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Journal Articles

Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Y. Lucy Liu, Nan Wang, Nicholas Neoman, Carolyn Wong, Bertil Glader, Raymond T. Doty, Mark C Wilkes, Janis L. Abkowitz, Kathleen M. Sakamoto

Blood (2023) 142 (Supplement 1): 944.

https://doi.org/10.1182/blood-2023-187734

Published: 2023

Journal Articles

Preclinical Studies of the GlyT1 Inhibitor Bitopertin in Diamond-Blackfan Anemia

Raymond T. Doty, Adam D. Munday, Hannah Cottnair, Sarah E. Funk, Janis L. Abkowitz

Blood (2023) 142 (Supplement 1): 1355.

https://doi.org/10.1182/blood-2023-174293

Published: 2023

Journal Articles

Atg4a Promotes Mitochondrial Quality Control and Hemoglobin Production In Vivo

Massiel Chavez Stolla, Raymond T. Doty, Janis L. Abkowitz, Sergei Doulatov

Blood (2023) 142 (Supplement 1): 3826.

https://doi.org/10.1182/blood-2023-190593

Published: 2023

Journal Articles

A Phase I/II, Intra-Patient Dose-Escalation Study of Bitopertin, a Selective Inhibitor of GlyT1 and Heme Synthesis, for Steroid-Refractory Diamond-Blackfan Anemia

David J. Young, Tania Rene Machado, Raymond T. Doty, Colin O. Wu, Janis L. Abkowitz, William Savage, Cynthia E. Dunbar

Blood (2023) 142 (Supplement 1): 1086.

https://doi.org/10.1182/blood-2023-173821

Published: 2023

Journal Articles

The Molecular Pathophysiology of Ineffective Erythropoiesis at Single Cell Resolution

Raymond T. Doty, Christopher G. Lausted, Adam D. Munday, Janis L. Abkowitz

Blood (2022) 140 (Supplement 1): 700.

https://doi.org/10.1182/blood-2022-167612

Published: 2022

Journal Articles

Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell–extrinsic contributions to erythropoiesis

Raymond T. Doty, Xing Fan, David J. Young, Jialiu Liang, Komudi Singh, Zahra Pakbaz, Ronan Desmond, Sara K. Young-Baird, Settara C. Chandrasekharappa, Frank X. Donovan, Susan R. Phelps, Thomas Winkler, Cynthia E. Dunbar, Janis L. Abkowitz

Blood (2022) 139 (23): 3439–3449.

https://doi.org/10.1182/blood.2021013507

Published: 2022

Includes: Supplemental data

Journal Articles

Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Raymond T. Doty, Xiaowei Yan, Christopher Lausted, Adam D. Munday, Zhantao Yang, Danielle Yi, Neda Jabbari, Li Liu, Siobán B. Keel, Qiang Tian, Janis L. Abkowitz

Blood (2019) 133 (5): 457–469.

https://doi.org/10.1182/blood-2018-05-850412

Published: 2019

Includes: Supplemental data

Journal Articles

Delayed Globin Synthesis Leads to Excessive Heme and the Macrocytic Anemia of Diamond Blackfan Anemia and del(5q) Myelodysplastic Syndrome

Janis L. Abkowitz, MD, Raymond T Doty, PhD, Zhantao Yang, MD, Xiaowei Yan, PhD, Christopher Lausted, MS, Qiang Tian, MD PhD

Blood (2017) 130 (Supplement 1): SCI-18.

https://doi.org/10.1182/blood.V130.Suppl_1.SCI-18.SCI-18

Published: 2017

Journal Articles

The Interplay of GATA1 with Heme Regulates an Erythroid Cell's Differentiation

Raymond T Doty, PhD, Xiaowei Yan, PhD, Christopher Lausted, MS, Zhantao Yang, MD, Li Liu, PhD, Neda Jabbari, PhD, Siobán B. Keel, MD, Qiang Tian, MD PhD, Janis L. Abkowitz, MD

Blood (2016) 128 (22): 541.

https://doi.org/10.1182/blood.V128.22.541.541

Published: 2016

Journal Articles

FLVCR1a But Not FLVCR1b Is Required For Effective Erythropoiesis In Adult Mice

Raymond T Doty, PhD, Marilyn Sanchez-Bonilla, Siobán B. Keel, MD, Janis L. Abkowitz, MD

Blood (2013) 122 (21): 308.

https://doi.org/10.1182/blood.V122.21.308.308

Published: 2013

Journal Articles

FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function

John C. H. Byon, Jing Chen, Raymond T. Doty, Janis L. Abkowitz

Blood (2013) 122 (16): 2903–2910.

https://doi.org/10.1182/blood-2012-10-465104

Published: 2013

Journal Articles

FLVCR Deletion Does Not Impact Normal Hematopoietic Stem Cell Function but Is Necessary for Erythroid and T-Cell Maturation and Enhances Platelet Formation

John Byon, MD, PhD, Jing Chen, MD, Raymond T Doty, PhD, Janis L. Abkowitz, MD

Blood (2011) 118 (21): 2363.

https://doi.org/10.1182/blood.V118.21.2363.2363

Published: 2011

Journal Articles

Why Do Erythroid Cells Need to Export Heme?

Janis L. Abkowitz, MD, Sioban B Keel, MD, Mary Philip, MD PhD, John C Byon, MD PhD, Raymond T Doty, PhD

Blood (2011) 118 (21): SCI-24.

https://doi.org/10.1182/blood.V118.21.SCI-24.SCI-24

Published: 2011

Journal Articles

Loss of FLVCR, a Heme Export Protein, Blocks Thymic T Cell Development at the CD4 + CD8 + Double-Positive Stage.

Mary Philip, MD, PhD, Jing Chen, MD, Raymond T Doty, PhD, Janis L. Abkowitz, MD

Blood (2009) 114 (22): 913.

https://doi.org/10.1182/blood.V114.22.913.913

Published: 2009

Journal Articles

A Heme Export Protein Is Required for Red Cell Differentiation and Iron Homeostasis.

Sioban B. Keel, MD, Raymond T. Doty, PhD, Sue Knoblaugh, DVM, Ivana De Domenico, PhD, Jerry Kaplan, PhD, Janis L. Abkowitz, MD

Blood (2007) 110 (11): 2658.

https://doi.org/10.1182/blood.V110.11.2658.2658

Published: 2007

Journal Articles

Evidence That Heme Export Via the Feline Leukemia Virus, Subgroup, C Receptor (FLVCR) Is Carrier Dependent and Its Physiological Implications.

Zhantao Yang, MD, Raymond T. Doty, PhD, Marie H. Nguyen, MD, Ann Smith, PhD, Janis L. Abkowitz, MD

Blood (2007) 110 (11): 2659.

https://doi.org/10.1182/blood.V110.11.2659.2659

Published: 2007

Journal Articles

A Heme Export Protein Is Required for Red Cell Differentiation and May Facilitate Iron Homeostasis.

Sioban B. Keel, MD, Raymond T. Doty, Ph.D., Zhantao Yang, M.D., James Palis, M.D., Janis L. Abkowitz, M.D.

Blood (2006) 108 (11): 1540.

https://doi.org/10.1182/blood.V108.11.1540.1540

Published: 2006

Journal Articles

Regulation of T-cell receptor Dβ1 promoter by KLF5 through reiterated GC-rich motifs

Xuexian O. Yang, Raymond T. Doty, Justin S. Hicks, Dennis M. Willerford

Blood (2003) 101 (11): 4492–4499.

https://doi.org/10.1182/blood-2002-08-2579

Published: 2003

Journal Articles

Promoter Element for Transcription of Unrearranged T-Cell Receptor β-Chain Gene in Pro-T Cells

Raymond T. Doty, Dong Xia, Suzanne P. Nguyen, Tanya R. Hathaway, Dennis M. Willerford

Blood (1999) 93 (9): 3017–3025.

https://doi.org/10.1182/blood.V93.9.3017

Published: 1999

NARROW

Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Preclinical Studies of the GlyT1 Inhibitor Bitopertin in Diamond-Blackfan Anemia

Atg4a Promotes Mitochondrial Quality Control and Hemoglobin Production In Vivo

A Phase I/II, Intra-Patient Dose-Escalation Study of Bitopertin, a Selective Inhibitor of GlyT1 and Heme Synthesis, for Steroid-Refractory Diamond-Blackfan Anemia

The Molecular Pathophysiology of Ineffective Erythropoiesis at Single Cell Resolution

Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell–extrinsic contributions to erythropoiesis

Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Delayed Globin Synthesis Leads to Excessive Heme and the Macrocytic Anemia of Diamond Blackfan Anemia and del(5q) Myelodysplastic Syndrome

The Interplay of GATA1 with Heme Regulates an Erythroid Cell's Differentiation

FLVCR1a But Not FLVCR1b Is Required For Effective Erythropoiesis In Adult Mice

FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function

FLVCR Deletion Does Not Impact Normal Hematopoietic Stem Cell Function but Is Necessary for Erythroid and T-Cell Maturation and Enhances Platelet Formation

Why Do Erythroid Cells Need to Export Heme?

Loss of FLVCR, a Heme Export Protein, Blocks Thymic T Cell Development at the CD4 + CD8 + Double-Positive Stage.

A Heme Export Protein Is Required for Red Cell Differentiation and Iron Homeostasis.

Evidence That Heme Export Via the Feline Leukemia Virus, Subgroup, C Receptor (FLVCR) Is Carrier Dependent and Its Physiological Implications.

A Heme Export Protein Is Required for Red Cell Differentiation and May Facilitate Iron Homeostasis.

Regulation of T-cell receptor Dβ1 promoter by KLF5 through reiterated GC-rich motifs

Promoter Element for Transcription of Unrearranged T-Cell Receptor β-Chain Gene in Pro-T Cells

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American Society of Hematology

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American Society of Hematology

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