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Jan Stetka
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Journal Articles

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2 -V617F–positive myeloproliferative neoplasms

Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C. Skoda
Journal: Blood
Blood (2024) 143 (24): 2490–2503.
https://doi.org/10.1182/blood.2023020270
Published: 2024
Includes: Supplemental data
Journal Articles

Iron is a modifier of the phenotypes of JAK2 -mutant myeloproliferative neoplasms

Jan Stetka, Marc Usart, Lucia Kubovcakova, Shivam Rai, Tata Nageswara Rao, Joshua Sutter, Hui Hao-Shen, Stefan Dirnhofer, Florian Geier, Michael S. Bader, Jakob R. Passweg, Vania Manolova, Franz Dürrenberger, Nouraiz Ahmed, Timm Schroeder, Tomas Ganz, Elizabeta Nemeth, Laura Silvestri, Antonella Nai, Clara Camaschella, Radek C. Skoda
Journal: Blood
Blood (2023) 141 (17): 2127–2140.
https://doi.org/10.1182/blood.2022017976
Published: 2023
Includes: Supplemental data
Journal Articles

The Second Generation Type II JAK2 Inhibitor, AJ1-10502, Demonstrates Enhanced Selectivity, Improved Therapeutic Efficacy and Reduced Mutant Cell Fraction Compared to Type I JAK2 Inhibitors in Models of Myeloproliferative Neoplasms (MPNs)

Shivam Rai, Jan Stetka, MARC Usart, Hui Hao-Shen, Young Park, Remie Houston, Anthony R. Martinez Benitez, Matthew Wereski, Emily Guzzardi, Sonali Persaud, Hailey Ramzan, Alan Futran, Charley Xu, Jeremy Greenwood, Sayan Mondal, Craig Masse, Ross L. Levine, Radek C. Skoda, Andrew Dunbar
Journal: Blood
Blood (2022) 140 (Supplement 1): 6722–6723.
https://doi.org/10.1182/blood-2022-162621
Published: 2022
Journal Articles

Combination of 5-Azacytidine and Pegifna Is Able to Overcome Resistance in JAK2 -V617F Positive MPN with Loss of Dnmt3a

Melissa Lock, Damien Luque Paz, Nils Hansen, Tiago Almeida Fonseca, MARC Usart, Shivam Rai, Hui Hao-Shen, Gabriele Mild, Stephan Dirnhofer, Radek C. Skoda, Jan Stetka
Journal: Blood
Blood (2022) 140 (Supplement 1): 3876–3877.
https://doi.org/10.1182/blood-2022-167002
Published: 2022
Journal Articles

Inhibiting Glutamine Metabolism with CB-839 Reduces Erythrocytosis in MPN Mice

MARC Usart, Shivam Rai, Nils Hansen, Alexandre Guy, Jan Stetka, Hui Hao-Shen, Tata Nageswara Rao, Radek C. Skoda
Journal: Blood
Blood (2021) 138 (Supplement 1): 3585.
https://doi.org/10.1182/blood-2021-150321
Published: 2021
Journal Articles

JAK2 -V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

Tata Nageswara Rao, Nils Hansen, Jan Stetka, Damien Luque Paz, Milena Kalmer, Julian Hilfiker, Max Endele, Nouraiz Ahmed, Lucia Kubovcakova, Margareta Rybarikova, Hui Hao-Shen, Florian Geier, Christian Beisel, Stefan Dirnhofer, Timm Schroeder, Tim H. Brümmendorf, Dominik Wolf, Steffen Koschmieder, Radek C. Skoda
Journal: Blood
Blood (2021) 137 (16): 2139–2151.
https://doi.org/10.1182/blood.2020005563
Published: 2021
Includes: Supplemental data
Journal Articles

Loss of Dnmt3a Confers Resistance to Pegifnα in JAK2 -V617F Mouse Model

Jan Stetka, Nils Hansen, Lucia Kubovcakova, Hui Hao-Shen, Stefan Dirnhofer, Radek C. Skoda
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-140548
Published: 2020
Journal Articles

JAK2 V617F Progenitors Utilize Adaptations to Cell-Autonomous and Microenvironment-Dependent Inflammatory Stress in Polycythemia Vera, Likely Exhibiting Barrier Against Rapid Transformation to Myelofibrosis

Jan Stetka, MSc, Pavla Luzna, PhD, Lucie Lanikova, PhD, Pavla Koralkova, MSc, Jan Gursky, PhD, Zdenek Hodny, MD PhD, Jiri Bartek, MD, Vladimir Divoky, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1667.
https://doi.org/10.1182/blood.V130.Suppl_1.1667.1667
Published: 2017
Journal Articles

Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model

Leona Raskova Kafkova, Zuzana Somikova, Jana Kucerova, MSc, Lenka Calabkova, Pavla Luzna, Jan Stetka, Dana Simkova, Dalibor Dolezal, Vladimir Divoky, PhD
Journal: Blood
Blood (2015) 126 (23): 3351.
https://doi.org/10.1182/blood.V126.23.3351.3351
Published: 2015