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Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Blood (2024) 144 (Supplement 1): 3179.

https://doi.org/10.1182/blood-2024-200999

Published: 2024

Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Blood (2024) 144 (Supplement 1): 655.

https://doi.org/10.1182/blood-2024-200312

Published: 2024

Journal Articles

Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients

Blood (2023) 142 (Supplement 1): 626.

https://doi.org/10.1182/blood-2023-180164

Published: 2023

Journal Articles

Preliminary Data from the Phase I/II Study of TP-3654, a Selective Oral PIM1 Kinase Inhibitor, in Patients with Myelofibrosis Previously Treated with or Ineligible for JAK Inhibitor Therapy

Firas El Chaer, James McCloskey, Lindsay A.M. Rein, Randy A. Brown, Steven D. Green, Jeffrey J. Pu, Shuichi Shirane, Kazuya Shimoda, Michiko Ichii, Junichiro Yuda, Joseph Scandura, Sujan Kabir, Jason M Foulks, Jian Mei, Huyuan Yang, Mark Wade, Carl Stapinski, Claudia Lebedinsky, Raajit K Rampal

Blood (2022) 140 (Supplement 1): 594–595.

https://doi.org/10.1182/blood-2022-159086

Published: 2022

Journal Articles

Ectonucleosidase CD39 Is Highly Expressed on ATLL Cells and Suppresses the Immune Response through the Adenosine Pathway

Yasuhiro Nagate, MD, Sachiko Ezoe, MD PhD, Jiro Fujita, MD PhD, Takafumi Yokota, MD PhD, Michiko Ichii, MD PhD, Akira Tanimura, Yukiko Doi, Tomoaki Ueda, Jun Toda, MD, Hirohiko Shibayama, MD PhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 3720.

https://doi.org/10.1182/blood-2018-99-118555

Published: 2018

Journal Articles

ESAM on the Cells of Endothelial Lineage Plays an Important Role in the Development of Definitive Hematopoiesis

Tomoaki Ueda, Takafumi Yokota, MD PhD, Yoshihiro Uno, Tomoji Mashimo, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Yasuhiro Shingai, MD, Akira Tanimura, Michiko Ichii, MD PhD, Sachiko Ezoe, MD PhD, Hirohiko Shibayama, MD PhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 3848.

https://doi.org/10.1182/blood-2018-99-111491

Published: 2018

Journal Articles

Monitoring ESAM Expression Levels Reveals Autonomous Fluctuation of Leukemia Stem Cells By Autocrine/Paracrine Cytokine Signaling

Yasuhiro Shingai, MD, Takafumi Yokota, MD PhD, Takayuki Ozawa, MD, Tomoaki Ueda, Yukiko Doi, Tomohiko Ishibashi, Akira Tanimura, Michiko Ichii, MD PhD, Hirohiko Shibayama, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 3950.

https://doi.org/10.1182/blood-2018-99-111085

Published: 2018

Journal Articles

Role of Signal Transducing Adaptor Protein-1 (STAP-1) in Chronic Myelogenous Leukemia Stem Cells

Jun Toda, MD, Michiko Ichii, MD PhD, Hirohiko Shibayama, MD PhD, Hideaki Saito, MD, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Tadashi Matsuda, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 4245.

https://doi.org/10.1182/blood-2018-99-113725

Published: 2018

Journal Articles

Signal Transducing Adaptor Protein (STAP) Family Accelerates Gut and Thymic Graft-Versus-Host-Disease in Murine Model

Hideaki Saito, MD, Michiko Ichii, MD PhD, Jun Toda, MD, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Hirohiko Shibayama, MD PhD, Tadashi Matsuda, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 4516.

https://doi.org/10.1182/blood-2018-99-112803

Published: 2018

Journal Articles

Variable Expression Levels of the Hematopoietic Stem Cell Surface Antigen ESAM Depict Heterogeneity and Fluctuations in Leukemic Stem Cells

Yasuhiro Shingai, Takafumi Yokota, MD PhD, Tomoaki Ueda, Yukiko Doi, Tomohiko Ishibashi, Akira Tanimura, Michiko Ichii, MD PhD, Sachiko Ezoe, Hirohiko Shibayama, MD PhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2017) 130 (Supplement 1): 1252.

https://doi.org/10.1182/blood.V130.Suppl_1.1252.1252

Published: 2017

Journal Articles

Signal-Transducing Adaptor Protein-2 Blocks B Cell Recovery Under Hematological Stress at Pre-B Stage Via TLR4 Signaling

Michiko Ichii, MD PhD, Kenji Oritani, MD PhD, Hirohiko Shibayama, MD PhD, Jun Toda, MD, Hideaki Saito, MD, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Tadashi Matsuda, Yuzuru Kanakura, MD PhD

Blood (2017) 130 (Supplement 1): 1155.

https://doi.org/10.1182/blood.V130.Suppl_1.1155.1155

Published: 2017

Journal Articles

Endothelial Cell-Selective Adhesion Molecule (ESAM) Plays Important Roles in the Adult-Type Hemoglobin Synthesis during Fetal Erythropoiesis

Tomoaki Ueda, Takafumi Yokota, MD PhD, Yasuhiro Shingai, Yukiko Doi, Tomohiko Ishibashi, Takao Sudo, Akira Tanimura, Michiko Ichii, MD PhD, Sachiko Ezoe, Hirohiko Shibayama, MD PhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2017) 130 (Supplement 1): 1157.

https://doi.org/10.1182/blood.V130.Suppl_1.1157.1157

Published: 2017

Journal Articles

Role of Signal Transducing Adaptor Protein (STAP) Family in Chronic Myelogenous Leukemia

Blood (2017) 130 (Supplement 1): 1583.

https://doi.org/10.1182/blood.V130.Suppl_1.1583.1583

Published: 2017

Journal Articles

SATB1 Expression Helps in Identification of the Lymphoid-Lineage-Biased Trajectory of Functionally Fluctuating Hematopoietic Stem Cells

Yukiko Doi, MD, Takafumi Yokota, MD PhD, Yusuke Satoh, MD PhD, Tomoaki Ueda, MD, Yasuhiro Shingai, MD, Michiko Ichii, MD PhD, Akira Tanimura, MD PhD, Sachiko Ezoe, MD PhD, Hirohiko Shibayama, MD PhD, Kenji Oritani, MD PhD, Terumi Kohwi-Shigematsu, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2016) 128 (22): 424.

https://doi.org/10.1182/blood.V128.22.424.424

Published: 2016

Journal Articles

Endothelial Cell-Selective Adhesion Molecule (ESAM) Is Required for the Ontogeny of Definitive Hematopoietic System in Mice

Tomoaki Ueda, MD, Takafumi Yokota, MD PhD, Yasuhiro Shingai, MD, Yukiko Doi, MD, Tomohiko Ishibashi, MD PhD, Takao Sudo, MD PhD, Yasuhiro Nagate, MD, Akira Tanimura, MD PhD, Masahiro Tokunaga, MD PhD, Jiro Fujita, MD PhD, Michiko Ichii, MD PhD, Sachiko Ezoe, MD PhD, Hirohiko Shibayama, MDPhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2016) 128 (22): 3874.

https://doi.org/10.1182/blood.V128.22.3874.3874

Published: 2016

Journal Articles

SATB1 Expression Marks Lymphoid-Lineage-Biased Hematopoietic Stem Cells in Mouse Bone Marrow

Yukiko Doi, MD, Takafumi Yokota, MD PhD, Tomohiko Ishibashi, MD, Yusuke Satoh, MD PhD, Michiko Ichii, MD PhD, Akira Tanimura, MD PhD, Sachiko Ezoe, MD PhD, Hirohiko Shibayama, MDPhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2015) 126 (23): 2356.

https://doi.org/10.1182/blood.V126.23.2356.2356

Published: 2015

Journal Articles

ESAM Is a Novel Human Hematopoietic Stem Cell Marker Associated with a Subset of Human Leukemias

Tomohiko Ishibashi, MD, Takafumi Yokota, MD PhD, Hirokazu Tanaka, MD PhD, Michiko Ichii, MD PhD, Takao Sudo, MD PhD, Yusuke Satoh, MD PhD, Yukiko Doi, MD, Akira Tanimura, MD PhD, Yuri Hamanaka, MD, Sachiko Ezoe, MD PhD, Hirohiko Shibayama, MDPhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2015) 126 (23): 1154.

https://doi.org/10.1182/blood.V126.23.1154.1154

Published: 2015

Journal Articles

An Impdh Inhibitor, FF-10501 Possesses Activating Effects on Myeloid Differentiation As Well As Anti-Proliferation

Michiko Ichii, MD PhD, Motohiko Murase, MSc, Kensuke Komatsu, PhD, Motoki Saito, PhD, Jun Toda, MD, Kenji Oritani, MD PhD, Hiroyuki Iwamura, PhD, Yuzuru Kanakura, MD PhD

Blood (2015) 126 (23): 3679.

https://doi.org/10.1182/blood.V126.23.3679.3679

Published: 2015

Journal Articles

The Role of Signal-Transducing Adaptor Protein-2 in Early T Lymphopoiesis in Thymus

Michiko Ichii, Natsuko Fujita, Daisuke Okuzaki, Tetsuo Maeda, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda, Yuzuru Kanakura

Blood (2014) 124 (21): 752.

https://doi.org/10.1182/blood.V124.21.752.752

Published: 2014

Journal Articles

An Anti-Apoptotic Molecule, Anamorsin, Is Upregulated in Anemia and Essential for Imperative Erytropoiesis

Akira Tanimura, Hirohiko Shibayama, Hamanaka Yuri, Natsuko Fujita, Nagate Yasuhiro, Tomohiko Ishibashi, Norimitsu Saitoh, Michiko Ichii, Takafumi Yokota, Sachiko Ezoe, Kenji Oritani, Yuzuru Kanakura

Blood (2014) 124 (21): 4014.

https://doi.org/10.1182/blood.V124.21.4014.4014

Published: 2014

NARROW

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients

Preliminary Data from the Phase I/II Study of TP-3654, a Selective Oral PIM1 Kinase Inhibitor, in Patients with Myelofibrosis Previously Treated with or Ineligible for JAK Inhibitor Therapy

Ectonucleosidase CD39 Is Highly Expressed on ATLL Cells and Suppresses the Immune Response through the Adenosine Pathway

ESAM on the Cells of Endothelial Lineage Plays an Important Role in the Development of Definitive Hematopoiesis

Monitoring ESAM Expression Levels Reveals Autonomous Fluctuation of Leukemia Stem Cells By Autocrine/Paracrine Cytokine Signaling

Role of Signal Transducing Adaptor Protein-1 (STAP-1) in Chronic Myelogenous Leukemia Stem Cells

Signal Transducing Adaptor Protein (STAP) Family Accelerates Gut and Thymic Graft-Versus-Host-Disease in Murine Model

Variable Expression Levels of the Hematopoietic Stem Cell Surface Antigen ESAM Depict Heterogeneity and Fluctuations in Leukemic Stem Cells

Signal-Transducing Adaptor Protein-2 Blocks B Cell Recovery Under Hematological Stress at Pre-B Stage Via TLR4 Signaling

Endothelial Cell-Selective Adhesion Molecule (ESAM) Plays Important Roles in the Adult-Type Hemoglobin Synthesis during Fetal Erythropoiesis

Role of Signal Transducing Adaptor Protein (STAP) Family in Chronic Myelogenous Leukemia

SATB1 Expression Helps in Identification of the Lymphoid-Lineage-Biased Trajectory of Functionally Fluctuating Hematopoietic Stem Cells

Endothelial Cell-Selective Adhesion Molecule (ESAM) Is Required for the Ontogeny of Definitive Hematopoietic System in Mice

SATB1 Expression Marks Lymphoid-Lineage-Biased Hematopoietic Stem Cells in Mouse Bone Marrow

ESAM Is a Novel Human Hematopoietic Stem Cell Marker Associated with a Subset of Human Leukemias

An Impdh Inhibitor, FF-10501 Possesses Activating Effects on Myeloid Differentiation As Well As Anti-Proliferation

The Role of Signal-Transducing Adaptor Protein-2 in Early T Lymphopoiesis in Thymus

An Anti-Apoptotic Molecule, Anamorsin, Is Upregulated in Anemia and Essential for Imperative Erytropoiesis

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American Society of Hematology

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American Society of Hematology

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