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Journal Articles

Ex Vivo Expansion of Human Hematopoietic Stem Cells By Mimicking Intrinsic and Extrinsic Factors in Adult Bone Marrow

Xinjian Mao, Ning Zhang, Xi He, Ruochen Dong, Zhe Yang, Michael Epp, Linda Zhang, Allison Scott, Kate Hall, Anoja Perera, Jeff Haug, Hua Li, Cheng Luo, Chuan He, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 4042.
https://doi.org/10.1182/blood-2024-208449
Published: 2024
Journal Articles

Effectiveness of Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria in China: A Real World Study

He LI, Xinmei Yu, Juan Qiu, Lei Jia, Huanling Zhu, Ting Niu, Zhigang Liu, Chuan He
Journal: Blood
Blood (2024) 144 (Supplement 1): 5696.
https://doi.org/10.1182/blood-2024-212316
Published: 2024
Journal Articles

Identifying 5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA and Treatment Response in Multiple Myeloma with a Multi-Step Machine Learning Approach

Bei Wang, Benjamin A Derman, Zhou Zhang, Krissana Kowitwanich, John F. Cursio, Daniel Appelbaum, Chuan He, Wei Zhang, Andrzej J Jakubowiak, Brian Chiu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3336.
https://doi.org/10.1182/blood-2024-204305
Published: 2024
Journal Articles

Evi1 Governs Kdm6b-Mediated Histone Demethylation to Regulate the Laptm4b-Driven mTOR Pathway in Hematopoietic Progenitor Cells

Qiong Wu, Chunjie Yu, Fang Yu, Yiran Guo, Yue Sheng, Liping Li, Yafang Li, Yutao Zhang, Chao Hu, Jue Wang, Tong-Chuan He, Yong Huang, Hongyu Ni, Zhigang Hou, Wenshu Wu, Greg G Wang, Jianxin Lyu, Zhijian Qian
Journal: Blood
Blood (2024) 144 (Supplement 1): 1337.
https://doi.org/10.1182/blood-2024-206390
Published: 2024
Journal Articles

Venetoclax Combined with Hag Regimen in Newly Diagnosed ETP-ALL: Interim Analysis of a Prospective, Multicenter, Phase 2 Trial

Shanshan Suo, Wen-Juan Yu, Ying Lu, Jiejing Qian, Liping Mao, Jin Wang, Lijing Shen, Bingzong Li, Huafeng Wang, Wenyuan MAI, Wanzhuo Xie, Xiaomin Wang, Dan Zhao, Yuanfang Liu, Chuan He, Jie Jin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2869.
https://doi.org/10.1182/blood-2023-191190
Published: 2023
Journal Articles

Results from the First Phase 3 Crovalimab (C5 Inhibitor) Study (COMMODORE 3): Efficacy and Safety in Complement Inhibitor-Naive Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Hui Liu, Linghui Xia, Jianyu Weng, Fengkui Zhang, Chuan He, Sujun Gao, Jinsong Jia, Alice C. Chang, Pontus Lundberg, Camelia S. Sima, Jane Shi, Zhenyu Xiao, Yuchen Zhang, Zilu Zhang, Rong Fu
Journal: Blood
Blood (2022) 140 (Supplement 1): 714–716.
https://doi.org/10.1182/blood-2022-162452
Published: 2022
Journal Articles

Requirement for N 6 -Methyladenosine mRNA Methylation during Human Erythropoiesis

Daniel Kuppers, Yong Peng, Sonali Arora, Cindy Wladyka, Anne Wilhite, Derek Stirewalt, Beverly Torok-Storb, Andrew Hsieh, Chuan He, Patrick Paddison
Journal: Blood
Blood (2022) 140 (Supplement 1): 8163.
https://doi.org/10.1182/blood-2022-168316
Published: 2022
Journal Articles

A critical role of nuclear m 6 A reader YTHDC1 in leukemogenesis by regulating MCM complex–mediated DNA replication

Yue Sheng, Jiangbo Wei, Fang Yu, Huanzhou Xu, Chunjie Yu, Qiong Wu, Yin Liu, Lei Li, Xiao-long Cui, Xueying Gu, Bin Shen, Wei Li, Yong Huang, Sumita Bhaduri-McIntosh, Chuan He, Zhijian Qian
Journal: Blood
Blood (2021) 138 (26): 2838–2852.
https://doi.org/10.1182/blood.2021011707
Published: 2021
Includes: Supplemental data
Journal Articles

5hmC Gene Signature Predicts the Treatment Response to Azacitidine with High-Dose Cytarabine and Mitoxantrone in AML

Kirk Cahill, Linchen Wang, Guanghao Liang, Qiancheng You, Chuanyuan Chen, Wei Zhang, Noreen Fulton, Wendy Stock, Olatoyosi Odenike, Chuan He, Dali Han
Journal: Blood
Blood (2021) 138 (Supplement 1): 1305.
https://doi.org/10.1182/blood-2021-151951
Published: 2021
Journal Articles

FLT3 inhibition upregulates HDAC8 via FOXO to inactivate p53 and promote maintenance of FLT3-ITD + acute myeloid leukemia

Jun Long, Ming-Yuan Jia, Wei-Yue Fang, Xin-Jie Chen, Li-Li Mu, Zhong-Yu Wang, Yan Shen, Ru-Fang Xiang, Li-Ning Wang, Ling Wang, Chuan-He Jiang, Jie-Ling Jiang, Wen-Jun Zhang, Yi-Dan Sun, Li Chang, Wen-Hui Gao, Ying Wang, Jun-Min Li, Deng-Li Hong, Ai-Bin Liang, Jiong Hu
Journal: Blood
Blood (2020) 135 (17): 1472–1483.
https://doi.org/10.1182/blood.2019003538
Published: 2020
Includes: Supplemental data
Journal Articles

Peritoneal Cavity Cells Ameliorate Graft-Versus-Host Disease of Mice after MHC Mismatched Bone Marrow Transplantation

Zhigang Liu, MD, Wanhua Zhang, MD, Xinchuan Chen, MD, Chuan He, MD, Jie Ji, MD, Ting Liu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5675.
https://doi.org/10.1182/blood-2018-99-114510
Published: 2018
Journal Articles

5-Hydroxymethylcytosines of Circulating Cell-Free DNA and Prognosis in Diffuse Large B-Cell Lymphoma

Brian C.-H. Chiu, PhD, Zhou Zhang, PhD, Qiancheng You, BS, Elizabeth Stepniak, MPH, Paige Bracci, PhD, Rudyard I Chiu, Xu Zhang, PhD, Girish Venkataraman, MD MBBS, Sonali M. Smith, MD, Chuan He, Wei Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2985.
https://doi.org/10.1182/blood-2018-99-114375
Published: 2018
Journal Articles

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

Xi Jiang, PhD, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, PhD, Liting Cheng, Zhixiang Zuo, PhD, William Seibel, PhD, Chunjiang He, PhD, Yixuan Tang, Jennifer R Skibbe, Mark Wunderlich, MS, William C Reinhold, Lei Dong, PhD, Chao Shen, PhD, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, PhD, Hengyou Weng, PhD, Rui Su, PhD, Huilin Huang, PhD, Yungui Wang, PhD, Chenying Li, MD, Xi Qin, James C. Mulloy, PhD, Yi Zheng, PhD, Jiajie Diao, PhD, Jie Jin, Chong Li, PhD, Paul P Liu, MD, Chuan He, PhD, Yuan Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 857.
https://doi.org/10.1182/blood.V130.Suppl_1.857.857
Published: 2017
Journal Articles

RNA:m 5 c/Methyltransferases Mediate Chromatin Organization and 5-Azacytidine Response/Resistance in Leukemia

Jason Cheng, MD PhD, Li Chen, PhD MD, Yuan Li, MD, Ming Yue, PhD, Adam Cloe, MD, PhD, Jamile M. Shammo, MD FASCP, FACP, Richard A. Larson, MD, Chuan He, PhD, Michelle M. Le Beau, PhD, James W. Vardiman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2471.
https://doi.org/10.1182/blood.V130.Suppl_1.2471.2471
Published: 2017
Journal Articles

5-Hydroxymethylcytosine of Circulating Cell-Free DNA in Plasma: A Novel Non-Invasive Marker for Progression and Prognosis in Multiple Myeloma

Brian C.-H. Chiu, PhD, Qiancheng You, BS, Zhou Zhang, PhD, Elizabeth Stepniak, MPH, Xu Zhang, PhD, Meytal Chernoff, BS, Todd M. Zimmerman, Chuan He, PhD, Wei Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4336.
https://doi.org/10.1182/blood.V130.Suppl_1.4336.4336
Published: 2017
Journal Articles

Fto Plays an Oncogenic Role in Acute Myeloid Leukemia As a N 6 -Methyladenosine RNA Demethylase

Rui Su, PhD, Zejuan Li, MD PhD, Hengyou Weng, PhD, Xiaocheng Weng, PhD, Zhixiang Zuo, Chenying Li, Huilin Huang, PhD, Chao Hu, PhD, Xi Qin, Lichuan Tang, PhD, Yungui Wang, PhD, Gia-Ming Hong, PhD, Hao Huang, PhD, Xiao Wang, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Yuanyuan Li, Shenglai Li, Jennifer Strong, Mary Elizabeth Neilly, Richard A. Larson, Xi Jiang, PhD, Pumin Zhang, Jie Jin, MD PhD, Chuan He, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 2706.
https://doi.org/10.1182/blood.V128.22.2706.2706
Published: 2016
Journal Articles

Retrospective Treatment Analysis of a Series of 104 Patients with Adult Onset Hemophagocytic Lymphohistiocytosis in a Single Institution of China

Xiao Shuai, MD, Juan Xu, MD, Xushu Zhong, MD, Yan Li, MD, Wenjiao Tang, MD, Huanling Zhu, MD, Ting Niu, MD& PhD, Yu Wu, MD& PhD, Yongqian Jia, MD, Xu Cui, MD, Ling Pan, MD& PhD, Hong Chang, MD, Yuping Gong, MD& PhD, Bing Xiang, MD, Jie Huang, MD, Jianjun Li, MD, Chuan He, MD, Xinchuan Chen, MD, Liping Xie, MD& PhD, Hongbing Ma, MD, Jie Ji, MD, Yang Dai, MD & PhD, Zhigang Liu, MD, Ting Liu, MD & PhD
Journal: Blood
Blood (2016) 128 (22): 4882.
https://doi.org/10.1182/blood.V128.22.4882.4882
Published: 2016
Journal Articles

Bromodomain and Extra-Terminal Motif Proteins (BETs) Mediate 5-Azacitidine Resistance in Myeloid Leukemia through Recruitment of an Active RNA Polymerase II Complex

Li Chen, MD PhD, Yuan Li, MD, Ming Yue, PhD, Adam Cloe, MD PhD, Michelle M. Le Beau, PhD, Chuan He, PhD, Richard A. Larson, MD, James W. Vardiman, MD, Jason X. Cheng, MD PhD
Journal: Blood
Blood (2016) 128 (22): 746.
https://doi.org/10.1182/blood.V128.22.746.746
Published: 2016
Journal Articles

The N 6 -Adenine Methyltransferase METTL14 Plays an Oncogenic Role in Acute Myeloid Leukemia

Huilin Huang, PhD, Hengyou Weng, PhD, Xi Qin, Boxuan Simen Zhao, PhD, Lou Dore, Jennifer Strong, Rui Su, PhD, Kyle Ferchen, Chenying Li, Lei Dong, Xi Jiang, PhD, Chuan He, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 1536.
https://doi.org/10.1182/blood.V128.22.1536.1536
Published: 2016
Journal Articles

DNA Hydroxymethylation Profiling Reveals That WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Raajit K. Rampal, MD PhD, Altuna Alkalin, Jozef Madzo, PhD, Aparna Vasanthakumar, BSc, MSc, PhD, Elodie Pronier, PhD, Jay P. Patel, Yushan Li, Jihae Ahn, BS, Omar Abdel-Wahab, MD, Alan H. Shih, MDPhD, Chao Lu, Patrick Ward, Jennifer J Tsai, MD, Todd Hricik, Jacob Tallman, Valeria Tosello, PhD, Xinyang Zhao, PhD, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, PhD, Chuan He, PhD, François Fuks, Martin S. Tallman, MD, Adolfo A. Ferrando, MD PhD, Stephen Nimer, MD, Elisabeth Paietta, PhD, Craig B. Thompson, MD, Jonathan D. Licht, MD, Christopher E Mason, PhD, Lucy A Godley, MD PhD, Ari M Melnick, MD, Maria E Figueroa, MD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 365.
https://doi.org/10.1182/blood.V124.21.365.365
Published: 2014