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Journal Articles

Risk prediction for clonal cytopenia: multicenter real-world evidence

Clinical Trials & Observations
Zhuoer Xie, Rami Komrokji, Najla Al Ali, Alexandra Regelson, Susan Geyer, Anand Patel, Caner Saygin, Amer M. Zeidan, Jan Philipp Bewersdorf, Lourdes Mendez, Ashwin Kishtagari, Joshua F. Zeidner, Catherine C. Coombs, Yazan F. Madanat, Stephen Chung, Talha Badar, James Foran, Pinkal Desai, Charlton Tsai, Elizabeth A. Griffiths, Monzr M. Al Malki, Idoroenyi Amanam, Catherine Lai, H. Joachim Deeg, Lionel Ades, Cecilia Arana Yi, Afaf E. G. Osman, Shira Dinner, Yasmin Abaza, Justin Taylor, Namrata Chandhok, Deborah Soong, Andrew M. Brunner, Hetty E. Carraway, Abhay Singh, Chiara Elena, Jacqueline Ferrari, Anna Gallì, Sara Pozzi, Eric Padron, Mrinal M. Patnaik, Luca Malcovati, Michael R. Savona, Aref Al-Kali
Journal: Blood
Blood (2024) 144 (19): 2033–2044.
https://doi.org/10.1182/blood.2024024756
Published: 2024
Includes: Supplemental data
Journal Articles

Final Analysis of Phase 2a Study of Adding Itacitinib to Tacrolimus/Sirolimus Gvhd Prophylaxis after Fludarabine/Melphalan-Based Conditioning Hematopoietic Cell Transplantation for Acute Leukemias, Myelodysplastic Syndrome (MDS), or Myelofibrosis (MF)

Haris Ali, Dongyun Yang, NI-Chun Tsai, Sally Mokhtari, Tim W Synold, Idoroenyi Amanam, Andrew Artz, Peter T. Curtin, Karamjeet S Sandhu, Anthony S. Stein, Shukaib Arslan, Salman Otoukesh, Firoozeh Sahebi, Joshua Mansour, Paul B. Koller, Amandeep Salhotra, Ibrahim Aldoss, Vinod Pullarkat, Brian J. Ball, Stephen J. Forman, Guido Marcucci, MHD Monzr M. Al Malki, Ryotaro Nakamura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1043.
https://doi.org/10.1182/blood-2024-206169
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Outcomes of Hypomethylating Agents/Venetoclax (HMA/VEN) Treatment for Relapse of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) after Allogeneic Hematopoietic Cell Transplant (alloHCT)

Diana T Samuels, Brian J. Ball, NI-Chun Tsai, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Idoroenyi Amanam, Paul B. Koller, Shukaib Arslan, Salman Otoukesh, Karamjeet S Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, MHD Monzr M. Al Malki, Andrew Artz, Pamela S. Becker, Ahmed Aribi, Eileen Patricia Smith, Stephen J. Forman, Anthony S. Stein, Guido Marcucci, Ryotaro Nakamura, Vinod Pullarkat
Journal: Blood
Blood (2024) 144 (Supplement 1): 4935.
https://doi.org/10.1182/blood-2024-210956
Published: 2024
Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Impact of Prior Chimeric Antigen Receptor T-Cell Treatment on Graft-Vs-Host Disease and Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplantation: A Case-Control Propensity Matching Analysis

Tamer Othman, Dongyun Yang, Sally Mokhtari, Ibrahim Aldoss, Geoffrey Shouse, Shukaib Arslan, Leonardo Farol, Leslie L. Popplewell, Ahmed Aribi, Alex F. Herrera, Lihua E. Budde, Joshua Mansour, Matthew Mei, Karamjeet S Sandhu, Tanya Siddiqi, Jasmine Zain, Vaibhav Agrawal, Idoroenyi Amanam, Vinod Pullarkat, Tycel J. Phillips, Ryotaro Nakamura, Stephen J. Forman, MHD Monzr M. Al Malki
Journal: Blood
Blood (2024) 144 (Supplement 1): 3534.
https://doi.org/10.1182/blood-2024-207125
Published: 2024
Journal Articles

TP53 Mutations Increased the Risk of CD19 Negative Relapse Following Blinatumomab in Adults with B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Ibrahim Aldoss, Jeffrey Li, Jianying Zhang, Mary C Clark, Vaibhav Agrawal, Hoda Pourhassan, Paul B. Koller, Ahmed Aribi, Haris Ali, Amanda Blackmon, Salman Otoukesh, Karamjeet S Sandhu, Brian J. Ball, Andrew Artz, Idoroenyi Amanam, MHD Monzr M. Al Malki, Amandeep Salhotra, Lindsey A. Murphy, Dat Ngo, Jose Tinajero, Zhaohui Gu, Pamela S. Becker, Ryotaro Nakamura, Anthony S. Stein, Guido Marcucci, Stephen J. Forman, Vinod Pullarkat
Journal: Blood
Blood (2024) 144 (Supplement 1): 729.
https://doi.org/10.1182/blood-2024-208674
Published: 2024
Journal Articles

Consolidation with First and Second Allogeneic Transplants in Adults with Relapsed/Refractory B-ALL Following Response to CD19CAR T Cell Therapy

Ibrahim Aldoss, Haoyue Shan, Dongyun Yang, Mary C Clark, Monzr M. Al Malki, Ahmed Aribi, Karamjeet S. Sandhu, Amandeep Salhotra, Vaibhav Agrawal, Hoda Pourhassan, Paul B. Koller, Haris Ali, Andrew Artz, Idoroenyi Amanam, Nicole Karras, Anna Pawlowska, Lindsey Murphy, Joycelynne Michelle Palmer, Guido Marcucci, Anthony Stein, Vinod Pullarkat, Ryotaro Nakamura, Stephen J. Forman
Journal: Blood
Blood (2023) 142 (Supplement 1): 4981.
https://doi.org/10.1182/blood-2023-182058
Published: 2023
Journal Articles

Outcomes of Patients Undergoing Fludarabine and Melphalan-Based Conditioning with Post-Transplant Cyclophosphamide for Peripheral Blood Stem Cell Allogeneic Hematopoietic Cell Transplant: Donor Type Effect

Tamer Othman, Paul B. Koller, Dongyun Yang, Sally Mokhtari, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Brian J. Ball, Idoroenyi Amanam, Shukaib Arslan, Salman Otoukesh, Karamjeet S. Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, Ahmed Aribi, Andrew Artz, Yazeed Samara, Pamela S. Becker, Vinod Pullarkat, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 2151.
https://doi.org/10.1182/blood-2023-187687
Published: 2023
Journal Articles

Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients

Lindsay A.M Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, James McCloskey, Akiyoshi Takami, Tamanna Haque, Michiko Ichii, Shuichi Shirane, Masafumi Fukaya, Joseph M. Scandura, Terrence Bradley, Pankit Vachhani, Takayuki Tabayashi, Steven Green, Stanley Cheung, Prithviraj Bose, Sharad Khurana, Casey L. O'Connell, Idoroenyi Amanam, David M. Ross, Sujan Kabir, Masataka Seki, Mark Wade, Vishnu Peddagali, Zhonggai Li, Jatin Shah, Raajit K. Rampal
Journal: Blood
Blood (2023) 142 (Supplement 1): 626.
https://doi.org/10.1182/blood-2023-180164
Published: 2023
Journal Articles

Combined Cytokine Blocking Therapy (CCBT) Using Basiliximab and Infliximab for Treatment of Steroid-Refractory Graft Versus Host Disease (SR-GvHD)

Hoda Pourhassan, Tina Nguyen, Dongyun Yang, Tamer Othman, Paul B. Koller, Amanda Blackmon, Vaibhav Agrawal, Brian J. Ball, Idoroenyi Amanam, Shukaib Arslan, Salman Otoukesh, Karamjeet S. Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, Ahmed Aribi, Andrew Artz, Pamela S. Becker, Vinod Pullarkat, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 4944.
https://doi.org/10.1182/blood-2023-190808
Published: 2023
Journal Articles

Favorable Survival Outcomes in AML Patients Undergoing Allogeneic Hematopoietic Cell Transplant with Fludarabine/Melphalan-Conditioning with Tacrolimus/Sirolimus-Based Gvhd Prophylaxis

Amandeep Salhotra, Monzr M. Al Malki, Dongyun Yang, Sally Mokhtari, Ibrahim Aldoss, Ahmed Aribi, Idoroenyi Amanam, Haris Ali, Karamjeet S. Sandhu, Vaibhav Agrawal, Paul B. Koller, Brian J. Ball, Shukaib Arslan, Salman Otoukesh, Amanda Blackmon, Hoda Pourhassan, Yazeed Samara, Tamer Othman, Pamela S. Becker, Vinod Pullarkat, Ricardo Spielberger, Forest Marc Stewart, Eileen Patricia Smith, Andrew Artz, Stephen J. Forman, Guido Marcucci, Anthony Stein, Ryotaro Nakamura
Journal: Blood
Blood (2023) 142 (Supplement 1): 4959.
https://doi.org/10.1182/blood-2023-187156
Published: 2023
Journal Articles

Fractionated Total Body Irradiation and Fludarabine Based Conditioning Regimen with Post-Transplant Cyclophosphamide (PTCy) for Mismatched Related and Unrelated Donors HCT for Acute Leukemia and MDS

Shukaib Arslan, Amrita Desai, Dongyun Yang, Sally Mokhtari, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Brian J. Ball, Idoroenyi Amanam, Salman Otoukesh, Paul B. Koller, Karamjeet S. Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, Tamer Othman, Ahmed Aribi, Andrew Artz, Pamela S. Becker, Vinod Pullarkat, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 3537.
https://doi.org/10.1182/blood-2023-187728
Published: 2023
Journal Articles

Clinical Factors but Not Somatic Mutations Predict for Survival in Patients with Myelofibrosis Undergoing Allogeneic Hematopoietic Cell Transplant: Analysis of the North American Myelofibrosis Transplant Outcome (NAMTO) Study

Helen Ajufo, Andriy Derkach, Raajit K. Rampal, Christopher Famulare, David Nemirovsky, Jordan Chervin, Vincent Ho, Vikas Gupta, Auro Viswabandya, H. Joachim Deeg, Tim Monahan, Tania Jain, Richard J. Jones, Jeanne Palmer, Aaron T. Gerds, Alla Keyzner, Jonathan Lagdameo, Alexandra Gomez-Arteaga, Koen Van Besien, Nikolai A. Podoltsev, Christian Puzo, Satyajit Kosuri, Idoroenyi Amanam, Roni Tamari
Journal: Blood
Blood (2023) 142 (Supplement 1): 3181.
https://doi.org/10.1182/blood-2023-173441
Published: 2023
Journal Articles

A Pilot Study of Reduced Intensity HLA-Haploidentical Hematopoietic Cell Transplantation (HaploHCT) with Post-Transplant Cyclophosphamide in Patients with Advanced Myelofibrosis

Haris Ali, Dongyun Yang, Sally Mokhtari, Ahmed Aribi, Joshua Mansour, Firoozeh Sahebi, Geoffrey P. Shouse, Idoroenyi Amanam, Salman Otoukesh, Anthony Stein, Stephen J. Forman, Guido Marcucci, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 3566.
https://doi.org/10.1182/blood-2023-190449
Published: 2023
Journal Articles

IL1RAP-Specific T Cell Engager (TCE) Antibody Efficiently Depletes Acute Myeloid Leukemia (AML) Leukemic Stem Cells (LSCs)

Yi Zhang, Miso Park, Bin Zhang, Lucy Y. Ghoda, Dandan Zhao, Melissa Valerio, Ebtesam Nafie, Xubo Gong, Fang Chen, Yongfang Xu, Katrina Estrella, Kaito Harada, Shawn Sharkas, Hyunjun Kang, Dinh Hoa Hoang, Le Xuan Truong Nguyen, Stephen J. Forman, Idoroenyi Amanam, Flavia Pichiorri, Jie Jin, John C. Williams, Guido Marcucci
Journal: Blood
Blood (2023) 142 (Supplement 1): 586.
https://doi.org/10.1182/blood-2023-185405
Published: 2023
Journal Articles

Toxicities Associated with Tyrosine Kinase Inhibitor Maintenance Following Allogeneic Hematopoietic Cell Transplantation in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Tamer Othman, Paul B. Koller, NI-Chun Tsai, Dat Ngo, Jason Chen, Amanda Blackmon, Hoda Pourhassan, Vaibhav Agrawal, Idoroenyi Amanam, Brian J. Ball, Salman Otoukesh, Amandeep Salhotra, Shukaib Arslan, Monzr M. Al Malki, Haris Ali, Karamjeet S. Sandhu, Ahmed Aribi, Andrew Artz, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Ryotaro Nakamura, Vinod Pullarkat, Ibrahim Aldoss, Matthew Genyeh Mei
Journal: Blood
Blood (2023) 142 (Supplement 1): 2873.
https://doi.org/10.1182/blood-2023-187460
Published: 2023
Journal Articles

Single Center Retrospective Study of Midostaurin Plus Intensive Chemotherapy for Older Patients with Newly Diagnosed FLT-3 Mutated Acute Myelogenous Leukemia

Jose Tinajero, Dat Ngo, Jianying Zhang, NI-Chun Tsai, Joycelynne Michelle Palmer, Ahmed Aribi, Ibrahim Aldoss, Vaibhav Agrawal, Shukaib Arslan, Idoroenyi Amanam, Hoda Pourhassan, Karamjeet S. Sandhu, Monzr M. Al Malki, Vinod Pullarkat, Pamela S. Becker, Ryotaro Nakamura, Anthony Stein, Guido Marcucci, Andrew Artz, Paul B. Koller, Amandeep Salhotra
Journal: Blood
Blood (2023) 142 (Supplement 1): 5937.
https://doi.org/10.1182/blood-2023-173978
Published: 2023
Journal Articles

Improving Outcomes of Peripheral Blood Stem Cell (PBSC) HLA-Mismatched Unrelated Donor (MMUD) Hematopoietic Cell Transplantation (HCT): Effect of Graft Versus Host Disease (GVHD) Prophylaxis

Vaibhav Agrawal, Dongyun Yang, Sally Mokhtari, Tamer Othman, Yazeed Samara, Amanda Blackmon, Hoda Pourhassan, Brian J. Ball, Idoroenyi Amanam, Shukaib Arslan, Salman Otoukesh, Paul B. Koller, Karamjeet S. Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, Ahmed Aribi, Andrew Artz, Pamela S. Becker, Vinod Pullarkat, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 4896.
https://doi.org/10.1182/blood-2023-187909
Published: 2023
Journal Articles

The Characteristics and Prognosis of Patients with Clonal Cytopenias of Undetermined Significance, Including Cancer and Therapy-Related Clonal Cytopenias

Zhuoer Xie, Alexandra Smith, Rami S. Komrokji, Najla Al Ali, Anand Ashwin Patel, Caner Saygin, Amer M. Zeidan, Jan Philipp Bewersdorf, Ashwin Kishtagari, Joshua F. Zeidner, Catherine C. Coombs, Yazan F. Madanat, James M. Foran, Talha Badar, Pinkal Desai, Charlton Tsai, Elizabeth A. Griffiths, Monzr M. Al Malki, Idoroenyi Amanam, Catherine Lai, Joachim Deeg, Lionel Ades, Cecilia Arana Yi, Afaf Osman, Shira Dinner, Yasmin Abaza, Namrata Chandhok, Deborah Soong, Justin Taylor, Andrew M. Brunner, Hetty E. Carraway, Abhay Singh Singh, Susan M. Geyer, Eric Padron, Mrinal M.M. Patnaik, Michael R. Savona, Aref Al-Kali
Journal: Blood
Blood (2022) 140 (Supplement 1): 2887–2890.
https://doi.org/10.1182/blood-2022-162367
Published: 2022