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Journal Articles

High HDAC8 Creates Targetable Vulnerabilities in Acute Myeloid Leukemia through Dysregulation of BRCA1-Related RNA Splicing Machinery and Defective DNA Damage Repair

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Xin He, Wancheng Guo, Yinghui Zhu, Ying-Chieh Chen, Zhenhua Chen, Haojie Dong, Lei Zhang, Bin Zhang, Jeremy Stark, Ling Li, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2024-208137
Published: 2024
Journal Articles

Metabolic Signature of Oxidative Phosphorylation Deficiency with Activated Nucleotide Biosynthesis in Early T-Cell Precursor Acute Lymphoblastic Leukemia

Yinghui Zhu, Bowen Wu, Tianyi Chen, Miaomiao Liu, Shangyu Hou, Xuemei Wang, Yiyi Yao, Tao Zeng, Jinyan Huang, Jie Jin, Huafeng Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2748.
https://doi.org/10.1182/blood-2024-205224
Published: 2024
Journal Articles

A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ–induced CD38 expression

Mariam Murtadha, Miso Park, Yinghui Zhu, Enrico Caserta, Ottavio Napolitano, Theophilus Tandoh, Milad Moloudizargari, Alex Pozhitkov, Mahmoud Singer, Ada Alice Dona, Hawa Vahed, Asaul Gonzalez, Kevin Ly, Ching Ouyang, James F. Sanchez, Lokesh Nigam, Amanda Duplan, Arnab Chowdhury, Lucy Ghoda, Ling Li, Bin Zhang, Amrita Krishnan, Guido Marcucci, John C. Williams, Flavia Pichiorri
Journal: Blood
Blood (2024) 143 (16): 1599–1615.
https://doi.org/10.1182/blood.2023021570
Published: 2024
Includes: Supplemental data
Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5700.
https://doi.org/10.1182/blood-2023-182215
Published: 2023
Journal Articles

CD38-Directed, Single-Chain T Cell-Engager Targets Leukemia Stem Cells through IFNγ-Induced CD38 Expression

Mariam Murtadha, Miso Park, Yinghui Zhu, Enrico Caserta, Ottavio Napolitano, Theophilus Tandoh, Milad Moloudizargari, Alexander Pozhitkov, Mahmoud Singer, Ada Alice Dona, Hawa Vahed, Asaul Gonzalez, Kevin Ly, Ching Ouyang, James Sanchez, Lokesh Nigam, Arnab Chowdhury, Lucy Y. Ghoda, Ling Li, Bin Zhang, Amrita Krishnan, Guido Marcucci, John C. Williams, Flavia Pichiorri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2797.
https://doi.org/10.1182/blood-2023-189901
Published: 2023
Journal Articles

Herpesvirus Entry Mediator As a Novel Therapeutic Target in Multiple Myeloma

Milad Moloudizargari, Ada Alice Dona, Miso Park, Theophilus Tandoh, Mariam Murtadha, Enrico Caserta, Alexander Pozhitkov, Yinghui Zhu, Ottavio Napolitano, James Sanchez, Lokesh Nigam, Amanda Duplan, Arnab Chowdhury, Lucy Y. Ghoda, Jonathan Keats, Scott R. Goldsmith, Michael Rosenzweig, Amrita Krishnan, John C. Williams, Flavia Pichiorri
Journal: Blood
Blood (2023) 142 (Supplement 1): 3296.
https://doi.org/10.1182/blood-2023-190157
Published: 2023
Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 8692–8693.
https://doi.org/10.1182/blood-2022-160280
Published: 2022
Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yichun Lin, Songbai Liu, Huafeng Wang, Wenfeng Huang, Sierra Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 4931–4933.
https://doi.org/10.1182/blood-2022-167366
Published: 2022
Journal Articles

CD84 Is a Therapeutically Targetable Driver of Leukemogenesis Via Disruption of Energy Supply in Acute Myeloid Leukemia

Yinghui Zhu, Miso Park, Mariam Murtadha, Enrico Caserta, Le Xuan Truong Nguyen, Mahmoud Singer, Marc Denisse Estepa, Lokesh Nigam, Ada Alice Dona', James F Sanchez, Theophilus Tandoh, Man Li, Bin Zhang, Ya-Huei Kuo, Guido Marcucci, John C Williams, Flavia Pichiorri
Journal: Blood
Blood (2022) 140 (Supplement 1): 89–90.
https://doi.org/10.1182/blood-2022-170300
Published: 2022
Journal Articles

OM301, a Synthetic Polypeptide Containing the p53TA (Transactivation) Domain, Impairs Mitochondrial Activity and Survival of Myeloma Cells

Lokesh Nigam, Yinghui Zhu, Estelle Troadec, Enrico Caserta, Ada Dona', James F Sanchez, Amrita Y. Krishnan, Le Xuan Truong Nguyen, Guido Marcucci, Flavia Pichiorri
Journal: Blood
Blood (2021) 138 (Supplement 1): 2661.
https://doi.org/10.1182/blood-2021-151506
Published: 2021
Journal Articles

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yuhui Wu, Yinghui Zhu, Hanying Wang, Wenfeng Huang, Yichun Lin, Lianjun Zhang, Dandan Zhao, Juan Du, Rui Su, Ya-Huei Kuo, Jianjun Chen, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2021) 138 (Supplement 1): 358.
https://doi.org/10.1182/blood-2021-151679
Published: 2021
Journal Articles

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

Hanying Wang, Xin He, MD, Feiteng Huang, MS, Haojie Dong, PhD, Wei Chen, PhD, Zheng Li, MS, Jie Sun, PhD, Yinghui Zhu, PhD, Lei Zhang, MD, Yuhui Wu, MD, Lifeng Feng, PhD, Jing Zhang, PhD, Samer Khaled, MD, Guido Marcucci, MD, David Sykes, MD PhD, Hongchuan Jin, MD PhD, Xian Wang, MD PhD, Ling Li, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26.
https://doi.org/10.1182/blood-2020-139922
Published: 2020
Journal Articles

HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation

Dijiong Wu, MD, Man Li, PhD, Lianjun Zhang, PhD, Jing Qi, PhD, Chun-Wei David Chen, PhD, Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Jie Sun, PhD, Ling Li, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 642.
https://doi.org/10.1182/blood-2019-124134
Published: 2019
Journal Articles

Protein Arginine Methyltransferase 1 Is Required for Maintenance of Normal Adult Hematopoiesis

Lei Zhu, MD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Yinghui Zhu, PhD, Feiteng Huang, Jingying Zou, Xiaoying Zhao, MD, Ling Li, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3708.
https://doi.org/10.1182/blood-2019-126050
Published: 2019
Journal Articles

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL -rearranged acute lymphoblastic leukemia

Yinghui Zhu, Xin He, Yi-Chun Lin, Haojie Dong, Lei Zhang, Xianwei Chen, Zhihao Wang, Yudao Shen, Min Li, Hanying Wang, Jie Sun, Le Xuan Nguyen, Han Zhang, Wenjuan Jiang, Yanzhong Yang, Jianjun Chen, Markus Müschen, Chun-Wei Chen, Marina Y. Konopleva, Weili Sun, Jian Jin, Nadia Carlesso, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2019) 134 (15): 1257–1268.
https://doi.org/10.1182/blood.2019002457
Published: 2019
Includes: Supplemental data
Journal Articles

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD + acute myeloid leukemia

Xin He, Yinghui Zhu, Yi-Chun Lin, Min Li, Juan Du, Haojie Dong, Jie Sun, Lei Zhu, Hanying Wang, Zonghui Ding, Lei Zhang, Lianjun Zhang, Dandan Zhao, Zhihao Wang, Herman Wu, Han Zhang, Wenjuan Jiang, Yang Xu, Jian Jin, Yudao Shen, Jeff Perry, Xinyang Zhao, Bin Zhang, Songbai Liu, Sheng-Li Xue, Binghui Shen, Chun-Wei Chen, Jianjun Chen, Samer Khaled, Ya-Huei Kuo, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2019) 134 (6): 548–560.
https://doi.org/10.1182/blood.2019001282
Published: 2019
Includes: Supplemental data
Journal Articles

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

Yinghui Zhu, PhD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Lei Zhang, PhD, Yunan Miao, PhD, Jian Jin, PhD, Yudao Shen, PhD, Jianjun Chen, PhD, Markus Muschen, MD, Chun-Wei Chen, PhD, Marina Y. Konopleva, MD PhD, Weili Sun, MD PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD PhD, Guido Marcucci, Ling Li, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 892.
https://doi.org/10.1182/blood-2018-99-115139
Published: 2018
Journal Articles

PRMT1 Mediated FLT3 Methylation As a Therapeutic Vulnerability in FLT3-ITD + AML

Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Sierra Min Li, Zonghui Ding, PhD, Jie Sun, PhD, Juan Du, MDPhD, Hanying Wang, PhD, Lianjun Zhang, PhD, Yudao Shen, PhD, Hairui Su, BS, PhD, Samer K. Khaled, MD, Dandan Zhao, MD, Lei Zhang, PhD, Robert Hickey, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Xinyang Zhao, PhD, Jian Jin, PhD, Nadia Carlesso, MD PhD, Jianjun Chen, PhD, Yang Xu, MD, Guido Marcucci, Ling Li, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 760.
https://doi.org/10.1182/blood-2018-99-112766
Published: 2018
Journal Articles

Activation of SIRT1 Deacetylase As a Therapeutic Approach for Myelodysplastic Syndromes By Restoring TET2 Function

Jie Sun, PhD, Yinghui Zhu, PhD, Xin He, MD, Zonghui Ding, PhD, Haojie DONG, PhD, Yimei Feng, MD PhD, Xiaochun Yu, MD PhD, Dandan Zhao, MD, Herman Wu, BS, Lifeng Feng, PhD, Kaoru Tohyama, MD, Hongchuan Jin, MD PhD, Philipp Oberdoerffer, PhD, Yang Jo Chung, PhD, Peter D. Aplan, MD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Ravi Bhatia, MD, Andrea Pellagatti, PhD, Jacqueline Boultwood, PhD, Nadia Carlesso, MD PhD, Guido Marcucci, MD, Ling Li, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2497.
https://doi.org/10.1182/blood.V130.Suppl_1.2497.2497
Published: 2017
Journal Articles

TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome

Jie Sun, MS, Yinghui Zhu, PhD, Zonghui Ding, PhD, Haojie Dong, PhD, Yimei Feng, PhD MD, Qiang Chen, PhD, Xiaochun Yu, PhD MD, Dandan Zhao, MD, Herman Wu, BS, Lifeng Feng, PhD, Kaoru Tohyama, MD PhD, Philipp Oberdoerffer, PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Ravi Bhatia, MD, Hongchuan Jin, PhD MD, Guido Marcucci, MD, Ling Li, PhD
Journal: Blood
Blood (2016) 128 (22): 1053.
https://doi.org/10.1182/blood.V128.22.1053.1053
Published: 2016