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Journal Articles

The Arginine Methyltransferase PRMT5 Regulates Maintenance and TKI Resistance of Self-Renewing FLT3-ITD AML LSC

Harish Kumar, Mostafa Mohamed, Aditi Dhir, George M Burslem, Xinyang Zhao, Rui Lu, Erin Ahn, Ravi Bhatia
Journal: Blood
Blood (2024) 144 (Supplement 1): 1391.
https://doi.org/10.1182/blood-2024-205644
Published: 2024
Journal Articles

Protein Arginine Methyltransferase 1 Expands and Mobilizes Immune Megakaryocytes and Generates Hyperactive Platelets in Stress Conditions

Peipei Zhang, Anlun Li, Yanyan Liu, X. Long Zheng, Xinyang Zhao
Journal: Blood
Blood (2024) 144 (Supplement 1): 1164.
https://doi.org/10.1182/blood-2024-208526
Published: 2024
Journal Articles

Preliminary Results of a Phase Ⅱ Study of Lenalidomide Combined with Immunochemotherapy in Patients with Primary Central Nervous System Lymphoma

Shuna Yao, Zhihua Yao, Zheng Yan, Haiying Wang, Junfeng Chu, Shuang Zhao, Xinyang Zhao, Yanyan Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1758.
https://doi.org/10.1182/blood-2023-189345
Published: 2023
Journal Articles

Intracerebral Hemorrhage Leads to Anemia By Disrupting Erythropoiesis and Erythromyeloblastic Islands

Shijie Zhang, Peijun Jia, Qinfeng Peng, Jiaming Cao, Yuanlin Xu, Chao Jiang, Hongtao Ji, Fuyou Guo, Yan Li, Jingxin Zhang, Huan Zhang, Jiaxin Li, Ying Zhang, Xinyang Zhao, Xuemei Chen, Jian Wang, Xiuli An
Journal: Blood
Blood (2023) 142 (Supplement 1): 3821.
https://doi.org/10.1182/blood-2023-186235
Published: 2023
Journal Articles

AURKA Kinase Controls Erythroblast Enucleation Via Regulation of Centrosome Localization and ECT2 Degradation

Yuanlin Xu, Yating Li, Wanxin Li, Yazhe Zhen, Peijun Jia, Yan Li, Jingxin Zhang, Huan Zhang, Jiaming Cao, Ying Zhang, Xinyang Zhao, Xiuli An, Shijie Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3834.
https://doi.org/10.1182/blood-2023-189444
Published: 2023
Journal Articles

Preliminary Results of a Phase Ⅱ Study of Zanubrutinib Combined with Immunochemotherapy in Patients with CD79A/CD79B-Mutant Diffuse Large B-Cell Lymphoma

Zhihua Yao, Zheng Yan, Shuna Yao, Haiying Wang, Junfeng Chu, Shuang Zhao, Jie Ma, Bing Wei, Jiawen Zheng, Quande Lin, Zheng Xu, Xinyang Zhao, Yanyan Liu
Journal: Blood
Blood (2022) 140 (Supplement 1): 3767–3768.
https://doi.org/10.1182/blood-2022-165944
Published: 2022
Journal Articles

Arginine Methylation on ADAMTS13 By Protein Arginine Methyltransferase 1 (PRMT1) Affects ADAMTS13 Secretion and Proteolytic Activity

Szumam Liu, Xinyang Zhao, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 331–332.
https://doi.org/10.1182/blood-2022-162950
Published: 2022
Journal Articles

PRMT5 Inhibition Enhances Elimination of FLT3-ITD AML Stem Cells in Combination with TKI Treatment

Harish Kumar, Aditi Dhir, Andrew J. Paterson, Nick R Anderson, Shaowei Qiu, Xinyang Zhao, Rui Lu, Ravi Bhatia
Journal: Blood
Blood (2022) 140 (Supplement 1): 3073–3074.
https://doi.org/10.1182/blood-2022-168326
Published: 2022
Journal Articles

Protein Arginine Methyltransferase 1 (PRMT1) Dampens Self-Renewal and Promotes Differentiation of Hematopoietic Stem Cells in Mouse Models

Hairui Su, PhD, Szu-Mam Liu, PhD, Chiao-Wang Sun, PhD, Mark T. Bedford, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2460.
https://doi.org/10.1182/blood-2019-127226
Published: 2019
Journal Articles

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD + acute myeloid leukemia

Xin He, Yinghui Zhu, Yi-Chun Lin, Min Li, Juan Du, Haojie Dong, Jie Sun, Lei Zhu, Hanying Wang, Zonghui Ding, Lei Zhang, Lianjun Zhang, Dandan Zhao, Zhihao Wang, Herman Wu, Han Zhang, Wenjuan Jiang, Yang Xu, Jian Jin, Yudao Shen, Jeff Perry, Xinyang Zhao, Bin Zhang, Songbai Liu, Sheng-Li Xue, Binghui Shen, Chun-Wei Chen, Jianjun Chen, Samer Khaled, Ya-Huei Kuo, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2019) 134 (6): 548–560.
https://doi.org/10.1182/blood.2019001282
Published: 2019
Includes: Supplemental data
Journal Articles

PRMT1 Mediated FLT3 Methylation As a Therapeutic Vulnerability in FLT3-ITD + AML

Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Sierra Min Li, Zonghui Ding, PhD, Jie Sun, PhD, Juan Du, MDPhD, Hanying Wang, PhD, Lianjun Zhang, PhD, Yudao Shen, PhD, Hairui Su, BS, PhD, Samer K. Khaled, MD, Dandan Zhao, MD, Lei Zhang, PhD, Robert Hickey, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Xinyang Zhao, PhD, Jian Jin, PhD, Nadia Carlesso, MD PhD, Jianjun Chen, PhD, Yang Xu, MD, Guido Marcucci, Ling Li, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 760.
https://doi.org/10.1182/blood-2018-99-112766
Published: 2018
Journal Articles

Targeting PARP1 As an Effective Treatment for Diffuse Large B-Cell Lymphoma with High Level of γH2AX

Yanyan Liu, Peipei Zhang, Jiuyang Zhang, Wenping Zhou, Jialin Ma, Xinyang Zhao, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5799.
https://doi.org/10.1182/blood-2018-99-117590
Published: 2018
Journal Articles

Targeting PRMT1 As a Novel Curative Therapy for Acute Myeloid Leukemia

Hairui Su, BS, PhD, Shuiling Jin, PhD, Yudao Shen, Matthew A. Kutny, MD, Jian Jin, PhD, Minkui Luo, Xinyang Zhao, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2650.
https://doi.org/10.1182/blood.V130.Suppl_1.2650.2650
Published: 2017
Journal Articles

Identification of Long Non-Coding RNA Genes Important for Normal Hematopoiesis and Leukemogenesis Using Bioinformatics Tools

Sarah Zhao, Lana Chen, Shuiling Jin, PhD, Lele Zhang, Hairui Su, BS, PhD, Christopher Klug, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2693.
https://doi.org/10.1182/blood.V130.Suppl_1.2693.2693
Published: 2017
Journal Articles

High PRMT1 Expression Promotes the Progression of Acute Megakaryocytic Leukemia Via Controlling Metabolic Pathways

Hairui Su, BS, Han Guo, PhD, Ngoc-Tung Tran, PhD, Minkui Luo, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2016) 128 (22): 1551.
https://doi.org/10.1182/blood.V128.22.1551.1551
Published: 2016
Journal Articles

The TAL1 Short Isoform Generated By PRMT1-Mediated Alternative RNA Splicing Promotes Erythroid Differentiation

Shuiling Jin, MD, Ngoc-Tung Tran, PhD, Hairui Su, BS, Suming Huang, PhD, Xinyang Zhao, PhD, Yanyan Liu, MDand PhD
Journal: Blood
Blood (2016) 128 (22): 1249.
https://doi.org/10.1182/blood.V128.22.1249.1249
Published: 2016
Journal Articles

Prmt5 Negatively Regulates Erythropoiesis By Multiple Mechanisms, Including Controlling DNA Methyltransferase 3A Protein Levels

Pierre-Jacques Hamard, PhD, Luisa Luciani, PhD, Fan Liu, PhD, Guoyan Cheng, PhD, Megan A. Hatlen, PhD, Olga A Guryanova, MD, PhD, Xinyang Zhao, PhD, Ross L. Levine, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2015) 126 (23): 1181.
https://doi.org/10.1182/blood.V126.23.1181.1181
Published: 2015
Journal Articles

PRMT1-Mediated Methylation of DUSP4 Determines Megakaryocyte-Erythroid Lineage Choice By Regulating p38 Signaling

Hairui Su, BS, Ngoc-Tung Tran, PhD, Han Guo, PhD, Minkui Luo, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2015) 126 (23): 2387.
https://doi.org/10.1182/blood.V126.23.2387.2387
Published: 2015
Journal Articles

RBM15-Mediated RNA Splicing Fine-Tunes Epigenetic Program through Interaction with SF3B1

Tran Ngoc-Tung, Hairui Su, BS, Yuheng Lu, Christina S Leslie, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2015) 126 (23): 4110.
https://doi.org/10.1182/blood.V126.23.4110.4110
Published: 2015
Journal Articles

DNA Hydroxymethylation Profiling Reveals That WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Raajit K. Rampal, MD PhD, Altuna Alkalin, Jozef Madzo, PhD, Aparna Vasanthakumar, BSc, MSc, PhD, Elodie Pronier, PhD, Jay P. Patel, Yushan Li, Jihae Ahn, BS, Omar Abdel-Wahab, MD, Alan H. Shih, MDPhD, Chao Lu, Patrick Ward, Jennifer J Tsai, MD, Todd Hricik, Jacob Tallman, Valeria Tosello, PhD, Xinyang Zhao, PhD, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, PhD, Chuan He, PhD, François Fuks, Martin S. Tallman, MD, Adolfo A. Ferrando, MD PhD, Stephen Nimer, MD, Elisabeth Paietta, PhD, Craig B. Thompson, MD, Jonathan D. Licht, MD, Christopher E Mason, PhD, Lucy A Godley, MD PhD, Ari M Melnick, MD, Maria E Figueroa, MD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 365.
https://doi.org/10.1182/blood.V124.21.365.365
Published: 2014