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Ruben Abagyan
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Journal Articles

A Novel Selective BCL2 Inhibitor with Limited Immune Suppression and Improved Safety Compared to Venetoclax

Chia Sharpe, Sara Elgamal, Sydney Fobare, Casie Furby, Marissa Long, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Megan E. Johnstone, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Volodymyr Kysil, Hovhannes Gukasyan, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Kate Dokukina, Alexei Pushechnikov, Nikolay Savchuk, Iain Dukes, Amy Burd, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 4153.
https://doi.org/10.1182/blood-2023-189266
Published: 2023
Journal Articles

Therapeutic Targeting of FLT3 Gate Keeper Mutation with E2082-0047 in Traditional and a Novel Immunocompetent Murine Adoptive Transfer Model of AML

Ola A. Elgamal, Juan Carlos Zapata, Haishan Li, Chia Sharpe, Sydney Fobare, Blaise Stearns, James R. Lerma, Kinsey Bryant, Casie Furby, Marissa Long, Kaytlynn Fyock, Megan E. Johnstone, Thomas M. Sesterhenn, Benjamin Wronowski, Jianmin Pan, Shesh N. Rai, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Kate Dokukina, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Daniel T. Starczynowski, Amy Burd, C. David Pauza, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1544.
https://doi.org/10.1182/blood-2023-189259
Published: 2023
Journal Articles

A Novel Inhibitor of FLT3 and Its Drug-Resistant Mutants with Superior Activity to Gilteritinib in Molm-13 Preclinical Acute Myeloid Leukemia Xenograft Model

Ola A Elgamal, James R Lerma, Allison Mullaney, Emily Stahl, Blaise Stearns, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Oleg Mitkin, Ruben Karapetian, Alexei Riakhovskii, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Sharyn Baker, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 3352–3353.
https://doi.org/10.1182/blood-2022-165675
Published: 2022
Journal Articles

Small Molecule Inhibitor of Neutrophil Elastase Normalizes Myeloid Differentiation and Improves Impaired Cell Survival Triggered by Elastase Mutations In Patients with Severe Congenital Neutropenia and Acute Myeloid Leukemia

Andrew A. Aprikyan, PhD, Vahagn Makaryan, MD, Maxim Totrov, PhD, Ruben Abagyan, PhD, David C. Dale, MD
Journal: Blood
Blood (2010) 116 (21): 386.
https://doi.org/10.1182/blood.V116.21.386.386
Published: 2010
Journal Articles

Small Molecule Inhibitor of Neutrophil Elastase and Severe Congenital Neutropenia.

Andrew A Aprikyan, PhD, Vahagn Makaryan, MD, Maxim Totrov, PhD, Ruben Abagyan, PhD, David C. Dale, MD
Journal: Blood
Blood (2009) 114 (22): 552.
https://doi.org/10.1182/blood.V114.22.552.552
Published: 2009
Journal Articles

Small Molecule Inhibitor of Neutrophil Elastase Restores Impaired Production of Human Myeloid Cells Observed in Severe Congenital Neutropenia.

Andrew A. Aprikyan, PhD, Vahagn Makaryan, MD, Qian Si, PhD, Kelly Treonze, PhD, Nara Markosyan, BS, Paul Finke, PhD, Maxim Totrov, PhD, Ruben Abagyan, PhD, Richard Mumford, BA, David Dale, MD
Journal: Blood
Blood (2007) 110 (11): 664.
https://doi.org/10.1182/blood.V110.11.664.664
Published: 2007
Journal Articles

Diversity and Molecular Modeling of Neutrophil Elastase Mutations in Patients with Severe Congenital Neutropenia and Acute Myelogenous Leukemia.

Andrew A.G. Aprikyan, PhD, Steve Stein, MD, Nara A. Markosyan, Maxim Totrov, PhD, Ruben Abagyan, PhD, David C. Dale, MD
Journal: Blood
Blood (2004) 104 (11): 1454.
https://doi.org/10.1182/blood.V104.11.1454.1454
Published: 2004