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Journal Articles

Pharmacological targeting of CTPS1 elicits macrophage-mediated anti-leukemia immunity

Meng Liu, Lei Zhang, Xin He, Haojie Dong, Yang Li, Shuaishuai Ge, Guohua Wu, Umesh Yadav, wei chen, Pinghui Feng, Guido Marcucci, Ling Li

Blood (2025) 146 (Supplement 1): 1490.

https://doi.org/10.1182/blood-2025-1490

Published: 2025

Journal Articles

Targeting PRMT7 enhances the anti-AML immunity by regulating MHC-I

Shuaishuai Ge, Kaixiu luo, Lei Zhang, Meng Liu, Xin He, Guohua Wu, Yang Li, Umesh Yadav, Haojie Dong, Shengli Xue, Jian Jin, Ling Li

Blood (2025) 146 (Supplement 1): 387.

https://doi.org/10.1182/blood-2025-387

Published: 2025

Journal Articles

Targeting adss overcomes venetoclax resistance in TP53-mutated acute myeloid leukemia

Blood (2025) 146 (Supplement 1): 213.

https://doi.org/10.1182/blood-2025-213

Published: 2025

Journal Articles

Targeting PRMT9 Overcomes Venetoclax Resistance in AML By Modulating Splicing and Inhibiting Translation

Yang Li, Xin He, Haojie Dong, Lei Zhang, Umesh Yadav, Meng Liu, Lianjun Zhang, Guido Marcucci, Shaoyuan Wang, Ling Li

Blood (2024) 144 (Supplement 1): 54.

https://doi.org/10.1182/blood-2024-203923

Published: 2024

Journal Articles

Targeting Cytidine Triphosphate Synthase 1 Promotes Anti-AML Immunity

Meng Liu, Lei Zhang, Haojie Dong, Xin He, Yang Li, Umesh Yadav, Guido Marcucci, Ling Li

Blood (2024) 144 (Supplement 1): 3590.

https://doi.org/10.1182/blood-2024-203905

Published: 2024

Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo

Blood (2024) 144 (Supplement 1): 1398.

https://doi.org/10.1182/blood-2024-208137

Published: 2024

Journal Articles

Targeting ADSS2 Enhances BH3 Mimetics Treatment Induced Mitochondrial Apoptosis in AML Cells

Xin He, Lei Zhang, Yang Li, Haojie Dong, Lianjun Zhang, Daisuke Nakada, Guido Marcucci, Yun Luo, Ling Li

Blood (2023) 142 (Supplement 1): 577.

https://doi.org/10.1182/blood-2023-186907

Published: 2023

Journal Articles

SAMHD1 Inhibitor Combined with Immune Checkpoint Inhibitor Elicits an Anti-AML Immunity

Lei Zhang, Haojie Dong, Xin He, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li

Blood (2023) 142 (Supplement 1): 47.

https://doi.org/10.1182/blood-2023-182463

Published: 2023

Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo

Blood (2023) 142 (Supplement 1): 5700.

https://doi.org/10.1182/blood-2023-182215

Published: 2023

Journal Articles

Targeting SAMHD1 Promotes Anti-Tumor Immunity in Acute Myeloid Leukemia

Lei Zhang, Haojie Dong, Xin He, Yichun Lin, Weidong Hu, Amandeep Salhotra, Saro H. Armenian, Guido Marcucci, Yun Luo, Ling Li

Blood (2022) 140 (Supplement 1): 679–680.

https://doi.org/10.1182/blood-2022-167653

Published: 2022

Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo

Blood (2022) 140 (Supplement 1): 8692–8693.

https://doi.org/10.1182/blood-2022-160280

Published: 2022

Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Blood (2022) 140 (Supplement 1): 4931–4933.

https://doi.org/10.1182/blood-2022-167366

Published: 2022

Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Blood (2022) 139 (26): 3752–3770.

https://doi.org/10.1182/blood.2021015108

Published: 2022

Includes: Supplemental data

Journal Articles

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yuhui Wu, Yinghui Zhu, Hanying Wang, Wenfeng Huang, Yichun Lin, Lianjun Zhang, Dandan Zhao, Juan Du, Rui Su, Ya-Huei Kuo, Jianjun Chen, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li

Blood (2021) 138 (Supplement 1): 358.

https://doi.org/10.1182/blood-2021-151679

Published: 2021

Journal Articles

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

Hanying Wang, Xin He, MD, Feiteng Huang, MS, Haojie Dong, PhD, Wei Chen, PhD, Zheng Li, MS, Jie Sun, PhD, Yinghui Zhu, PhD, Lei Zhang, MD, Yuhui Wu, MD, Lifeng Feng, PhD, Jing Zhang, PhD, Samer Khaled, MD, Guido Marcucci, MD, David Sykes, MD PhD, Hongchuan Jin, MD PhD, Xian Wang, MD PhD, Ling Li, PhD

Blood (2020) 136 (Supplement 1): 26.

https://doi.org/10.1182/blood-2020-139922

Published: 2020

Journal Articles

HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation

Dijiong Wu, MD, Man Li, PhD, Lianjun Zhang, PhD, Jing Qi, PhD, Chun-Wei David Chen, PhD, Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Jie Sun, PhD, Ling Li, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD

Blood (2019) 134 (Supplement_1): 642.

https://doi.org/10.1182/blood-2019-124134

Published: 2019

Journal Articles

Protein Arginine Methyltransferase 1 Is Required for Maintenance of Normal Adult Hematopoiesis

Lei Zhu, MD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Yinghui Zhu, PhD, Feiteng Huang, Jingying Zou, Xiaoying Zhao, MD, Ling Li, PhD

Blood (2019) 134 (Supplement_1): 3708.

https://doi.org/10.1182/blood-2019-126050

Published: 2019

Journal Articles

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL -rearranged acute lymphoblastic leukemia

Blood (2019) 134 (15): 1257–1268.

https://doi.org/10.1182/blood.2019002457

Published: 2019

Includes: Supplemental data

Journal Articles

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD + acute myeloid leukemia

Blood (2019) 134 (6): 548–560.

https://doi.org/10.1182/blood.2019001282

Published: 2019

Includes: Supplemental data

Journal Articles

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

Yinghui Zhu, PhD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Lei Zhang, PhD, Yunan Miao, PhD, Jian Jin, PhD, Yudao Shen, PhD, Jianjun Chen, PhD, Markus Muschen, MD, Chun-Wei Chen, PhD, Marina Y. Konopleva, MD PhD, Weili Sun, MD PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD PhD, Guido Marcucci, Ling Li, PhD

Blood (2018) 132 (Supplement 1): 892.

https://doi.org/10.1182/blood-2018-99-115139

Published: 2018

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Pharmacological targeting of CTPS1 elicits macrophage-mediated anti-leukemia immunity

Targeting PRMT7 enhances the anti-AML immunity by regulating MHC-I

Targeting adss overcomes venetoclax resistance in TP53-mutated acute myeloid leukemia

Targeting PRMT9 Overcomes Venetoclax Resistance in AML By Modulating Splicing and Inhibiting Translation

Targeting Cytidine Triphosphate Synthase 1 Promotes Anti-AML Immunity

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Targeting ADSS2 Enhances BH3 Mimetics Treatment Induced Mitochondrial Apoptosis in AML Cells

SAMHD1 Inhibitor Combined with Immune Checkpoint Inhibitor Elicits an Anti-AML Immunity

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Targeting SAMHD1 Promotes Anti-Tumor Immunity in Acute Myeloid Leukemia

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation

Protein Arginine Methyltransferase 1 Is Required for Maintenance of Normal Adult Hematopoiesis

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL -rearranged acute lymphoblastic leukemia

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD + acute myeloid leukemia

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

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