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Journal Articles

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

Bo Yu, Yicheng Mao, Li-Yuan Bai, Sarah E. M. Herman, Xinmei Wang, Asha Ramanunni, Yan Jin, Xiaokui Mo, Carolyn Cheney, Kenneth K. Chan, David Jarjoura, Guido Marcucci, Robert J. Lee, John C. Byrd, L. James Lee, Natarajan Muthusamy

Blood (2013) 121 (1): 136–147.

https://doi.org/10.1182/blood-2012-01-407742

Published: 2013

Includes: Supplemental data

Journal Articles

A Transgenic Mouse Model of Aggressive B-Cell Malignancy for Evaluating Anti-Human CD37 Therapeutics

Kyle A Beckwith, B.S., Frank W Frissora, M.S., Matthew R Stefanovski, B.S., Jutta Deckert, Ph.D., Carlo M Croce, M.D., Xiaokui Mo, PhD, David Jarjoura, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2012) 120 (21): 188.

https://doi.org/10.1182/blood.V120.21.188.188

Published: 2012

Journal Articles

The Hsp90 Inhibitor 17-DMAG Increases SOCS3 and Regulates Cytokine Production, Migration and Cell Death in Chronic Lymphocytic Leukemia

Erin K Hertlein, PhD, Timothy L. Chen, Rainer Claus, MD, Christoph Plass, PhD, Amy Lehman, David Jarjoura, PhD, Kami Maddocks, MD, Jeffrey A. Jones, MD, MPH, David M. Lucas, PhD, Amy J. Johnson, PhD, John C. Byrd, MD

Blood (2012) 120 (21): 1362.

https://doi.org/10.1182/blood.V120.21.1362.1362

Published: 2012

Journal Articles

Aberrant Epigenetic Suppression of the Ptprot Gene Encoding a Protein Tyrosine Phosphatase Targeting KIT in Acute Myeloid Leukemia

Tasneem Motiwala, PhD, Satavisha Roy, Shujun Liu, Ph.D, Sebastian Schwind, MD, Rainer Claus, MD, Xiaokui Mo, PhD, Ramiro Garzon, MD, Hartmut Dohner, MD, Konstanze Dohner, MD, PhD, David Jarjoura, PhD, Christoph Plass, PhD, Guido Marcucci, MD, Samson T. Jacob, PhD

Blood (2012) 120 (21): 1322.

https://doi.org/10.1182/blood.V120.21.1322.1322

Published: 2012

Journal Articles

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Nicholas A. Zorko, Kelsie M. Bernot, Susan P. Whitman, Ronald F. Siebenaler, Elshafa H. Ahmed, Gabriele G. Marcucci, Daniel A. Yanes, Kathleen K. McConnell, Charlene Mao, Chidimma Kalu, Xiaoli Zhang, David Jarjoura, Adrienne M. Dorrance, Nyla A. Heerema, Benjamin H. Lee, Gang Huang, Guido Marcucci, Michael A. Caligiuri

Blood (2012) 120 (5): 1130–1136.

https://doi.org/10.1182/blood-2012-03-415067

Published: 2012

Journal Articles

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

Tasneem Motiwala, Nicola Zanesi, Jharna Datta, Satavisha Roy, Huban Kutay, Allyn M. Checovich, Mohamed Kaou, Yiming Zhong, Amy J. Johnson, David M. Lucas, Nyla A. Heerema, John Hagan, Xiaokui Mo, David Jarjoura, John C. Byrd, Carlo M. Croce, Samson T. Jacob

Blood (2011) 118 (23): 6132–6140.

https://doi.org/10.1182/blood-2011-01-323147

Published: 2011

Includes: Supplemental data

Journal Articles

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

Sarwish Rafiq, MS, Jonathan P. Butchar, PhD, Carolyn Cheney, Xiaokui Mo, PhD, David Jarjoura, PhD, Susheela Tridandapani, PhD, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD

Blood (2011) 118 (21): 3717.

https://doi.org/10.1182/blood.V118.21.3717.3717

Published: 2011

Journal Articles

Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,

Lapo Alinari, MD., Ph.D., Ryan B. Edwards, Courtney J. Prince, William H. Towns, Rajeswaran Mani, DVM, Amy Lehman, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Li Pan, PhD, A. Douglas Kinghorn, PhD, DSc, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D., David M. Lucas, PhD

Blood (2011) 118 (21): 3498.

https://doi.org/10.1182/blood.V118.21.3498.3498

Published: 2011

Journal Articles

Dinaciclib (SCH727965) Is a Novel Cyclin Dependent Kinase Inhibitor That Promotes Selective Apoptosis In CLL Cells and Abrogates the Protective Effects of Microenvironment Cytokines

Amy J. Johnson, PhD, Lisa L. Smith, Amy J. Wagner, Joshua Hessler, Joseph M. Flynn, DO, MPH, Jeffrey A. Jones, MD, MPH, Xiaoli Zhang, Amy Lehman, David Jarjoura, Michael R. Grever, M.D., Rajat Bannerji, MD, PHD, John C. Byrd, MD

Blood (2010) 116 (21): 971.

https://doi.org/10.1182/blood.V116.21.971.971

Published: 2010

Journal Articles

GlycoVariant Anti-CD37 Small Modular Immuno-Pharmaceutical Exhibits Superior Natural Killer Cell Mediated Cytotoxicity Against Chronic Lymphocytic Leukemia Cells at Low Concentrations and Low Antigen Density

Sarwish Rafiq, MA, Carolyn M Cheney, BS, Gerard Lozanski, MD, Rosa Lapalombella, PhD, Xiaokui Mo, PhD, Anthony Siadak, MD, David Jarjoura, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, PhD

Blood (2010) 116 (21): 1847.

https://doi.org/10.1182/blood.V116.21.1847.1847

Published: 2010

Journal Articles

Liposomal Targeted Delivery Overcomes Immunostimulatory Effects of Oligonucleotide Based Therapy In Chronic Lymphocytic Leukemia.

Bo Yu, Yicheng Mao, Li-Yuan Bai, Sarah E.M. Herman, Asha Ramanunni, Yan Jin, Xiaokui Mo, PhD, Carolyn Cheney, Kenneth K. Chan, PhD, David Jarjoura, Guido Marcucci, MD, Robert Lee, L.James Lee, John C. Byrd, MD, Natarajan Muthusamy, DVM, PhD

Blood (2010) 116 (21): 1475.

https://doi.org/10.1182/blood.V116.21.1475.1475

Published: 2010

Journal Articles

The Mll PTD and Flt3 ITD Double Knock-In Mouse Develops Acute Leukemia and Recapitulates Phenotypic, Molecular and Epigenetic Characteristics of the Counterpart Human Acute Myeloid Leukemia

Nicholas Zorko, Susan P. Whitman, PhD, Kelsie Bernot, PhD, Myntee T. Ngangana, Ronald Siebenaler, Shujun Liu, Ph.D., Yue-Zhong Wu, MS, Chidimma Kalu, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Zhiliang Xie, MD, Kenneth K. Chan, PhD, Adrienne M. Dorrance, PhD, Benjamin H. Lee, MD, PhD, Roger Briesewitz, PhD, Danilo Perrotti, MD, PhD, Guido Marcucci, MD, Michael A. Caligiuri, MD

Blood (2010) 116 (21): 150.

https://doi.org/10.1182/blood.V116.21.150.150

Published: 2010

Journal Articles

Micro-RNA and Gene Expression In CLL: Network Analysis Elucidating the Complex Role of the NF-κB Signaling Pathway In Disease.

Erin K Hertlein, PhD, Lianbo Yu, Jianying Zhang, Amy J. Johnson, PhD, David Lucas, PhD, Guido Marcucci, MD, David Jarjoura, John C. Byrd, MD

Blood (2010) 116 (21): 3642.

https://doi.org/10.1182/blood.V116.21.3642.3642

Published: 2010

Journal Articles

Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells

Erin Hertlein, Georgia Triantafillou, Ellen J. Sass, Joshua D. Hessler, Xiaoli Zhang, David Jarjoura, David M. Lucas, Natarajan Muthusamy, David M. Goldenberg, Robert J. Lee, John C. Byrd

Blood (2010) 116 (14): 2554–2558.

https://doi.org/10.1182/blood-2009-11-253203

Published: 2010

Includes: Supplemental data

Journal Articles

17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

Erin Hertlein, Amy J. Wagner, Jeffrey Jones, Thomas S. Lin, Kami J. Maddocks, William H. Towns, III, Virginia M. Goettl, Xiaoli Zhang, David Jarjoura, Chelsey A. Raymond, Derek A. West, Carlo M. Croce, John C. Byrd, Amy J. Johnson

Blood (2010) 116 (1): 45–53.

https://doi.org/10.1182/blood-2010-01-263756

Published: 2010

Includes: Supplemental data

Journal Articles

Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway

Blood (2010) 115 (13): 2619–2629.

https://doi.org/10.1182/blood-2009-09-242438

Published: 2010

Includes: Supplemental data

Journal Articles

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

Farrukh T. Awan, Rosa Lapalombella, Rossana Trotta, Jonathan P. Butchar, Bo Yu, Don M. Benson, Jr, Julie M. Roda, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Jones, Joseph Flynn, David Jarjoura, John R. Desjarlais, Susheela Tridandapani, Michael A. Caligiuri, Natarajan Muthusamy, John C. Byrd

Blood (2010) 115 (6): 1204–1213.

https://doi.org/10.1182/blood-2009-06-229039

Published: 2010

Journal Articles

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

Farrukh Awan, MD, MS, Rosa Lapalombella, PhD, Rossana Trotta, PhD, Jonathan P Butchar, Ph.D., Bo Yu, Don Benson, MD, PhD, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Alan Jones, MD, MPH, Joseph M Flynn, David Jarjoura, Robert A. Baiocchi, MD, PhD, John Desjarlais, Susheela Tridandapani, Ph.D., Michael A. Caligiuri, M.D., Natarajan Muthusamy, PhD, John C. Byrd

Blood (2009) 114 (22): 3725.

https://doi.org/10.1182/blood.V114.22.3725.3725

Published: 2009

Journal Articles

OSU-DY7, a Novel D -Tyrosinol Derivative, Mediates Cytotoxicity in Chronic Lymphocytic Leukemia and Lymphoblastic Lymphoma through p38 Mitogen-Activated Protein Kinase Pathway.

Li-Yuan Bai, MD, Yihui Ma, Samuel K Kulp, Shu-Huei Wang, PhD, Chang-Fang Chiu, MD, DMS, Frank Frissora, Xiaokui Mo, David Jarjoura, John C. Byrd, Ching-Shih Chen, Natarajan Muthusamy, DVM., PhD

Blood (2009) 114 (22): 3778.

https://doi.org/10.1182/blood.V114.22.3778.3778

Published: 2009

Journal Articles

TLR7/8 Differentially Regulates Fcγ Receptor Expression and Function.

Jonathan P Butchar, Ph.D., Payal Mehta, M.S., Steven E Justiniano, Ph.D., Kristan D Guenterberg, M.D., Thirumala-Devi Kanneganti, Ph.D., Amal Amer, M.D., Ph.D., Natarajan Muthusamy, Ph.D., David Jarjoura, Ph.D., Clay B Marsh, M.D., William E Carson, III, M.D., John C Byrd, M.D., Susheela Tridandapani, Ph.D.

Blood (2009) 114 (22): 3594.

https://doi.org/10.1182/blood.V114.22.3594.3594

Published: 2009

NARROW

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

A Transgenic Mouse Model of Aggressive B-Cell Malignancy for Evaluating Anti-Human CD37 Therapeutics

The Hsp90 Inhibitor 17-DMAG Increases SOCS3 and Regulates Cytokine Production, Migration and Cell Death in Chronic Lymphocytic Leukemia

Aberrant Epigenetic Suppression of the Ptprot Gene Encoding a Protein Tyrosine Phosphatase Targeting KIT in Acute Myeloid Leukemia

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,

Dinaciclib (SCH727965) Is a Novel Cyclin Dependent Kinase Inhibitor That Promotes Selective Apoptosis In CLL Cells and Abrogates the Protective Effects of Microenvironment Cytokines

GlycoVariant Anti-CD37 Small Modular Immuno-Pharmaceutical Exhibits Superior Natural Killer Cell Mediated Cytotoxicity Against Chronic Lymphocytic Leukemia Cells at Low Concentrations and Low Antigen Density

Liposomal Targeted Delivery Overcomes Immunostimulatory Effects of Oligonucleotide Based Therapy In Chronic Lymphocytic Leukemia.

The Mll PTD and Flt3 ITD Double Knock-In Mouse Develops Acute Leukemia and Recapitulates Phenotypic, Molecular and Epigenetic Characteristics of the Counterpart Human Acute Myeloid Leukemia

Micro-RNA and Gene Expression In CLL: Network Analysis Elucidating the Complex Role of the NF-κB Signaling Pathway In Disease.

Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells

17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

OSU-DY7, a Novel D -Tyrosinol Derivative, Mediates Cytotoxicity in Chronic Lymphocytic Leukemia and Lymphoblastic Lymphoma through p38 Mitogen-Activated Protein Kinase Pathway.

TLR7/8 Differentially Regulates Fcγ Receptor Expression and Function.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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