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Brian Ledwith
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Journal Articles

A randomized placebo-controlled Phase 1 trial in healthy volunteers investigating safety, pharmacokinetics and pharmacodynamics of a novel menin inhibitor, balomenib (ZE63-0302): Interim analysis.

Free
Amy Burd, Brian Ledwith, Megan Johnstone, Erin Hertlein, Alexander Khvat, Ola Elgamal, Ruben Karapetian, Kate Dokukina, Fraser Pickersgill, Peter Schrader, Nikolay Savchuk, Iain Dukes, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 5067.
https://doi.org/10.1182/blood-2025-5067
Published: 2025
Journal Articles

A novel: Plasma apoptosis assay to demonstrate CLL cell target engagement in first-in-human study of a highly selective oral bcl-2 inhibitor lonitoclax (ZE50-0134)

Free
John Byrd, Brian Ledwith, Fraser Pickersgill, Kate Dokukina, Ruben Karapetian, Chia Sharpe, Erin Hertlein, Megan Johnstone, Alexei Pushechnikov, Christopher Argent, Nikolay Savchuk, Iain Dukes, Amy Burd
Journal: Blood
Blood (2025) 146 (Supplement 1): 6819.
https://doi.org/10.1182/blood-2025-6819
Published: 2025
Journal Articles

A healthy volunteer study with lomonitinib predicts pharmacokinetics and pharmacodynamics in a relapsed refractory AML study

Free
John Byrd, Brian Ledwith, Fraser Pickersgill, Kate Dokukina, Ruben Karapetian, Megan Johnstone, Erin Hertlein, Ola Elgamal, Alexei Pushechnikov, Carolyn Grove, Shaun Fleming, Stephen Ting, Genevieve Douglas, Tara Lin, Joshua Zeidner, Alice Mims, Peter Schrader, Iain Dukes, Nikolay Savchuk, Amy Burd
Journal: Blood
Blood (2025) 146 (Supplement 1): 6781.
https://doi.org/10.1182/blood-2025-6781
Published: 2025
Journal Articles

ZE74-0282 is a novel JH2 domain JAK2 inhibitor with promising pre-clinical activity in JAK2 V617F mutant diseases

Free
Shailaja Hegde, Alexander Khvat, Ruben Karapetian, Brian Ledwith, Fraser Pickersgill, Megan Johnstone, Eric Vick, Emily Curran, Iain Dukes, Amy Burd, Nikolay Savchuk, Vladislav Parchincky, Igor Rezekin, Erin Hertlein, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 1988.
https://doi.org/10.1182/blood-2025-1988
Published: 2025
Journal Articles

A Randomized Placebo-Controlled Phase 1 Trial in Healthy Volunteers Investigating the Safety, Pharmacokinetics and Pharmacodynamics of a Novel FLT3/IRAK4 Inhibitor, Lomonitinib (ZE46-0134)

Free
John C. Byrd, Amy Burd, Brian Ledwith, Fraser Pickersgill, Kate Dokukina, Ruben Karapetian, Megan E. Johnstone, Erin K. Hertlein, Ola A. Elgamal, Alexei Pushechnikov, Nikolay Savchuk, Iain Dukes
Journal: Blood
Blood (2024) 144 (Supplement 1): 1396.
https://doi.org/10.1182/blood-2024-211491
Published: 2024