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Benjamin H. Lee
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Journal Articles

CBX250 Is a Novel Cathepsin G Peptide-HLA-Targeting T Cell Engager That Exhibits High Tumor Antigen Selectivity and Potent Antileukemic Activity In Vivo

Benjamin H. Lee, Geraldine Paulus, Jennifer Helble, Preethi Sankaran, Tanzila Rahman, Delainey O'Connor, Melissa Bikowitz, Sarah Jaffe, Alona Kulesha, Bhupal Ban, Nga Sze Amanda Mak, Michael Princiotta, Chunhua Shi, Jun Yan, Hong He, Ningping Feng, Jeffrey J. Molldrem, Timothy Heffernan, Gheath Alatrash, Dmitri Wiederschain
Journal: Blood
Blood (2024) 144 (Supplement 1): 208.
https://doi.org/10.1182/blood-2024-201699
Published: 2024
Journal Articles

The Fully Human Anti-CD47 Antibody SRF231 Has Dual-Mechanism Antitumor Activity Against Chronic Lymphocytic Leukemia (CLL) Cells and Increases the Activity of Both Rituximab and Venetoclax

Rebecca Valentin, MD, Marisa O. Peluso, MS, Timothy Z. Lehmberg, BA, Ammar Adam, DVM, Li Zhang, MA, Caroline M. Armet, BS, Jennifer L. Guerriero, PhD, Benjamin H. Lee, MD PhD, Vito J. Palombella, PhD, Pamela M. Holland, PhD, Alison M. Paterson, PhD, Matthew S. Davids, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4393.
https://doi.org/10.1182/blood-2018-99-110181
Published: 2018
Journal Articles

Phosphoglycerate Mutase 1 Promotes Leukemia Metabolism by Coordinating Glycolysis and Biosynthesis, and Represnts a Therapuetic Target in Leukemia Treatment

Taro Hitosugi, PhD, Lu Zhou, PhD, Jun Fan, PhD, Martha Arellano, MD, Hanna J. Khoury, MD, Benjamin H. Lee, MD, PhD, Titus Boggon, PhD, Sumin Kang, PhD, Chuan He, Jing Chen, PhD
Journal: Blood
Blood (2012) 120 (21): 860.
https://doi.org/10.1182/blood.V120.21.860.860
Published: 2012
Journal Articles

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Nicholas A. Zorko, Kelsie M. Bernot, Susan P. Whitman, Ronald F. Siebenaler, Elshafa H. Ahmed, Gabriele G. Marcucci, Daniel A. Yanes, Kathleen K. McConnell, Charlene Mao, Chidimma Kalu, Xiaoli Zhang, David Jarjoura, Adrienne M. Dorrance, Nyla A. Heerema, Benjamin H. Lee, Gang Huang, Guido Marcucci, Michael A. Caligiuri
Journal: Blood
Blood (2012) 120 (5): 1130–1136.
https://doi.org/10.1182/blood-2012-03-415067
Published: 2012
Journal Articles

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang
Journal: Blood
Blood (2011) 117 (25): 6885–6894.
https://doi.org/10.1182/blood-2010-10-315721
Published: 2011
Includes: Supplemental data
Journal Articles

The Mll PTD and Flt3 ITD Double Knock-In Mouse Develops Acute Leukemia and Recapitulates Phenotypic, Molecular and Epigenetic Characteristics of the Counterpart Human Acute Myeloid Leukemia

Nicholas Zorko, Susan P. Whitman, PhD, Kelsie Bernot, PhD, Myntee T. Ngangana, Ronald Siebenaler, Shujun Liu, Ph.D., Yue-Zhong Wu, MS, Chidimma Kalu, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Zhiliang Xie, MD, Kenneth K. Chan, PhD, Adrienne M. Dorrance, PhD, Benjamin H. Lee, MD, PhD, Roger Briesewitz, PhD, Danilo Perrotti, MD, PhD, Guido Marcucci, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2010) 116 (21): 150.
https://doi.org/10.1182/blood.V116.21.150.150
Published: 2010
Journal Articles

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

Melanie G. Cornejo, Michael G. Kharas, Miriam B. Werneck, Séverine Le Bras, Sandra A. Moore, Brian Ball, Marie Beylot-Barry, Scott J. Rodig, Jon C. Aster, Benjamin H. Lee, Harvey Cantor, Jean-Philippe Merlio, D. Gary Gilliland, Thomas Mercher
Journal: Blood
Blood (2009) 113 (12): 2746–2754.
https://doi.org/10.1182/blood-2008-06-164368
Published: 2009
Includes: Supplemental data
Journal Articles

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoiesis and Leukemogenesis.

Inga Hofmann Zhang, MD, Elizabeth H. Stover, Dana E. Cullen, Junhao Mao, PhD, Kelly J. Morgan, PhD, Benjamin H. Lee, MD, PhD, Michael G. Kharas, PhD, Peter G. Miller, Rachel Okabe, Scott A. Armstrong, MD, PhD, Nico Ghilardi, PhD, Stephen Gould, PhD, Fred J. deSauvage, PhD, Andrew P. McMahon, PhD, D. Gary Gilliland, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1391.
https://doi.org/10.1182/blood.V112.11.1391.1391
Published: 2008
Journal Articles

Common Self-Renewal Pathways Contribute to the Induction of Acute Myeloid Leukemias Associated with Different Oncogenes

Brynn T Kvinlaug, BSc, MSc, Wai-In Chan, PhD, Lars Bullinger, MD, Christopher Sears, Donna Paul, Rachel Okabe, BSc, Benjamin H Lee, MD, PhD, Inusha De Silva, PhD, Scott Armstrong, MD, PhD, Hartmut Dohner, MD, D. Gary Gilliland, Brian JP Huntly, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 505.
https://doi.org/10.1182/blood.V112.11.505.505
Published: 2008
Journal Articles

OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Thomas Mercher, Ph.D, Glen D. Raffel, MD, PhD, Sandra A Moore, Melanie G Cornejo, Dominique Baudry-Bluteau, Ph.D, Nicolas Cagnard, Jonathan Jesneck, Yana Pikman, Dana E. Cullen, Ifor Williams, Koichi Akashi, MD, PhD, Hirokazu Shigematsu, Jean-Pierre Bourquin, MD, PhD, Marco Giovannini, MD, PhD, William Vainchenker, Ross L Levine, MD, Benjamin H. Lee, MD, PhD, Olivier Bernard, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (11): 508.
https://doi.org/10.1182/blood.V112.11.508.508
Published: 2008
Journal Articles

K-Ras G12D –induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors

Thomas Kindler, Melanie G. Cornejo, Claudia Scholl, Jianing Liu, Dena S. Leeman, J. Erika Haydu, Stefan Fröhling, Benjamin H. Lee, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (8): 3373–3382.
https://doi.org/10.1182/blood-2008-03-147587
Published: 2008
Journal Articles

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells

Winnie F. Tam, Ting-Lei Gu, Jing Chen, Benjamin H. Lee, Lars Bullinger, Stefan Fröhling, Andrew Wang, Stefano Monti, Todd R. Golub, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (5): 1981–1992.
https://doi.org/10.1182/blood-2007-07-103010
Published: 2008
Includes: Supplemental data
Journal Articles

Leukemogenic FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitor Cells in a Murine Model of Chronic Myelomonocytic Leukemia.

Benjamin H. Lee, Zuzana Tothova, Ross L. Levine, Kristina Anderson, Natalija Buza-Vidas, Dana E. Cullen, Elizabeth P. McDowell, Jennifer Adelsperger, Stefan Frohling, Brian J.P. Huntly, Miloslav Beran, Sten Eirik Jacobsen, D. Gary Gilliland
Journal: Blood
Blood (2007) 110 (11): 1613.
https://doi.org/10.1182/blood.V110.11.1613.1613
Published: 2007
Journal Articles

Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles.

Stefan Frohling, Claudia Scholl, Ross L. Levine, Marc Loriaux, Titus J. Boggon, Olivier A. Bernard, Roland Berger, Hartmut Dohner, Konstanze Dohner, Benjamin L. Ebert, Sewit Teckie, Todd R. Golub, Marcus M. Schittenhelm, Benjamin H. Lee, James D. Griffin, Richard M. Stone, Michael C. Heinrich, Michael W.N. Deininger, Brian J. Druker, D. Gary Gilliland
Journal: Blood
Blood (2007) 110 (11): 206.
https://doi.org/10.1182/blood.V110.11.206.206
Published: 2007
Journal Articles

Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera.

Gerlinde Wernig, MD, Michael G. Kharas, PhD, Rachel Okabe, Sandra A. Moore, Dena S. Leeman, Dana E. Cullen, Maricel Gozo, Elizabeth P. McDowell, Ross L. Levine, John Doukas, Chi Ching Mak, Glenn Noronha, Michael Martin, Yon D. Ko, Benjamin H. Lee, Richard Soll, Ayalew Tefferi, John D. Hood, D. Gary Gilliland
Journal: Blood
Blood (2007) 110 (11): 556.
https://doi.org/10.1182/blood.V110.11.556.556
Published: 2007
Journal Articles

Cdx4 Upregulates Hox Gene Expression and Generates Acute Myeloid Leukemia Alone and in Cooperation with Meis1a in a Murine Model.

Dimple Bansal, PhD, Claudia Scholl, M.D, Stefan Frohling, M.D, Elizabeth Mcdowell, B.S, Benjamin H. Lee, M.D, Ph.D., Konstanze Dohner, M.D., Patricia Ernst, Ph.D., Alan J. Davidson, Ph.D., George Q. Daley, M.D., Ph.D, Leonard I. Zon, M.D., D. Gary Gilliland, M. D, Ph. D, Brian J. Huntly, M. D, Ph.D
Journal: Blood
Blood (2006) 108 (11): 10.
https://doi.org/10.1182/blood.V108.11.10.10
Published: 2006
Journal Articles

FoxO Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress.

Zuzana Tothova, Ramya Kollipara, Brian J. Huntly, Benjamin H. Lee, Diego H. Castrillon, Emmanuelle A. Passegue, Dana E. Cullen, Elizabeth P. McDowell, Suzan Lazo-Kallanian, Ifor R. Williams, Ronald A. DePinho, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (11): 439.
https://doi.org/10.1182/blood.V108.11.439.439
Published: 2006
Journal Articles

Myeloproliferative Disease Induced by TEL-PDGFRB Displays Dynamic Range Sensitivity to Stat5 Gene Dosage in Mice.

Jennifer A. Cain, Jing Chen, Zhifu Xiang, Julie O’Neal, Benjamin H. Lee, Friederike Kreisel, Ifor Williams, AnnaLynn Colson, Michael H. Tomasson
Journal: Blood
Blood (2006) 108 (11): 3620.
https://doi.org/10.1182/blood.V108.11.3620.3620
Published: 2006
Journal Articles

Development of a Myeloproliferative Disease or a T Cell Lymphoblastic Leukemia in a Murine Bone Marrow Transplant Model of NUP214-ABL1.

Jennifer L. Rocnik, Melanie Cornejo, Benjamin H. Lee, Rachel Okabe, Elizabeth McDowell, Maricel Gozo, Kim De Keersmaecker, Jan Cools, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (11): 618.
https://doi.org/10.1182/blood.V108.11.618.618
Published: 2006
Journal Articles

Inhibition of the NPM-ALK Fusion Tyrosine Kinase in Hematopoietic Neoplasia by the Small Molecule Tyrosine Kinase Antagonist TAE684.

David W. Sternberg, MD, PhD, Arghya Ray, PhD, Benjamin H. Lee, MD, PhD, Jennifer Adelsperger, Nicole Duclos, Elizabeth McDowell, Naznin Haq, Patricia Imbach, Osamu Ohmori, Toshiyuki Honda, Markus Warmuth, Doriano Fabbro, PhD, James D. Griffin, MD, Johannes Roesel, PhD
Journal: Blood
Blood (2006) 108 (11): 828.
https://doi.org/10.1182/blood.V108.11.828.828
Published: 2006