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Journal Articles

Activation of the MAPK pathway mediates resistance to PI3K inhibitors in chronic lymphocytic leukemia

Ishwarya Murali, Siddha Kasar, Aishath Naeem, Svitlana Tyekucheva, Jasneet K. Khalsa, Emily M. Thrash, Gilad Itchaki, Dimitri Livitz, Ignaty Leshchiner, Shuai Dong, Stacey M. Fernandes, Gad Getz, Amy Johnson, Jennifer R. Brown
Journal: Blood
Blood (2021) 138 (1): 44–56.
https://doi.org/10.1182/blood.2020006765
Published: 2021
Includes: Supplemental data
Journal Articles

Activating MAPK Pathway Mutations Mediate Primary Resistance to PI3K Inhibitors in Chronic Lymphocytic Leukemia (CLL)

Ishwarya Murali, PhD BS, Siddha Kasar, PhD, Emily M. McWilliams, PhD, Gilad Itchaki, Svitlana Tyekucheva, PhD, Dimitri Livitz, BS, Ignaty Leshchiner, PhD, Shuai Dong, PhD, Stacey M. Fernandes, BS, Gad Getz, PhD, Amy J. Johnson, PhD, Jennifer R. Brown, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 587.
https://doi.org/10.1182/blood-2018-99-115304
Published: 2018
Journal Articles

Genetic Inhibition of PI3K p110delta Antagonizes Survival Signals and Induces Immune Activation in Chronic Lymphocytic Leukemia (CLL)

Shuai Dong, MS, John C. Byrd, MD, Amy J. Johnson, PhD
Journal: Blood
Blood (2015) 126 (23): 1711.
https://doi.org/10.1182/blood.V126.23.1711.1711
Published: 2015
Journal Articles

Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

Ta-Ming Liu, Jennifer A. Woyach, Yiming Zhong, Arletta Lozanski, Gerard Lozanski, Shuai Dong, Ethan Strattan, Amy Lehman, Xiaoli Zhang, Jeffrey A. Jones, Joseph Flynn, Leslie A. Andritsos, Kami Maddocks, Samantha M. Jaglowski, Kristie A. Blum, John C. Byrd, Jason A. Dubovsky, Amy J. Johnson
Journal: Blood
Blood (2015) 126 (1): 61–68.
https://doi.org/10.1182/blood-2015-02-626846
Published: 2015
Includes: Supplemental data
Journal Articles

Pharmacologic Inhibition with Duvelisib (IPI-145) and Genetic Inhibition of PI3K p110δ Antagonizes Intrinsic and Extrinsic Survival Signals in Chronic Lymphocytic Leukemia (CLL)

Shuai Dong, MS, Daphne Guinn, Jason A Dubovsky, PhD, Yiming Zhong, PhD, Amy Lehman, Jeff Kutok, MD, PhD, Jennifer A. Woyach, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Journal: Blood
Blood (2014) 124 (21): 3324.
https://doi.org/10.1182/blood.V124.21.3324.3324
Published: 2014
Journal Articles

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

Yiming Zhong, PhD, Shuai Dong, MS, Kelsey Thornton, Anjali Mishra, PhD, Pierluigi Porcu, MD, Michael Bradshaw, Angelina Bisconte, Timothy Owens, Erik Verner, Ken Brameld, Jens Oliver Funk, MD, Ronald Hill, Amy J. Johnson, PhD, Jason A Dubovsky, PhD
Journal: Blood
Blood (2014) 124 (21): 272.
https://doi.org/10.1182/blood.V124.21.272.272
Published: 2014
Journal Articles

IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

Brief Report
Shuai Dong, Daphne Guinn, Jason A. Dubovsky, Yiming Zhong, Amy Lehman, Jeffery Kutok, Jennifer A. Woyach, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2014) 124 (24): 3583–3586.
https://doi.org/10.1182/blood-2014-07-587279
Published: 2014
Includes: Supplemental data