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Journal Articles

MDS-Associated SF3B1 Mutations Promote Aberrant Hematopoietic Cell Fate Choice By Disrupting Mediator Kinase Module Component CDK8

Elizabeth Alice Bonner, Axia Song, Erica A Arriaga-Gomez, Katherine Gadek, Laura Baquero Galvis, Jonathan Linton, Rasika A Venkataraman, Sayantani Sinha, Anthony Rongvaux, Myron Evans, II, Sergei Doulatov, Stanley C. Lee

Blood (2024) 144 (Supplement 1): 344.

https://doi.org/10.1182/blood-2024-204075

Published: 2024

Journal Articles

iPSC Reprogramming Identifies the Role of Cryptic Drivers in Preleukemic Clonal Evolution

Blood (2024) 144 (Supplement 1): 1293.

https://doi.org/10.1182/blood-2024-205098

Published: 2024

Journal Articles

Loss of 5q Drives Evolution to Aneuploidy in an iPSC Model of Complex Karyotype AML

J. Philip Creamer, Suhita Ray, Sintra Stewart, Jacob S. Appelbaum, Min Fang, Elizabeth Swisher, Sergei Doulatov

Blood (2024) 144 (Supplement 1): 629.

https://doi.org/10.1182/blood-2024-206210

Published: 2024

Journal Articles

Synthetic Introns Identify the Novel RNA Splicing Factor GPATCH8 As Required for Mis-Splicing Induced By SF3B1 Mutations

Salima Benbarche, Jose Maria Bello Pineda, Laura Baquero Galvis, Bo Liu, Jeetayu Biswas, Eric Wang, K. Ashley Lyttle, Alexander M. Lewis, Martina Sarchi, Sanjoy Mehta, Ralph Garippa, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Robert Stanley, Sergei Doulatov, Robert K. Bradley, Omar Abdel-Wahab

Blood (2023) 142 (Supplement 1): 3.

https://doi.org/10.1182/blood-2023-179848

Published: 2023

Journal Articles

Atg4a Promotes Mitochondrial Quality Control and Hemoglobin Production In Vivo

Massiel Chavez Stolla, Raymond T. Doty, Janis L. Abkowitz, Sergei Doulatov

Blood (2023) 142 (Supplement 1): 3826.

https://doi.org/10.1182/blood-2023-190593

Published: 2023

Journal Articles

Mitotic Dysregulation Sensitizes Malignant Stem Cells to CHK1 Inhibition in SF3B1 -Mutant Myeloid Neoplasms

Martina Sarchi, Courtnee A. Clough, Edie I. Crosse, Jason Kim, Laura D. Baquero Galvis, Anna Gallì, J. Philip Creamer, Sintra Stewart, Sara Pozzi, Elisabetta Molteni, Chiara Elena, Robert K. Bradley, Luca Malcovati, Sergei Doulatov

Blood (2023) 142 (Supplement 1): 313.

https://doi.org/10.1182/blood-2023-188476

Published: 2023

Journal Articles

Therapeutic Targeting of Spliceosome Mutant Myeloid Neoplasms Via PARP1 Inhibition

Sayantani Sinha, Zhiyan Silvia Liu, Maxwell Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Martina Sarchi, Elizabeth Bonner, Victor Corral, Cassandra Leibson, Wannasiri Chiraphapphaiboon, Derek Stirewalt, Joachim Deeg, Sumit Rai, Matthew J Walter, Timothy A. Graubert, Sergei Doulatov, Dang Hai Nguyen, Stanley Chun-Wei Lee

Blood (2022) 140 (Supplement 1): 217–219.

https://doi.org/10.1182/blood-2022-170574

Published: 2022

Journal Articles

Clonal Trajectories and Therapeutic Targeting of High-Risk SF3B1 -Mutant Myelodysplastic Syndromes

Martina Sarchi, Courtnee A Clough, Anna Gallì, Gabriele Todisco, J. Philip Creamer, Luca Malcovati, Sergei Doulatov

Blood (2022) 140 (Supplement 1): 211–212.

https://doi.org/10.1182/blood-2022-164833

Published: 2022

Journal Articles

Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome

Courtnee A. Clough, Joseph Pangallo, Martina Sarchi, Janine O. Ilagan, Khrystyna North, Rochelle Bergantinos, Massiel C. Stolla, Jasmine Naru, Patrick Nugent, Eunhee Kim, Derek L. Stirewalt, Arvind R. Subramaniam, Omar Abdel-Wahab, Janis L. Abkowitz, Robert K. Bradley, Sergei Doulatov

Blood (2022) 139 (13): 2038–2049.

https://doi.org/10.1182/blood.2021012652

Published: 2022

Includes: Supplemental data

Journal Articles

Loss of Lamin B1 in Myeloid Neoplasms with 5q Deletion Causes Myeloid-Biased Hematopoiesis and Pelger-Huet Nuclear Anomaly

Andreea Reilly, J. Philip Creamer, Massiel Chavez Stolla, Yuchuan Wang, Jing Du, Rachel Wellington, Stephanie Busch, Elihu H. Estey, Pamela S. Becker, Min Fang, Sioban B. Keel, Janis L. Abkowitz, Lorinda A. Soma, Jian Ma, Zhijun Duan, Sergei Doulatov

Blood (2021) 138 (Supplement 1): 502.

https://doi.org/10.1182/blood-2021-154121

Published: 2021

Journal Articles

Modeling Clonal Progression in SF3B1 -Mutant Myelodysplastic Syndrome

Martina Sarchi, Anna Gallì, Courtnee A Clough, Gabriele Todisco, J. Philip Creamer, Luca Malcovati, Sergei Doulatov

Blood (2021) 138 (Supplement 1): 149.

https://doi.org/10.1182/blood-2021-151619

Published: 2021

Journal Articles

A Shared SF3B1 Neoantigen Is Presented on Primary Malignant Cells and Induced Pluripotent Stem Cell-Derived Hematopoietic Lines

Melinda Ann Biernacki, Kimberly A Foster, Courtnee Clough, Stephanie Busch, B.S., Carrie Cummings, Vivian G. Oehler, MD, Derek Stirewalt, MD, Sergei Doulatov, PhD, Marie Bleakley, MBBS MMSc PhD

Blood (2020) 136 (Supplement 1): 13–14.

https://doi.org/10.1182/blood-2020-139907

Published: 2020

Journal Articles

Coordinated Mis-Splicing of Multiple Mitochondrial Iron Metabolism Genes Causes Ring Sideroblast Formation in SF3B1-Mutant MDS

Courtnee Clough, Joseph Pangallo, PhD, Martina Sarchi, MD, Stephanie Busch, B.S., Janis L. Abkowitz, MD, Robert K. Bradley, PhD, Sergei Doulatov, PhD

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-140817

Published: 2020

Journal Articles

ATG4A is a Novel Regulator of Mitophagy during Human Erythropoiesis

Massiel Chavez Stolla, PhD, Neele Thom, B.S., Andreea Reilly, Courtnee Clough, Janis L. Abkowitz, MD, Sergei Doulatov, PhD

Blood (2019) 134 (Supplement_1): 3522.

https://doi.org/10.1182/blood-2019-130567

Published: 2019

Journal Articles

Probing Aberrant Splicing in a Novel Model of SF3B1-Mutant Myelodysplastic Syndromes

Courtnee Clough, Stephanie Busch, B.S., Joey Pangallo, B.S., Robert K. Bradley, PhD, Sergei Doulatov, PhD

Blood (2019) 134 (Supplement_1): 1706.

https://doi.org/10.1182/blood-2019-129176

Published: 2019

Journal Articles

Deletions of 5q Promote Genome Instability in TP53-Mutant MDS/AML

Andreea Reilly, Stephanie Busch, B.S., Janis L. Abkowitz, MD, Pamela S. Becker, MD PhD, Sergei Doulatov, PhD

Blood (2019) 134 (Supplement_1): 1244.

https://doi.org/10.1182/blood-2019-127038

Published: 2019

Journal Articles

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

Jasper Hsu, Andreea Reilly, Brian J. Hayes, Courtnee A. Clough, Eric Q. Konnick, Beverly Torok-Storb, Suleyman Gulsuner, David Wu, Pamela S. Becker, Siobán B. Keel, Janis L. Abkowitz, Sergei Doulatov

Blood (2019) 134 (2): 186–198.

https://doi.org/10.1182/blood.2018884338

Published: 2019

Includes: Supplemental data

Journal Articles

Targeting Autophagy as a Therapeutic Pathway in Diamond-Blackfan Anemia

Sergei Doulatov, PhD

Blood (2018) 132 (Supplement 1): SCI-28.

https://doi.org/10.1182/blood-2018-99-109478

Published: 2018

Journal Articles

Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells Via Transcription Factor Conversion of Hemogenic Endothelium

Ryohichi Sugimura, MDPhD, Areum Han, PhD, Deepak Jha, PhD, Yi-Fen Lu, PhD, Jeremy A Goettel, PhD, Erik Serrao, PhD, Robert Grant Rowe, MD PhD, Irene Wong, Patricia Sousa, Andrea Ditadi, PhD, Gordon Keller, PhD, Alan Engelman, PhD, Scott Snapper, MD PhD, Sergei Doulatov, PhD, George Q. Daley, MD PhD

Blood (2016) 128 (22): 371.

https://doi.org/10.1182/blood.V128.22.371.371

Published: 2016

Journal Articles

Modeling Diamond Blackfan Anemia in Vivo Using Human Induced Pluripotent Stem Cells

Sergei Doulatov, PhD, Linda T Vo, Elizabeth R Macari, PhD, Stephanie S Chou, Manav Gupta, Michelle Godfrey, Katherine McGrath, Thorsten M Schlaeger, PhD, Leonard I. Zon, MD, George Q. Daley, MD PhD

Blood (2014) 124 (21): 359.

https://doi.org/10.1182/blood.V124.21.359.359

Published: 2014

NARROW

MDS-Associated SF3B1 Mutations Promote Aberrant Hematopoietic Cell Fate Choice By Disrupting Mediator Kinase Module Component CDK8

iPSC Reprogramming Identifies the Role of Cryptic Drivers in Preleukemic Clonal Evolution

Loss of 5q Drives Evolution to Aneuploidy in an iPSC Model of Complex Karyotype AML

Synthetic Introns Identify the Novel RNA Splicing Factor GPATCH8 As Required for Mis-Splicing Induced By SF3B1 Mutations

Atg4a Promotes Mitochondrial Quality Control and Hemoglobin Production In Vivo

Mitotic Dysregulation Sensitizes Malignant Stem Cells to CHK1 Inhibition in SF3B1 -Mutant Myeloid Neoplasms

Therapeutic Targeting of Spliceosome Mutant Myeloid Neoplasms Via PARP1 Inhibition

Clonal Trajectories and Therapeutic Targeting of High-Risk SF3B1 -Mutant Myelodysplastic Syndromes

Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome

Loss of Lamin B1 in Myeloid Neoplasms with 5q Deletion Causes Myeloid-Biased Hematopoiesis and Pelger-Huet Nuclear Anomaly

Modeling Clonal Progression in SF3B1 -Mutant Myelodysplastic Syndrome

A Shared SF3B1 Neoantigen Is Presented on Primary Malignant Cells and Induced Pluripotent Stem Cell-Derived Hematopoietic Lines

Coordinated Mis-Splicing of Multiple Mitochondrial Iron Metabolism Genes Causes Ring Sideroblast Formation in SF3B1-Mutant MDS

ATG4A is a Novel Regulator of Mitophagy during Human Erythropoiesis

Probing Aberrant Splicing in a Novel Model of SF3B1-Mutant Myelodysplastic Syndromes

Deletions of 5q Promote Genome Instability in TP53-Mutant MDS/AML

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

Targeting Autophagy as a Therapeutic Pathway in Diamond-Blackfan Anemia

Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells Via Transcription Factor Conversion of Hemogenic Endothelium

Modeling Diamond Blackfan Anemia in Vivo Using Human Induced Pluripotent Stem Cells

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American Society of Hematology

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American Society of Hematology

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