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Journal Articles

BP43131, a Phase 1 Dose Escalation Study: CD19 Targeted CD28 Costimulatory Agonist (RO7443904) Combined with Glofitamab Shows Promising Efficacy in Patients with Relapsed/Refractory Aggressive B-NHL

Michael J. Dickinson, Martin Hutchings, Franck Morschhauser, Carmelo Carlo-Stella, Lorenzo Falchi, Paolo F. Caimi, Natalie Dimier, Lance Smith, Matt Whayman, Johannes Sam, Abiraj Keelara, Koorosh Korfi, Candice Jamois, Jeremy Gallien, Nicole Martin, Iris Martinez Quetglas, Heather Hinton, Isabel Prieto, Francesca Michielin, Katharina Lechner, Giuseppe Gritti
Journal: Blood
Blood (2024) 144 (Supplement 1): 3123.
https://doi.org/10.1182/blood-2024-205544
Published: 2024
Journal Articles

Englumafusp Alfa (CD19-4-1BBL) Combined with Glofitamab Is Safe and Efficacious in Patients with r/r B-NHL: Extended Follow up Analysis of the Dose-Escalation Part of Phase 1 Trial BP41072

Martin Hutchings, Michael J. Dickinson, Giuseppe Gritti, Carmelo Carlo-Stella, William Townsend, Francesc Bosch, Nancy L. Bartlett, Guillaume Cartron, Herve Ghesquieres, Roch Houot, Harriet S. Walter, Fritz Offner, Natalie Dimier, Candice Jamois, Lance Smith, Sylvia Herter, Denis Sahin, Abiraj Keelara, Koorosh Korfi, Jeremy Gallien, Marie-Helene Wasmer, Heather Hinton, Matt Whayman, Isabel Prieto, Georgios Kazantzidis, Katharina Lechner, Franck Morschhauser
Journal: Blood
Blood (2024) 144 (Supplement 1): 990.
https://doi.org/10.1182/blood-2024-200096
Published: 2024
Journal Articles

CD19-CD28 (RO7443904) Combination with Glofitamab Enhances T-Cell Proliferation and Effector Function in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (R/R NHL)

Koorosh Korfi, Sabine Wilson, Zhiwen Jiang, Ailsa Christiansen, Sreenath Krishnan, Candice Jamois, Annika Blank, Alexandra Epp, Abraham Silva, Philip Knuckles, Joanne Hayward, Johannes Sam, Katharina Lechner, Natalie Dimier, Paolo F. Caimi, Lorenzo Falchi, Giuseppe Gritti, Franck Morschhauser, Martin Hutchings, Michael J. Dickinson, Carmelo Carlo-Stella
Journal: Blood
Blood (2024) 144 (Supplement 1): 644.
https://doi.org/10.1182/blood-2024-201406
Published: 2024
Journal Articles

Integrated Quantitative Clinical Pharmacology Analysis Identifies Optimal Englumafusp Alfa Dose Range for Proof-of-Concept Study with Glofitamab in Second-Line Large B-Cell Lymphoma Patients

Candice Jamois, Koorosh Korfi, Sylvia Herter, Sabine Wilson, Sreenath Krishnan, Marie-Helene Wasmer, Isabel Prieto, Heather Hinton, Wouter Driessen, Georgios Kazantzidis, Denis Sahin, Akiko Tagawa, Natalie Dimier, Katharina Lechner
Journal: Blood
Blood (2024) 144 (Supplement 1): 4180.
https://doi.org/10.1182/blood-2024-201466
Published: 2024
Journal Articles

Early Assessment of Circulating Tumor (ct)DNA and Analysis of TP53 mutations in Patients with Relapsed/Refractory (R/R) Large B-Cell Lymphoma Treated with Glofitamab Monotherapy

Cristina Zucchinetti, Chiara Signori, Martina di Trani, Maria Cristina Pirosa, Alessio Bruscaggin, Koorosh Korfi, Alessia Bottos, Eleonora Calabretta, Francesco Corrado, Davide Rossi, Carmelo Carlo-Stella
Journal: Blood
Blood (2024) 144 (Supplement 1): 4356.
https://doi.org/10.1182/blood-2024-207596
Published: 2024
Journal Articles

CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy

Johannes Sam, Thomas Hofer, Christine Kuettel, Christina Claus, Jenny Thom, Sylvia Herter, Guy Georges, Koorosh Korfi, Martin Lechmann, Miro Julian Eigenmann, Daniel Marbach, Candice Jamois, Katharina Lechner, Sreenath M. Krishnan, Brenda Gaillard, Joana Marinho, Sven Kronenberg, Leo Kunz, Sabine Wilson, Stefanie Briner, Samuel Gebhardt, Ahmet Varol, Birte Appelt, Valeria Nicolini, Dario Speziale, Miriam Bez, Esther Bommer, Jan Eckmann, Carina Hage, Florian Limani, Silvia Jenni, Anne Schoenle, Marine Le Clech, Jean-Baptiste Pierre Vallier, Sara Colombetti, Marina Bacac, Stephan Gasser, Christian Klein, Pablo Umaña
Journal: Blood
Blood (2024) 143 (21): 2152–2165.
https://doi.org/10.1182/blood.2023023381
Published: 2024
Includes: Supplemental data
Journal Articles

Englumafusp Alfa (CD19-4-1BBL) and Glofitamab Combination in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (R/R NHL): Biomarker Results from a Phase I Dose-Escalation Trial

Koorosh Korfi, Ailsa Christiansen, Zhiwen Jiang, Sabine Wilson, Samuel Tracy, Annika Blank, Sylvia Herter, Natalie Dimier, Bruno Gomes, Pablo Umana, Herve Ghesquieres, Roch Houot, Fritz Offner, Harriet Walter, Nancy L. Bartlett, Guillaume Cartron, Michael Dickinson, William Townsend, Giuseppe Gritti, Francesc Bosch Albareda, Franck Morschhauser, Martin Hutchings, Carmelo Carlo-Stella, Katharina Lechner
Journal: Blood
Blood (2023) 142 (Supplement 1): 3017.
https://doi.org/10.1182/blood-2023-173677
Published: 2023
Journal Articles

Dose Escalation of HLA-A2-WT1 CD3 T-Cell Bispecific Antibody in a Phase I Study in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

Martin Hutchings, Pau Montesinos, Armando Santoro, Hsin-An Hou, Maria Pilar Martinez-Sanchez, Susana Vives, Sara Galimberti, Tsai-Yun Chen, Marco Frigeni, Sylvain Garciaz, Olga Salamero, Su-Peng Yeh, Karen Yee, Gabriel Schnetzler, Teresa Barata, Silke Simon, Heather Hinton, Koorosh Korfi, Muriel Richard, Nino Keshelava, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 1537.
https://doi.org/10.1182/blood-2023-173302
Published: 2023
Journal Articles

Fine Tuning Bispecific Activity in CLL: Harmonizing a CD19/20-T Cell Bispecific with a CD28 or 4-1BBL Costimulatory Bispecific

Giulia Petra Rappa, Monika Sponheimer, Gerulf Hänel, Anne-Sophie Neumann, Nora Philipp, Koorosh Korfi, Sylvia Herter, Johannes Sam, Franz Schuler, Christian Klein, Marina Bacac, Pablo Umana, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2058.
https://doi.org/10.1182/blood-2023-180785
Published: 2023
Journal Articles

Molecular Mechanisms Underlying Response and Resistance to Glofitamab

Sina Nassiri, Stephan Schmeing, Gabrielle Leclercq, Sylvia Herter, Llucia Alberti Servera, Tamara Hüsser, Emilio Yángüez, Diana Dunshee, Koorosh Korfi, Pablo Umana, Ann-Marie E. Bröske, Alessia Bottos, Marina Bacac
Journal: Blood
Blood (2023) 142 (Supplement 1): 1619.
https://doi.org/10.1182/blood-2023-179776
Published: 2023
Journal Articles

CD19 4-1BBL (RO7227166) a Novel Costimulatory Bispecific Antibody Can be Safely Combined with the T-Cell-Engaging Bispecific Antibody Glofitamab in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Martin Hutchings, Carmelo Carlo-Stella, Giuseppe Gritti, Francesc Bosch, Franck Morschhauser, William Townsend, Fritz Offner, Harriet S Walter, Herve Ghesquieres, Roch Houot, Guillaume Cartron, Natalie Dimier, Stephen Fowler, Emma Harrop, Sylvia Herter, Abiraj Keelara, Koorosh Korfi, Jeff Luong, Claudia Mueller, Robert Nutbrown, Giuseppe Palldino, Matt Whayman, Isabel Prieto, Sarah Louise Mycroft, Daria Rukina, Katharina E Lechner, Michael Dickinson
Journal: Blood
Blood (2022) 140 (Supplement 1): 9461–9463.
https://doi.org/10.1182/blood-2022-157011
Published: 2022
Journal Articles

CD25 Targeting Eliminates Regulatory T Cells and CD25+ Blasts in Acute Myeloid Leukemia

Laurene Pousse, Bruno C. Medeiros, Koorosh Korfi, Marco Berrera, Nadine Kumpesa, Vera Griesser, Jan Eckmann, Vaios Karanikas, Christian Klein, Maria Amann
Journal: Blood
Blood (2022) 140 (Supplement 1): 6291–6292.
https://doi.org/10.1182/blood-2022-158189
Published: 2022
Journal Articles

Phase 1 Study of CD19 Targeted CD28 Costimulatory Agonist in Combination with Glofitamab to Enhance T Cell Effector Function in Relapsed/Refractory B Cell Lymphoma

Michael Dickinson, Giuseppe Gritti, Carmelo Carlo-Stella, Harriet S Walter, David Carlile, Nicole Getzmann, Samira Curdt, Emma Harrop, Abiraj Keelara, Koorosh Korfi, Remi Labatut, Francesca Michielin, Sarah Louise Mycroft, Tom Moore, Robert Nutbrown, Giuseppe Palldino, Matt Whayman, Johannes Sam, Martin Weisser, Katharina E Lechner, Franck Morschhauser, Martin Hutchings
Journal: Blood
Blood (2022) 140 (Supplement 1): 3818–3820.
https://doi.org/10.1182/blood-2022-156808
Published: 2022
Journal Articles

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

James Heward, Lola Koniali, Annalisa D’Avola, Karina Close, Alison Yeomans, Martin Philpott, James Dunford, Tahrima Rahim, Ahad F. Al Seraihi, Jun Wang, Koorosh Korfi, Shamzah Araf, Sameena Iqbal, Findlay Bewicke-Copley, Emil Kumar, Darko Barisic, Maria Calaminici, Andrew Clear, John Gribben, Peter Johnson, Richard Neve, Pedro Cutillas, Jessica Okosun, Udo Oppermann, Ari Melnick, Graham Packham, Jude Fitzgibbon
Journal: Blood
Blood (2021) 138 (5): 370–381.
https://doi.org/10.1182/blood.2020008743
Published: 2021
Includes: Supplemental data
Journal Articles

Phase 1 Study of CD19 Targeted 4-1BBL Costimulatory Agonist to Enhance T Cell (Glofitamab Combination) or NK Cell Effector Function (Obinutuzumab Combination) in Relapsed/Refractory B Cell Lymphoma

Martin Hutchings, MD PhD, Fritz C. Offner, MD PhD, Francesc Bosch, MD PhD, Giuseppe Gritti, MD PhD, Carmelo Carlo-Stella, MD, Harriet Walter, William Townsend, MRCP,MDFRCPath, Franck Morschhauser, MD PhD, Guillaume Cartron, MD PhD, Hervé Ghesquieres, MD PhD, Sophie de Guibert, MD, Sylvia Herter, PhD, Koorosh Korfi, PhD, Veronica Craine, Sarah Louise Mycroft, Matt Whayman, Claudia Mueller, Natalie Dimier, PhD, Tom Moore, MBChB, Sara Belli, Martin Kornacker, MD, Katharina Lechner, Michael Dickinson, DMed Sci
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-136571
Published: 2020
Journal Articles

CD20-TCB, a Novel T-Cell-Engaging Bispecific Antibody, Induces T-Cell-Mediated Killing in Relapsed or Refractory Non-Hodgkin Lymphoma: Biomarker Results From a Phase I Dose-Escalation Trial

Ann-Marie E Bröske, PhD, Ian James, PhD, Anton Belousov, PhD, Enrique Gomez, PhD, Marta Canamero, MD PhD, Chia-Huey Ooi, PhD, Nils Grabole, PhD, Sabine Wilson, PhD, Koorosh Korfi, PhD, Nicole A Kratochwil, PhD, Peter N Morcos, PharmD, Cristiano Ferlini, MD, Denise Thomas, MSc, Natalie Dimier, PhD, Tom Moore, MBChB, Marina Bacac, PhD, Martin Weisser, MD, Michael Dickinson, MBBS,FRACP,FRCPA
Journal: Blood
Blood (2019) 134 (Supplement_1): 5319.
https://doi.org/10.1182/blood-2019-123979
Published: 2019
Journal Articles

Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel

Findlay Bewicke-Copley, PhD MSc, BSc, Koorosh Korfi, PhD BSc, Shamzah Araf, MRCP, MBBS, PhD, Emil Arjun Kumar, BCh,BM, Thomas E C Cummin, MRCP MBBCh BSc, Margaret Ashton-Key, MD, Sharon Barrans, Suzan Van Hoppe, Cathy Burton, Mohamed Elshiekh, Simon Rule, Nicola Crosbie, Andrew James Clear, BSc, Maria Calaminici, MD PhD, David W. Scott, MBChB, PhD, Lisa M. Rimsza, MD, Menon Geetha, Chulin Sha, Michael A Bentley, Ai Nagano, PhD, Andrew Davies, MD PhD, Daniel Painter, BSc, Alexandra Smith, PhD, John G. Gribben, MD DSc, Kikkeri Naresh, David R Westhead, Jessica Okosun, MD PhD, Peter Johnson, MDFRCP, Jun Wang, PhD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2769.
https://doi.org/10.1182/blood-2019-124352
Published: 2019
Journal Articles

Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma

Shamzah Araf, MRCP, MBBS, Jun Wang, PhD, Koorosh Korfi, PhD BSc, Celine Pangault, PhD, Eleni Kotsiou, PhD, Ana Rio-Machin, PhD, Tahrima Rahim, BSc, James Andrew Heward, PhD BSc, Andrew James Clear, BSc, Sameena Iqbal, Jeff Davies, MBBS, PhD, Peter Johnson, MD FRCP, Maria Calaminici, MD PhD, Silvia Montoto, Rebecca Auer, MD PhD, Claude Chelala, PhD, John G. Gribben, MDDSc FMedSci, Trevor Graham, PhD, Thierry Fest, MD PhD, Jude Fitzgibbon, PhD, Jessica Okosun, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2730.
https://doi.org/10.1182/blood.V130.Suppl_1.2730.2730
Published: 2017
Journal Articles

Longitudinal Analyses of the Genomic, Transcriptomic, and T Cell Repertoire in Diffuse Large B Cell Lymphoma Demonstrates Changes in Signaling and Immune Recognition at Relapse

Shamzah Araf, MRCP, MBBS, Koorosh Korfi, PhD BSc, Ai Nagano, PhD, Thomas E C Cummin, MRCP MBBCh BSc, Michael Bentley, PhD, Aaron R. Thorner, PhD, Margaret Ashton-Key, MD, Maria Calaminici, MD PhD, Andrew James Clear, BSc, Andrew Davies, PhD, Sharon Barrans, Suzan Van Hoppe, Cathy Burton, Simon Rule, MD, Nicola Crosbie, Daniel Painter, BSc, Alexandra Smith, PhD, David M. Weinstock, MD, David R Westhead, Jessica Okosun, MD PhD, John G. Gribben, MDDSc FMedSci, Peter Johnson, MD FRCP, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2734.
https://doi.org/10.1182/blood.V130.Suppl_1.2734.2734
Published: 2017
Journal Articles

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression

Anuradha Tarafdar, Lisa E. M. Hopcroft, Paolo Gallipoli, Francesca Pellicano, Jennifer Cassels, Alan Hair, Koorosh Korfi, Heather G. Jørgensen, David Vetrie, Tessa L. Holyoake, Alison M. Michie
Journal: Blood
Blood (2017) 129 (2): 199–208.
https://doi.org/10.1182/blood-2016-09-742049
Published: 2017
Includes: Supplemental data