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Yiming Zhong
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Journal Articles

Cancer Predisposition Genetic Testing Among Children with Hematologic Malignancies

Haley Newman, Mary Egan Clark, Suzanne P MacFarland, Garrett M. Brodeur, Stephen P Hunger, Timothy S Olson, Jinhua Wu, Jeffrey Schubert, Netta Golenberg, Maha Patel, Elizabeth Denenberg, Elizabeth Fanning, Jiani Chen, Tamara Luke, Daniel Gallo, Kajia Cao, Weixian Fu, Zhiqian Fan, Minjie Luo, Lea Surrey, Gerald Wertheim, Marilyn M. Li, Yiming Zhong
Journal: Blood
Blood (2023) 142 (Supplement 1): 1458.
https://doi.org/10.1182/blood-2023-180008
Published: 2023
Journal Articles

Dissecting the Knowns for the Unknowns: Refining the Classification of Genomic Variations in Hematological Diseases By the Clingen Hematological Cancer Taskforce (HCT)

Yuwen Li, Jason Saliba, Nathan Kopp, Coumarane Mani, Heather E Williams, Wenying Zhang, Jianhua Zhao, Kilannin Krysiak, Arpad Danos, Xiangqiang Shao, Rong He, Panieh Terraf, Nikita N Mehta, Shivani Golem, Jie Liu, Destiney Allen, Chimene Kesserwan, Hagop Kantarjian, Torsten Haferlach, Piers Blombery, Madhu M Ouseph, Ella Thompson, Yiming Zhong, Xiaonan Zhao, Yasmina Jaufeerally Fakim, Sheeja T Pullarkat, Obi L. Griffith, Malachi Griffith, Rashmi Kanagal-Shamanna, Xinjie Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 11810–11811.
https://doi.org/10.1182/blood-2022-170989
Published: 2022
Journal Articles

Expert Curation of Somatic FLT3 Variants By the Clingen Somatic Hematologic Cancer Taskforce (ClinGen HCT)

Xiangqiang Shao, Shruti Rao, Coumarane Mani, Jason Saliba, Rong He, Chimene Kesserwan, Arpad Danos, Lana Sheta, Panieh Terraf, Gordana Raca, Heather Williams, Piers Blombery, David S Viswanatha, Celeste Eno, Nan Jiang, Kevin C Vavra, Liying Zhang, Zonggao Shi, Peng Li, Yuwen Li, Madhu Michael Ouseph, Ella R Thompson, Yiming Zhong, Kilannin Krysiak, Alex Wagner, Matthew McCoy, Mariam T Matthew, Kristin Deeb, Fengli Zhang, Jie Liu, Xiaonan Zhao, Alejandro Ferrer, Nathan Kopp, Wenying Zhang, Santhi Pondugula, Yasmina Jaufeerally Fakim, David Wu, Sheeja T Pullarkat, Shashikant Kulkarni, Subha Madhavan, Obi L. Griffith, Malachi Griffith, Rashmi Kanagal-Shamanna, Xinjie Xu
Journal: Blood
Blood (2021) 138 (Supplement 1): 4387.
https://doi.org/10.1182/blood-2021-153546
Published: 2021
Journal Articles

Expert Curation of Somatic Variants in Hematological Malignancies By the Clingen Somatic Hematological Cancer Taskforce (ClinGen HCT)

Rashmi Kanagal-Shamanna, MD, Shruti Rao, MS, MBA, Panieh Terraf, PhD, Gordana Raca, MD PhD, Jason Saliba, PhD, Arpad Danos, PhD, Coumarane Mani, PhD, Heather Williams, PhD, Nan Jiang, PhD, Kevin C Vavra, PhD, Liying Zhang, MD PhD, Zonggao Shi, PhD, Peng Li, MD PhD, Yuwen Li, MD PhD, Madhu Michael Ouseph, MD PhD, Ella R Thompson, PhD BSc, Yiming Zhong, PhD, Nicole Hinceman, PhD, Rong He, MD, Kilannin Krysiak, PhD, Alex Wagner, PhD, Matthew McCoy, PhD, Mariam T Matthew, PhD, Kristin Deeb, PhD, Fengli Zhang, PhD, Jie Liu, PhD, David S. Viswanatha, MD, Piers Blombery, MBBS, David Wu, MD PhD, Shashikant Kulkarni, MS, PhD FACMG, Subha Madhavan, PhD, Xinjie Xu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23.
https://doi.org/10.1182/blood-2020-143028
Published: 2020
Journal Articles

Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

Ta-Ming Liu, Jennifer A. Woyach, Yiming Zhong, Arletta Lozanski, Gerard Lozanski, Shuai Dong, Ethan Strattan, Amy Lehman, Xiaoli Zhang, Jeffrey A. Jones, Joseph Flynn, Leslie A. Andritsos, Kami Maddocks, Samantha M. Jaglowski, Kristie A. Blum, John C. Byrd, Jason A. Dubovsky, Amy J. Johnson
Journal: Blood
Blood (2015) 126 (1): 61–68.
https://doi.org/10.1182/blood-2015-02-626846
Published: 2015
Includes: Supplemental data
Journal Articles

Pharmacologic Inhibition with Duvelisib (IPI-145) and Genetic Inhibition of PI3K p110δ Antagonizes Intrinsic and Extrinsic Survival Signals in Chronic Lymphocytic Leukemia (CLL)

Shuai Dong, MS, Daphne Guinn, Jason A Dubovsky, PhD, Yiming Zhong, PhD, Amy Lehman, Jeff Kutok, MD, PhD, Jennifer A. Woyach, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Journal: Blood
Blood (2014) 124 (21): 3324.
https://doi.org/10.1182/blood.V124.21.3324.3324
Published: 2014
Journal Articles

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

Yiming Zhong, PhD, Shuai Dong, MS, Kelsey Thornton, Anjali Mishra, PhD, Pierluigi Porcu, MD, Michael Bradshaw, Angelina Bisconte, Timothy Owens, Erik Verner, Ken Brameld, Jens Oliver Funk, MD, Ronald Hill, Amy J. Johnson, PhD, Jason A Dubovsky, PhD
Journal: Blood
Blood (2014) 124 (21): 272.
https://doi.org/10.1182/blood.V124.21.272.272
Published: 2014
Journal Articles

IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

Brief Report
Shuai Dong, Daphne Guinn, Jason A. Dubovsky, Yiming Zhong, Amy Lehman, Jeffery Kutok, Jennifer A. Woyach, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2014) 124 (24): 3583–3586.
https://doi.org/10.1182/blood-2014-07-587279
Published: 2014
Includes: Supplemental data
Journal Articles

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL

Dalia El-Gamal, Katie Williams, Taylor D. LaFollette, Matthew Cannon, James S. Blachly, Yiming Zhong, Jennifer A. Woyach, Erich Williams, Farrukh T. Awan, Jeffrey Jones, Leslie Andritsos, Kami Maddocks, Chia-Hsien Wu, Ching-Shih Chen, Amy Lehman, Xiaoli Zhang, Rosa Lapalombella, John C. Byrd
Journal: Blood
Blood (2014) 124 (9): 1481–1491.
https://doi.org/10.1182/blood-2014-05-574830
Published: 2014
Includes: Supplemental data
Journal Articles

Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy

Clinical Trials & Observations
Jennifer A. Woyach, Kelly Smucker, Lisa L. Smith, Arletta Lozanski, Yiming Zhong, Amy S. Ruppert, David Lucas, Katie Williams, Weiqiang Zhao, Laura Rassenti, Emanuela Ghia, Thomas J. Kipps, Rose Mantel, Jeffrey Jones, Joseph Flynn, Kami Maddocks, Susan O’Brien, Richard R. Furman, Danelle F. James, Fong Clow, Gerard Lozanski, Amy J. Johnson, John C. Byrd
Journal: Blood
Blood (2014) 123 (12): 1810–1817.
https://doi.org/10.1182/blood-2013-09-527853
Published: 2014
Includes: Supplemental data
Journal Articles

PKC Inhibitor AEB071 Demonstrates Pre-Clinical Activity In Chronic Lymphocytic Leukemia

Dalia ElGamal, PhD, Yiming Zhong, PhD, Katie Williams, MS, Chia-Hsien Wu, Ching-Shih Chen, PhD, Rosa Lapalombella, PhD, John C. Byrd, MD
Journal: Blood
Blood (2013) 122 (21): 4187.
https://doi.org/10.1182/blood.V122.21.4187.4187
Published: 2013
Journal Articles

IRF4 −/− Vh11 mice: a novel mouse model of CLL

Yiming Zhong, John C. Byrd
Journal: Blood
Blood (2013) 122 (16): 2769–2770.
https://doi.org/10.1182/blood-2013-08-521120
Published: 2013
Journal Articles

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

Jason A. Dubovsky, Kyle A. Beckwith, Gayathri Natarajan, Jennifer A. Woyach, Samantha Jaglowski, Yiming Zhong, Joshua D. Hessler, Ta-Ming Liu, Betty Y. Chang, Karilyn M. Larkin, Matthew R. Stefanovski, Danielle L. Chappell, Frank W. Frissora, Lisa L. Smith, Kelly A. Smucker, Joseph M. Flynn, Jeffrey A. Jones, Leslie A. Andritsos, Kami Maddocks, Amy M. Lehman, Richard Furman, Jeff Sharman, Anjali Mishra, Michael A. Caligiuri, Abhay R. Satoskar, Joseph J. Buggy, Natarajan Muthusamy, Amy J. Johnson, John C. Byrd
Journal: Blood
Blood (2013) 122 (15): 2539–2549.
https://doi.org/10.1182/blood-2013-06-507947
Published: 2013
Includes: Supplemental data
Journal Articles

UGT2B17 as a disease accelerator in CLL

Yiming Zhong, John C. Byrd
Journal: Blood
Blood (2013) 121 (7): 1067–1068.
https://doi.org/10.1182/blood-2012-12-469965
Published: 2013
Journal Articles

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Rosa Lapalombella, Qingxiang Sun, Katie Williams, Larissa Tangeman, Shruti Jha, Yiming Zhong, Virginia Goettl, Emilia Mahoney, Caroline Berglund, Sneha Gupta, Alicia Farmer, Rajeswaran Mani, Amy J. Johnson, David Lucas, Xiaokui Mo, Dirk Daelemans, Vincent Sandanayaka, Sharon Shechter, Dilara McCauley, Sharon Shacham, Michael Kauffman, Yuh Min Chook, John C. Byrd
Journal: Blood
Blood (2012) 120 (23): 4621–4634.
https://doi.org/10.1182/blood-2012-05-429506
Published: 2012
Includes: Supplemental data
Journal Articles

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

Tasneem Motiwala, Nicola Zanesi, Jharna Datta, Satavisha Roy, Huban Kutay, Allyn M. Checovich, Mohamed Kaou, Yiming Zhong, Amy J. Johnson, David M. Lucas, Nyla A. Heerema, John Hagan, Xiaokui Mo, David Jarjoura, John C. Byrd, Carlo M. Croce, Samson T. Jacob
Journal: Blood
Blood (2011) 118 (23): 6132–6140.
https://doi.org/10.1182/blood-2011-01-323147
Published: 2011
Includes: Supplemental data