adam Ivey, BSc, MSc, PhD, Tse-Chieh Teh, MD, Paul G Ekert, Laurence Kraus-Berthier, Ioana Kloos, Marie Schoumacher, Daniel Gray, Andrew H Wei, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1426.
https://doi.org/10.1182/blood-2018-99-117403
Published: 2018
Journal Articles

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, PhD, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W. Roberts, MBBS, PhD, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei, MBBS,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 567.
https://doi.org/10.1182/blood-2018-99-114051
Published: 2018
Journal Articles

Germline TIM-3 Mutations Characterize Sub-Cutaneous Panniculitis T-Cell Lymphomas with Hemophagocytic Lymphohistiocytic Syndrome

Dong-Anh Khuong-Quang, MD PhD, Tenzin Gayden, PhD, Fernando Sepulveda, Jonathan Pratt, Elvis Valera, Alexandrine Garrigue, Susan Kelso, Frank Sicheri, Leonie Mikael, Nancy Hamel, Andrea Bajic, Rola Dali, Dzana Dervovic, Daniel Schramek, Frederic Guerin, Mikko Taipale, Hamid Nikbakht, Jacek Majewski, Despina Moshous, Janie Charlebois, Sharon Abish, MD, Christine Bole-Feysot, Patrick Nitschke, Brigitte Bader-Meunier, David Mitchell, Catherine Thieblemont, MD, Maxime Battistella, MD PhD, Simon Gravel, Van-Hung Nguyen, Rachel Conyers, MD PhD, Jean-Sebastien Diana, MD, Christopher McCormack, H. Miles Prince, MD FRACP, FRCPA, Marianne Besnard, Stephane Blanche, MD, Paul G Ekert, Sylvie Fraitag, William D Foulkes, Alain Fischer, MD PhD, Benedicte Neven, MD, David Michonneau, MD, Genevieve de Saint Basile, Nada Jabado
Journal: Blood
Blood (2018) 132 (Supplement 1): 1569.
https://doi.org/10.1182/blood-2018-99-120297
Published: 2018
Journal Articles

Microrna-211 - a Novel Oncogene in Acute Myeloid Leukemia

Nisha Narayan, PhD, Leah Morenos, PhD, Hiu Lam Agnes Yuen, MBBS, Melissa Chen, Maarten Fornerod, C. Michel Zwaan, George Grigoriadis, MBBS PhDFRACP FRCPA, Paul G Ekert, MBBS,PhDFRACP
Journal: Blood
Blood (2017) 130 (Supplement 1): 2507.
https://doi.org/10.1182/blood.V130.Suppl_1.2507.2507
Published: 2017
Journal Articles

The Dose-Dependent Effects of Microrna-155 in Acute Myeloid Leukemia

Nisha Narayan, PhD, Leah Morenos, PhD, Belinda Phipson, PhD, Gabriella Brumatti, PhD, Stefanie Eggers, PhD, Richard Saffery, PhD, Simon Willis, PhD, Alicia Oshlack, PhD, Gregory J Goodall, PhD, Paul G Ekert, MB.BS, PhD FRACP
Journal: Blood
Blood (2016) 128 (22): 2841.
https://doi.org/10.1182/blood.V128.22.2841.2841
Published: 2016
Journal Articles

The Role of Receptor Interacting Protein Kinase in Myelopoiesis in Health and Disease

John Silke, PhD, Chunyan Ma, Gabriela Brumatti, PhD, Najoua Lalaoui, PhD, Paul G Ekert, MB.BS, PhD FRACP
Journal: Blood
Blood (2015) 126 (23): SCI-29.
https://doi.org/10.1182/blood.V126.23.SCI-29.SCI-29
Published: 2015
Journal Articles

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A. Powell, Francois Vergez, David H. Segal, Nhu-Y. N. Nguyen, Adele Baker, Tse-Chieh Teh, Emma F. Barry, Jean-Emmanuel Sarry, Erwin M. Lee, Tracy L. Nero, Anissa M. Jabbour, Giovanna Pomilio, Benjamin D. Green, Stéphane Manenti, Stefan P. Glaser, Michael W. Parker, Angel F. Lopez, Paul G. Ekert, Richard B. Lock, David C. S. Huang, Susie K. Nilsson, Christian Récher, Andrew H. Wei, Mark A. Guthridge
Journal: Blood
Blood (2013) 122 (5): 738–748.
https://doi.org/10.1182/blood-2012-08-447441
Published: 2013
Includes: Supplemental data
Journal Articles

Role for BH3-Only Protein NOXA In Growth-Factor Deprivation and Early Erythropoiesis

Christian R. Geest, PhD, Felix M. Wensveen, PhD, Sten F.W.M. Libregts, PhD, Alex M. de Bruin, PhD, Ingrid A.M. Derks, PhD, Paul G. Ekert, Verena Labi, PhD, Andreas Villunger, PhD, Martijn A. Nolte, PhD, Eric Eldering, PhD
Journal: Blood
Blood (2010) 116 (21): 4235.
https://doi.org/10.1182/blood.V116.21.4235.4235
Published: 2010
Journal Articles

GATA2 is a New Predisposition Gene for Familial Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Hamish S Scott, PhD, Christopher N Hahn, PhD, Catherine L Carmichael, PhD, Ella J Wilkins, BSc(Hon), Chan-Eng Chong, MSc, Peter J Brautigan, BSc(Hon), Xiao-Chun Li, MSc, Milena Stankovic, BSc(Hon), Ming Lin, BSc(Hon), Amandine Carmagnac, BSc, Carolyn M Butcher, MMedSc(Hon), Kathryn L Friend, PhD, Paul G Ekert, MBBS, PhD, Chung H Kok, BSc(Hon), Anna L Brown, PhD, Ian D Lewis, MBBS, PhD, L. Bik To, MD, Andrew E Timms, PhD, Jan Storek, MD, PhD, Sarah Moore, BSc(Hon), Meryl Altree, BNg, Robert Escher, MD, Peter G Bardy, MBBS, Graeme K Suthers, MBBS, PhD, Richard J D'Andrea, PhD, Marshall S Horwitz, MD, PhD
Journal: Blood
Blood (2010) 116 (21): LBA-3.
https://doi.org/10.1182/blood.V116.21.LBA-3.LBA-3
Published: 2010
Journal Articles

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

Anissa M. Jabbour, Carmel P. Daunt, Benjamin D. Green, Sandra Vogel, Lavinia Gordon, Rachel S. Lee, Natasha Silke, Richard B. Pearson, Cassandra J. Vandenberg, Priscilla N. Kelly, Stephen L. Nutt, Andreas Strasser, Christoph Borner, Paul G. Ekert
Journal: Blood
Blood (2010) 115 (2): 344–352.
https://doi.org/10.1182/blood-2009-07-230730
Published: 2010
Includes: Supplemental data
Journal Articles

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Timothy R. Hercus, Daniel Thomas, Mark A. Guthridge, Paul G. Ekert, Jack King-Scott, Michael W. Parker, Angel F. Lopez
Journal: Blood
Blood (2009) 114 (7): 1289–1298.
https://doi.org/10.1182/blood-2008-12-164004
Published: 2009
Journal Articles

Regulated Hox Gene Expression Reveals a Novel Role for Hox Genes in Myeloid Cell Proliferation and Survival

Marika Salmanidis, Gabi Brumatti, Anissa M Jabbour, Benjamin D Green, John Silke, Philippe Bouillet, Paul G Ekert, MB.BS, PhD, FRACP
Journal: Blood
Blood (2008) 112 (11): 5323.
https://doi.org/10.1182/blood.V112.11.5323.5323
Published: 2008
Journal Articles

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

Paul G. Ekert, Anissa M. Jabbour, Anand Manoharan, Jacki E. Heraud, Jai Yu, Miha Pakusch, Ewa M. Michalak, Priscilla N. Kelly, Bernard Callus, Thomas Kiefer, Anne Verhagen, John Silke, Andreas Strasser, Christoph Borner, David L. Vaux
Journal: Blood
Blood (2006) 108 (5): 1461–1468.
https://doi.org/10.1182/blood-2006-03-014209
Published: 2006
Includes: Supplemental data