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Erin Hertlein
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Journal Articles

Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy

Erin Hertlein, Chad Bennett, Ola A Elgamal, Sandip Vibhute, Sharyn Baker, Thomas E Goodwin, Don M. Benson, Jr., Christopher Coss, Jeffrey Patrick, Gerald Hilinski, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 10695–10696.
https://doi.org/10.1182/blood-2022-167671
Published: 2022
Journal Articles

Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia

Ola A Elgamal, Sandip Vibhute, Blaise Stearns, Susheela Tridandapani, Thomas E Goodwin, Gerard Hilinski, Chad Bennett, Jeffrey Patrick, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 3322–3323.
https://doi.org/10.1182/blood-2022-165611
Published: 2022
Journal Articles

Elucidating the Mechanism of Action (MOA) of Navtemadlin, an MDM2 Inhibitor, and Its Synergy with Gilteritinib in Myeloid Malignancies

Sara Elgamal, Tracy Clevenger, Michael Gulrajani, Jean Cheung, Erin G. Jeremy, Sydney Fobare, Shelley Orwick, Ellen J. Sass, Erin Hertlein, Karilyn T. Larkin, Todd Covey, Wayne P. Rothbaum, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 5936–5938.
https://doi.org/10.1182/blood-2022-159568
Published: 2022
Journal Articles

Age and Sex Differences in the Eμ-TCL1 Adoptive Transfer Mouse Model of CLL

Chia Sharpe, Elizabeth Perry, Erin Hertlein, Natarajan Muthusamy, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 12367–12368.
https://doi.org/10.1182/blood-2022-162900
Published: 2022
Journal Articles

A Novel Inhibitor of FLT3 and Its Drug-Resistant Mutants with Superior Activity to Gilteritinib in Molm-13 Preclinical Acute Myeloid Leukemia Xenograft Model

Ola A Elgamal, James R Lerma, Allison Mullaney, Emily Stahl, Blaise Stearns, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Oleg Mitkin, Ruben Karapetian, Alexei Riakhovskii, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Sharyn Baker, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 3352–3353.
https://doi.org/10.1182/blood-2022-165675
Published: 2022
Journal Articles

A Novel Ptpn11 E76K / Npm1 cA Murine Model of AML Identifies a Unique Immune Population Relevant to Human Disease

Sydney Fobare, Chia Sharpe, Carolyn Cheney, Allison Mullaney, Casie Furby, Marissa Long, Jean Truxall, Megan Johnstone, Ann-Kathrin Eisfeld, John C. Byrd, Erin Hertlein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5831–5832.
https://doi.org/10.1182/blood-2022-160093
Published: 2022
Journal Articles

Identification of PTPN11 mutations As Early Events in the Development of Acute Myeloid Leukemia

Sydney Fobare, Shelley Orwick, Jessica Kohlschmidt, Tom Sesterhenn, Krzysztof Mrózek, Ben Wronowski, Megan Johnstone, Andrew J. Carroll, Richard M. Stone, Eunice S. Wang, Jonathan E. Kolitz, Bayard L. Powell, John P Perentesis, Ann-Kathrin Eisfeld, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 743–744.
https://doi.org/10.1182/blood-2022-160323
Published: 2022
Journal Articles

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi-Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo-Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy
Journal: Blood
Blood (2022) 139 (9): 1340–1358.
https://doi.org/10.1182/blood.2020010344
Published: 2022
Includes: Supplemental data
Journal Articles

Clinical and Prognostic Implications of PTPN11 Mutations in Acute Myeloid Leukemia (Alliance)

Sydney Fobare, Jessica Kohlschmidt, PhD, Hatice Gulcin Ozer, PhD, Krzysztof Mrózek, MDPhD, Deedra Nicolet, MS, Alice S. Mims, MD, Ramiro Garzon, MD, James S. Blachly, MD, Shelley Orwick, BS, Andrew J Carroll, PhD, Richard M. Stone, MD, Eunice S. Wang, MD, Jonathan E. Kolitz, MD, Bayard L. Powell, MD, Christopher C. Oakes, PhD, Ann-Kathrin Eisfeld, MD, Erin Hertlein, PhD, John C. Byrd, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-135887
Published: 2020
Journal Articles

NF-κB p50 ( nfkb1 ) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia

Timothy L. Chen, Minh Tran, Aparna Lakshmanan, Bonnie K. Harrington, Nikhil Gupta, Virginia M. Goettl, Amy M. Lehman, Stephen Trudeau, David M. Lucas, Amy J. Johnson, John C. Byrd, Erin Hertlein
Journal: Blood
Blood (2017) 130 (3): 376–379.
https://doi.org/10.1182/blood-2017-01-761130
Published: 2017
Includes: Supplemental data
Journal Articles

OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells

Ta-Ming Liu, Yonghua Ling, Jennifer A. Woyach, Kyle Beckwith, Yuh-Ying Yeh, Erin Hertlein, Xiaoli Zhang, Amy Lehman, Farrukh Awan, Jeffrey A. Jones, Leslie A. Andritsos, Kami Maddocks, Jessica MacMurray, Santosh B. Salunke, Ching-Shih Chen, Mitch A. Phelps, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2015) 125 (2): 284–295.
https://doi.org/10.1182/blood-2014-06-583518
Published: 2015
Includes: Supplemental data
Journal Articles

A FOXy target in B-cell survival

Erin Hertlein
Journal: Blood
Blood (2014) 124 (23): 3340–3341.
https://doi.org/10.1182/blood-2014-10-605014
Published: 2014
Journal Articles

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

Sarah E. M. Herman, Amber L. Gordon, Erin Hertlein, Asha Ramanunni, Xiaoli Zhang, Samantha Jaglowski, Joseph Flynn, Jeffrey Jones, Kristie A. Blum, Joseph J. Buggy, Ahmed Hamdy, Amy J. Johnson, John C. Byrd
Journal: Blood
Blood (2011) 117 (23): 6287–6296.
https://doi.org/10.1182/blood-2011-01-328484
Published: 2011
Journal Articles

Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma

Lapo Alinari, Bo Yu, Beth A. Christian, Fengting Yan, Jungook Shin, Rosa Lapalombella, Erin Hertlein, Mark E. Lustberg, Carl Quinion, Xiaoli Zhang, Gerard Lozanski, Natarajan Muthusamy, Mette Prætorius-Ibba, Owen A. O'Connor, David M. Goldenberg, John C. Byrd, Kristie A. Blum, Robert A. Baiocchi
Journal: Blood
Blood (2011) 117 (17): 4530–4541.
https://doi.org/10.1182/blood-2010-08-303354
Published: 2011
Includes: Supplemental data
Journal Articles

Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells

Brief Report
Erin Hertlein, Georgia Triantafillou, Ellen J. Sass, Joshua D. Hessler, Xiaoli Zhang, David Jarjoura, David M. Lucas, Natarajan Muthusamy, David M. Goldenberg, Robert J. Lee, John C. Byrd
Journal: Blood
Blood (2010) 116 (14): 2554–2558.
https://doi.org/10.1182/blood-2009-11-253203
Published: 2010
Includes: Supplemental data
Journal Articles

17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

Erin Hertlein, Amy J. Wagner, Jeffrey Jones, Thomas S. Lin, Kami J. Maddocks, William H. Towns, III, Virginia M. Goettl, Xiaoli Zhang, David Jarjoura, Chelsey A. Raymond, Derek A. West, Carlo M. Croce, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2010) 116 (1): 45–53.
https://doi.org/10.1182/blood-2010-01-263756
Published: 2010
Includes: Supplemental data
Journal Articles

HLA-DR meets ERK

Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2010) 115 (25): 5126–5127.
https://doi.org/10.1182/blood-2010-03-270256
Published: 2010
Journal Articles

Combination Anti-CD74 (Milatuzumab) and CD20 (Rituximab) Monoclonal Antibody Therapy Has in Vitro and in Vivo Activity in Mantle Cell Lymphoma

Lapo Alinari, MD, Erin Hertlein, PhD, David M. Goldenberg, ScD, MD, Rosa Lapalombella, PhD, Fengting Yan, MD, PhD, Xiaoli Zhang, PhD, David M. Lucas, PhD, Natarajan Muthusamy, PhD, John C. Byrd, MD, Robert A. Baiocchi, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 886.
https://doi.org/10.1182/blood.V112.11.886.886
Published: 2008
Journal Articles

CLL and activated NF-κB: living partnership

Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2008) 111 (9): 4427.
https://doi.org/10.1182/blood-2008-02-137802
Published: 2008