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Journal Articles

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

Shanshan Suo, Dandan Zhao, Fenglin Li, Sonia Rodriguez, Junjing Qiao, Chen Liang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Nadia Carlesso, Bin Zhang, Guido Marcucci, Jie Jin

Blood (2022) 140 (Supplement 1): 362–363.

https://doi.org/10.1182/blood-2022-169679

Published: 2022

Journal Articles

METTL3 Dysregulates RNA Splicing by Translational Control of Splicing Factors via m 6 A Modification in CLL

Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn Hart, Aijun Liao, Stacey M. Fernandes, Tinisha McDonald, Lucy Ghoda, Daniel Roeth, Markus Kalkum, Raju Pillai, Jianjun Chen, Jennifer R Brown, Alexey V. Danilov, Steven T. Rosen, Tanya Siddiqi, Lili Wang

Blood (2021) 138 (Supplement 1): 499.

https://doi.org/10.1182/blood-2021-149691

Published: 2021

Journal Articles

Acute Myeloid Leukemia Cell-Intrinsic PD-1 Functions Promoting Leukemia Development By Recruiting SHP2

Shanshan Suo, Le Xuan Truong Nguyen, Fenglin Li, Dandan Zhao, Junjing Qiao, Chen Liang, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Bin Amber Zhang, Jie Jin, Guido Marcucci

Blood (2021) 138 (Supplement 1): 1173.

https://doi.org/10.1182/blood-2021-154467

Published: 2021

Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan

Blood (2021) 138 (16): 1465–1480.

https://doi.org/10.1182/blood.2020009871

Published: 2021

Includes: Supplemental data

Journal Articles

Integrative Transcriptome and Quantitative Proteome Analyses Identify METTL3 As a Key Regulator for Aberrant RNA Processing in Chronic Lymphocytic Leukemia

Yiming Wu, PhD, Meiling Jin, PhD, Kevyn Hart, BS, Aijun Liao, MD PhD, Stacey M. Fernandes, BS, Tinisha McDonald, BS, Lucy Brown, PhD, Daniel Roeth, PhD, Markus Kalkum, PhD, Raju Pillai, MD, Jianjun Chen, PhD, Jennifer R Brown, MD PhD, Steven T. Rosen, MD, Tanya Siddiqi, MD, Lili Wang, MDPhD

Blood (2020) 136 (Supplement 1): 12.

https://doi.org/10.1182/blood-2020-139841

Published: 2020

Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD

Blood (2020) 136 (Supplement 1): 39.

https://doi.org/10.1182/blood-2020-140044

Published: 2020

Journal Articles

Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia

Huafeng Wang, MD, Jie Sun, PhD, Dandan Zhao, MD, Hongyan Tong, Herman Wu, BS, Xia Li, PhD, Yingwan Luo, MD, Dan Dong, PhD, Tinisha McDonald, MS, Anthony Stein, MD, Monzr M. Al Malki, MD, Flavia Pichiorri, PhD, Nadia Carlesso, MD, Ya-Huei Kuo, PhD, Bin Zhang, PhD, Guido Marcucci, MD, Ling Li, PhD, Jie Jin, MD PhD

Blood (2019) 134 (Supplement_1): 1707.

https://doi.org/10.1182/blood-2019-130375

Published: 2019

Journal Articles

Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target?

Blood (2018) 132 (Supplement 1): 1338.

https://doi.org/10.1182/blood-2018-99-119599

Published: 2018

Journal Articles

Immune Mediated Mechanisms of Resistance to Daratumumab

Domenico Viola, Ada Dona, Emine Gulsen Gunes, PhD, Estelle Troadec, Xiwei Wu, Sergio Branciamore, Tinisha McDonald, MS, Lucy Ghoda, PhD, Ashish Streatfield, James F Sanchez, PhD, Chatchada Karanes, Myo Htut, Michael Rosenzweig, Jonathan J Keats, PhD, Steven T Rosen, Guido Marcucci, Amrita Krishnan, MD, Flavia Pichiorri, PhD

Blood (2018) 132 (Supplement 1): 3201.

https://doi.org/10.1182/blood-2018-99-117441

Published: 2018

Journal Articles

PNC ¯ 27 Targeting Plasma Membrane HDM2: A Potentially Novel Therapeutic Approach for Acute Myeloid Leukemia (AML)

Huafeng Wang, Bin Zhang, PhD, Dandan Zhao, MD, Estelle Troadec, PhD, Weixu Meng, PhD MD, Allen Lin, Anthony S. Stein, MD, Monzr M. Al Malki, MD, Herman Wu, BS, Tinisha Mcdonald, Jie Jin, Guido Marcucci, MD

Blood (2017) 130 (Supplement 1): 2518.

https://doi.org/10.1182/blood.V130.Suppl_1.2518.2518

Published: 2017

Journal Articles

Anti-IL1RAP/CD3 Bispecific Antibody (BsAb) Is a Promising Novel and Effective Therapy for Acute Myeloid Leukemia (AML)

Blood (2017) 130 (Supplement 1): 1361.

https://doi.org/10.1182/blood.V130.Suppl_1.1361.1361

Published: 2017

Journal Articles

Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target CML LSC

Yann Pierre Kevin Duchartre, PhD, Ling Li, PhD, Tinisha McDonald, B.S., YinWei Ho, Yao-Te Hsieh, Ravi Bhatia, MD

Blood (2014) 124 (21): 4521.

https://doi.org/10.1182/blood.V124.21.4521.4521

Published: 2014

Journal Articles

Role of Enhanced Microenvironmental Interleukin-1 (IL-1) Expression and Increased IL-1 Responsiveness in Persistence of Leukemia Stem Cells in TKI Treated CML Patients

Bin Zhang, PhD, YinWei Ho, Tinisha McDonald, B.S., Allen Lin, David S Snyder, MD, Vu N. Ngo, PhD, Tessa L. Holyoake, MD PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 4357.

https://doi.org/10.1182/blood.V124.21.4357.4357

Published: 2014

Journal Articles

Inhibition of HDAC8 Reactivates p53 and Abrogates Leukemia Stem Cell Activity in CBFβ-SMMHC Associated Acute Myeloid Leukemia

Jing Qi, PhD, Qi Cai, PhD, Sandeep Singh, Ling Li, PhD, Hongjun Liu, Tinisha McDonald, B.S., Allen Lin, Ravi Bhatia, MD, wei-Jan Huang, PhD, chung-I Chang, ya-Huei Kuo, PhD

Blood (2014) 124 (21): 363.

https://doi.org/10.1182/blood.V124.21.363.363

Published: 2014

Journal Articles

Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche.

Bijender Kumar, PhD, Mayra Garcia, PhD, Lihong Weng, Xiaoman Lewis, Jodi Murakami, Xingbin Hu, Tinisha McDonald, B.S., David DiGiusto, PhD, Ashish Kumar, MBBS, PhD, Ravi Bhatia, MD, Ching-Cheng Chen, PhD

Blood (2014) 124 (21): 352.

https://doi.org/10.1182/blood.V124.21.352.352

Published: 2014

Journal Articles

Leukemia-Derived Exosomes Reorganize Bone Marrow Microenvironment In AML

Bijender Kumar, Ph.D., Lihong Weng, Xiaoman Lewis, Jodi Murakami, Xingbin Hu, Tinisha McDonald, Ashish Kumar, MBBS, PhD, David DiGiusto, Ph.D., Ravi Bhatia, MD, Ching-Cheng Cheng Chen, Ph.D.

Blood (2013) 122 (21): 2455.

https://doi.org/10.1182/blood.V122.21.2455.2455

Published: 2013

Journal Articles

Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment

Ling Li, PhD, Tereza Osdal, MSc, YinWei Ho, MA, Tinisha McDonald, Sookhee Chun, Su Chu, MD, Allen Lin, Cedric Dos Santos, Ph.D, Mihaela Lucia Popa, VMD, Bjorn T Gjertsen, MD PhD, Wenyong Chen, PhD, Sonia Lain, Emmet McCormack, PhD, Ravi Bhatia, MD

Blood (2013) 122 (21): 2685.

https://doi.org/10.1182/blood.V122.21.2685.2685

Published: 2013

Journal Articles

Selective Targeting Of Inv(16)+ AML Stem Progenitor Cells By Inhibiting HDAC8

Jing Qi, PhD, Sandeep Singh, Qi Cai, PhD, Ling Li, PhD, Hongjun Liu, Hieu Vu, wei-Jan Huang, PhD, Tinisha McDonald, Allen Lin, chung-I Chang, Ravi Bhatia, MD, Ya-Huei Kuo, PhD

Blood (2013) 122 (21): 224.

https://doi.org/10.1182/blood.V122.21.224.224

Published: 2013

Journal Articles

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Armen Mardiros, Cedric Dos Santos, Tinisha McDonald, Christine E. Brown, Xiuli Wang, L. Elizabeth Budde, Lauren Hoffman, Brenda Aguilar, Wen-Chung Chang, William Bretzlaff, Brenda Chang, Mahesh Jonnalagadda, Renate Starr, Julie R. Ostberg, Michael C. Jensen, Ravi Bhatia, Stephen J. Forman

Blood (2013) 122 (18): 3138–3148.

https://doi.org/10.1182/blood-2012-12-474056

Published: 2013

Includes: Supplemental data

Journal Articles

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents

Cedric Dos Santos, Tinisha McDonald, Yin Wei Ho, Hongjun Liu, Allen Lin, Stephen J. Forman, Ya-Huei Kuo, Ravi Bhatia

Blood (2013) 122 (11): 1900–1913.

https://doi.org/10.1182/blood-2012-11-466425

Published: 2013

Includes: Supplemental data

NARROW

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

METTL3 Dysregulates RNA Splicing by Translational Control of Splicing Factors via m 6 A Modification in CLL

Acute Myeloid Leukemia Cell-Intrinsic PD-1 Functions Promoting Leukemia Development By Recruiting SHP2

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Integrative Transcriptome and Quantitative Proteome Analyses Identify METTL3 As a Key Regulator for Aberrant RNA Processing in Chronic Lymphocytic Leukemia

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia

Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target?

Immune Mediated Mechanisms of Resistance to Daratumumab

PNC ¯ 27 Targeting Plasma Membrane HDM2: A Potentially Novel Therapeutic Approach for Acute Myeloid Leukemia (AML)

Anti-IL1RAP/CD3 Bispecific Antibody (BsAb) Is a Promising Novel and Effective Therapy for Acute Myeloid Leukemia (AML)

Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target CML LSC

Role of Enhanced Microenvironmental Interleukin-1 (IL-1) Expression and Increased IL-1 Responsiveness in Persistence of Leukemia Stem Cells in TKI Treated CML Patients

Inhibition of HDAC8 Reactivates p53 and Abrogates Leukemia Stem Cell Activity in CBFβ-SMMHC Associated Acute Myeloid Leukemia

Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche.

Leukemia-Derived Exosomes Reorganize Bone Marrow Microenvironment In AML

Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment

Selective Targeting Of Inv(16)+ AML Stem Progenitor Cells By Inhibiting HDAC8

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents

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American Society of Hematology

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American Society of Hematology

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