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Quinlan L. Sievers
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Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

Adam S. Sperling, Michael Burgess, Hasmik Keshishian, Jessica A. Gasser, Shruti Bhatt, Max Jan, Mikołaj Słabicki, Rob S. Sellar, Emma C. Fink, Peter G. Miller, Brian J. Liddicoat, Quinlan L. Sievers, Rohan Sharma, Dylan N. Adams, Elyse A. Olesinski, Mariateresa Fulciniti, Namrata D. Udeshi, Eric Kuhn, Anthony Letai, Nikhil C. Munshi, Steven A. Carr, Benjamin L. Ebert
Journal: Blood
Blood (2019) 134 (2): 160–170.
https://doi.org/10.1182/blood.2019000789
Published: 2019
Includes: Supplemental data
Journal Articles

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4 CRBN activity

Quinlan L. Sievers, Jessica A. Gasser, Glenn S. Cowley, Eric S. Fischer, Benjamin L. Ebert
Journal: Blood
Blood (2018) 132 (12): 1293–1303.
https://doi.org/10.1182/blood-2018-01-821769
Published: 2018
Includes: Supplemental data
Journal Articles

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL

Lili Wang, Alex K. Shalek, Mike Lawrence, Ruihua Ding, Jellert T. Gaublomme, Nathalie Pochet, Petar Stojanov, Carrie Sougnez, Sachet A. Shukla, Kristen E. Stevenson, Wandi Zhang, Jessica Wong, Quinlan L. Sievers, Bryan T. MacDonald, Alexander R. Vartanov, Natalie R. Goldstein, Donna Neuberg, Xi He, Eric Lander, Nir Hacohen, Aviv Regev, Gad Getz, Jennifer R. Brown, Hongkun Park, Catherine J. Wu
Journal: Blood
Blood (2014) 124 (7): 1089–1098.
https://doi.org/10.1182/blood-2014-01-552067
Published: 2014
Includes: Supplemental data
Journal Articles

Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1

Youzhong Wan, Michael S Lawrence, Lili Wang, Petar Stojanov, Carrie Sougnez, Kristen Stevenson, M.S., Lillian Werner, MS, Wandi Zhang, Eric G Folco, Bethany Tesar, Quinlan L Sievers, Stacey Gabriel, Nir Hacohen, Robin Reed, Matthew Meyerson, Todd R. Golub, MD, Eric S Lander, Donna Neuberg, ScD, Jennifer R. Brown, MD, PhD, Gad Getz, Catherine J Wu, MD
Journal: Blood
Blood (2011) 118 (21): 463.
https://doi.org/10.1182/blood.V118.21.463.463
Published: 2011
Journal Articles

Whole Genome Sequencing Identifies Functional Mutations In the Wnt Pathway In CLL

Lili Wang, Nathalie Pochet, Kristian Cibulskis, Wandi Zhang, Mike Lawrence, Quinlan L. Sievers, Erica Shefler, Donna Neuberg, ScD, Stacey Gabriel, Carrie Sougnez, Aviv Regev, Gad Getz, Nir Hacohen, Jennifer R Brown, MD, PhD, Catherine J Wu, MD
Journal: Blood
Blood (2010) 116 (21): 693.
https://doi.org/10.1182/blood.V116.21.693.693
Published: 2010
Journal Articles

Marrow-Infiltrating T Cells In Patients with Chronic Lymphocytic Leukemia Display Markers of Functional Impairment and Express PD-1

Ursula Hainz, Quinlan L. Sievers, Kristen Stevenson, Natalie R. Goldstein, David Dorfman, MD, PhD, Jennifer R Brown, MD, PhD, Gordon J. Freeman, Catherine J Wu, MD
Journal: Blood
Blood (2010) 116 (21): 2417.
https://doi.org/10.1182/blood.V116.21.2417.2417
Published: 2010