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Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Silvia Buonamici, PhD, Akihide Yoshimi, MD PhD, Michael Thomas, Michael Seiler, PhD, Betty Chan, PhD, Benjamin Caleb, Rachel Darman, PhD, Peter Fekkes, PhD, Craig Karr, PhD, Gregg F. Keaney, PhD, Virginia M. Klimek, MD, Kaiko Kunii, Linda Lee, Stanley Chun-Wei Lee, PhD, Xiang Liu, PhD, Carol Meeske, Yoshiharu Mizui, PhD, Eric Padron, MD, Eunice Park, PhD, Ermira Pazolli, PhD, Sudeep Prajapati, PhD, Justin Taylor, MD, John Wang, PhD, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, MD, Omar Abdel-Wahab, MD, Peter G Smith, PhD
Journal: Blood
Blood (2016) 128 (22): 966.
https://doi.org/10.1182/blood.V128.22.966.966
Published: 2016
Journal Articles

Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells

Silvia Buonamici, PhD, Rachel Darman, PhD, Samantha Perino, BS, Anant Agrawal, PhD, Shouyong Peng, PhD, Michael Seiler, PhD, Kian Huat Lim, PhD, Erica B. Bhavsar, Jacob Feala, PhD, Esther A. Obeng, MDPhD, Suzanna Bailey, PhD, Betty Chan, PhD, Peter Fekkes, PhD, Gregg F. Keaney, PhD, Pavan Kumar, PhD, Kaiko Kunii, Linda Lee, MS, Crystal Mackenzie, Mark Matijevic, Yoshiharu Mizui, PhD, Khin Myint, Eunice Park, Ermira Pazolli, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Richard R. Furman, MD, Benjamin L Ebert, MD PhD, Peter G Smith, PhD
Journal: Blood
Blood (2015) 126 (23): 1643.
https://doi.org/10.1182/blood.V126.23.1643.1643
Published: 2015
Journal Articles

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

Silvia Buonamici, PhD, Samantha Perino, Kian Huat Lim, Jacob Feala, Esther A. Obeng, MDPhD, Michelle Aicher, Daniel Aird, Suzanna Bailey, Anna Berkenblit, Betty Chan, Corcoran Erik, Laura Corson, PhD, Rachel Darman, Peter Fekkes, Richard R. Furman, MD, Gregg F Keaney, PhD, Pavan Kumar, Kaiko Kunii, Linda Lee, Crystal Mackenzie, Eunice Park, Xiaoling Puyang, Anand Selvaraj, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Yoshiharu Mizui, PhD, Benjamin L. Ebert, MDPhD, Peter G Smith, PhD
Journal: Blood
Blood (2014) 124 (21): 4615.
https://doi.org/10.1182/blood.V124.21.4615.4615
Published: 2014
Journal Articles

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL

Sarah Decker, Katja Zirlik, Lauritte Djebatchie, David Hartmann, Gabriele Ihorst, Annette Schmitt-Graeff, Dieter Herchenbach, Hassan Jumaa, Markus Warmuth, Hendrik Veelken, Christine Dierks
Journal: Blood
Blood (2012) 119 (4): 997–1007.
https://doi.org/10.1182/blood-2011-06-359075
Published: 2012
Includes: Supplemental data
Journal Articles

Expansion of BCR-ABL Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation.

Christine Dierks, MD, Ronak Beigi, Mario Stegert, PhD, Katja Zirlik, MD, Annette Schmitt-Graeff, Hendrik Veelken, Markus Warmuth, MD
Journal: Blood
Blood (2007) 110 (11): 3379.
https://doi.org/10.1182/blood.V110.11.3379.3379
Published: 2007
Journal Articles

ITK-SYK Induces T-Cell Lymphoma with Accompanying Inflammatory Disease in Mice.

Christine Dierks, MD, Hong Ma, Hendrik Veelken, Markus Warmuth, MD, Francisco Adrian, PhD
Journal: Blood
Blood (2007) 110 (11): 693.
https://doi.org/10.1182/blood.V110.11.693.693
Published: 2007
Journal Articles

Hedgehog Pathway: A New Target for B-Cell Lymphomas an Multiple Myeloma.

Christine Dierks, MD, Jovana Grbic, Katja Zirlik, MD, Roland H. Mertelsman, MD, Markus Warmuth, MD
Journal: Blood
Blood (2006) 108 (11): 389.
https://doi.org/10.1182/blood.V108.11.389.389
Published: 2006
Journal Articles

Inhibition of the NPM-ALK Fusion Tyrosine Kinase in Hematopoietic Neoplasia by the Small Molecule Tyrosine Kinase Antagonist TAE684.

David W. Sternberg, MD, PhD, Arghya Ray, PhD, Benjamin H. Lee, MD, PhD, Jennifer Adelsperger, Nicole Duclos, Elizabeth McDowell, Naznin Haq, Patricia Imbach, Osamu Ohmori, Toshiyuki Honda, Markus Warmuth, Doriano Fabbro, PhD, James D. Griffin, MD, Johannes Roesel, PhD
Journal: Blood
Blood (2006) 108 (11): 828.
https://doi.org/10.1182/blood.V108.11.828.828
Published: 2006
Journal Articles

The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate

Christine Schuster, Karin Forster, Henning Dierks, Annika Elsässer, Gerhard Behre, Nicola Simon, Susanne Danhauser-Riedl, Michael Hallek, Markus Warmuth
Journal: Blood
Blood (2003) 101 (2): 655–663.
https://doi.org/10.1182/blood-2002-01-0043
Published: 2003
Journal Articles

Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate–resistant Bcr-Abl kinases

Markus Warmuth, Nicola Simon, Olga Mitina, Ruth Mathes, Doriano Fabbro, Paul W. Manley, Elisabeth Buchdunger, Karin Forster, Ismail Moarefi, Michael Hallek
Journal: Blood
Blood (2003) 101 (2): 664–672.
https://doi.org/10.1182/blood-2002-01-0288
Published: 2003