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Journal Articles

Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia

Shanshan Suo, Dandan Zhao, Fenglin Li, Yi Zhang, Sonia Rodriguez-Rodriguez, Le Xuan Truong Nguyen, Lucy Ghoda, Nadia Carlesso, Guido Marcucci, Bin Zhang, Jie Jin
Journal: Blood
Blood (2024) 144 (12): 1343–1347.
https://doi.org/10.1182/blood.2023023400
Published: 2024
Includes: Supplemental data
Journal Articles

Glofitamab stimulates immune cell infiltration of CNS tumors and induces clinical responses in secondary CNS lymphoma

James K. Godfrey, Lei Gao, Geoffrey Shouse, Joo Y. Song, Stacy Pak, Brian Lee, Bihong T. Chen, Avyakta Kallam, John H. Baird, Guido Marcucci, Lucy Ghoda, Stephanie Vauleon, Alexey V. Danilov, Alex F. Herrera, Larry W. Kwak, Lihua E. Budde
Journal: Blood
Blood (2024) 144 (4): 457–461.
https://doi.org/10.1182/blood.2024024168
Published: 2024
Includes: Supplemental data
Journal Articles

A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ–induced CD38 expression

Mariam Murtadha, Miso Park, Yinghui Zhu, Enrico Caserta, Ottavio Napolitano, Theophilus Tandoh, Milad Moloudizargari, Alex Pozhitkov, Mahmoud Singer, Ada Alice Dona, Hawa Vahed, Asaul Gonzalez, Kevin Ly, Ching Ouyang, James F. Sanchez, Lokesh Nigam, Amanda Duplan, Arnab Chowdhury, Lucy Ghoda, Ling Li, Bin Zhang, Amrita Krishnan, Guido Marcucci, John C. Williams, Flavia Pichiorri
Journal: Blood
Blood (2024) 143 (16): 1599–1615.
https://doi.org/10.1182/blood.2023021570
Published: 2024
Includes: Supplemental data
Journal Articles

Pharmacology of a CpG-Linked Anti-Mir-126 Oligonucleotide Targeting Acute Myeloid Leukemia (AML) in Rats and Non-Human Primates (NHP)

Lucy Ghoda, Kokilah Muthaiyah, Bin Amber Zhang, Marcin Kortylewski, James Simpson, Le Xuan Truong Nguyen, Marjorie Robbins, Guido Marcucci, Tim Synold
Journal: Blood
Blood (2023) 142 (Supplement 1): 5754.
https://doi.org/10.1182/blood-2023-191202
Published: 2023
Journal Articles

Homoharringtonine Synergizes Strongly with Venetoclax Against the Early T-Cell Progenitor Acute Lymphoblastic Leukemia：from Bench to Bed

Shanshan Suo, Shu SUN, Jiejing Qian, Dandan Zhao, Wenjuan Yu, Yinjun Lou, Honghu Zhu, Hongyan Tong, Min Yang, Xin Huang, Shuqi Zhao, Junjing Qiao, Chen Liang, Fenglin Li, Huafeng Wang, Yi Zhang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Jie Sun, Ivan Rodriguez, Lucy Ghoda, Ling Li, Bin Zhang, Guido Marcucci, Jie Jin
Journal: Blood
Blood (2022) 140 (Supplement 1): 2263–2264.
https://doi.org/10.1182/blood-2022-170604
Published: 2022
Journal Articles

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

Shanshan Suo, Dandan Zhao, Fenglin Li, Sonia Rodriguez, Junjing Qiao, Chen Liang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Nadia Carlesso, Bin Zhang, Guido Marcucci, Jie Jin
Journal: Blood
Blood (2022) 140 (Supplement 1): 362–363.
https://doi.org/10.1182/blood-2022-169679
Published: 2022
Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yichun Lin, Songbai Liu, Huafeng Wang, Wenfeng Huang, Sierra Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 4931–4933.
https://doi.org/10.1182/blood-2022-167366
Published: 2022
Journal Articles

The Impact of Hypomethylating Agents and BCL-2 Inhibitor on HLA Expression on THP-1 Cells

Benjamin Peton, Melissa Valerio, Michiko Taniguchi, Ivan Rodriguez, Ebtsesam Nafie, Guido Marcucci, Monzr M. Al Malki, Lucy Ghoda, Ketevan Gendzekhadze
Journal: Blood
Blood (2021) 138 (Supplement 1): 3990.
https://doi.org/10.1182/blood-2021-145801
Published: 2021
Journal Articles

Acute Myeloid Leukemia Cell-Intrinsic PD-1 Functions Promoting Leukemia Development By Recruiting SHP2

Shanshan Suo, Le Xuan Truong Nguyen, Fenglin Li, Dandan Zhao, Junjing Qiao, Chen Liang, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Bin Amber Zhang, Jie Jin, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 1173.
https://doi.org/10.1182/blood-2021-154467
Published: 2021
Journal Articles

METTL3 Dysregulates RNA Splicing by Translational Control of Splicing Factors via m 6 A Modification in CLL

Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn Hart, Aijun Liao, Stacey M. Fernandes, Tinisha McDonald, Lucy Ghoda, Daniel Roeth, Markus Kalkum, Raju Pillai, Jianjun Chen, Jennifer R Brown, Alexey V. Danilov, Steven T. Rosen, Tanya Siddiqi, Lili Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 499.
https://doi.org/10.1182/blood-2021-149691
Published: 2021
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

Venetoclax Synergizes with the RNA-Directed Nucleoside Analog 8-Chloro-Adenosine in Acute Myeloid Leukemia in Vitro and In Vivo

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Corey James Morales, BA, BS, Lisa S Chen, PhD, Timothy Synold, PhD, Dinh Hoa Hoang, BS, Bin Amber Zhang, PhD, Lucy Ghoda, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-143240
Published: 2020
Journal Articles

Microrna-142 Deficiency Promotes Chronic Myeloid Leukemia (CML) Transformation from Chronic Phase (CP) to Blast Crisis (BC)

Bin Amber Zhang, PhD, Dandan Zhao, MD, Huafeng Wang, MD, Chen Liang, MD, Le Xuan Truong Nguyen, PhD, Junjing Qiao, MD PhD, Shanshan Suo, MD, Yasmin Elhajmoussa, Lucy Ghoda, PhD, David Frankhouser, Russell Rockne, PhD, Ling Li, PhD, Ya-Huei Kuo, PhD, Mark Boldin, MD PhD, Guido Marcucci, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-143202
Published: 2020
Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-140044
Published: 2020
Journal Articles

Antileukemic Activity of 8-Chloro-Adenosine (8-Cl-Ado) Is Mediated By Mir-155 Degradation and ErbB3 Binding Protein (Ebp1)-Dependent p53 Activation: A Novel Therapeutic Approach for FLT3-ITD Acute Myeloid Leukemia (AML)

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Bijender Kumar, PhD, Corey James Morales, BA, BS, Chao Liu, PhD, Lisa S Chen, PhD, Tea Pemovska, PhD, Ryan Thompson, BS, Ling Li, PhD, Dinh Hoa Hoang, BS, Bin Zhang, PhD, Lucy Ghoda, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Calum Leitch, PhD, Xiaochun Yu, MD PhD, Ching-Cheng Chen, PhD, David Horne, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2018-99-119880
Published: 2018
Journal Articles

Immune Mediated Mechanisms of Resistance to Daratumumab

Domenico Viola, Ada Dona, Emine Gulsen Gunes, PhD, Estelle Troadec, Xiwei Wu, Sergio Branciamore, Tinisha McDonald, MS, Lucy Ghoda, PhD, Ashish Streatfield, James F Sanchez, PhD, Chatchada Karanes, Myo Htut, Michael Rosenzweig, Jonathan J Keats, PhD, Steven T Rosen, Guido Marcucci, Amrita Krishnan, MD, Flavia Pichiorri, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3201.
https://doi.org/10.1182/blood-2018-99-117441
Published: 2018