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Journal Articles

A First-in-Human Dose Escalation Clinical Trial of Engineered Natural Killer Cell Therapy in Non-Small Cell Lung Cancer Patients Refractory to Immune Check Point Inhibitors

Miguel A Villalona, Lei Tian, Xiaochen Li, Joycelynne Michelle Palmer, Claudia Aceves, Hans Meisen, Catherine Cortez, Tim W Synold, Colt Egelston, Jeffery Vandeusen, Ivone Bruno, Lei Zhang, Eliezer Romeu-Bonilla, Omer Butt, Stephen J. Forman, Michael A Caligiuri, Jianhua Yu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7206.
https://doi.org/10.1182/blood-2024-202132
Published: 2024
Journal Articles

Human ILC1s Target Leukemia Stem Cells and Control Development of AML

Zhenlong Li, Hejun Tang, Victoria Chen, Rui Ma, Jianying Zhang, Guido Marcucci, Jianhua Yu, Michael A Caligiuri
Journal: Blood
Blood (2023) 142 (Supplement 1): 886.
https://doi.org/10.1182/blood-2023-190767
Published: 2023
Journal Articles

The NK Cell Receptor NKp46 Acts As an Essential Regulator of ILC1 Proliferation, Effector Function and Anti-AML Activity

Rui Ma, Zhenlong Li, Hejun Tang, Lei Tian, Zahir Shah, Tasha Barr, Amy Peng, Jianying Zhang, Srividya Swaminathan, Michael A Caligiuri, Jianhua Yu
Journal: Blood
Blood (2023) 142 (Supplement 1): 3925.
https://doi.org/10.1182/blood-2023-191070
Published: 2023
Journal Articles

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

Fang Chen, Dandan Zhao, Yi Zhang, Yongfang Xu, Min-Hsuan Chen, Khyatiben V. Pathak, Yong Liang, Wei-Le Wang, Katrina Estrella, Xiwei Wu, Lucy Y. Ghoda, Ya-Huei Kuo, Haris Ali, Jianhua Yu, Michael A Caligiuri, Mark Boldin, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3152.
https://doi.org/10.1182/blood-2023-182587
Published: 2023
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-140044
Published: 2020
Journal Articles

The ETS1 Transcription Factor Is Implicated in Human and Murine Intermediate NK Cell Development Stages

Eileen Hu, BS, Jessica Waibl-Polania, BS, Frank Frissora, MS, Larry State Beaver, Kevan Zapolnik, BS, Bethany L Mundy-Bosse, PhD, Anjali Mishra, PhD, Aharon G. Freud, MD PhD, Jianhua Yu, PhD, John C. Byrd, MD, Christopher C. Oakes, Michael Ostrowski, PhD, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2567.
https://doi.org/10.1182/blood-2018-99-115261
Published: 2018
Journal Articles

Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function

Steven D. Scoville, Ansel P. Nalin, Luxi Chen, Li Chen, Michael H. Zhang, Kathleen McConnell, Susana Beceiro Casas, Gabrielle Ernst, Abd Al-Rahman Traboulsi, Naima Hashi, Monica Williams, Xiaoli Zhang, Tiffany Hughes, Anjali Mishra, Don M. Benson, Jennifer N. Saultz, Jianhua Yu, Aharon G. Freud, Michael A. Caligiuri, Bethany L. Mundy-Bosse
Journal: Blood
Blood (2018) 132 (17): 1792–1804.
https://doi.org/10.1182/blood-2018-03-838474
Published: 2018
Includes: Supplemental data
Journal Articles

Combination Therapy with Daratumumab and CAR-NK Targeting CS1 for Multiple Myeloma

Yibo Zhang, PhD, Lichao Chen, Yufeng Wang, Xinxin Li, Tiffany Hughes, Hans Klingemann, Don M Benson, MD PhD, Jianhua Yu, PhD
Journal: Blood
Blood (2016) 128 (22): 1342.
https://doi.org/10.1182/blood.V128.22.1342.1342
Published: 2016
Journal Articles

Decitabine enhances anti-CD33 monoclonal antibody BI 836858–mediated natural killer ADCC against AML blasts

Sumithira Vasu, Shun He, Carolyn Cheney, Bhavani Gopalakrishnan, Rajeswaran Mani, Gerard Lozanski, Xiaokui Mo, Veronica Groh, Susan P. Whitman, Renate Konopitzky, Christian Kössl, Donna Bucci, David M. Lucas, Jianhua Yu, Michael A. Caligiuri, William Blum, Paul J. Adam, Eric Borges, Bjoern Rueter, Karl-Heinz Heider, Guido Marcucci, Natarajan Muthusamy
Journal: Blood
Blood (2016) 127 (23): 2879–2889.
https://doi.org/10.1182/blood-2015-11-680546
Published: 2016
Includes: Supplemental data
Journal Articles

Enhancement of Natural Killer Cell Interferon-Gamma Production By the Derivatives of the Natural Product Phyllanthusmins Via TLR-Mediated NF-Kb and STAT3 Signaling Pathways

Luxi Chen, Long Yi, Yuning Ren, Jianying Zhang, A. Douglas Kinghorn, Michael A. Caligiuri, MD, Jianhua Yu, PhD
Journal: Blood
Blood (2015) 126 (23): 1031.
https://doi.org/10.1182/blood.V126.23.1031.1031
Published: 2015
Journal Articles

Modulation of Natural Killer Cell Activity in the Setting of Oncolytic Virotherapy and with a Chimeric Antigen Receptor

Chen Xilin, Jianfeng Han, Chu Jianhong, Walter Meisen, Zhang Jianying, E. Antonio Chiocca, Balveen Kaur, Michael A. Caligiuri, MD, Jianhua Yu, PhD
Journal: Blood
Blood (2015) 126 (23): 210.
https://doi.org/10.1182/blood.V126.23.210.210
Published: 2015
Journal Articles

Remission of a Heavily Pre-Treated Relapsed/Refractory ALK-Positive Anaplastic Large Cell Lymphoma after Treatment with Metronomic Therapy

Yuan Shunzong, MD, Haverkos Brad, Hang Su, Jianhua Yu, PhD
Journal: Blood
Blood (2014) 124 (21): 5456.
https://doi.org/10.1182/blood.V124.21.5456.5456
Published: 2014
Journal Articles

Acute Myeloid Leukemia Alters Natural Killer Cell Maturation and Functional Activation

Bethany Mundy-Bosse, PhD, McConnell Kathleen, Charlene Mao, Elshafa Ahmed, Li Chen, Steven D Scoville, Aharon G. Freud, MD PhD, Jianhua Yu, PhD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2014) 124 (21): 754.
https://doi.org/10.1182/blood.V124.21.754.754
Published: 2014
Journal Articles

Nanoparticle-Encapsulated Allogeneic T Cells Mitigate Graft-Versus-Host Disease but Retain Graft-Versus-Leukemia Activity

Lingling Zhang, PhDMD, Shuting Zhao, Steven M. Devine, MD, Xiaoming He, PhD, Jianhua Yu, PhD
Journal: Blood
Blood (2014) 124 (21): 3820.
https://doi.org/10.1182/blood.V124.21.3820.3820
Published: 2014
Journal Articles

CS1-Specific Chimeric Antigen Receptor (CAR)-Engineered NK Cells and T Cells Enhance In Vitro and In Vivo Anti-Tumor Activity Against Human Multiple Myeloma

Jianhong Chu, PhD, Youcai Deng, Don M. Benson, Jr., MD, PhD, Shun He, Tiffany L. Hughes, Jianying Zhang, Yong Peng, Hsiaoyin Mao, Ling Yi, Kalpana Ghoshal, Xiaoming He, Steven M. Devine, MD, Xiaoliu Zhang, Michael A. Caligiuri, MD, Craig C. Hofmeister, MD, Jianhua Yu, PhD
Journal: Blood
Blood (2013) 122 (21): 14.
https://doi.org/10.1182/blood.V122.21.14.14
Published: 2013
Journal Articles

Decitabine Or 5-Azacitidine Pre-Treatment Does Not Compromise The Novel Fc-Engineered Antibody Mab 33.1-Mediated ADCC Against Primary AML Blasts - A Rationale For Combination Therapy

Shun He, PhD, Carolyn Cheney, Susan P. Whitman, PhD, Jianhua Yu, PhD, Sumithira Vasu, MBBS, William Blum, MD, Karl-Heinz Heider, PhD, Guido Marcucci, MD, Natarajan Muthusamy, DVM, Ph.D
Journal: Blood
Blood (2013) 122 (21): 3959.
https://doi.org/10.1182/blood.V122.21.3959.3959
Published: 2013
Journal Articles

FLT3L and AMD3100 Combination Increases Hematopoietic Stem Cell Mobilization and Leads To Improved Transplantation Outcome

Shun He, PhD, Deng Youcai, MS, Sumithira Vasu, MBBS, Jianhong Chu, Shunzong Yuan, Jianying Zhang, Zhijin Fan, Craig C Hofmeister, MD, Xiaoming He, Henry March, Steven M. Devine, MD, Jianhua Yu, PhD
Journal: Blood
Blood (2013) 122 (21): 901.
https://doi.org/10.1182/blood.V122.21.901.901
Published: 2013
Journal Articles

MicroRNAs activate natural killer cells through Toll-like receptor signaling

Shun He, Jianhong Chu, Lai-Chu Wu, Hsiaoyin Mao, Yong Peng, Christopher A. Alvarez-Breckenridge, Tiffany Hughes, Min Wei, Jianying Zhang, Shunzong Yuan, Sumeet Sandhu, Sumithira Vasu, Don M. Benson, Jr, Craig C. Hofmeister, Xiaoming He, Kalpana Ghoshal, Steven M. Devine, Michael A. Caligiuri, Jianhua Yu
Journal: Blood
Blood (2013) 121 (23): 4663–4671.
https://doi.org/10.1182/blood-2012-07-441360
Published: 2013
Includes: Supplemental data
Journal Articles

Micrornas Promote Activation and Maturation of Natural Killer Cells Through Toll-Like Receptor Signaling.

Jianhua Yu, PhD, Shun He, Lai-Chu Wu, PhD, Hsiaoyin Mao, Sumithira Vasu, MBBS, Samantha M. Jaglowski, MD, MPH, Yong Peng, Christopher Alvarez-Breckenridge, Shunzong Yuan, Ph.D., M.D., Min Wei, Jianying Zhang, Tiffany L Hughes, Kalpana Ghoshal, Steven M. Devine, MD, Michael A. Caligiuri, M.D.
Journal: Blood
Blood (2012) 120 (21): 2160.
https://doi.org/10.1182/blood.V120.21.2160.2160
Published: 2012