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Journal Articles

Spatial Transcriptomics Characterize Dynamic and Polarized Niche for Embryonic Hematopoiesis at Single-Cell Level

Xinjian Mao, Ning Zhang, Xi He, Laura F Bennett, Kate Hall, Kaitlyn Petentler, Allison Scott, Seth Malloy, Jeff Haug, Hua Li, Anoja Perera, Jay Unruh, Brian Slaughter, Paul Trainor, Nancy Speck, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 559.
https://doi.org/10.1182/blood-2024-208339
Published: 2024
Journal Articles

Characterization of Multicellular Niches Supporting Hematopoietic Stem Cells within Distinct Zones

Ruochen Dong, Hua Li, Xi He, Chen Wang, Anoja Perera, Seth Malloy, Jonathon Russell, Wenting Li, Kaitlyn Petentler, Xinjian Mao, Zhe Yang, Michael Epp, Kate Hall, Allison Scott, Mary C McKinney, Shengping Huang, Sarah Smith, Mark Hembree, Yongfu Wang, Zulin Yu, Jeff Haug, Jay Unruh, Brian Slaughter, Xunlei Kang, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 1306.
https://doi.org/10.1182/blood-2024-208450
Published: 2024
Journal Articles

Overcoming Immune Escape Via Targeting Akt-Wnt/β-Catenin By Artificial-Intelligence-Powered Peptide-Producing mRNAs

Zhe Yang, Negin Manshour, Xi He, Michael Epp, Jay Unruh, Xinjian Mao, Ruochen Dong, Dan Bradford, Shengping Huang, Fengyan Deng, Mark Hembree, Chongbei Zhao, Liang Xu, Dong Xu, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 1062.
https://doi.org/10.1182/blood-2024-200368
Published: 2024
Journal Articles

Ex Vivo Expansion of Human Hematopoietic Stem Cells By Mimicking Intrinsic and Extrinsic Factors in Adult Bone Marrow

Xinjian Mao, Ning Zhang, Xi He, Ruochen Dong, Zhe Yang, Michael Epp, Linda Zhang, Allison Scott, Kate Hall, Anoja Perera, Jeff Haug, Hua Li, Cheng Luo, Chuan He, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 4042.
https://doi.org/10.1182/blood-2024-208449
Published: 2024
Journal Articles

Spatial Transcriptomics Reveals Distinct Hematopoietic Stem Cell Niches in Mouse Fetal Liver

Ruochen Dong, Hua Li, Xi He, Anoja Perera, Seth Malloy, Jonathon Russell, Wenting Li, Kaitlyn Petentler, Xinjian Mao, Zhe Yang, Michael Epp, Kate Hall, Allison Scott, Sarah Smith, Mark Hembree, Yongfu Wang, Sean McKinney, Jeff Haug, Jay Unruh, Brian Slaughter, Linheng Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 2700.
https://doi.org/10.1182/blood-2023-189880
Published: 2023
Journal Articles

Characterization of Niche Cells and Signals Regulating Stepwise Embryonic Hematopoiesis Using Slide-Seq and Merfish Spatial Transcriptomics

Xinjian Mao, Ning Zhang, Xi He, Kate Hall, Kaitlyn Petentler, Allison Scott, Seth Malloy, Jeff Haug, Hua Li, Anoja Perera, Jay Unruh, Brian Slaughter, Nancy Speck, Linheng Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 4051.
https://doi.org/10.1182/blood-2023-190096
Published: 2023
Journal Articles

Treatment with Low-Dose Daunorubicin Reduces the Number of Leukemia Stem Cells in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Tara L. Lin, MD, John M. Perry, PhD, Xi He, MD, Raymond P. Perez, MD, Gregory Reed, PhD, Margaret M. Brophy, Na Zhang, PhD, Scott Weir, PharmD, PhD, Joseph P. McGuirk, DO, Linheng Li, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1336.
https://doi.org/10.1182/blood.V130.Suppl_1.1336.1336
Published: 2017
Journal Articles

Metabolic Activity Distinguish Reserve and Primed HSCs

Zhenrui Li, BS, MS, Xi He, MD, Ariel Paulson, Meng Zhao, PhD, Pengxu Qian, PhD, Fang Tao, Wenxing Ding, PhD, Rick Dobrowsky, PhD, Linheng Li, PhD
Journal: Blood
Blood (2014) 124 (21): 2898.
https://doi.org/10.1182/blood.V124.21.2898.2898
Published: 2014
Journal Articles

The Imprinted Dlk1-Gtl2 Locus Epigenetically Regulates Primitive Hematopoietic Stem Cell Mitochondrial Function and Energy Metabolism Via Repression of PI3K/Akt/mTOR Pathway

Pengxu Qian, PhD, Xi He, MD, Ariel Paulson, Jeffrey S. Haug, BS, Linheng Li, PhD
Journal: Blood
Blood (2014) 124 (21): 243.
https://doi.org/10.1182/blood.V124.21.243.243
Published: 2014
Journal Articles

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL

Lili Wang, Alex K. Shalek, Mike Lawrence, Ruihua Ding, Jellert T. Gaublomme, Nathalie Pochet, Petar Stojanov, Carrie Sougnez, Sachet A. Shukla, Kristen E. Stevenson, Wandi Zhang, Jessica Wong, Quinlan L. Sievers, Bryan T. MacDonald, Alexander R. Vartanov, Natalie R. Goldstein, Donna Neuberg, Xi He, Eric Lander, Nir Hacohen, Aviv Regev, Gad Getz, Jennifer R. Brown, Hongkun Park, Catherine J. Wu
Journal: Blood
Blood (2014) 124 (7): 1089–1098.
https://doi.org/10.1182/blood-2014-01-552067
Published: 2014
Includes: Supplemental data
Journal Articles

Canonical Wnt signaling in megakaryocytes regulates proplatelet formation

Iain C. Macaulay, Jonathan N. Thon, Marloes R. Tijssen, Brian M. Steele, Bryan T. MacDonald, Gerardene Meade, Philippa Burns, Augusto Rendon, Vishal Salunkhe, Ronan P. Murphy, Cavan Bennett, Nicholas A. Watkins, Xi He, Desmond J. Fitzgerald, Joseph E. Italiano, Jr, Patricia B. Maguire
Journal: Blood
Blood (2013) 121 (1): 188–196.
https://doi.org/10.1182/blood-2012-03-416875
Published: 2013
Includes: Supplemental data
Journal Articles

Wnt/β-catenin and Pten/Akt Signaling Interaction Drives Hematopoietic Stem Cell Self-Renewal and Leukemogenesis.

John M. Perry, Ph.D., Justin C. Grindley, Ph.D., Xi He, MD, Linheng Li, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 1392.
https://doi.org/10.1182/blood.V112.11.1392.1392
Published: 2008
Journal Articles

Detection of Functional Hematopoietic Stem Cell Niche Using Real-Time Imaging

Tong Yin, Yucai Xie, Winfried Wiegraebe, Xi He, Linheng Li
Journal: Blood
Blood (2008) 112 (11): 550.
https://doi.org/10.1182/blood.V112.11.550.550
Published: 2008
Journal Articles

The Roles of Pten in Hematopoietic Stem Cell Regulation and Leukemogenesis.

Jiwang Zhang, PhD, Xi He, MD, Sach Jayasinghe, Jason Ross, Jeff Haug, Linheng Li, Ph.D
Journal: Blood
Blood (2005) 106 (11): 468.
https://doi.org/10.1182/blood.V106.11.468.468
Published: 2005
Journal Articles

Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

Koichi Akashi, Xi He, Jie Chen, Hiromi Iwasaki, Chao Niu, Brooke Steenhard, Jiwang Zhang, Jeff Haug, Linheng Li
Journal: Blood
Blood (2003) 101 (2): 383–389.
https://doi.org/10.1182/blood-2002-06-1780
Published: 2003