1-11 of 11
A. Douglas Kinghorn
Close
Sort by
Journal Articles

Characterization of Cytotoxic Macrophages in a Pre-Clinical Model of Epstein-Barr Virus (EBV)-Driven Lymphoproliferative Disease

John Patton, Emily Smith, Zahary Smith, Andrew Stiff, A. Douglas Kinghorn, Yiping Yang, Michael R Grever, David M. Lucas, Robert Baiocchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3502.
https://doi.org/10.1182/blood-2021-154161
Published: 2021
Journal Articles

Enhancement of Natural Killer Cell Interferon-Gamma Production By the Derivatives of the Natural Product Phyllanthusmins Via TLR-Mediated NF-Kb and STAT3 Signaling Pathways

Luxi Chen, Long Yi, Yuning Ren, Jianying Zhang, A. Douglas Kinghorn, Michael A. Caligiuri, MD, Jianhua Yu, PhD
Journal: Blood
Blood (2015) 126 (23): 1031.
https://doi.org/10.1182/blood.V126.23.1031.1031
Published: 2015
Journal Articles

Identifying and Targeting Cytotoxic Tumor-Associated Macrophages in Epstein-Barr Virus-Driven Lymphoproliferative Disease

John T. Patton, PhD, Monica L Mitchell, Li Pan, PhD, A. Douglas Kinghorn, PhD, D.Sc, Michael R. Grever, MD, David M. Lucas, PhD, Robert A. Baiocchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4489.
https://doi.org/10.1182/blood.V124.21.4489.4489
Published: 2014
Journal Articles

Silvestrol Modulates Indirect Anti-Tumor Activity and Potentiates Immune Response To Epstein-Barr Virus-Driven Lymphoproliferative Disease

John T. Patton, Alex S. Hartlage, Li Pan, PhD, Mark E Lustberg, MD, PhD, Callie M. Drohan, Marisa F. Martin, A. Douglas Kinghorn, Ph.D., D.Sc, Michael A. Caligiuri, MD, Michael R. Grever, MD, David M. Lucas, PhD, Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 4422.
https://doi.org/10.1182/blood.V122.21.4422.4422
Published: 2013
Journal Articles

Translational Research From the Tropical Forest: Silvestrol, a Natural Product From the Plant Aglaia Foveolata inhibits the Expression of Tyrosine Kinases and Shows a Significant In Vivo Activity in Acute Myeloid Leukemia (AML)

Houda Alachkar, PharmD, M.S, Ramasamy Santhanam, PhD, David M. Lucas, PhD, Sebastian Schwind, MD, Christopher Hickey, M.S, Jiuxia Pang, Danilo Perrotti, MD, PhD, Li Pan, PhD, A Douglas Kinghorn, Ph.D., D.Sc, Guido Marcucci, MD, Michael R Grever, MD
Journal: Blood
Blood (2011) 118 (21): 2616.
https://doi.org/10.1182/blood.V118.21.2616.2616
Published: 2011
Journal Articles

Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,

Lapo Alinari, MD., Ph.D., Ryan B. Edwards, Courtney J. Prince, William H. Towns, Rajeswaran Mani, DVM, Amy Lehman, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Li Pan, PhD, A. Douglas Kinghorn, PhD, DSc, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D., David M. Lucas, PhD
Journal: Blood
Blood (2011) 118 (21): 3498.
https://doi.org/10.1182/blood.V118.21.3498.3498
Published: 2011
Journal Articles

Silvestrol Modulates Direct Anti-Tumor Activity Against Epstein-Barr Virus (EBV)-Associated Lymphomas While Sparing Innate and Antigen Specific Adaptive Immunity

John T. Patton, Mark E Lustberg, MD, PhD, Sabrina L Garman, A Douglas Kinghorn, Ph.D., D.Sc, Li Pan, PhD, David M. Lucas, PhD, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 104.
https://doi.org/10.1182/blood.V118.21.104.104
Published: 2011
Journal Articles

Resistance to the Novel Translation Inhibitor Silvestrol Is Mediated by Elevated Mcl-1 Expression.

David M. Lucas, Ellen J. Sass, Ryan B. Edwards, Li Pan, Gerard Lozanski, Nyla A. Heerema, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Blood
Blood (2009) 114 (22): 1737.
https://doi.org/10.1182/blood.V114.22.1737.1737
Published: 2009
Journal Articles

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

David M. Lucas, Ryan B. Edwards, Gerard Lozanski, Derek A. West, Jungook D. Shin, Melissa A. Vargo, Melanie E. Davis, Darlene M. Rozewski, Amy J. Johnson, Bao-Ning Su, Virginia M. Goettl, Nyla A. Heerema, Thomas S. Lin, Amy Lehman, Xiaoli Zhang, David Jarjoura, David J. Newman, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Blood
Blood (2009) 113 (19): 4656–4666.
https://doi.org/10.1182/blood-2008-09-175430
Published: 2009
Journal Articles

The Plant-Derived Agent Silvestrol Has B-Cell Selective Activity In Vitro in Chronic Lymphocytic Leukemia Patient Cells and In Vivo in the Tcl-1 Mouse Model of CLL.

David M. Lucas, PhD, Ryan B. Edwards, Michael D. De Lay, Derek A. West, Gerard Lozanski, MD, Amy J. Johnson, PhD, Angela A. Salim, PhD, Thomas S. Lin, MD, PhD, John C. Byrd, MD, A. Douglas Kinghorn, PhD, Michael R. Grever, MD
Journal: Blood
Blood (2007) 110 (11): 3123.
https://doi.org/10.1182/blood.V110.11.3123.3123
Published: 2007
Journal Articles

Silvestrol, a Rocaglate Derivative from the Indonesian Plant Aglaia foveolata , Has Significant Bcl-2- and p53-Independent Anti-Tumor Activity against Chronic Lymphocytic Leukemia Cells.

Ryan B. Edwards, BS, David M. Lucas, PhD, Gerard Lozanski, MD, Amy J. Johnson, PhD, Bao-Ning Su, PhD, Thomas S. Lin, MD, John C. Byrd, MD, A. Douglas Kinghorn, PhD, Michael R. Grever, MD
Journal: Blood
Blood (2006) 108 (11): 2600.
https://doi.org/10.1182/blood.V108.11.2600.2600
Published: 2006