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Ola A Elgamal
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Journal Articles

A Randomized Placebo-Controlled Phase 1 Trial in Healthy Volunteers Investigating the Safety, Pharmacokinetics and Pharmacodynamics of a Novel FLT3/IRAK4 Inhibitor, Lomonitinib (ZE46-0134)

John C. Byrd, Amy Burd, Brian Ledwith, Fraser Pickersgill, Kate Dokukina, Ruben Karapetian, Megan E. Johnstone, Erin K. Hertlein, Ola A. Elgamal, Alexei Pushechnikov, Nikolay Savchuk, Iain Dukes
Journal: Blood
Blood (2024) 144 (Supplement 1): 1396.
https://doi.org/10.1182/blood-2024-211491
Published: 2024
Journal Articles

The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy

Gerard Hilinski, Blaise Stearns, Sandip Vibhute, Tiffany Hughes, Susheela Tridandapani, Megan E. Johnstone, Thomas E. Goodwin, Jeffrey Patrick, Chad E. Bennett, Don Benson, John C. Byrd, Ola A. Elgamal, Erin K. Hertlein
Journal: Blood
Blood (2023) 142 (Supplement 1): 4692.
https://doi.org/10.1182/blood-2023-189238
Published: 2023
Journal Articles

Therapeutic Targeting of FLT3 Gate Keeper Mutation with E2082-0047 in Traditional and a Novel Immunocompetent Murine Adoptive Transfer Model of AML

Ola A. Elgamal, Juan Carlos Zapata, Haishan Li, Chia Sharpe, Sydney Fobare, Blaise Stearns, James R. Lerma, Kinsey Bryant, Casie Furby, Marissa Long, Kaytlynn Fyock, Megan E. Johnstone, Thomas M. Sesterhenn, Benjamin Wronowski, Jianmin Pan, Shesh N. Rai, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Kate Dokukina, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Daniel T. Starczynowski, Amy Burd, C. David Pauza, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1544.
https://doi.org/10.1182/blood-2023-189259
Published: 2023
Journal Articles

Development of a Fully Immunocompetent Adoptive Transfer In Vivo Model of Npm1 cA ;Idh2 R140Q ;Flt3 ITD AML

Chia Sharpe, Mariah Johnson, Sydney Fobare, Ola A. Elgamal, Bonnie K. Harrington, Allison Mustonen, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Jean Truxall, Casie Furby, Marissa Long, Kaytlynn Fyock, Alan Shih, Ross L Levine, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1386.
https://doi.org/10.1182/blood-2023-189975
Published: 2023
Journal Articles

Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy

Erin Hertlein, Chad Bennett, Ola A Elgamal, Sandip Vibhute, Sharyn Baker, Thomas E Goodwin, Don M. Benson, Jr., Christopher Coss, Jeffrey Patrick, Gerald Hilinski, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 10695–10696.
https://doi.org/10.1182/blood-2022-167671
Published: 2022
Journal Articles

Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia

Ola A Elgamal, Sandip Vibhute, Blaise Stearns, Susheela Tridandapani, Thomas E Goodwin, Gerard Hilinski, Chad Bennett, Jeffrey Patrick, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 3322–3323.
https://doi.org/10.1182/blood-2022-165611
Published: 2022
Journal Articles

A Novel Inhibitor of FLT3 and Its Drug-Resistant Mutants with Superior Activity to Gilteritinib in Molm-13 Preclinical Acute Myeloid Leukemia Xenograft Model

Ola A Elgamal, James R Lerma, Allison Mullaney, Emily Stahl, Blaise Stearns, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Oleg Mitkin, Ruben Karapetian, Alexei Riakhovskii, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Sharyn Baker, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 3352–3353.
https://doi.org/10.1182/blood-2022-165675
Published: 2022