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Mark C Wilkes
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Journal Articles

Small Molecule Inhibitor Targeting Nemo-like Kinase Improves Erythropoiesis in Human and Mouse Models of Diamond Blackfan Anemia

Aya Shibuya, Lucy Liu, Mark C Wilkes, Nan Wang, Leonardo Daniels, Jayla Taylor, Bertil Glader, Kathleen M. Sakamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 2728.
https://doi.org/10.1182/blood-2023-182445
Published: 2023
Journal Articles

Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Y. Lucy Liu, Nan Wang, Nicholas Neoman, Carolyn Wong, Bertil Glader, Raymond T. Doty, Mark C Wilkes, Janis L. Abkowitz, Kathleen M. Sakamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 944.
https://doi.org/10.1182/blood-2023-187734
Published: 2023
Journal Articles

The Serine Threonine Kinase Inhibitor Ots-167 Improves Erythropoiesis through Suppression of Nlk Activity in Diamond Blackfan Anemia Models

Aya Shibuya, Mark C Wilkes, Manuel Serrano, Johan Flygare, Bert Glader, Anupama Narla, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 2179.
https://doi.org/10.1182/blood-2021-150070
Published: 2021
Journal Articles

SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia

Mark C Wilkes, Aya Shibuya, Vanessa M Scanlon, Hee-Don Chae, Anupama Narla, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 2189.
https://doi.org/10.1182/blood-2021-153814
Published: 2021
Journal Articles

Nutritional Supplements, Ginseng and Leucine, Increase Erythropoiesis in Diamond Blackfan Anemia Models through Inhibition of Nemo-like Kinase

Mark C Wilkes, Aya Shibuya, Jacqueline D Mercado, Anupama Narla, Bert Glader, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 1129.
https://doi.org/10.1182/blood-2021-153728
Published: 2021
Journal Articles

Genetic Modulators of Niclosamide Sensitivity and Resistance in Acute Myeloid Leukemia

Anna Wojcicki, BS, Hee-Don Chae, PhD, Kyuho Han, PhD, Minyoung Youn, PhD, Mark C Wilkes, PhD, Norman J. Lacayo, MD, Michael Bassik, PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-137340
Published: 2020
Journal Articles

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Mark C Wilkes, PhD, Kavitha Siva, PhD, Jacqueline D Mercado, Ethan Patrick Wentworth, Mallika Saxena, Jun Chen, MD PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Shuo Lin, PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-137170
Published: 2020
Journal Articles

SATB1 Regulates GATA1 Protein Expression in Early Hematopoiesis and Is Deregulated in Diamond Blackfan Anemia

Mark C Wilkes, PhD, Hee-Don Chae, PhD, Ethan Patrick Wentworth, Toshinobu Nishimura, PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Hiromitsu Nakauchi, Joanna Wysocka, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-140437
Published: 2020
Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 455.
https://doi.org/10.1182/blood-2019-129570
Published: 2019
Journal Articles

Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia

Mark C Wilkes, Kaoru Takasaki, MD, Minyoung Youn, PhD, Hee-Don Chae, PhD, Anupama Narla, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2591.
https://doi.org/10.1182/blood-2018-99-119729
Published: 2018
Journal Articles

Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, Jun Chen, MD PhD, Kavitha Siva, PhD, Gianluca Veretti, PhD, Daniel P. Dever, PhD, Minyoung Youn, PhD, Hee-Don Chae, PhD, Jacqueline D Mercado, Mallika Saxena, Anupama Narla, MD, Bertil Glader, MD, Matthew Porteus, MD PhD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 754.
https://doi.org/10.1182/blood-2018-99-119954
Published: 2018
Journal Articles

MMP9 Inhibition Rescues the Erythroid Defect in RPS14-Deficient Del(5q) MDS Models

Minyoung Youn, PhD, Haigen Huang, PhD, Cheng Chen, Sharon Kam, BS, Mark C Wilkes, Hee-Don Chae, PhD, Anupama Narla, MD, Shuo Lin, PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 756.
https://doi.org/10.1182/blood-2018-99-117508
Published: 2018
Journal Articles

Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

Mark C Wilkes, Jae Wook Lee, Sriya Kudaravalli, Anupama Narla, MD, Bertil Glader, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 78.
https://doi.org/10.1182/blood.V130.Suppl_1.78.78
Published: 2017