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Journal Articles

The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy

Gerard Hilinski, Blaise Stearns, Sandip Vibhute, Tiffany Hughes, Susheela Tridandapani, Megan E. Johnstone, Thomas E. Goodwin, Jeffrey Patrick, Chad E. Bennett, Don Benson, John C. Byrd, Ola A. Elgamal, Erin K. Hertlein

Blood (2023) 142 (Supplement 1): 4692.

https://doi.org/10.1182/blood-2023-189238

Published: 2023

Journal Articles

Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia

Ola A Elgamal, Sandip Vibhute, Blaise Stearns, Susheela Tridandapani, Thomas E Goodwin, Gerard Hilinski, Chad Bennett, Jeffrey Patrick, Erin Hertlein, John C. Byrd

Blood (2022) 140 (Supplement 1): 3322–3323.

https://doi.org/10.1182/blood-2022-165611

Published: 2022

Journal Articles

Effects of the Btk Inhibitor Ibrutinib on Monocyte Responses to Antibodies

Li Ren, Amanda Campbell, Shalini Gautam, Huiqing Fang, Kavin Fatehchand, Andrew Stiff, Payal Mehta, Xiaokui Mo, PhD MAS, Xuexun Fang, John C. Byrd, MD, William Carson, Jonathan P. Butchar, PhD, Susheela Tridandapani, PhD

Blood (2015) 126 (23): 1017.

https://doi.org/10.1182/blood.V126.23.1017.1017

Published: 2015

Journal Articles

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

Noura Ismail, Yijie Wang, Duaa Dakhlallah, Leni Moldovan, Kitty Agarwal, Kara Batte, Prexy Shah, Jon Wisler, Tim D. Eubank, Susheela Tridandapani, Michael E. Paulaitis, Melissa G. Piper, Clay B. Marsh

Blood (2013) 121 (6): 984–995.

https://doi.org/10.1182/blood-2011-08-374793

Published: 2013

Includes: Supplemental data

Journal Articles

TLR7/8 Agonists Overcome the Suppression of FcγR Activity in Monocytes From Chronic Lymphocytic Leukemia Patients

Jonathan P. Butchar, Ph.D., Prexy Shah, B. Sci, Hemal Patel, B. Sci, Kavin Fatehchand, Sarwish Rafiq, MS, Carolyn Cheney, B.S, John P Vasilakos, Ph.D., Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD, Susheela Tridandapani, PhD

Blood (2012) 120 (21): 4595.

https://doi.org/10.1182/blood.V120.21.4595.4595

Published: 2012

Journal Articles

miR-155 regulates IFN-γ production in natural killer cells

Rossana Trotta, Li Chen, David Ciarlariello, Srirama Josyula, Charlene Mao, Stefan Costinean, Lianbo Yu, Jonathan P. Butchar, Susheela Tridandapani, Carlo M. Croce, Michael A. Caligiuri

Blood (2012) 119 (15): 3478–3485.

https://doi.org/10.1182/blood-2011-12-398099

Published: 2012

Journal Articles

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

Sarwish Rafiq, MS, Jonathan P. Butchar, PhD, Carolyn Cheney, Xiaokui Mo, PhD, David Jarjoura, PhD, Susheela Tridandapani, PhD, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD

Blood (2011) 118 (21): 3717.

https://doi.org/10.1182/blood.V118.21.3717.3717

Published: 2011

Journal Articles

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

Farrukh T. Awan, Rosa Lapalombella, Rossana Trotta, Jonathan P. Butchar, Bo Yu, Don M. Benson, Jr, Julie M. Roda, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Jones, Joseph Flynn, David Jarjoura, John R. Desjarlais, Susheela Tridandapani, Michael A. Caligiuri, Natarajan Muthusamy, John C. Byrd

Blood (2010) 115 (6): 1204–1213.

https://doi.org/10.1182/blood-2009-06-229039

Published: 2010

Journal Articles

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

Farrukh Awan, MD, MS, Rosa Lapalombella, PhD, Rossana Trotta, PhD, Jonathan P Butchar, Ph.D., Bo Yu, Don Benson, MD, PhD, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Alan Jones, MD, MPH, Joseph M Flynn, David Jarjoura, Robert A. Baiocchi, MD, PhD, John Desjarlais, Susheela Tridandapani, Ph.D., Michael A. Caligiuri, M.D., Natarajan Muthusamy, PhD, John C. Byrd

Blood (2009) 114 (22): 3725.

https://doi.org/10.1182/blood.V114.22.3725.3725

Published: 2009

Journal Articles

TLR7/8 Differentially Regulates Fcγ Receptor Expression and Function.

Jonathan P Butchar, Ph.D., Payal Mehta, M.S., Steven E Justiniano, Ph.D., Kristan D Guenterberg, M.D., Thirumala-Devi Kanneganti, Ph.D., Amal Amer, M.D., Ph.D., Natarajan Muthusamy, Ph.D., David Jarjoura, Ph.D., Clay B Marsh, M.D., William E Carson, III, M.D., John C Byrd, M.D., Susheela Tridandapani, Ph.D.

Blood (2009) 114 (22): 3594.

https://doi.org/10.1182/blood.V114.22.3594.3594

Published: 2009

Journal Articles

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

Blood (2008) 112 (13): 5180–5189.

https://doi.org/10.1182/blood-2008-01-133108

Published: 2008

Journal Articles

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Aruna Gowda, Julie Roda, Syed-Rehan A. Hussain, Asha Ramanunni, Trupti Joshi, Susan Schmidt, Xiaoli Zhang, Amy Lehman, David Jarjoura, William E. Carson, Wayne Kindsvogel, Carolyn Cheney, Michael A. Caligiuri, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd

Blood (2008) 111 (9): 4723–4730.

https://doi.org/10.1182/blood-2007-07-099531

Published: 2008

Journal Articles

Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-γ

Sri Vidya Kondadasula, Julie M. Roda, Robin Parihar, Jianhua Yu, Amy Lehman, Michael A. Caligiuri, Susheela Tridandapani, Richard W. Burry, William E. Carson, III

Blood (2008) 111 (8): 4173–4183.

https://doi.org/10.1182/blood-2007-01-068908

Published: 2008

Journal Articles

Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical

Xiaobin Zhao, Rosa Lapalombella, Trupti Joshi, Carolyn Cheney, Aruna Gowda, Martha S. Hayden-Ledbetter, Peter R. Baum, Thomas S. Lin, David Jarjoura, Amy Lehman, Donna Kussewitt, Robert J. Lee, Michael A. Caligiuri, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd

Blood (2007) 110 (7): 2569–2577.

https://doi.org/10.1182/blood-2006-12-062927

Published: 2007

Journal Articles

NK Cells Contribute Significantly to the Innate Immune Effector Role of CD37-Specific SMIP in CLL and NHL.

Xiaobin B. Zhao, MS, Joshi Trupti, B.S., Rosa Lapalombella, Ph. D., Carolyn Cheney, B.S., Aruna Gowda, M.D., Martha S. Hayden-Ledbetter, Ph. D., Peter R. Baum, Ph.D., Thomas S. Lin, M.D., Ph.D., David Jarjoura, Ph.D., Amy Lehman, M.S., Robert J. Lee, Ph.D., Michael A. Caligiuri, M.D., Susheela Tridandapani, Ph.D., Natarajan Muthusamy, Ph.D., John C. Byrd, M.D.

Blood (2006) 108 (11): 135.

https://doi.org/10.1182/blood.V108.11.135.135

Published: 2006

Journal Articles

FcγR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways

Latha P. Ganesan, Trupti Joshi, Huiqing Fang, Vijay Kumar Kutala, Julie Roda, Rossana Trotta, Amy Lehman, Periannan Kuppusamy, John C. Byrd, William E. Carson, Michael A. Caligiuri, Susheela Tridandapani

Blood (2006) 108 (2): 718–725.

https://doi.org/10.1182/blood-2005-09-3889

Published: 2006

Journal Articles

The inositol phosphatase SHIP-2 down-regulates FcγR-mediated phagocytosis in murine macrophages independently of SHIP-1

Jing Ai, Amita Maturu, Wesley Johnson, Yijie Wang, Clay B. Marsh, Susheela Tridandapani

Blood (2006) 107 (2): 813–820.

https://doi.org/10.1182/blood-2005-05-1841

Published: 2006

Journal Articles

Akt Activation Regulates Macrophage Survival and Differentiation: Role of M-CSF and Endogenous ROS.

Yijie Wang, MS, Mandy M. Zeigler, BS, Greg K. Lam, MD, Melissa G. Hunter, PhD, Tim D. Eubank, PhD, Susheela Tridandapani, PhD, Michael C. Ostrowski, PhD, Clay B. Marsh, MD

Blood (2005) 106 (11): 2208.

https://doi.org/10.1182/blood.V106.11.2208.2208

Published: 2005

Journal Articles

Differential expression of SHIP1 in CD56 bright and CD56 dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation

Rossana Trotta, Robin Parihar, Jianhua Yu, Brian Becknell, Jeffrey Allard, II, Jing Wen, Wei Ding, Hsiaoyin Mao, Susheela Tridandapani, William E. Carson, Michael A. Caligiuri

Blood (2005) 105 (8): 3011–3018.

https://doi.org/10.1182/blood-2004-10-4072

Published: 2005

NARROW

The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy

Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia

Effects of the Btk Inhibitor Ibrutinib on Monocyte Responses to Antibodies

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

TLR7/8 Agonists Overcome the Suppression of FcγR Activity in Monocytes From Chronic Lymphocytic Leukemia Patients

miR-155 regulates IFN-γ production in natural killer cells

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

TLR7/8 Differentially Regulates Fcγ Receptor Expression and Function.

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-γ

Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical

NK Cells Contribute Significantly to the Innate Immune Effector Role of CD37-Specific SMIP in CLL and NHL.

FcγR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways

The inositol phosphatase SHIP-2 down-regulates FcγR-mediated phagocytosis in murine macrophages independently of SHIP-1

Akt Activation Regulates Macrophage Survival and Differentiation: Role of M-CSF and Endogenous ROS.

Differential expression of SHIP1 in CD56 bright and CD56 dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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