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Journal Articles

Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia

Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Virginia Veasey, Amanda Tajik, Cecilia Restelli, Steven Moreira, Pengcheng Zhang, Yanfeng Zhang, Kristin J. Hope, Yang Zhou, Changde Cheng, Ravi Bhatia, Rui Lu

Blood (2024) 144 (19): 2018–2032.

https://doi.org/10.1182/blood.2023023644

Published: 2024

Includes: Supplemental data

Journal Articles

The Arginine Methyltransferase PRMT5 Regulates Maintenance and TKI Resistance of Self-Renewing FLT3-ITD AML LSC

Harish Kumar, Mostafa Mohamed, Aditi Dhir, George M Burslem, Xinyang Zhao, Rui Lu, Erin Ahn, Ravi Bhatia

Blood (2024) 144 (Supplement 1): 1391.

https://doi.org/10.1182/blood-2024-205644

Published: 2024

Journal Articles

Combined Human and In Vivo Analyses Implicate the Critical Importance of Acute Myeloid Leukemia Associated CD8 T Cells and Identifies Their Molecular Dysfunction

Y. Emily Chu, Matthew A Cottam, Chad R Potts, Kirsten M Dickerson, Matthew T Jenkins, Justin A Cartailler, Rui Lu, Stanley C. Lee, Ross L Levine, Robert L. Bowman, Robert Welner, P. Brent Ferrell, Jr.

Blood (2024) 144 (Supplement 1): 2939.

https://doi.org/10.1182/blood-2024-205733

Published: 2024

Journal Articles

Multi-Omics Analysis Reveals That TET2 Loss Epigenetically Primes Monocytes for Inflammatory Responses Via AP-1 Signaling

Matthew Jenkins, Yunli Chu, Sajesan Aryal, Xinyue Zhou, Kirsten Dickerson, Rebecca Dubin, Chad R Potts, Valeriya Kuznetsova, Alana Franceski, Paran Goel, Stanley C Lee, Rui Lu, Robert Welner, P. Brent Ferrell, Jr.

Blood (2023) 142 (Supplement 1): 4061.

https://doi.org/10.1182/blood-2023-182278

Published: 2023

Journal Articles

Decoding the Epigenetic Drivers of Menin-MLL Inhibitor Resistance in KMT2A-Rearranged Acute Myeloid Leukemia

Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Steven Moreira, Virginia Veasey, Kristin J. Hope, Rui Lu

Blood (2023) 142 (Supplement 1): 587.

https://doi.org/10.1182/blood-2023-185353

Published: 2023

Journal Articles

Functional Interrogation of Clinically Associated Venetoclax-Sensitive Genes Identifies an Essential Role of Transcription Factor ZNF740 in Therapeutic Response

Lixia Zhang, Rui Lu

Blood (2023) 142 (Supplement 1): 5748.

https://doi.org/10.1182/blood-2023-180074

Published: 2023

Journal Articles

A Mouse Model of Zhu-Tokita-Takenouchi-Kim Syndrome Reveals Indispensable Son Functions in Myeloid-Lymphoid Lineage Balance and Terminal Differentiation

Leah Gehrs, Lana Vukadin, Mostafa Mohamed, Bohye Park, Huashi Li, Amr Elkholy, Hyung-Gyoon Kim, Xinyue Zhou, Sajesan Aryal, Steve Lim, Rui Lu, Erin Ahn

Blood (2023) 142 (Supplement 1): 1301.

https://doi.org/10.1182/blood-2023-190317

Published: 2023

Journal Articles

Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells

Shaowei Qiu, Vipul Sheth, Chengcheng Yan, Juan Liu, Balu K. Chacko, Hui Li, David K. Crossman, Seth D. Fortmann, Sajesan Aryal, Ashley Rennhack, Maria B. Grant, Robert S. Welner, Andrew J. Paterson, Adam R. Wende, Victor M. Darley-Usmar, Rui Lu, Jason W. Locasale, Ravi Bhatia

Blood (2023) 142 (6): 574–588.

https://doi.org/10.1182/blood.2022018196

Published: 2023

Includes: Supplemental data

Journal Articles

Metabolic Adaptation to Tyrosine Kinase Inhibition in Chronic Myelogenous Leukemia Stem Cells

Shaowei Qiu, Vipul Sheth, Chengcheng Yan, Juan Liu, Balu K. Chacko, Hui Li, David Crossman, Seth D. Fortmann, Sajesan Aryal, Maria B. Grant, Robert S. Welner, Andrew J. Paterson, Adam R. Wende, Victor M Darley-Usmar, Rui Lu, Jason W. Locasale, Ravi Bhatia

Blood (2022) 140 (Supplement 1): 3874–3875.

https://doi.org/10.1182/blood-2022-156631

Published: 2022

Journal Articles

PRMT5 Inhibition Enhances Elimination of FLT3-ITD AML Stem Cells in Combination with TKI Treatment

Harish Kumar, Aditi Dhir, Andrew J. Paterson, Nick R Anderson, Shaowei Qiu, Xinyang Zhao, Rui Lu, Ravi Bhatia

Blood (2022) 140 (Supplement 1): 3073–3074.

https://doi.org/10.1182/blood-2022-168326

Published: 2022

Journal Articles

Activating a Non-Genetic MYC-Regulating Pathway Sensitizes Acute Myeloid Leukemia to Bromodomain Inhibition

Xinyue Zhou, Steven Moreira, Hong Wang, Pengcheng Zhang, Yang Zhou, Ravi Bhatia, Chunliang Li, Kristin Hope, Rui Lu

Blood (2022) 140 (Supplement 1): 8735.

https://doi.org/10.1182/blood-2022-167049

Published: 2022

Journal Articles

Interrogating Novel Bromodomain Inhibition Resistance Mechanism in Mllr Leukemia

Chunliang Li, Shaela Wright, Jianzhong Hu, Yang Zhang, Judith Hyle, Rui Lu

Blood (2021) 138 (Supplement 1): 26.

https://doi.org/10.1182/blood-2021-147003

Published: 2021

Journal Articles

Essential Roles of Transcription Factor MEF2D in the Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Pengcheng Zhang, Lianzhong Zhao, Shaowei Qiu, Ravi Bhatia, Rui Lu

Blood (2021) 138 (Supplement 1): 2218.

https://doi.org/10.1182/blood-2021-149232

Published: 2021

Journal Articles

E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia

Wen-Chieh Pi, Jun Wang, Miho Shimada, Jia-Wei Lin, Huimin Geng, Yu-Ling Lee, Rui Lu, Dongxu Li, Gang Greg Wang, Robert G. Roeder, Wei-Yi Chen

Blood (2020) 136 (1): 11–23.

https://doi.org/10.1182/blood.2019003312

Published: 2020

Includes: Supplemental data

Journal Articles

Role of Autophagy in Resistance of FLT3-ITD AML Stem Cells to FLT3 TKI Treatment

Shaowei Qiu, MD, Chengcheng Yan, MD, Andrew J Paterson, PhD, Hui Li, BS, Nick Anderson, BS, Ajay Abraham, PhD, Jianbo He, MD, Mansi Shah, PhD, Puneet Agarwal, Jing Yang, PhD, Min Xie, MD, Rui Lu, PhD, Rob S. Welner, PhD, Ravi Bhatia, MD

Blood (2019) 134 (Supplement_1): 2548.

https://doi.org/10.1182/blood-2019-124948

Published: 2019

Journal Articles

A New Valuable Technique in Diagnosis and Treatment Monitoring of Myeloproliferative Neoplasms

Yiqian Hu, Sanyun Wu, Yanan Liu, Mengxiao Zhang, Yingying Wang, Liang Shao, Bei Xiong, Xiaoyan Liu, Yicheng Zhang, Rui Lu, Yalan Yu, Ping Luo, Xuelan Zuo

Blood (2019) 134 (Supplement_1): 5377.

https://doi.org/10.1182/blood-2019-128709

Published: 2019

Journal Articles

Epigenetic Reprogramming of Cis-Regulatory Sites By R882 -Mutated DNMT3A Potentiates Aberrant Stem Cell Gene Program and Acute Leukemia Development

Rui Lu, PhD, Ping Wang, PhD, Trevor Parton, Deyou Zheng, PhD, Gang Greg Wang, PhD

Blood (2015) 126 (23): 2430.

https://doi.org/10.1182/blood.V126.23.2430.2430

Published: 2015

NARROW

Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia

The Arginine Methyltransferase PRMT5 Regulates Maintenance and TKI Resistance of Self-Renewing FLT3-ITD AML LSC

Combined Human and In Vivo Analyses Implicate the Critical Importance of Acute Myeloid Leukemia Associated CD8 T Cells and Identifies Their Molecular Dysfunction

Multi-Omics Analysis Reveals That TET2 Loss Epigenetically Primes Monocytes for Inflammatory Responses Via AP-1 Signaling

Decoding the Epigenetic Drivers of Menin-MLL Inhibitor Resistance in KMT2A-Rearranged Acute Myeloid Leukemia

Functional Interrogation of Clinically Associated Venetoclax-Sensitive Genes Identifies an Essential Role of Transcription Factor ZNF740 in Therapeutic Response

A Mouse Model of Zhu-Tokita-Takenouchi-Kim Syndrome Reveals Indispensable Son Functions in Myeloid-Lymphoid Lineage Balance and Terminal Differentiation

Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells

Metabolic Adaptation to Tyrosine Kinase Inhibition in Chronic Myelogenous Leukemia Stem Cells

PRMT5 Inhibition Enhances Elimination of FLT3-ITD AML Stem Cells in Combination with TKI Treatment

Activating a Non-Genetic MYC-Regulating Pathway Sensitizes Acute Myeloid Leukemia to Bromodomain Inhibition

Interrogating Novel Bromodomain Inhibition Resistance Mechanism in Mllr Leukemia

Essential Roles of Transcription Factor MEF2D in the Maintenance of MLL-Rearranged Acute Myeloid Leukemia

E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia

Role of Autophagy in Resistance of FLT3-ITD AML Stem Cells to FLT3 TKI Treatment

A New Valuable Technique in Diagnosis and Treatment Monitoring of Myeloproliferative Neoplasms

Epigenetic Reprogramming of Cis-Regulatory Sites By R882 -Mutated DNMT3A Potentiates Aberrant Stem Cell Gene Program and Acute Leukemia Development

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American Society of Hematology

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ASH Publications

American Society of Hematology

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