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Shivam Rai
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Journal Articles

Zinpentraxin Alfa Reduces Myelofibrosis in a JAK2 -V617F Mouse Model of Myeloproliferative Neoplasms

Shivam Rai, Hui Hao-Shen, Stefan Dirnhofer, Julien Roux, Rajbharan Yadav, Anamarija Pfeiffer, Jakob Vowinckel, Audrey Arjomandi, Brian Higgins, Lyrialle Han, Kerstin Trunzer, Pontus Lundberg, Radek C. Skoda
Journal: Blood
Blood (2023) 142 (Supplement 1): 1787.
https://doi.org/10.1182/blood-2023-186631
Published: 2023
Journal Articles

Cellular Barcoding of JAK2 -V617F Hematopoietic Stem Cells Reveals No Substantial Preferences in the Contribution of Individual Stem Cell Clones to Erythroid Versus Megakaryocytic Lineages

Marc Usart, Tiago Almeida, Julien Roux, Athimed El Taher, Riikka Karjalainen, Quentin Kimmerlin, Shivam Rai, Hui Hao-Shen, Radek C. Skoda
Journal: Blood
Blood (2023) 142 (Supplement 1): 859.
https://doi.org/10.1182/blood-2023-181695
Published: 2023
Journal Articles

Iron is a modifier of the phenotypes of JAK2 -mutant myeloproliferative neoplasms

Jan Stetka, Marc Usart, Lucia Kubovcakova, Shivam Rai, Tata Nageswara Rao, Joshua Sutter, Hui Hao-Shen, Stefan Dirnhofer, Florian Geier, Michael S. Bader, Jakob R. Passweg, Vania Manolova, Franz Dürrenberger, Nouraiz Ahmed, Timm Schroeder, Tomas Ganz, Elizabeta Nemeth, Laura Silvestri, Antonella Nai, Clara Camaschella, Radek C. Skoda
Journal: Blood
Blood (2023) 141 (17): 2127–2140.
https://doi.org/10.1182/blood.2022017976
Published: 2023
Includes: Supplemental data
Journal Articles

The Second Generation Type II JAK2 Inhibitor, AJ1-10502, Demonstrates Enhanced Selectivity, Improved Therapeutic Efficacy and Reduced Mutant Cell Fraction Compared to Type I JAK2 Inhibitors in Models of Myeloproliferative Neoplasms (MPNs)

Shivam Rai, Jan Stetka, MARC Usart, Hui Hao-Shen, Young Park, Remie Houston, Anthony R. Martinez Benitez, Matthew Wereski, Emily Guzzardi, Sonali Persaud, Hailey Ramzan, Alan Futran, Charley Xu, Jeremy Greenwood, Sayan Mondal, Craig Masse, Ross L. Levine, Radek C. Skoda, Andrew Dunbar
Journal: Blood
Blood (2022) 140 (Supplement 1): 6722–6723.
https://doi.org/10.1182/blood-2022-162621
Published: 2022
Journal Articles

Combination of 5-Azacytidine and Pegifna Is Able to Overcome Resistance in JAK2 -V617F Positive MPN with Loss of Dnmt3a

Melissa Lock, Damien Luque Paz, Nils Hansen, Tiago Almeida Fonseca, MARC Usart, Shivam Rai, Hui Hao-Shen, Gabriele Mild, Stephan Dirnhofer, Radek C. Skoda, Jan Stetka
Journal: Blood
Blood (2022) 140 (Supplement 1): 3876–3877.
https://doi.org/10.1182/blood-2022-167002
Published: 2022
Journal Articles

Inhibiting Glutamine Metabolism with CB-839 Reduces Erythrocytosis in MPN Mice

MARC Usart, Shivam Rai, Nils Hansen, Alexandre Guy, Jan Stetka, Hui Hao-Shen, Tata Nageswara Rao, Radek C. Skoda
Journal: Blood
Blood (2021) 138 (Supplement 1): 3585.
https://doi.org/10.1182/blood-2021-150321
Published: 2021
Journal Articles

MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineages

Ronny Nienhold, Peter Ashcroft, Jakub Zmajkovic, Shivam Rai, Tata Nageswara Rao, Beatrice Drexler, Sara C. Meyer, Pontus Lundberg, Jakob R. Passweg, Danijela Leković, Vladan Čokić, Sebastian Bonhoeffer, Radek C. Skoda
Journal: Blood
Blood (2020) 136 (22): 2591–2595.
https://doi.org/10.1182/blood.2019002943
Published: 2020
Includes: Supplemental data
Journal Articles

JAK2 -mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms

Tata Nageswara Rao, Nils Hansen, Julian Hilfiker, Shivam Rai, Julia-Magdalena Majewska, Danijela Leković, Deniz Gezer, Nicola Andina, Serena Galli, Teresa Cassel, Florian Geier, Julien Delezie, Ronny Nienhold, Hui Hao-Shen, Christian Beisel, Serena Di Palma, Sarah Dimeloe, Jonel Trebicka, Dominik Wolf, Max Gassmann, Teresa W.-M. Fan, Andrew N. Lane, Christoph Handschin, Stefan Dirnhofer, Nicolaus Kröger, Christoph Hess, Thomas Radimerski, Steffen Koschmieder, Vladan P. Čokić, Radek C. Skoda
Journal: Blood
Blood (2019) 134 (21): 1832–1846.
https://doi.org/10.1182/blood.2019000162
Published: 2019
Includes: Supplemental data
Journal Articles

IL-1β Secreted from Mutant Cells Carrying JAK2- V617Ffavors Early Clonal Expansion and Promotes MPN Disease Initiation and Progression

Shivam Rai, Nils Hansen, Hui Hao-Shen, Stefan Dirnhofer, Nageswara Rao Tata, Radek C. Skoda
Journal: Blood
Blood (2019) 134 (Supplement_1): 307.
https://doi.org/10.1182/blood-2019-129800
Published: 2019