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Journal Articles

To Catch a Killer: Delineating the Mechanistic Role of Siglec-6, a Novel Glycoprotein Target, for the Treatment of Chronic Lymphocytic Leukemia

Jessica Nunes, Ann Ventura, Kevan Zapolnik, Xiaokui Mo, Liwen Zhang, John C. Byrd, Christoph Rader, Natarajan Muthusamy
Journal: Blood
Blood (2022) 140 (Supplement 1): 9836–9837.
https://doi.org/10.1182/blood-2022-171078
Published: 2022
Journal Articles

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi-Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo-Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy
Journal: Blood
Blood (2022) 139 (9): 1340–1358.
https://doi.org/10.1182/blood.2020010344
Published: 2022
Includes: Supplemental data
Journal Articles

Defining the Biochemical Role of Sialic Acid-Binding Immunoglobulin-like Lectin-6 in Adhesion and Migration in Chronic Lymphocytic Leukemia

Jessica Nunes, Ann Ventura, Kevan Zapolnik, Eileen Hu, Liwen Zhang, Xiaokui Mo, John C. Byrd, Christoph Rader, Raj Muthusamy
Journal: Blood
Blood (2021) 138 (Supplement 1): 2623.
https://doi.org/10.1182/blood-2021-152477
Published: 2021
Journal Articles

Protein Phosphatase 2A Activation Dependent Down Regulation of PGC1-Alpha and FOXO1 Phosphorylation with OSU-2S in Human Lymphoma Cells

Sohaila Mohamed Khalil, Swagata Goswami, MSc, Xiaokui Mo, PhD MAS, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3977.
https://doi.org/10.1182/blood-2019-129224
Published: 2019
Journal Articles

IL-21-Expanded Natural Killer Cells As Autologous Cell Therapy for CLL

Max Yano, Jennie Rachel Lance, Xiaokui Mo, PhD MAS, Dean Anthony Lee, MD PhD, Natarajan Muthusamy, DVM,PhD, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4302.
https://doi.org/10.1182/blood-2019-127620
Published: 2019
Journal Articles

IL-21-Expanded NK Cells As Autologous Cell Therapy for CLL

Jennie Rachel Lance, Max Yano, Xiaokui Mo, PhD MAS, Dean Anthony Lee, MD PhD, Natarajan Muthusamy, DVM,PhD, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4303.
https://doi.org/10.1182/blood-2019-131034
Published: 2019
Journal Articles

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM,PhD, Xiaokui Mo, PhD MAS, Pearlly S. Yan, PhD, Michael B Broe, PhD, Ralf Bundschuh, PhD, Larry State Beaver, Kevan Zapolnik, BS, Zhiliang Xie, Donna Bucci, David M. Lucas, PhD, Allison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B. Klisovic, MD, Ching-Shih Chen, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MDMBBS, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1247.
https://doi.org/10.1182/blood.V130.Suppl_1.1247.1247
Published: 2017
Journal Articles

Par-4 Overexpression Impedes Leukemogenesis in the Eµ-TCL1 Leukemia Model

Joseph Thomas Greene, BS, Rahul Ramaswamy, Mary K McKenna, BS, Rajeswaran Mani, DVM,PhD, Frank Frissora, MS, Ronni Wasmuth, BS, Minh Tran, BS, Xiaokui Mo, PhD MAS, Carlo M. Croce, MD, Vivek Rangnekar, PhD, John C. Byrd, MD, Subbarao Bondada, PhD, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1223.
https://doi.org/10.1182/blood.V130.Suppl_1.1223.1223
Published: 2017
Journal Articles

Leukemic Cell Expressed CTLA-4 Suppresses T Cells Via Down-Modulation of CD80 By Trans-Endocytosis

Priscilla Do, BS, Kyle A. Beckwith, PhD, Larry Beaver, Brittany G. Griffin, Xiaokui Mo, PhD MAS, Jeffrey Jones, MD MPH, Erin K. Hertlein, PhD, Natarajan Muthusamy, DVM, PhD, John C. Byrd, MD
Journal: Blood
Blood (2016) 128 (22): 3221.
https://doi.org/10.1182/blood.V128.22.3221.3221
Published: 2016
Journal Articles

SL-401 Mediates Potent Cytotoxicity Against CD123+ AML and MDS with Excess Blasts and Demonstrates Therapeutic Benefit in PDX Model

Rajeswaran Mani, DVM PhD, Swagata Goswami, MS, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, PhD MAS, Amber Gordon, MLS, Donna Bucci, David Lucas, PhD, Christopher L. Brooks, PhD, Alison R. Walker, MD MPH, William Blum, MD, John C. Byrd, MD, Gerard Lozanski, MD, Sumithra Vasu, MBBS, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2016) 128 (22): 580.
https://doi.org/10.1182/blood.V128.22.580.580
Published: 2016
Journal Articles

CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM PhD, Chi-Ling Chiang, MS, Frank W Frissora, M.S., Xiaokui Mo, PhD MAS, Zhiliang Xie, Donna Bucci, Amber Gordon, MLS, David M. Lucas, PhD, William Blum, MD, Alison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B Klisovic, MD, Ching-Shih Chen, PhD, Robert J Lee, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MBBS, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2016) 128 (22): 2748.
https://doi.org/10.1182/blood.V128.22.2748.2748
Published: 2016
Journal Articles

BI 836826, a Novel Fc-Engineered Antibody in Combination with Phosphoinositide-3-Kinase Inhibitor for Treatment of High Risk Chronic Lymphocytic Leukemia and Lymphoma

Deborah M Stephens, DO, Kyle A. Beckwith, PhD, Priscilla Do, BS, Carolyn Cheney, BS, Xiaokui Mo, PhD MAS, Karilyn Larkin, MD, Jeffrey Jones, MD MPH, Farrukh T. Awan, Laura Grosmaire, PhD, Randy Jones, PhD, Julie DiPaolo, PhD, Stacey Tannheimer, Karl-Heinz Heider, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2016) 128 (22): 2767.
https://doi.org/10.1182/blood.V128.22.2767.2767
Published: 2016
Journal Articles

Decitabine enhances anti-CD33 monoclonal antibody BI 836858–mediated natural killer ADCC against AML blasts

Sumithira Vasu, Shun He, Carolyn Cheney, Bhavani Gopalakrishnan, Rajeswaran Mani, Gerard Lozanski, Xiaokui Mo, Veronica Groh, Susan P. Whitman, Renate Konopitzky, Christian Kössl, Donna Bucci, David M. Lucas, Jianhua Yu, Michael A. Caligiuri, William Blum, Paul J. Adam, Eric Borges, Bjoern Rueter, Karl-Heinz Heider, Guido Marcucci, Natarajan Muthusamy
Journal: Blood
Blood (2016) 127 (23): 2879–2889.
https://doi.org/10.1182/blood-2015-11-680546
Published: 2016
Includes: Supplemental data
Journal Articles

Effects of the Btk Inhibitor Ibrutinib on Monocyte Responses to Antibodies

Li Ren, Amanda Campbell, Shalini Gautam, Huiqing Fang, Kavin Fatehchand, Andrew Stiff, Payal Mehta, Xiaokui Mo, PhD MAS, Xuexun Fang, John C. Byrd, MD, William Carson, Jonathan P. Butchar, PhD, Susheela Tridandapani, PhD
Journal: Blood
Blood (2015) 126 (23): 1017.
https://doi.org/10.1182/blood.V126.23.1017.1017
Published: 2015
Journal Articles

BI 836826, a Novel Fc-Engineered Antibody in Combination with Phosphoinositide-3-Kinase Inhibitor for Treatment of High Risk Chronic Lymphocytic Leukemia

Deborah M Stephens, DO, Kyle A Beckwith, B.S., Carolyn Cheney, B.S, Xiaokui Mo, PhD MAS, Joseph M Flynn, D.O., MPH, Jeffrey A. Jones, MD, Kami J. Maddocks, MD, Karl-Heinz Heider, PhD, Natarajan Muthusamy, DVM, PhD, John C. Byrd, MD
Journal: Blood
Blood (2014) 124 (21): 4681.
https://doi.org/10.1182/blood.V124.21.4681.4681
Published: 2014
Journal Articles

Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia

Rajeswaran Mani, DVM, Yicheng Mao, PhD, Frank W Frissora, M.S., Chi-ling Chiang, Jiang Wang, Yuan Zhao, Yun Wu, Bo Yu, Ph.D., Ribai Yan, Xiaokui Mo, PhD, Sivasubramanian Baskar, PhD, Christoph Rader, Ph.D., Mitch A. Phelps, PhD, Robert J. Lee, Ph.D, Ching-Shih Chen, PhD, James Lee, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D
Journal: Blood
Blood (2013) 122 (21): 4168.
https://doi.org/10.1182/blood.V122.21.4168.4168
Published: 2013
Journal Articles

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

Bo Yu, Yicheng Mao, Li-Yuan Bai, Sarah E. M. Herman, Xinmei Wang, Asha Ramanunni, Yan Jin, Xiaokui Mo, Carolyn Cheney, Kenneth K. Chan, David Jarjoura, Guido Marcucci, Robert J. Lee, John C. Byrd, L. James Lee, Natarajan Muthusamy
Journal: Blood
Blood (2013) 121 (1): 136–147.
https://doi.org/10.1182/blood-2012-01-407742
Published: 2013
Includes: Supplemental data
Journal Articles

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Rosa Lapalombella, Qingxiang Sun, Katie Williams, Larissa Tangeman, Shruti Jha, Yiming Zhong, Virginia Goettl, Emilia Mahoney, Caroline Berglund, Sneha Gupta, Alicia Farmer, Rajeswaran Mani, Amy J. Johnson, David Lucas, Xiaokui Mo, Dirk Daelemans, Vincent Sandanayaka, Sharon Shechter, Dilara McCauley, Sharon Shacham, Michael Kauffman, Yuh Min Chook, John C. Byrd
Journal: Blood
Blood (2012) 120 (23): 4621–4634.
https://doi.org/10.1182/blood-2012-05-429506
Published: 2012
Includes: Supplemental data
Journal Articles

A Transgenic Mouse Model of Aggressive B-Cell Malignancy for Evaluating Anti-Human CD37 Therapeutics

Kyle A Beckwith, B.S., Frank W Frissora, M.S., Matthew R Stefanovski, B.S., Jutta Deckert, Ph.D., Carlo M Croce, M.D., Xiaokui Mo, PhD, David Jarjoura, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D
Journal: Blood
Blood (2012) 120 (21): 188.
https://doi.org/10.1182/blood.V120.21.188.188
Published: 2012
Journal Articles

Aberrant Epigenetic Suppression of the Ptprot Gene Encoding a Protein Tyrosine Phosphatase Targeting KIT in Acute Myeloid Leukemia

Tasneem Motiwala, PhD, Satavisha Roy, Shujun Liu, Ph.D, Sebastian Schwind, MD, Rainer Claus, MD, Xiaokui Mo, PhD, Ramiro Garzon, MD, Hartmut Dohner, MD, Konstanze Dohner, MD, PhD, David Jarjoura, PhD, Christoph Plass, PhD, Guido Marcucci, MD, Samson T. Jacob, PhD
Journal: Blood
Blood (2012) 120 (21): 1322.
https://doi.org/10.1182/blood.V120.21.1322.1322
Published: 2012