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Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD + Acute Myeloid Leukemia

Steven Sher, Pu Zhang, Lindsey Brinton, Mehdi Gharghabi, Katie Williams, Matthew Cannon, Janek S. Walker, Daniel Canfield, Larry Beaver, Casey B. Cempre, Hannah Phillips, Xuyong Chen, Pearlly S. Yan, Amy M. Lehman, Peggy Scherle, Min Wang, Kris Vaddi, Robert A. Baiocchi, Ruoning Wang, Deepa Sampath, Lapo Alinari, James S. Blachly, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 681–682.
https://doi.org/10.1182/blood-2022-165573
Published: 2022
Journal Articles

NAMPT Inhibitor KPT-9274 Selectively Targets Self-Renewal Capacity in Acute Myeloid Leukemia

Shaneice Renee Mitchell, BS, Nicole Grieselhuber, MD PhD, Yerdanos Asemelash, Matthew Cannon, BA, Shelley Orwick, BS, Pratibha Sharma, PhD, Virginia Goettl, DVM, PhD, Vinay K Puduvalli, MD MBBS, Deepa Sampath, PhD, Alice S. Mims, MD, James S. Blachly, MD, Amy M. Lehman, PhD, Bonnie K. Harrington, DVM, Justin Breitbach, Erkan Baloglu, William Senapedis, PhD, Rosa Lapalombella, PhD, John C. Byrd, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3931.
https://doi.org/10.1182/blood-2018-99-119358
Published: 2018
Journal Articles

High-Throughput Mirna Analysis Suggests Pro-Inflammatory Profile in Sickle Cell Disease

Matthew Cannon, BA, Sarah Glass, Sidney Smith, Melanie Heinlein, Rosa Lapalombella, PhD, Payal C Desai, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1077.
https://doi.org/10.1182/blood-2018-99-110812
Published: 2018
Journal Articles

In Vitro and In Vivo Anti-Leukemic Effects of KPT-9274, a Reported PAK4 Allosteric Modulator, in Acute Myeloid Leukemia: Promising Results Justifying Further Development in This Disease

Shaneice Mitchell, BS, Shelley Orwick, BS, Matthew Cannon, BS, Virginia M. Goettl, DVM , PhD, Taylor D. LaFollette, Erkan Baloglu, PhD, William Senapedis, PhD, Alison R. Walker, MD, Bhavana Bhatnagar, Alice S. Mims, MD, Rebecca B. Klisovic, MD, Sumithira Vasu, MBBS, William Blum, MD, David M. Lucas, PhD, James S. Blachly, MD, Ramiro Garzon, MD, Clara D. Bloomfield, MD, Rosa Lapalombella, PhD, John C. Byrd, MD
Journal: Blood
Blood (2015) 126 (23): 2471.
https://doi.org/10.1182/blood.V126.23.2471.2471
Published: 2015
Journal Articles

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL

Dalia El-Gamal, Katie Williams, Taylor D. LaFollette, Matthew Cannon, James S. Blachly, Yiming Zhong, Jennifer A. Woyach, Erich Williams, Farrukh T. Awan, Jeffrey Jones, Leslie Andritsos, Kami Maddocks, Chia-Hsien Wu, Ching-Shih Chen, Amy Lehman, Xiaoli Zhang, Rosa Lapalombella, John C. Byrd
Journal: Blood
Blood (2014) 124 (9): 1481–1491.
https://doi.org/10.1182/blood-2014-05-574830
Published: 2014
Includes: Supplemental data
Journal Articles

Targeting The PRMT5 Enzyme To Induce γ -Globin Gene Derepression In Sickle Cell Anemia

Necrisha Roach, MSc., Matthew Cannon, Dalia El-Gamal, PhD, Payal C Desai, MD, Eric H. Kraut, MD, James E. Bradner, M.D., Rosa Lapalombella, PhD, Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1007.
https://doi.org/10.1182/blood.V122.21.1007.1007
Published: 2013