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Janis L. Abkowitz
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Journal Articles

Extended Follow-up of Dose-Adjusted EPOCH (DA-EPOCH) Plus Inotuzumab Ozogamicin (InO) in Adults with Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL): A Safe and Effective Salvage Therapy

Noam E. Kopmar, Henry Le, Kim Quach, Ted Gooley, Christen Martino, Ashtyn Sherrow, Sindhu Cherian, Mary-Elizabeth M. Percival, Anna B. Halpern, Cristina Maria Ghiuzeli, Janis L. Abkowitz, Roland B. Walter, Ryan D. Cassaday
Journal: Blood
Blood (2024) 144 (Supplement 1): 4209.
https://doi.org/10.1182/blood-2024-208875
Published: 2024
Journal Articles

iPSC Reprogramming Identifies the Role of Cryptic Drivers in Preleukemic Clonal Evolution

Martina Sarchi, Sintra Stewart, Jason Kim, Ksenia R. Safina, Stephanie Busch, Hayden Gizinski, Nelli Aydinyan, Andreea Reilly, J. Philip Creamer, Rochelle Bergantinos, Jasper Hsu, Jonathan Good, Malgorzata Olszewska, Anna Gallì, Luca Malcovati, Sioban Keel, David Wu, Janis L. Abkowitz, Pamela S. Becker, Eirini Papapetrou, Kelley Harris, Peter van Galen, Suleyman Gulsuner, Sergei Doulatov
Journal: Blood
Blood (2024) 144 (Supplement 1): 1293.
https://doi.org/10.1182/blood-2024-205098
Published: 2024
Journal Articles

Preclinical Studies of the GlyT1 Inhibitor Bitopertin in Diamond-Blackfan Anemia

Raymond T. Doty, Adam D. Munday, Hannah Cottnair, Sarah E. Funk, Janis L. Abkowitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1355.
https://doi.org/10.1182/blood-2023-174293
Published: 2023
Journal Articles

Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Y. Lucy Liu, Nan Wang, Nicholas Neoman, Carolyn Wong, Bertil Glader, Raymond T. Doty, Mark C Wilkes, Janis L. Abkowitz, Kathleen M. Sakamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 944.
https://doi.org/10.1182/blood-2023-187734
Published: 2023
Journal Articles

Atg4a Promotes Mitochondrial Quality Control and Hemoglobin Production In Vivo

Massiel Chavez Stolla, Raymond T. Doty, Janis L. Abkowitz, Sergei Doulatov
Journal: Blood
Blood (2023) 142 (Supplement 1): 3826.
https://doi.org/10.1182/blood-2023-190593
Published: 2023
Journal Articles

A Phase I/II, Intra-Patient Dose-Escalation Study of Bitopertin, a Selective Inhibitor of GlyT1 and Heme Synthesis, for Steroid-Refractory Diamond-Blackfan Anemia

David J. Young, Tania Rene Machado, Raymond T. Doty, Colin O. Wu, Janis L. Abkowitz, William Savage, Cynthia E. Dunbar
Journal: Blood
Blood (2023) 142 (Supplement 1): 1086.
https://doi.org/10.1182/blood-2023-173821
Published: 2023
Journal Articles

How I diagnose and treat acute graft-versus-host disease after solid organ transplantation

Jason P. Cooper, Janis L. Abkowitz
Journal: Blood
Blood (2023) 141 (10): 1136–1146.
https://doi.org/10.1182/blood.2022015954
Published: 2023
Journal Articles

Addition of Sorafenib to Cladribine, High-Dose Cytarabine, G-CSF, and Mitoxantrone (CLAG-M) in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) and High-Grade Myeloid Neoplasms Independent of FLT3-Mutation Status: Final Results of a Phase 1/2 Study

Anna B. Halpern, Eduardo P Rodríguez-Arbolí, Megan Othus, Kelsey-Leigh A Garcia, Mary-Elizabeth M. Percival, Ryan D. Cassaday, Vivian G. Oehler, Pamela S. Becker, Jacob S. Appelbaum, Janis L. Abkowitz, Johnnie J. Orozco, Sioban B. Keel, Paul C. Hendrie, Bart L. Scott, Cristina Ghiuzeli, Roland B. Walter, Elihu H. Estey
Journal: Blood
Blood (2022) 140 (Supplement 1): 8999–9001.
https://doi.org/10.1182/blood-2022-159882
Published: 2022
Journal Articles

The Molecular Pathophysiology of Ineffective Erythropoiesis at Single Cell Resolution

Raymond T. Doty, Christopher G. Lausted, Adam D. Munday, Janis L. Abkowitz
Journal: Blood
Blood (2022) 140 (Supplement 1): 700.
https://doi.org/10.1182/blood-2022-167612
Published: 2022
Journal Articles

Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell–extrinsic contributions to erythropoiesis

Raymond T. Doty, Xing Fan, David J. Young, Jialiu Liang, Komudi Singh, Zahra Pakbaz, Ronan Desmond, Sara K. Young-Baird, Settara C. Chandrasekharappa, Frank X. Donovan, Susan R. Phelps, Thomas Winkler, Cynthia E. Dunbar, Janis L. Abkowitz
Journal: Blood
Blood (2022) 139 (23): 3439–3449.
https://doi.org/10.1182/blood.2021013507
Published: 2022
Includes: Supplemental data
Journal Articles

Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome

Courtnee A. Clough, Joseph Pangallo, Martina Sarchi, Janine O. Ilagan, Khrystyna North, Rochelle Bergantinos, Massiel C. Stolla, Jasmine Naru, Patrick Nugent, Eunhee Kim, Derek L. Stirewalt, Arvind R. Subramaniam, Omar Abdel-Wahab, Janis L. Abkowitz, Robert K. Bradley, Sergei Doulatov
Journal: Blood
Blood (2022) 139 (13): 2038–2049.
https://doi.org/10.1182/blood.2021012652
Published: 2022
Includes: Supplemental data
Journal Articles

A Phase 1/2 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) or Other High-Grade Myeloid Neoplasm

Colin D. Godwin, Megan Othus, Mary-Elizabeth M. Percival, Paul C. Hendrie, Bart L. Scott, Jacob S. Appelbaum, Anna B. Halpern, Vivian G. Oehler, Johnnie J. Orozco, Sioban B. Keel, Janis L. Abkowitz, Jason P. Cooper, Ryan D. Cassaday, Kaysey F. Orlowski, Anise J. Marshall, Clarisa N. Brown, Elihu H. Estey, Roland B. Walter
Journal: Blood
Blood (2021) 138 (Supplement 1): 34.
https://doi.org/10.1182/blood-2021-151658
Published: 2021
Journal Articles

Loss of Lamin B1 in Myeloid Neoplasms with 5q Deletion Causes Myeloid-Biased Hematopoiesis and Pelger-Huet Nuclear Anomaly

Andreea Reilly, J. Philip Creamer, Massiel Chavez Stolla, Yuchuan Wang, Jing Du, Rachel Wellington, Stephanie Busch, Elihu H. Estey, Pamela S. Becker, Min Fang, Sioban B. Keel, Janis L. Abkowitz, Lorinda A. Soma, Jian Ma, Zhijun Duan, Sergei Doulatov
Journal: Blood
Blood (2021) 138 (Supplement 1): 502.
https://doi.org/10.1182/blood-2021-154121
Published: 2021
Journal Articles

A simple Rx for congenital erythropoietic porphyria

Janis L. Abkowitz
Journal: Blood
Blood (2020) 136 (21): 2371–2372.
https://doi.org/10.1182/blood.2020007968
Published: 2020
Journal Articles

Coordinated Mis-Splicing of Multiple Mitochondrial Iron Metabolism Genes Causes Ring Sideroblast Formation in SF3B1-Mutant MDS

Courtnee Clough, Joseph Pangallo, PhD, Martina Sarchi, MD, Stephanie Busch, B.S., Janis L. Abkowitz, MD, Robert K. Bradley, PhD, Sergei Doulatov, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-140817
Published: 2020
Journal Articles

Deletions of 5q Promote Genome Instability in TP53-Mutant MDS/AML

Andreea Reilly, Stephanie Busch, B.S., Janis L. Abkowitz, MD, Pamela S. Becker, MD PhD, Sergei Doulatov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1244.
https://doi.org/10.1182/blood-2019-127038
Published: 2019
Journal Articles

ATG4A is a Novel Regulator of Mitophagy during Human Erythropoiesis

Massiel Chavez Stolla, PhD, Neele Thom, B.S., Andreea Reilly, Courtnee Clough, Janis L. Abkowitz, MD, Sergei Doulatov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3522.
https://doi.org/10.1182/blood-2019-130567
Published: 2019
Journal Articles

Myelodysplastic Syndrome with Excess Blasts and Secondary Acute Myeloid Leukemia: Same Disease with Different Blast Count

Xueyan Chen, MD, Megan Othus, PhD, Brent L Wood, MD PhD, Roland B. Walter, MD PhD MS, Pamela S. Becker, MD PhD, Mary-Elizabeth M. Percival, MD, Janis L. Abkowitz, MD, Frederick R. Appelbaum, MD, Elihu H. Estey, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2692.
https://doi.org/10.1182/blood-2019-124977
Published: 2019
Journal Articles

Phase 1 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) or Other High-Grade Myeloid Neoplasm

Colin D. Godwin, MDMPhil, Megan Othus, PhD, Mary-Elizabeth M. Percival, MD, Bart L. Scott, MD, Pamela S. Becker, MD PhD, Kelda M. Gardner, PA-C, Sioban B. Keel, MD, Tejaswini M. Dhawale, MD, Vivian G. Oehler, MD, Janis L. Abkowitz, MD, Anna B. Halpern, MD, Paul C. Hendrie, MD PhD, Kaysey F. Orlowski, Alice Woo, Elihu H. Estey, MD, Roland B. Walter, MD PhD MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3892.
https://doi.org/10.1182/blood-2019-126009
Published: 2019
Journal Articles

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

Jasper Hsu, Andreea Reilly, Brian J. Hayes, Courtnee A. Clough, Eric Q. Konnick, Beverly Torok-Storb, Suleyman Gulsuner, David Wu, Pamela S. Becker, Siobán B. Keel, Janis L. Abkowitz, Sergei Doulatov
Journal: Blood
Blood (2019) 134 (2): 186–198.
https://doi.org/10.1182/blood.2018884338
Published: 2019
Includes: Supplemental data