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Journal Articles

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Xueer Wang, Honghai Zhang, Lei Dong, Xiaoxu Zhang, Meilin Xue, Lili Ren, Hongjie Bi, Lucy Y. Ghoda, Mark Wunderlich, James C. Mulloy, Chun-Wei David Chen, Ling Li, Lin Xu, Bin Zhang, Guido Marcucci, Steven T. Rosen, Nora Heisterkamp, Marcin Kortylewski, Jianjun Chen, Rui Su
Journal: Blood
Blood (2024) 144 (Supplement 1): 625.
https://doi.org/10.1182/blood-2024-201916
Published: 2024
Journal Articles

Emicizumab Prophylaxis for the Treatment of Chinese Hemophilia A Patients in the Real World: A Multi-Center Retrospective Analysis

Yuan Xu, Ying Wang, Runhui Wu, Changcheng Zheng, Jianwen Xiao, Weiqun Xu, Xiaoqin Feng, Hua Wang, Xiangshan Cao, Liya He, Tianyang Xue, Mingwei Jin, Bingshou Xie, Jing Ling, Lirong Sun, Rui Su, Hongbo Cheng, Yongjun Fang, Bai Li, Ziqiang Yu, Ailing Xue, Mei Sun, Li Yang, Zeping Zhou, Hu Zhou, Jiao Jin, Min Zhou, Rong Chen, Wei Liu, Lei Zhang, Feng Xue, Renchi Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 2624.
https://doi.org/10.1182/blood-2023-174698
Published: 2023
Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yichun Lin, Songbai Liu, Huafeng Wang, Wenfeng Huang, Sierra Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 4931–4933.
https://doi.org/10.1182/blood-2022-167366
Published: 2022
Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2975–2977.
https://doi.org/10.1182/blood-2022-162619
Published: 2022
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yuhui Wu, Yinghui Zhu, Hanying Wang, Wenfeng Huang, Yichun Lin, Lianjun Zhang, Dandan Zhao, Juan Du, Rui Su, Ya-Huei Kuo, Jianjun Chen, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2021) 138 (Supplement 1): 358.
https://doi.org/10.1182/blood-2021-151679
Published: 2021
Journal Articles

RNA modifications in hematopoietic malignancies: a new research frontier

Ying Qing, Rui Su, Jianjun Chen
Journal: Blood
Blood (2021) 138 (8): 637–648.
https://doi.org/10.1182/blood.2019004263
Published: 2021
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Xi Qin, Rui Su, PhD, Lu Yang, PhD, Anthony K. N. Chan, PhD, Xiaolan Deng, Ying Qing, Lars Klemm, MS, Markus Müschen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1465.
https://doi.org/10.1182/blood-2019-129849
Published: 2019
Journal Articles

N 6 -Methyladenosine Modification Regulates Cell Metabolism in Acute Myeloid Leukemia

Hengyou Weng, PhD, Huilin Huang, PhD, Huizhe Wu, Mingli Sun, Savanna Stanford, Sean Robinson, zhen-Hua Chen, Xi Qin, Xiaolan Deng, Xi Jiang, PhD, Ying Qing, Chao Shen, PhD, Rui Su, PhD, Minjie Wei, Jianjun Chen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 880.
https://doi.org/10.1182/blood-2018-99-117455
Published: 2018
Journal Articles

ALKBH5 Functions As an Oncogene in Acute Myeloid Leukemia

Chao Shen, PhD, Yue Sheng, PhD, Rui Su, PhD, Xiaolan Deng, Sean Robinson, Zhe Yin, MD, Lei Dong, PhD, Huilin Huang, PhD, Hengyou Weng, PhD, Chenying Li, MD, Zhijian Qian, Xi Jiang, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3910.
https://doi.org/10.1182/blood-2018-99-118988
Published: 2018
Journal Articles

The Oncogenic Role of N 6 -Methyladenosine Reader Protein IGF2BP3 in Acute Myeloid Leukemia

Huilin Huang, PhD, Hengyou Weng, PhD, Mingli Sun, Huizhe Wu, Zhenhua Chen, PhD, Savanna Stanford, Xiaolan Deng, Rui Su, PhD, Minjie Wei, Jianjun Chen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1334.
https://doi.org/10.1182/blood-2018-99-117535
Published: 2018
Journal Articles

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

Xi Jiang, PhD, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, PhD, Liting Cheng, Zhixiang Zuo, PhD, William Seibel, PhD, Chunjiang He, PhD, Yixuan Tang, Jennifer R Skibbe, Mark Wunderlich, MS, William C Reinhold, Lei Dong, PhD, Chao Shen, PhD, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, PhD, Hengyou Weng, PhD, Rui Su, PhD, Huilin Huang, PhD, Yungui Wang, PhD, Chenying Li, MD, Xi Qin, James C. Mulloy, PhD, Yi Zheng, PhD, Jiajie Diao, PhD, Jie Jin, Chong Li, PhD, Paul P Liu, MD, Chuan He, PhD, Yuan Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 857.
https://doi.org/10.1182/blood.V130.Suppl_1.857.857
Published: 2017
Journal Articles

Fto Plays an Oncogenic Role in Acute Myeloid Leukemia As a N 6 -Methyladenosine RNA Demethylase

Rui Su, PhD, Zejuan Li, MD PhD, Hengyou Weng, PhD, Xiaocheng Weng, PhD, Zhixiang Zuo, Chenying Li, Huilin Huang, PhD, Chao Hu, PhD, Xi Qin, Lichuan Tang, PhD, Yungui Wang, PhD, Gia-Ming Hong, PhD, Hao Huang, PhD, Xiao Wang, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Yuanyuan Li, Shenglai Li, Jennifer Strong, Mary Elizabeth Neilly, Richard A. Larson, Xi Jiang, PhD, Pumin Zhang, Jie Jin, MD PhD, Chuan He, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 2706.
https://doi.org/10.1182/blood.V128.22.2706.2706
Published: 2016
Journal Articles

TET1 Regulates DNA Replication through Targeting of Minichromosome Maintenance Genes

Hengyou Weng, PhD, Huilin Huang, PhD, Xi Qin, He Huang, PhD, Okwang Kwon, Ping Chen, Xi Jiang, PhD, Chao Hu, PhD, Hao Huang, PhD, Yungui Wang, PhD, Stephen Arnovitz, Shenglai Li, Jennifer Strong, Kyle Ferchen, Rui Su, PhD, Lei Dong, Chenying Li, Mary Beth Neilly, Zejuan Li, MD PhD, Jason Stewart, PhD, Carolyn Price, Yingming Zhao, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 2687.
https://doi.org/10.1182/blood.V128.22.2687.2687
Published: 2016
Journal Articles

Alox5 Functions As Both Tumor Suppressor and Drug Sensitizer in AML

Xi Jiang, PhD, Yungui Wang, PhD, Chao Hu, PhD, Jennifer Strong, Lei Dong, PhD, Rui Su, PhD, Hengyou Weng, PhD, Huilin Huang, PhD, Chenying Li, Jie Jin, MD PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 2851.
https://doi.org/10.1182/blood.V128.22.2851.2851
Published: 2016
Journal Articles

The N 6 -Adenine Methyltransferase METTL14 Plays an Oncogenic Role in Acute Myeloid Leukemia

Huilin Huang, PhD, Hengyou Weng, PhD, Xi Qin, Boxuan Simen Zhao, PhD, Lou Dore, Jennifer Strong, Rui Su, PhD, Kyle Ferchen, Chenying Li, Lei Dong, Xi Jiang, PhD, Chuan He, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 1536.
https://doi.org/10.1182/blood.V128.22.1536.1536
Published: 2016
Journal Articles

Mircrorna-550 Functions As a Critical Tumor Suppressor in Acute Myeloid Leukemia

Chao Hu, Xi Jiang, PhD, Bryan Ulrich, Yungui Wang, PhD, Rui Su, PhD, Hengyou Weng, PhD, Huilin Huang, PhD, Jennifer Strong, Ping Chen, Shenglai Li, Jianjun Chen, PhD, Jie Jin, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1240.
https://doi.org/10.1182/blood.V126.23.1240.1240
Published: 2015
Journal Articles

Overexpression and Knockout of Mir-126 Both Promote Leukemogenesis through Targeting Distinct Gene Signaling

Rui Su, PhD, Zejuan Li, MD PhD, Ping Chen, Yuanyuan Li, Hu Chao, Yungui Wang, PhD, Stephen Arnovitz, Miao He, Sandeep Gurbuxani, MBBS, PhD, Zhixiang Zuo, Abdel G. Elkahloun, Shenglai Li, Hengyou Weng, PhD, Hao Huang, Mary Beth Neilly, Shusheng Wang, Richard A. Larson, MD, Jiwang Zhang, Xi Jiang, PhD, Minjie Wei, Jie Jin, MD PhD, Paul P. Liu, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3667.
https://doi.org/10.1182/blood.V126.23.3667.3667
Published: 2015
Journal Articles

Uncover TET1 Targets in MLL -Rearranged Leukemia

Hengyou Weng, PhD, Huilin Huang, PhD, He Huang, PhD, Okwang Kwon, Ping Chen, Xi Jiang, PhD, Chao Hu, Hao Huang, PhD, Yungui Wang, PhD, Xi Qin, Stephen Arnovitz, Shenglai Li, Jennifer Strong, Rui Su, PhD, Mary Beth Neilly, Zejuan Li, MD PhD, Yingming Zhao, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3632.
https://doi.org/10.1182/blood.V126.23.3632.3632
Published: 2015