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Journal Articles

Overcoming leukemia stem cells via targeting AKT-wnt/β-catenin by AI-powered mRNA-delivery of peptides

Free
Zhe Yang, Negin Manshour, Jay Unruh, Xi He, William Redwine, Xinjian Mao, Michael Epp, Ruochen Dong, Josh Gilmore, William Bradford, Shiyuan Chen, Allison Scott, Qian Jiang, Fengyan Deng, Jacob Yonke, Shengping Huang, Hannah Wilson, Xiaoqing Wu, Chunhui Xu, Mark Hembree, Jeffrey Haug, Anoja Perera, Hua Li, Kexi Yi, Chongbei Zhao, Ariel Bazzini, Alexander Garruss, Liang Xu, Dong Xu, Linheng Li
Journal: Blood
Blood (2025) 146 (Supplement 1): 5078.
https://doi.org/10.1182/blood-2025-5078
Published: 2025
Journal Articles

Spatial transcriptomics identified dynamic and spatial-resolved niche cell and signal architecture for hematopoietic stem cell specification

Free
Xinjian Mao, Ning Zhang, Xi He, Laura Bennett, Zhe Yang, Ruochen Dong, Kate Hall, Allison Scott, Seth Malloy, Sean McKinney, Anoja Perera, Jay Unruh, Brian Slaughter, Paul Trainor, Nancy Speck, Linheng Li
Journal: Blood
Blood (2025) 146 (Supplement 1): 3151.
https://doi.org/10.1182/blood-2025-3151
Published: 2025
Journal Articles

Identification of two distinct human hematopoietic stem cell subsets and their age-dependent dynamics by single-cell multi-omics

Free
Xinjian Mao, Ning Zhang, Xi He, Zhe Yang, Ruochen Dong, Allison Scott, Anoja Perera, Shannon McKinney-Freeman, Linheng Li
Journal: Blood
Blood (2025) 146 (Supplement 1): 4943.
https://doi.org/10.1182/blood-2025-4943
Published: 2025
Journal Articles

Overcoming Immune Escape Via Targeting Akt-Wnt/β-Catenin By Artificial-Intelligence-Powered Peptide-Producing mRNAs

Free
Zhe Yang, Negin Manshour, Xi He, Michael Epp, Jay Unruh, Xinjian Mao, Ruochen Dong, Dan Bradford, Shengping Huang, Fengyan Deng, Mark Hembree, Chongbei Zhao, Liang Xu, Dong Xu, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 1062.
https://doi.org/10.1182/blood-2024-200368
Published: 2024
Journal Articles

Characterization of Multicellular Niches Supporting Hematopoietic Stem Cells within Distinct Zones

Free
Ruochen Dong, Hua Li, Xi He, Chen Wang, Anoja Perera, Seth Malloy, Jonathon Russell, Wenting Li, Kaitlyn Petentler, Xinjian Mao, Zhe Yang, Michael Epp, Kate Hall, Allison Scott, Mary C McKinney, Shengping Huang, Sarah Smith, Mark Hembree, Yongfu Wang, Zulin Yu, Jeff Haug, Jay Unruh, Brian Slaughter, Xunlei Kang, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 1306.
https://doi.org/10.1182/blood-2024-208450
Published: 2024
Journal Articles

Ex Vivo Expansion of Human Hematopoietic Stem Cells By Mimicking Intrinsic and Extrinsic Factors in Adult Bone Marrow

Free
Xinjian Mao, Ning Zhang, Xi He, Ruochen Dong, Zhe Yang, Michael Epp, Linda Zhang, Allison Scott, Kate Hall, Anoja Perera, Jeff Haug, Hua Li, Cheng Luo, Chuan He, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 4042.
https://doi.org/10.1182/blood-2024-208449
Published: 2024
Journal Articles

Spatial Transcriptomics Characterize Dynamic and Polarized Niche for Embryonic Hematopoiesis at Single-Cell Level

Free
Xinjian Mao, Ning Zhang, Xi He, Laura F Bennett, Kate Hall, Kaitlyn Petentler, Allison Scott, Seth Malloy, Jeff Haug, Hua Li, Anoja Perera, Jay Unruh, Brian Slaughter, Paul Trainor, Nancy Speck, Linheng Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 559.
https://doi.org/10.1182/blood-2024-208339
Published: 2024
Journal Articles

Spatial Transcriptomics Reveals Distinct Hematopoietic Stem Cell Niches in Mouse Fetal Liver

Free
Ruochen Dong, Hua Li, Xi He, Anoja Perera, Seth Malloy, Jonathon Russell, Wenting Li, Kaitlyn Petentler, Xinjian Mao, Zhe Yang, Michael Epp, Kate Hall, Allison Scott, Sarah Smith, Mark Hembree, Yongfu Wang, Sean McKinney, Jeff Haug, Jay Unruh, Brian Slaughter, Linheng Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 2700.
https://doi.org/10.1182/blood-2023-189880
Published: 2023
Journal Articles

Characterization of Niche Cells and Signals Regulating Stepwise Embryonic Hematopoiesis Using Slide-Seq and Merfish Spatial Transcriptomics

Free
Xinjian Mao, Ning Zhang, Xi He, Kate Hall, Kaitlyn Petentler, Allison Scott, Seth Malloy, Jeff Haug, Hua Li, Anoja Perera, Jay Unruh, Brian Slaughter, Nancy Speck, Linheng Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 4051.
https://doi.org/10.1182/blood-2023-190096
Published: 2023
Journal Articles

Characterization of Dynamic Niche Signaling Modules during Embryonic Hematopoietic Development Using Spatial Transcriptomics

Free
Xinjian Mao, Ning Zhang, Kate Hall, Kaitlyn Petentler, Allison Scott, Seth Malloy, Fang Liu, Kevin Ferro, Jessica Bell, Erin Hamilton, Jeffrey Haug, Yongfu Wang, Hua Li, Anoja Perera, Jay Unruh, Brian Slaughter, Xi C He, Nancy Speck, Linheng Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 8568–8569.
https://doi.org/10.1182/blood-2022-160325
Published: 2022
Journal Articles

p57Kip2 indirectly regulates AGM HSCs

Free
Xinjian Mao, Linheng Li
Journal: Blood
Blood (2022) 140 (5): 411–412.
https://doi.org/10.1182/blood.2022017139
Published: 2022
Journal Articles

Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

Free
Yonghan He, MD, Jianhui Chang, Dongwen Lv, Ha-neui Kim, Maria Almeida, Xin Zhang, Xinjian Mao, PhD, Xinghui Zhao, PhD, Linheng Li, PhD, Judith Campisi, Ying Liang, MD PhD, Daohong Zhou
Journal: Blood
Blood (2019) 134 (Supplement_1): 1204.
https://doi.org/10.1182/blood-2019-123159
Published: 2019