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Journal Articles

Zinpentraxin Alfa Reduces Myelofibrosis in a JAK2 -V617F Mouse Model of Myeloproliferative Neoplasms

Shivam Rai, Hui Hao-Shen, Stefan Dirnhofer, Julien Roux, Rajbharan Yadav, Anamarija Pfeiffer, Jakob Vowinckel, Audrey Arjomandi, Brian Higgins, Lyrialle Han, Kerstin Trunzer, Pontus Lundberg, Radek C. Skoda

Blood (2023) 142 (Supplement 1): 1787.

https://doi.org/10.1182/blood-2023-186631

Published: 2023

Journal Articles

Quantitative Analysis of Bone Marrow Features Highlights Heterogeneity in Myelofibrosis Patients Treated with Zinpentraxin Alfa in a Phase II Clinical Study

Hosuk Ryou, Korsuk Sirinukunwattana, Ruby Wood, Alan Aberdeen, Jens Rittscher, Olga Weinberg, Robert Hasserjian, Olga Pozdnyakova, Frank Peale, Brian Higgins, Pontus Lundberg, Kerstin Trunzer, Claire N Harrison, Daniel Royston

Blood (2023) 142 (Supplement 1): 4558.

https://doi.org/10.1182/blood-2023-181784

Published: 2023

Journal Articles

Biomarker Analyses in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 Trial

Pontus Lundberg, Silvia de la Iglesia, Richard J Kelly, Austin Kulasekararaj, Jun-Ichi Nishimura, Antonio M Risitano, Alexander Roeth, Simon Buatois, Sammy Chebon, Himika Patel, Anna Kiialainen

Blood (2023) 142 (Supplement 1): 4088.

https://doi.org/10.1182/blood-2023-178694

Published: 2023

Journal Articles

Results from the First Phase 3 Crovalimab (C5 Inhibitor) Study (COMMODORE 3): Efficacy and Safety in Complement Inhibitor-Naive Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Hui Liu, Linghui Xia, Jianyu Weng, Fengkui Zhang, Chuan He, Sujun Gao, Jinsong Jia, Alice C. Chang, Pontus Lundberg, Camelia S. Sima, Jane Shi, Zhenyu Xiao, Yuchen Zhang, Zilu Zhang, Rong Fu

Blood (2022) 140 (Supplement 1): 714–716.

https://doi.org/10.1182/blood-2022-162452

Published: 2022

Journal Articles

MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineages

Ronny Nienhold, Peter Ashcroft, Jakub Zmajkovic, Shivam Rai, Tata Nageswara Rao, Beatrice Drexler, Sara C. Meyer, Pontus Lundberg, Jakob R. Passweg, Danijela Leković, Vladan Čokić, Sebastian Bonhoeffer, Radek C. Skoda

Blood (2020) 136 (22): 2591–2595.

https://doi.org/10.1182/blood.2019002943

Published: 2020

Includes: Supplemental data

Journal Articles

Night Transplantation and Catecholamine Exposure Accelerates In Vivo Leukemia Development By Enhancing Bone Marrow Homing Capacity in Leukemic Cells

Pauline Hanns, MSc, Anna M Paczulla, PhD, Martina Konantz, PhD, Marcelle Baer, MSc, Pontus Lundberg, PhD, Stefan Dirnhofer, MD, Claudia Lengerke, MD

Blood (2019) 134 (Supplement_1): 1446.

https://doi.org/10.1182/blood-2019-126984

Published: 2019

Journal Articles

Catecholamine Exposure Accelerates In Vivo Leukemogenesis in Acute Myeloid Leukemia Patient Derived Xenografts

Anna M Paczulla, PhD, Pauline Hanns, MSc, Martina Konantz, PhD, Pontus Lundberg, PhD, Stefan Dirnhofer, MD, Claudia Lengerke, MD

Blood (2018) 132 (Supplement 1): 1475.

https://doi.org/10.1182/blood-2018-99-119451

Published: 2018

Journal Articles

Absence of NKG2D Ligands Defines Human Acute Myeloid Leukaemia Stem Cells and Mediates Their Immune Evasion

Blood (2018) 132 (Supplement 1): 769.

https://doi.org/10.1182/blood-2018-99-118047

Published: 2018

Journal Articles

A Gain-of-Function Mutation in EPO Gene Causes Familial Erythrocytosis

Jakub Zmajkovic, MS, Pontus Lundberg, PhD, Ronny Nienhold, PhD, Anders Sundan, PhD, Anders Waage, MD PhD, Radek C. Skoda, MD

Blood (2017) 130 (Supplement 1): 1653.

https://doi.org/10.1182/blood.V130.Suppl_1.1653.1653

Published: 2017

Journal Articles

Molecular Risk Stratification Predicts Engraftment Latency of Human Acute Myeloid Leukemia Cells Transplanted in NOD/SCID/IL-2Rgc-Null Mice

Anna M Paczulla, M.Sc., Stephan Dirnhofer, Martina Konantz, PhD, Michael Medinger, MD, Helmut R. Salih, MD, Kathrin Rothfelder, MSc, Jakob Passweg, MD, Dimitrios Tsakiris, Pontus Lundberg, PhD, Claudia Lengerke, MD

Blood (2016) 128 (22): 2867.

https://doi.org/10.1182/blood.V128.22.2867.2867

Published: 2016

Journal Articles

Effects of the Sympathicomimetic Agonist Mirabegron on Disease Course, Mutant Allele Burden, Marrow Fibrosis, and Nestin Positive Stem Cell Niche in Patients with JAK2 -Mutated Myeloproliferative Neoplasms. a Prospective Multicenter Phase II Trial SAKK 33/14

Beatrice Drexler, MD, Jakob Passweg, MD, Martin Bigler, Alexandre PA Theocharides, MD, Nathan Cantoni, MD, Peter Keller, MD, Georg Stuessi, MD, Axel Rüfer, MD, Rudolf A. Benz, MD, Geneviève Favre, MD, Alexandar Tzankov, MD, Pontus Lundberg, PhD, Andrea Fuhrer, PhD, Christine Biaggi, Markus G Manz, MD, Mario Bargetzi, MD, Simon Mendez-Ferrer, PhD, Radek C. Skoda, MD

Blood (2016) 128 (22): 3108.

https://doi.org/10.1182/blood.V128.22.3108.3108

Published: 2016

Journal Articles

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis

Jean Grisouard, Sai Li, Lucia Kubovcakova, Tata Nageswara Rao, Sara C. Meyer, Pontus Lundberg, Hui Hao-Shen, Vincent Romanet, Masato Murakami, Thomas Radimerski, Stephan Dirnhofer, Radek C. Skoda

Blood (2016) 128 (6): 839–851.

https://doi.org/10.1182/blood-2015-12-689216

Published: 2016

Includes: Supplemental data

Journal Articles

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency

Alexandre P. A. Theocharides, Pontus Lundberg, Asvin K. K. Lakkaraju, Veronika Lysenko, Renier Myburgh, Adriano Aguzzi, Radek C. Skoda, Markus G. Manz

Blood (2016) 127 (25): 3253–3259.

https://doi.org/10.1182/blood-2016-02-696310

Published: 2016

Includes: Supplemental data

Journal Articles

JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease

Takafumi Shimizu, PhD, Hui Hao-Shen, Lucia Kubovcakova, PhD, Pontus Lundberg, PhD, Stephan Dirnhofer, Stuart H. Orkin, MD, Jean Grisouard, PhD, Yukiko Shimizu, Annalisa Pianta, PhD, Barbara Szczerba, Ronny Nienhold, Radek C. Skoda, MD

Blood (2014) 124 (21): 158.

https://doi.org/10.1182/blood.V124.21.158.158

Published: 2014

Journal Articles

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2 -V617F–driven mouse model of MPNs

Adrian Duek, Pontus Lundberg, Takafumi Shimizu, Jean Grisouard, Axel Karow, Lucia Kubovcakova, Hui Hao-Shen, Stephan Dirnhofer, Radek C. Skoda

Blood (2014) 123 (25): 3943–3950.

https://doi.org/10.1182/blood-2013-07-514208

Published: 2014

Journal Articles

Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms

Pontus Lundberg, Ronny Nienhold, Achille Ambrosetti, Francisco Cervantes, Manuel M. Pérez-Encinas, Radek C. Skoda

Blood (2014) 123 (17): 2744–2745.

https://doi.org/10.1182/blood-2014-01-550863

Published: 2014

Journal Articles

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser, Hui Hao-Shen, Ina Nissen, Sabine Girsberger, Thomas Lehmann, Jakob Passweg, Martin Stern, Christian Beisel, Robert Kralovics, Radek C. Skoda

Blood (2014) 123 (14): 2220–2228.

https://doi.org/10.1182/blood-2013-11-537167

Published: 2014

Includes: Supplemental data

Journal Articles

Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia

Jean Grisouard, Mario Ojeda-Uribe, Renate Looser, Hui Hao-Shen, Pontus Lundberg, Adrian Duek, Eric Jeandidier, Axel Karow, Radek C. Skoda

Blood (2013) 122 (22): 3694–3696.

https://doi.org/10.1182/blood-2013-07-516385

Published: 2013

Journal Articles

Hereditary Thrombocytosis Caused By a Novel Germ-Line Mutation In The Gelsolin Gene

Annalisa Pianta, PhD, Kun Liu, PhD, Pontus Lundberg, PhD, Takafumi Shimizu, PhD, Hui Hao-Shen, Stephan Dirnhofer, MD, Robert Kralovics, PhD, Amy D. Shapiro, MD, Radek C. Skoda, M.D.

Blood (2013) 122 (21): 265.

https://doi.org/10.1182/blood.V122.21.265.265

Published: 2013

Journal Articles

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2 -V617F polycythemia vera mouse model

Lucia Kubovcakova, Pontus Lundberg, Jean Grisouard, Hui Hao-Shen, Vincent Romanet, Rita Andraos, Masato Murakami, Stephan Dirnhofer, Kay-Uwe Wagner, Thomas Radimerski, Radek C. Skoda

Blood (2013) 121 (7): 1188–1199.

https://doi.org/10.1182/blood-2012-03-415646

Published: 2013

Includes: Supplemental data

NARROW

Zinpentraxin Alfa Reduces Myelofibrosis in a JAK2 -V617F Mouse Model of Myeloproliferative Neoplasms

Quantitative Analysis of Bone Marrow Features Highlights Heterogeneity in Myelofibrosis Patients Treated with Zinpentraxin Alfa in a Phase II Clinical Study

Biomarker Analyses in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 Trial

Results from the First Phase 3 Crovalimab (C5 Inhibitor) Study (COMMODORE 3): Efficacy and Safety in Complement Inhibitor-Naive Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineages

Night Transplantation and Catecholamine Exposure Accelerates In Vivo Leukemia Development By Enhancing Bone Marrow Homing Capacity in Leukemic Cells

Catecholamine Exposure Accelerates In Vivo Leukemogenesis in Acute Myeloid Leukemia Patient Derived Xenografts

Absence of NKG2D Ligands Defines Human Acute Myeloid Leukaemia Stem Cells and Mediates Their Immune Evasion

A Gain-of-Function Mutation in EPO Gene Causes Familial Erythrocytosis

Molecular Risk Stratification Predicts Engraftment Latency of Human Acute Myeloid Leukemia Cells Transplanted in NOD/SCID/IL-2Rgc-Null Mice

Effects of the Sympathicomimetic Agonist Mirabegron on Disease Course, Mutant Allele Burden, Marrow Fibrosis, and Nestin Positive Stem Cell Niche in Patients with JAK2 -Mutated Myeloproliferative Neoplasms. a Prospective Multicenter Phase II Trial SAKK 33/14

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency

JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2 -V617F–driven mouse model of MPNs

Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia

Hereditary Thrombocytosis Caused By a Novel Germ-Line Mutation In The Gelsolin Gene

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2 -V617F polycythemia vera mouse model

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American Society of Hematology

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